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1.发明申请Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesis 审中-公开用于抑制β-淀粉样蛋白肽释放和/或其合成的方法和化合物公开(公告)号：US20060223761A1
公开(公告)日：2006-10-05
申请号：US10768970
申请日：2004-02-02
申请人： James Audia , Thomas Britton , James Droste , Beverly Folmer , George Huffman , Varghese John , Lee Latimer , Thomas Mabry , Jeffrey Nissen , Warren Porter , Jon Reel , Eugene Thorsett , Jay Tung , Jing Wu , Clark Eid , William Scott
发明人： James Audia , Thomas Britton , James Droste , Beverly Folmer , George Huffman , Varghese John , Lee Latimer , Thomas Mabry , Jeffrey Nissen , Warren Porter , Jon Reel , Eugene Thorsett , Jay Tung , Jing Wu , Clark Eid , William Scott
IPC分类号： A61K38/04 , A61K31/47 , A61K31/405 , A61K31/4015 , A61K31/445
CPC分类号： C07K5/06191 , A61K31/00 , A61K31/4015 , A61K31/405 , A61K31/445 , A61K31/47 , A61K38/05 , A61K38/06 , C07K5/06078
摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease Also disclosed pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成，因此具有治疗阿尔茨海默病的效用的化合物。还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物，以及 用这种药物组合物预防性和治疗性地治疗阿尔茨海默病。
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公开(公告)号：US20050203080A1
公开(公告)日：2005-09-15
申请号：US10733877
申请日：2003-12-12
申请人： Jing Wu , Jay Tung , Eugene Thorsett , Michael Pleiss , Jeffrey Nissen , R. Neitz , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , James Droste , Steven Henry , Stacey McDaniel , William Scott , Russell Stucky , Warren Porter
发明人： Jing Wu , Jay Tung , Eugene Thorsett , Michael Pleiss , Jeffrey Nissen , R. Neitz , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , James Droste , Steven Henry , Stacey McDaniel , William Scott , Russell Stucky , Warren Porter
IPC分类号： A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/55 , A61K38/04 , A61K38/05 , A61P25/28 , C07D223/18 , C07D471/04 , C07D471/06 , C07D471/08
CPC分类号： C07D471/04 , A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/5513 , A61K38/05 , C07C237/22 , C07C2603/32 , C07D223/18 , C07D307/33 , C07D311/76 , C07D471/06 , C07D471/08
摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
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公开(公告)号：US20060079499A1
公开(公告)日：2006-04-13
申请号：US11001608
申请日：2004-12-02
申请人： Jing Wu , Jay Tung , Eugene Thorsett , Michael Pleiss , Jeffrey Nissen , R. Neitz , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , James Droste , Steven Henry , Stacey McDaniel , William Scott , Russell Stucky , Warren Porter
发明人： Jing Wu , Jay Tung , Eugene Thorsett , Michael Pleiss , Jeffrey Nissen , R. Neitz , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , James Droste , Steven Henry , Stacey McDaniel , William Scott , Russell Stucky , Warren Porter
IPC分类号： A61K31/55 , A61K31/445
CPC分类号： C07D471/04 , A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/5513 , A61K38/05 , C07C237/22 , C07C2603/32 , C07D223/18 , C07D307/33 , C07D311/76 , C07D471/06 , C07D471/08
摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
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公开(公告)号：US20050272666A1
公开(公告)日：2005-12-08
申请号：US11001610
申请日：2004-12-02
申请人： Jing Wu , Jay Tung , Eugene Thorsett , Michael Pleiss , Jeffrey Nissen , Jeffrey Neitz , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , James Droste , Steven Henry , Stacey McDaniel , William Scott , Russell Stucky , Warren Porter
发明人： Jing Wu , Jay Tung , Eugene Thorsett , Michael Pleiss , Jeffrey Nissen , Jeffrey Neitz , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , James Droste , Steven Henry , Stacey McDaniel , William Scott , Russell Stucky , Warren Porter
IPC分类号： A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/55 , A61K38/04 , A61K38/05 , A61P25/28 , C07D223/18 , C07D471/04 , C07D471/06 , C07D471/08
CPC分类号： C07D471/04 , A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/5513 , A61K38/05 , C07C237/22 , C07C2603/32 , C07D223/18 , C07D307/33 , C07D311/76 , C07D471/06 , C07D471/08
摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
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5.发明申请CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS 失效环己基，LACTAM，LACTONE和相关化合物，包含其的药物组合物，以及抑制β-淀粉样肽释放和/或通过使用这些化合物合成的方法公开(公告)号：US20050215541A1
公开(公告)日：2005-09-29
申请号：US10951992
申请日：2004-09-29
申请人： Jing Wu , Jay Tung , Eugene Thorsett , Michael Pleiss , Jeffrey Nissen , R. Jeffrey Neitz , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , James Droste , Steven Henry , Stacey McDaniel , William Scott , Russell Stucky , Warren Porter
发明人： Jing Wu , Jay Tung , Eugene Thorsett , Michael Pleiss , Jeffrey Nissen , R. Jeffrey Neitz , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , James Droste , Steven Henry , Stacey McDaniel , William Scott , Russell Stucky , Warren Porter
IPC分类号： A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/55 , A61K38/04 , A61K38/05 , A61P25/28 , C07D223/18 , C07D471/04 , C07D471/06 , C07D471/08
CPC分类号： C07D471/04 , A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/5513 , A61K38/05 , C07C237/22 , C07C2603/32 , C07D223/18 , C07D307/33 , C07D311/76 , C07D471/06 , C07D471/08
摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及用这种药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。
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6.发明申请Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds 审中-公开环烷基，内酰胺，内酯和相关化合物，包含其的药物组合物，以及通过使用这些化合物抑制β-淀粉样蛋白肽释放和/或其合成的方法公开(公告)号：US20050182046A1
公开(公告)日：2005-08-18
申请号：US10777247
申请日：2004-02-13
申请人： Jing Wu , Jay Tung , Eugene Thorsett , Michael Pleiss , Jeffrey Nissen , R. Neitz , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , James Droste , Steven Henry , Stacey McDaniel , William Scott , Russell Stucky , Warren Porter
发明人： Jing Wu , Jay Tung , Eugene Thorsett , Michael Pleiss , Jeffrey Nissen , R. Neitz , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , James Droste , Steven Henry , Stacey McDaniel , William Scott , Russell Stucky , Warren Porter
IPC分类号： A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/55 , A61K38/04 , A61K38/05 , A61P25/28 , C07D223/18 , C07D471/04 , C07D471/06 , C07D471/08
CPC分类号： C07D471/04 , A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/5513 , A61K38/05 , C07C237/22 , C07C2603/32 , C07D223/18 , C07D307/33 , C07D311/76 , C07D471/06 , C07D471/08
摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及用这种药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。
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公开(公告)号：USD832748S1
公开(公告)日：2018-11-06
申请号：US29609372
申请日：2017-06-29
申请人： William Scott
设计人： William Scott
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8.发明申请SAFETY MECHANISMS FOR POWER TOOLS, INCLUDING MAGNETORHELOGICAL BRAKE FOR BLADE 审中-公开用于电动工具的安全机构，包括用于刀片的磁力制动器公开(公告)号：US20150075343A1
公开(公告)日：2015-03-19
申请号：US14495311
申请日：2014-09-24
申请人： Andy Butler , Brian Lamb , Chris Tacklind , Clinton Lazzari , Edward Cooper , Eric Edward Schultz , Frank Buhrmann , John Gilbert , David Titzler , William Scott , Peter Domeny
发明人： Andy Butler , Brian Lamb , Chris Tacklind , Clinton Lazzari , Edward Cooper , Eric Edward Schultz , Frank Buhrmann , John Gilbert , David Titzler , William Scott , Peter Domeny
CPC分类号： B27B5/38 , B23D45/067 , B23D47/10 , B27B5/222 , B27B5/243 , Y10T83/081 , Y10T83/088 , Y10T83/089 , Y10T83/141 , Y10T83/613 , Y10T83/7697 , Y10T83/773 , Y10T83/7788 , Y10T83/8773
摘要： Various safety systems for power tools, and in particular table saws include detection systems for detecting a dangerous condition relative to a blade of the power tool, reaction systems for taking mitigation action in response to detection of a dangerous condition. The safety system may detect, prevent, and/or mitigate a dangerous condition associated with the power tool.
