公开(公告)号：US11759633B2

公开(公告)日：2023-09-19

申请号：US16771626

申请日：2018-11-29

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ki Hoon Ahn ,  Soo Hyun Lee

IPC: A61N1/36 ,  A61B5/00 ,  A61N1/05 ,  A61N1/372 ,  A61B5/391

CPC classification number: A61N1/36007 ,  A61B5/0002 ,  A61B5/391 ,  A61N1/0524 ,  A61N1/3606 ,  A61N1/36135 ,  A61N1/37223 ,  A61B2560/0406

Abstract: The present disclosure relates to neural electrode technology for measuring a biosignal of a human or applying a neural signal to the human, and a neural electrode assembly includes a body that is inserted into a uterus in a non-invasive manner, a recording neural electrode formed to measure a uterine contraction-evoked neural signal, the recording neural electrode being coupled to the body, and a stimulating neural electrode formed to stimulate a nerve entering the uterus to suppress the uterine contraction, the stimulating neural electrode being coupled to the body.

公开(公告)号：US20140100639A1

公开(公告)日：2014-04-10

申请号：US13688729

申请日：2012-11-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soo Hyun Lee ,  Ji Yoon Kang ,  Nakwon Choi

IPC: A61N1/05

CPC classification number: A61N1/0556 ,  A61B5/04001 ,  A61B2562/0209 ,  A61B2562/125 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/43 ,  A61L2400/12 ,  A61L2420/08 ,  A61N1/0553

Abstract: A nerve electrode that is inserted into a living body and that is configured to attach to nerves is provided. The nerve electrode that is inserted into a living body and that is configured to attach to nerves includes: i) a flexible substrate; ii) a plurality of electrodes that are separately positioned on the flexible substrate; and iii) an insulating layer that is positioned at a separation space of the plurality of electrodes and that insulates the plurality of electrodes. The plurality of electrodes include i) at least one linear electrode, and ii) a planar electrode that is separated from the linear electrode. An anti-inflammatory drug transfer layer is positioned on the planar electrode.

Abstract translation: 提供了插入生物体并被配置为附着于神经的神经电极。 插入到生物体中并被配置为附着到神经的神经电极包括：i）柔性基底; ii）分别定位在柔性基板上的多个电极; 以及iii）绝缘层，其位于所述多个电极的分离空间处并使所述多个电极绝缘。 多个电极包括i）至少一个线状电极，以及ii）与线状电极分离的平面电极。 将抗炎药物转移层定位在平面电极上。

公开(公告)号：US09061137B2

公开(公告)日：2015-06-23

申请号：US13688729

申请日：2012-11-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soo Hyun Lee ,  Ji Yoon Kang ,  Nakwon Choi

IPC: A61N1/05 ,  A61L31/16 ,  A61L31/10 ,  A61B5/04

CPC classification number: A61N1/0556 ,  A61B5/04001 ,  A61B2562/0209 ,  A61B2562/125 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/43 ,  A61L2400/12 ,  A61L2420/08 ,  A61N1/0553

Abstract: A nerve electrode that is inserted into a living body and that is configured to attach to nerves is provided. The nerve electrode that is inserted into a living body and that is configured to attach to nerves includes: i) a flexible substrate; ii) a plurality of electrodes that are separately positioned on the flexible substrate; and iii) an insulating layer that is positioned at a separation space of the plurality of electrodes and that insulates the plurality of electrodes. The plurality of electrodes include i) at least one linear electrode, and ii) a planar electrode that is separated from the linear electrode. An anti-inflammatory drug transfer layer is positioned on the planar electrode.

Abstract translation: 提供了插入生物体并被配置为附着于神经的神经电极。 插入到生物体中并被配置为附着到神经的神经电极包括：i）柔性基底; ii）分别定位在柔性基板上的多个电极; 以及iii）绝缘层，其位于所述多个电极的分离空间处并使所述多个电极绝缘。 多个电极包括i）至少一个线状电极，以及ii）与线状电极分离的平面电极。 将抗炎药物转移层定位在平面电极上。

公开(公告)号：US11668709B2

公开(公告)日：2023-06-06

申请号：US16579852

申请日：2019-09-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soo Hyun Lee ,  Ji Yoon Kang ,  Hyewhon Rhim ,  Yi Jae Lee ,  Hyewon Seo ,  Yun Kyung Kim

IPC: G01N33/543 ,  G01N33/68 ,  G16B40/10

CPC classification number: G01N33/54373 ,  G01N33/54326 ,  G01N33/6845 ,  G01N33/6896 ,  G16B40/10 ,  G01N2440/00 ,  G01N2440/14 ,  G01N2440/38 ,  G01N2800/2821

Abstract: The present disclosure relates to a system for monitoring post-translational modification of protein using a biosensor with a gap, which performs with high reliability a diagnosis of a disease associated with a target protein for which impedance is measured, by measuring an impedance of a sample introduced into a sensor and calculating a change rate of the measured impedance, and to a method of manufacturing the biosensor used for the system.

公开(公告)号：US11280781B2

公开(公告)日：2022-03-22

申请号：US16587062

申请日：2019-09-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soo Hyun Lee ,  Nakwon Choi ,  Byung Chul Lee ,  Hyungbeen Lee ,  Mintack Oh

IPC: G01N33/543 ,  C12M1/00 ,  G01N29/02 ,  C12N15/10

Abstract: The present disclosure relates to an apparatus and a method for extracting genome, capable of acquiring a sufficient amount of genome for genetic analysis with high extraction efficiency, even with a small amount of target sample.

公开(公告)号：US09304135B2

公开(公告)日：2016-04-05

申请号：US14315455

申请日：2014-06-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Byung Hwa Jung ,  Soo Hyun Lee ,  Myung Soo Kim

IPC: G01N33/49 ,  G01N30/72 ,  H01J49/00 ,  G01N33/574 ,  G01N33/68

CPC classification number: G01N33/57446 ,  G01N30/7233 ,  G01N33/492 ,  G01N33/6812 ,  G01N33/6848 ,  G01N2800/06 ,  G01N2800/60 ,  H01J49/00 ,  Y10T436/24

Abstract: The present disclosure relates to stomach cancer diagnosis using tryptophan metabolism rate in one aspect, and it relates to an invention using change of tryptophan metabolism rate in a stomach cancer patient, which is different from a normal person.

Abstract translation: 本公开涉及在一个方面中使用色氨酸代谢率的胃癌诊断，并且涉及使用与正常人不同的胃癌患者中色氨酸代谢率变化的发明。