公开(公告)号：US08604822B2

公开(公告)日：2013-12-10

申请号：US12956785

申请日：2010-11-30

申请人： Stefan Schroeder ,  Cyrus David Harbourt ,  Jie Shen

发明人： Stefan Schroeder ,  Cyrus David Harbourt ,  Jie Shen

IPC分类号： G01R31/40

CPC分类号： G01R31/42

摘要： A method of assembling a testing apparatus for a full-power converter assembly includes coupling an electric power supply apparatus to an electric power grid. The method also includes coupling a direct current (DC) generation apparatus to the electric power supply apparatus. The method further includes coupling an electric power grid simulation device to the DC generation apparatus. The method also includes coupling a full-power converter assembly test connection to the electric power grid simulation device.

摘要翻译： 一种组装全功率转换器组件的测试装置的方法包括将电力供应装置耦合到电力网。 该方法还包括将直流（DC）产生装置耦合到电力供应装置。 该方法还包括将电网模拟装置耦合到DC发生装置。 该方法还包括将全功率转换器组件测试连接耦合到电力网模拟设备。

公开(公告)号：US08144490B2

公开(公告)日：2012-03-27

申请号：US12615566

申请日：2009-11-10

申请人： Said Farouk Said El-Barbari ,  Robert Roesner ,  Jie Shen

发明人： Said Farouk Said El-Barbari ,  Robert Roesner ,  Jie Shen

IPC分类号： H02M7/487

CPC分类号： H02M7/487 ,  H02M7/5395 ,  Y10S323/906

摘要： A method of operating a three level converter includes controlling the output voltage of the converter when a DC link voltage of the three level converter is lower than one-half of a rated DC link voltage of the converter by, for each leg of the converter, alternately connecting an output terminal of the leg to the positive terminal or the negative terminal of the DC link. When the DC link voltage is at least one-half of the rated DC link voltage, the method includes controlling the output voltage of the converter by, for each leg, selectively connecting the output terminal of the converter to the positive terminal, the negative terminal, or a mid-point of the DC link.

摘要翻译： 一种操作三电平转换器的方法包括：当三电平转换器的直流母线电压低于转换器的额定直流母线电压的一半时，通过转换器的每个支路来控制转换器的输出电压， 交替地将脚的输出端连接到DC链路的正极或负极。 当直流母线电压至少为额定直流母线电压的一半时，该方法包括通过对每个支路选择性地将转换器的输出端连接到正极端子来控制转换器的输出电压，负极端子 ，或DC链路的中点。

公开(公告)号：US20100298205A1

公开(公告)日：2010-11-25

申请号：US12639627

申请日：2009-12-16

申请人： Jie Shen ,  Devin F. Welty ,  Diane D. Tang-Liu

发明人： Jie Shen ,  Devin F. Welty ,  Diane D. Tang-Liu

IPC分类号： A61K38/06 ,  A61K31/4439 ,  A61K31/47 ,  A61P1/00

CPC分类号： A61K31/4704 ,  A61K31/4439 ,  A61K38/06 ,  A61K45/06 ,  A61K2300/00

摘要： A method comprising orally administering to a mammal a proton pump inhibitor, or a pharmaceutically acceptable prodrug thereof, and a compound which modulates the activity of the MRP2 or other transporter proteins involved in efflux of a proton pump inhibitor or a prodrug, is disclosed herein, said method being effective for the prevention or treatment of a disease or condition related to gastric acid secretion. This method applied to compounds which both inhibit and stimulate MRP2 activity or activity of other transporter proteins involved in efflux of a proton pump inhibitor or a prodrug.Compositions, medicaments, and experimental results related thereto are also disclosed.

摘要翻译： 本文公开了一种方法，其包括向哺乳动物施用质子泵抑制剂或其药学上可接受的前药，以及调节参与质子泵抑制剂或前药流出的MRP2或其它转运蛋白的活性的化合物， 所述方法对于预防或治疗与胃酸分泌有关的疾病或病症是有效的。 该方法适用于抑制和刺激涉及质子泵抑制剂或前体药物流出的其他转运蛋白的MRP2活性或活性的化合物。 还公开了与其相关的组合物，药物和实验结果。

公开(公告)号：US07528612B2

公开(公告)日：2009-05-05

申请号：US11541137

申请日：2006-09-29

申请人： Neil Gollhardt ,  David L. Jensen ,  Fahed Awad ,  Jie Shen ,  David D. Brandt ,  David T. Rollay

发明人： Neil Gollhardt ,  David L. Jensen ,  Fahed Awad ,  Jie Shen ,  David D. Brandt ,  David T. Rollay

IPC分类号： G01R31/08 ,  H01R27/02

CPC分类号： H02B13/025 ,  H02B1/36 ,  H02B11/02 ,  H02H3/04 ,  H02H7/0822

摘要： A system, in one embodiment, includes a power distribution center having an enclosure with an access door configured to move between a closed position and an open position. The power distribution center includes a non-contact sensor disposed inside the enclosure, wherein the non-contact sensor includes a non-contact voltage sensor, or a non-contact temperature sensor, or a combination thereof. The power distribution center also includes an indicator viewable outside of the enclosure while the door is in the closed position, wherein the indicator is coupled to the non-contact sensor.

