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1.发明申请公开(公告)号：US20080090290A1
公开(公告)日：2008-04-17
申请号：US11668256
申请日：2007-01-29
申请人： Jill Giles-Komar , David Knight , David Peritt , Bernard Scallon , David Shealy
发明人： Jill Giles-Komar , David Knight , David Peritt , Bernard Scallon , David Shealy
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Isolated nucleic acids encoding an anti-IL-12 antibody or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders.
摘要翻译： 编码抗IL-12抗体或抗体部分的分离的核酸，载体，宿主细胞和制备方法可用于产生抗体或用于治疗和/或诊断IL-12相关病症和疾病的部分。
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公开(公告)号：US20050002937A1
公开(公告)日：2005-01-06
申请号：US10912994
申请日：2004-08-06
申请人： Jill Giles-Komar , David Knight , David Peritt , Bernard Scallon , David Shealy
发明人： Jill Giles-Komar , David Knight , David Peritt , Bernard Scallon , David Shealy
IPC分类号： A01H1/00 , A01K67/027 , A61K20060101 , A61K38/00 , A61K39/395 , A61K45/00 , A61P20060101 , A61P17/06 , A61P25/00 , A61P37/00 , A61P43/00 , C07K20060101 , C07K16/24 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N20060101 , C07H21/04 , C12N5/06
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to at least one novel anti-IL-12 antibodies, including isolated nucleic acids that encode at least one anti-IL-12 antibody, IL-12, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
摘要翻译： 本发明涉及至少一种新的抗IL-12抗体，包括编码至少一种抗IL-12抗体，IL-12，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 包括治疗组合物，方法和装置。
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3.发明授权公开(公告)号：US08329170B2
公开(公告)日：2012-12-11
申请号：US13299831
申请日：2011-11-18
申请人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
发明人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K31/137 , A61K31/56 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K51/00 , A61K2039/505 , C07K14/54 , C07K14/5434 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C12Q1/6876
摘要： An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in treating IL-12-related disorders, such as psoriasis.
摘要翻译： 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体，其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列，包括编码至少一种抗IL-12抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 并且其用途可用于治疗诸如银屑病的IL-12相关疾病。
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4.发明申请公开(公告)号：US20120207670A1
公开(公告)日：2012-08-16
申请号：US13299831
申请日：2011-11-18
申请人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
发明人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
IPC分类号： A61K39/395 , A61P29/00 , A61P23/00 , A61P37/00 , A61P37/04 , A61P5/00 , A61P37/06 , A61P23/02 , A61K51/00 , A61P21/00 , A61P21/02 , A61P25/20 , A61P17/06 , A61P31/00
CPC分类号： C07K16/244 , A61K31/137 , A61K31/56 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K51/00 , A61K2039/505 , C07K14/54 , C07K14/5434 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C12Q1/6876
摘要： An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in treating IL-12-related disorders, such as psoriasis.
摘要翻译： 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体，其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列，包括编码至少一种抗IL-12抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 并且其用途可用于治疗诸如银屑病的IL-12相关疾病。
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公开(公告)号：US20090202549A1
公开(公告)日：2009-08-13
申请号：US11722312
申请日：2005-12-20
申请人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
发明人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
IPC分类号： A61K39/395 , G01N33/53 , C12P21/04 , C12N5/10 , C12N5/02 , C12N15/63 , C07K16/24 , C07H21/04
CPC分类号： C07K16/244 , A61K31/137 , A61K31/56 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K51/00 , A61K2039/505 , C07K14/54 , C07K14/5434 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C12Q1/6876
摘要： An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译： 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体，其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列，包括编码至少一种抗IL-12抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。
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公开(公告)号：US20050214293A1
公开(公告)日：2005-09-29
申请号：US10975708
申请日：2004-10-28
申请人： Jill Giles-Komar , David Knight , David Peritt , Bernard Scallon , David Shealy
发明人： Jill Giles-Komar , David Knight , David Peritt , Bernard Scallon , David Shealy
IPC分类号： A01H1/00 , A01K67/027 , A61K20060101 , A61K38/00 , A61K39/395 , A61K45/00 , A61P20060101 , A61P17/06 , A61P25/00 , A61P37/00 , A61P43/00 , C07K20060101 , C07K16/24 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N20060101
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to an anti-IL-12 antibody, including isolated nucleic acids that encode an anti-IL-12 antibody, IL-12, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
摘要翻译： 本发明涉及抗IL-12抗体，包括编码抗IL-12抗体，IL-12，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用方法，包括 治疗组合物，方法和装置。
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公开(公告)号：US20050112127A1
公开(公告)日：2005-05-26
申请号：US10975883
申请日：2004-10-28
申请人： Jill Giles-Komar , David Knight , David Peritt , Bernard Scallon , David Shealy
发明人： Jill Giles-Komar , David Knight , David Peritt , Bernard Scallon , David Shealy
IPC分类号： A01H1/00 , A01K67/027 , A61K20060101 , A61K38/00 , A61K39/395 , A61K45/00 , A61P20060101 , A61P17/06 , A61P25/00 , A61P37/00 , A61P43/00 , C07K20060101 , C07K16/24 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N20060101
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to an anti-IL-12 antibody, including isolated nucleic acids that encode an anti-IL-12 antibody, IL-12, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
摘要翻译： 本发明涉及抗IL-12抗体，包括编码抗IL-12抗体，IL-12，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用方法，包括 治疗组合物，方法和装置。
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公开(公告)号：US08080247B2
公开(公告)日：2011-12-20
申请号：US11722312
申请日：2005-12-20
申请人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
发明人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/244 , A61K31/137 , A61K31/56 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K51/00 , A61K2039/505 , C07K14/54 , C07K14/5434 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C12Q1/6876
摘要： An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译： 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体，其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列，包括编码至少一种抗IL-12抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。
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公开(公告)号：US20050196838A1
公开(公告)日：2005-09-08
申请号：US10975740
申请日：2004-10-28
申请人： Jill Giles-Komar , David Knight , David Peritt , Bernard Scallon , David Shealy
发明人： Jill Giles-Komar , David Knight , David Peritt , Bernard Scallon , David Shealy
IPC分类号： A01H1/00 , A01K67/027 , A61K20060101 , A61K38/00 , A61K39/395 , A61K45/00 , A61P20060101 , A61P17/06 , A61P25/00 , A61P37/00 , A61P43/00 , C07K20060101 , C07K16/24 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N20060101 , C07H21/04 , C12N5/06
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to an anti-IL-12 antibody, including isolated nucleic acids that encode an anti-IL-12 antibody, IL-12, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
摘要翻译： 本发明涉及抗IL-12抗体，包括编码抗IL-12抗体，IL-12，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用方法，包括 治疗组合物，方法和装置。
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10.发明申请Anti-IL-12 Antibodies, Nucleic Acids Encoding Antibodies, and Methods of Production 有权抗IL-12抗体，编码抗体的核酸和生产方法公开(公告)号：US20090274707A1
公开(公告)日：2009-11-05
申请号：US12500120
申请日：2009-07-09
IPC分类号： A61K39/395 , C07K16/00 , C07H21/00 , C12N15/63 , C12N5/00 , C12N1/00 , C12N5/06 , C12N5/08 , C12N5/10 , C12P21/00 , C12Q1/02 , A01H5/00 , A61P37/00
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders.
摘要翻译： 分离的抗IL-12抗体，编码抗体或抗体部分的核酸，载体，宿主细胞和制备方法可用于产生抗体或用于治疗和/或诊断IL-12相关病症和疾病的部分。
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