摘要翻译： 用于电动工具，特别是台锯的各种安全系统包括用于检测相对于电动工具的叶片的危险状况的检测系统，用于响应于危险状况的检测而采取缓解作用的反应系统。 安全系统可以检测，防止和/或减轻与电动工具相关联的危险状况。
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公开(公告)号：US08919231B2
公开(公告)日：2014-12-30
申请号：US13129948
申请日：2009-11-19
申请人： Andy Butler , Brian Lamb , Chris Tacklind , Clinton Lazzari , Edward Cooper , Eric Edward Schultz , Frank Buhrmann , John Gilbert , David Titzler , William Scott , Peter L. Domeny
发明人： Andy Butler , Brian Lamb , Chris Tacklind , Clinton Lazzari , Edward Cooper , Eric Edward Schultz , Frank Buhrmann , John Gilbert , David Titzler , William Scott , Peter L. Domeny
CPC分类号： B27B5/38 , B27B5/222 , Y10T83/081 , Y10T83/088 , Y10T83/089 , Y10T83/141 , Y10T83/613 , Y10T83/7697 , Y10T83/773 , Y10T83/7788 , Y10T83/8773
摘要： Various safety systems for power tools, and in particular table saws, include detection systems for detecting a dangerous condition relative to a blade of the power tool, and reaction systems for taking mitigation action in response to detection of a dangerous condition. The safety system may detect, prevent, and/or mitigate a dangerous condition associated with the power tool.
摘要翻译： 用于电动工具，特别是台锯的各种安全系统包括用于检测相对于电动工具的叶片的危险状况的检测系统和用于响应于危险状况的检测而采取缓解作用的反应系统。 安全系统可以检测，防止和/或减轻与电动工具相关联的危险状况。
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![Sulfone substituted 2,3-dihydroimidazo [1,2-C] quinazoline derivatives useful for treating hyper-proliferative disorders and diseases with angiogenesis](/abs-image/US/2014/10/14/US08859572B2/abs.jpg.150x150.jpg)
10.发明授权Sulfone substituted 2,3-dihydroimidazo [1,2-C] quinazoline derivatives useful for treating hyper-proliferative disorders and diseases with angiogenesis 有权用于治疗高增殖性疾病和血管生成疾病的砜取代的2,3-二氢咪唑并[1,2-C]喹唑啉衍生物公开(公告)号：US08859572B2
公开(公告)日：2014-10-14
申请号：US12812911
申请日：2009-01-13
申请人： Martin F. Hentemann , William Scott , Jill Wood , Jeffrey Johnson , Aniko Redman , Ann-Marie Bullion , Leatte Guernon
发明人： Martin F. Hentemann , William Scott , Jill Wood , Jeffrey Johnson , Aniko Redman , Ann-Marie Bullion , Leatte Guernon
IPC分类号： A61K31/519 , A61K45/06 , A61K31/541 , C07D487/04
CPC分类号： A61K45/06 , A61K31/519 , A61K31/541 , A61K2300/00 , C07D487/04
摘要： This invention relates to novel sulfone 2I3-dihydroimidazo[1 l2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyper-proliferative and/or angiogenesis mediated disorders, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及新的砜2I3-二氢咪唑并[11l-c]喹唑啉化合物，含有这些化合物的药物组合物以及这些化合物或组合物用于磷脂酰肌醇-3-激酶（PI3K）的用途，其用于抑制和治疗与磷脂酰肌醇-3- 激酶（PI3K）活性，特别是治疗高增殖和/或血管发生介导的病症，作为唯一的药剂或与其它活性成分组合。
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