摘要翻译： 在一个实施例中，系统包括配电中心，配电中心具有外壳，其具有被配置为在关闭位置和打开位置之间移动的通道门。 配电中心包括设置在外壳内的非接触传感器，其中非接触式传感器包括非接触式电压传感器或非接触式温度传感器，或其组合。 在门处于关闭位置时，配电中心还包括可在外壳外部观察的指示器，其中指示器联接到非接触式传感器。

公开(公告)号：US20090090623A1

公开(公告)日：2009-04-09

申请号：US12153272

申请日：2008-05-15

申请人： Min-Chieh Chuang ,  Yun-Chu Ho ,  Tai-Kang Shing ,  Chung-Chiun Liu ,  Jie Shen

发明人： Min-Chieh Chuang ,  Yun-Chu Ho ,  Tai-Kang Shing ,  Chung-Chiun Liu ,  Jie Shen

IPC分类号： G01N33/50 ,  H01B1/22

CPC分类号： H01B1/22 ,  H01B1/24

摘要： The invention discloses a biosensor includes a strip having an integrated heating element and an electrode with metallized graphite including metal in the range of 0.1-5% in weight; graphite in the range of below 55% in weight; and polymer. The biosensor further includes an electric measuring device having a slot enabling the strip to insert therein.

摘要翻译： 本发明公开了一种生物传感器，其包括具有集成加热元件的条带和包含0.1-5重量％范围内金属的金属化石墨的电极; 石墨的重量在55％以下; 和聚合物。 生物传感器还包括具有能够将条插入其中的槽的电测量装置。

公开(公告)号：US07271313B2

公开(公告)日：2007-09-18

申请号：US10409672

申请日：2003-04-09

申请人： Jie Shen

发明人： Jie Shen

IPC分类号： A01K67/027 ,  C12N15/00

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0312 ,  C07K14/4711 ,  C12N15/8509 ,  C12N2800/30

摘要： The present invention is directed to recombinantly engineered mice that are deficient in the expression of both presenilin-1 and presenilin-2. The mice exhibit characteristics of age-dependent cognitive impairments and neurodegeneration similar to those seen in Alzheimer's disease patients. This presenilin-deficient mouse model can be used to screen compounds capable of slowing, preventing or reversing the progression of cognitive impairments and neurodegeneration. The invention is also directed to the development of treatments for Alzheimer's disease based on augmentation or restoration of presenilin function in the brain. On the basis of the findings described herein, the invention is further directed to the development of assays to detect functional presenilin deficiency in human individuals, preferably through analysis of presenilin substrates, which may provide biomarkers useful in the diagnosis of Alzheimer's disease.

摘要翻译： 本发明涉及缺乏早老素-1和早老蛋白-2的表达的重组工程小鼠。 老鼠显示与老年痴呆症患者相似的年龄依赖性认知障碍和神经变性的特征。 这种早老素缺乏型小鼠模型可用于筛选能够减缓，预防或逆转认知障碍和神经退行性进展的化合物。 本发明还涉及基于大脑中早老素功能的增强或恢复的阿尔茨海默病治疗的发展。 基于本文所述的发现，本发明进一步涉及开发用于检测人类个体中功能性早老素缺乏症的测定法，优选通过分析早老素底物，其可以提供可用于诊断阿尔茨海默氏病的生物标志物。

公开(公告)号：US20210244851A1

公开(公告)日：2021-08-12

申请号：US17170310

申请日：2021-02-08

申请人： Jie Shen ,  Jianjun Guan

发明人： Jie Shen ,  Jianjun Guan

IPC分类号： A61L27/22 ,  A61L27/58 ,  A61L27/18

摘要： Methods and formulations for promoting the healing of fracture nonunion sites under inflammatory conditions. The formulation includes a flexible biodegradable scaffold loaded with therapeutically effective amounts of CXCL12 and SPPI encapsulated in biodegradable microspheres. The method includes applying the formulation directly to a region of a fracture nonunion to effect sustained local release of the therapeutically effective amounts of CXCL12 and SPPI to the fracture nonunion region.

