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    POLYNUCLEOTIDE ENCODING A NOVEL ACYL COENZYME A, MONOACYLGLYCEROL ACYLTRANSFERASE-3 (MGAT3), AND USES THEREOF
    1.
    发明申请
    POLYNUCLEOTIDE ENCODING A NOVEL ACYL COENZYME A, MONOACYLGLYCEROL ACYLTRANSFERASE-3 (MGAT3), AND USES THEREOF 审中-公开
    多核苷酸编码新型ACYL COENZYME A，单乙酰胆碱酯酶3（MGAT3）及其用途

    公开(公告)号：US20080019958A1

    公开(公告)日：2008-01-24

    申请号：US11779308

    申请日：2007-07-18

    申请人： John Feder ,  Thomas Nelson ,  Jian Chen ,  Rupalie Meegalla ,  Michael Ramaker ,  Dong Cheng

    发明人： John Feder ,  Thomas Nelson ,  Jian Chen ,  Rupalie Meegalla ,  Michael Ramaker ,  Dong Cheng

    IPC分类号： C07K16/18 ,  A61K38/45 ,  C12N1/00 ,  C12P21/02 ,  C12Q1/48 ,  C12N9/10 ,  A61P1/00

    CPC分类号： C12N9/1029

    摘要： The present invention provides novel polynucleotides encoding MGAT3 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MGAT3 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, such as obesity. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码MGAT3多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型MGAT3多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症如肥胖症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotide encoding a novel acyl coenzyme A, monoacylglycerol acyltransferase-3 (MGAT3), and uses thereof
    2.
    发明授权
    Polynucleotide encoding a novel acyl coenzyme A, monoacylglycerol acyltransferase-3 (MGAT3), and uses thereof 有权
    编码新型酰基辅酶A，单酰基甘油酰基转移酶-3（MGAT3）的多核苷酸及其用途

    公开(公告)号：US07259002B2

    公开(公告)日：2007-08-21

    申请号：US10761905

    申请日：2004-01-21

    申请人： John N. Feder ,  Thomas C. Nelson ,  Jian Chen ,  Rupalie Meegalla ,  Michael Ramaker ,  Dong Cheng

    发明人： John N. Feder ,  Thomas C. Nelson ,  Jian Chen ,  Rupalie Meegalla ,  Michael Ramaker ,  Dong Cheng

    IPC分类号： C12N9/10 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

    CPC分类号： C12N9/1029

    摘要： The present invention provides novel polynucleotides encoding MGAT3 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing MGAT3 polypeptides, fragments, and homologues thereof. The invention further relates to diagnostic and therapeutic methods for applying these novel MGAT3 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, such as obesity. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码MGAT3多肽的新型多核苷酸，其片段及其同源物。 还提供载体，宿主细胞，抗体，以及用于产生MGAT3多肽，其片段及其同源物的重组和合成方法。 本发明还涉及将这些新型MGAT3多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症如肥胖症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。