公开(公告)号：US20130194881A1

公开(公告)日：2013-08-01

申请号：US13878419

申请日：2011-11-07

申请人： Steven C. Woo ,  Amir Amirkhany ,  Catherine Chen ,  David Secker ,  Jie Shen

发明人： Steven C. Woo ,  Amir Amirkhany ,  Catherine Chen ,  David Secker ,  Jie Shen

IPC分类号： G11C7/00

CPC分类号： G11C7/00 ,  G06F13/1694

摘要： One or more pins may be modally assigned to either the command/address (C/A) or data (DQ) blocks of a uniform-package, multi-modal PHY (physical signaling interface) of a memory controller, thus enabling those pins to be used as C/A pins when the PHY is connected to some memory types, and as DQ pins when the PHY is connected to other memory types.

摘要翻译： 一个或多个引脚可以被模式地分配给存储器控制器的均匀封装，多模态PHY（物理信令接口）的命令/地址（C / A）或数据（DQ）块，从而使得这些引脚 当PHY连接到某些存储器类型时，用作C / A引脚，当PHY连接到其他存储器类型时用作引脚。

公开(公告)号：US08441820B2

公开(公告)日：2013-05-14

申请号：US12893015

申请日：2010-09-29

申请人： Jie Shen ,  Stefan Schroeder ,  Robert Roesner

发明人： Jie Shen ,  Stefan Schroeder ,  Robert Roesner

IPC分类号： H02H7/122 ,  H02M7/537

CPC分类号： H02M7/487 ,  H02M2001/0025

摘要： A control system for a multilevel converter includes a differential mode current regulator, a neutral point (NP) controller and a PWM controller for generating switching pulses for the multilevel converter. The differential mode current regulator generates reference voltage command signals based on a difference between reference current command signals and actual current command signals, and the NP controller determines a modified neutral point current signal in response to a DC link voltage unbalance. The NP controller utilizes the modified neutral point current signal to generate a common mode reference voltage signal. The switching pulses are generated by the PWM controller based on the reference voltage command signals and the common mode reference voltage signal.

摘要翻译： 用于多电平转换器的控制系统包括差模电流调节器，中性点（NP）控制器和用于产生用于多电平转换器的开关脉冲的PWM控制器。 差分电流调节器基于参考电流指令信号和实际电流指令信号之间的差产生参考电压指令信号，并且NP控制器响应于直流链路电压不平衡来确定修正的中性点电流信号。 NP控制器利用修正的中性点电流信号产生共模参考电压信号。 开关脉冲由PWM控制器基于参考电压指令信号和共模参考电压信号产生。

公开(公告)号：US08354805B2

公开(公告)日：2013-01-15

申请号：US12740125

申请日：2008-11-03

申请人： Joseph Hendrik Anna Maria Jacobs ,  Jie Shen ,  Dirk Hente

发明人： Joseph Hendrik Anna Maria Jacobs ,  Jie Shen ,  Dirk Hente

IPC分类号： H05B37/02

CPC分类号： H05B33/0866 ,  H05B33/0818

摘要： Devices (10) for driving loads (20) such as organic/inorganic light emitting diodes are provided with drivers (11) for driving the loads (20), with converters (12) for converting first parameter signals defining parameters of the loads (20) into second parameter signals each being defined by one bit per time interval, and with digital controllers (13) for controlling the drivers (11) in response to the second parameter signals. The converter (12) may comprise a comparator circuit (40) and a timer circuit (41) for comparing the first parameter signal with a reference signal and for generating the second parameter signal having a respective first or second value of two possible values in case of a respective first or second comparison result. The parameter may be a current flowing through or light emitted by at least a part of the load (20). The driver (11) may be a buck/boost/buck boost/fly back converter.

摘要翻译： 用于驱动诸如有机/无机发光二极管的负载（20）的装置（10）设置有用于驱动负载（20）的驱动器（11），转换器（12）用于转换定义负载参数的第一参数信号（20 ）到每个由每个时间间隔一位定义的第二参数信号，以及用于响应于第二参数信号来控制驱动器（11）的数字控制器（13）。 转换器（12）可以包括比较器电路（40）和定时器电路（41），用于将第一参数信号与参考信号进行比较，并且用于产生具有相应的第一或第二值两个可能值的第二参数信号， 各自的第一或第二比较结果。 参数可以是流过或由至少一部分负载（20）发射的电流。 驱动器（11）可以是降压/升压/降压升压/回扫转换器。