公开(公告)号：US11679133B2

公开(公告)日：2023-06-20

申请号：US15780153

申请日：2016-11-28

Applicant: Kadimastem Ltd. ,  Yeda Research and Development Co. Ltd.

Inventor： Kfir Molakandov ,  Neta Lavon ,  Avital Beck ,  Michel Revel ,  Ofer Elhanani ,  Yoav Soen ,  Michael Walker ,  Arik Hasson

IPC: A61K35/39 ,  C12N5/00 ,  C12N5/071 ,  A61P5/50 ,  A61P3/10

CPC classification number: A61K35/39 ,  A61P3/10 ,  A61P5/50 ,  C12N5/0676 ,  C12N2500/25 ,  C12N2500/34 ,  C12N2500/38 ,  C12N2501/599 ,  C12N2506/02 ,  C12N2506/45

Abstract: The present invention relates to compositions and methods comprising cell surface markers for pluripotent-derived cells, in particular, pancreatic endoderm-type cells, derived from pluripotent stem cells.

公开(公告)号：US11406670B2

公开(公告)日：2022-08-09

申请号：US16281490

申请日：2019-02-21

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michel Revel ,  Judith Chebath ,  Michal Izrael ,  Rosalia Kaufman

IPC: A61K35/30 ,  C12N5/0793 ,  C12N5/079 ,  G01N33/50

Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.

公开(公告)号：US20190175658A1

公开(公告)日：2019-06-13

申请号：US16281490

申请日：2019-02-21

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michel Revel ,  Judith Chebath ,  Michal Izrael ,  Rosalia Kaufman

IPC: A61K35/30 ,  C12N5/079 ,  C12N5/0793

Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.

公开(公告)号：US10258651B2

公开(公告)日：2019-04-16

申请号：US15468020

申请日：2017-03-23

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michel Revel ,  Judith Chebath ,  Michal Izrael ,  Rosalia Kaufman

IPC: A61K48/00 ,  A61K35/30 ,  C12N5/0793 ,  C12N5/079 ,  G01N33/50

Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.

公开(公告)号：US20170362570A1

公开(公告)日：2017-12-21

申请号：US15468020

申请日：2017-03-23

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michel Revel ,  Judith Chebath ,  Michal Izrael ,  Rosalia Kaufman

IPC: C12N5/079 ,  G01N33/50 ,  A61K35/30 ,  C12N5/0793

CPC classification number: A61K35/30 ,  C12N5/0619 ,  C12N5/0622 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/155 ,  C12N2501/385 ,  C12N2501/41 ,  C12N2506/02 ,  C12N2533/52 ,  C12N2533/90 ,  G01N33/5058

Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.

公开(公告)号：US09631175B2

公开(公告)日：2017-04-25

申请号：US14329510

申请日：2014-07-11

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michel Revel ,  Judith Chebath ,  Michal Izrael ,  Rosalia Kaufman

IPC: A01N63/00 ,  C12N5/079 ,  C12N5/0793 ,  A61K35/30 ,  G01N33/50

CPC classification number: C12N5/0622 ,  A61K35/30 ,  C12N5/0619 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/155 ,  C12N2501/385 ,  C12N2501/41 ,  C12N2506/02 ,  C12N2533/52 ,  C12N2533/90 ,  G01N33/5058

Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.

公开(公告)号：US20210054334A1

公开(公告)日：2021-02-25

申请号：US16564893

申请日：2019-09-09

Applicant: Kadimastem Ltd.

Inventor： Michal Izrael ,  Michel Revel ,  Arik Hasson ,  Kfir Molakandov ,  Judith Chebath

IPC: C12N5/079 ,  A61K35/30 ,  G01N33/50 ,  C12N5/0793

Abstract: The present invention discloses a method of identifying agents that affect human astrocytes functionality using ex-vivo differentiated pluripotent stem cells (PSC). In addition, the use of human progenitor astrocytes or human astrocytes for the treatment of Amyotrophic Lateral Sclerosis (ALS) in a human subject is also disclosed.

公开(公告)号：US20180230427A1

公开(公告)日：2018-08-16

申请号：US15863016

申请日：2018-01-05

Applicant: Kadimastem Ltd.

Inventor： Michal Izrael ,  Michel Revel ,  Arik Hasson ,  Kfir Molakandov ,  Judith Chebath

IPC: C12N5/079 ,  C12N5/0793 ,  G01N33/50 ,  A61K35/30

CPC classification number: C12N5/0622 ,  A61K35/30 ,  C12N5/0619 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/385 ,  C12N2502/081 ,  C12N2502/086 ,  C12N2503/02 ,  C12N2503/04 ,  C12N2506/02 ,  C12N2533/32 ,  C12N2533/52 ,  C12N2533/90 ,  G01N33/5058 ,  G01N33/5073 ,  G01N2510/00

Abstract: The present invention discloses a method of identifying agents that affect human astrocytes functionality using ex-vivo differentiated pluripotent stem cells (PSC). In addition, the use of human progenitor astrocytes or human astrocytes for the treatment of Amyotrophic Lateral Sclerosis (ALS) in a human subject is also disclosed.

公开(公告)号：US20200003757A1

公开(公告)日：2020-01-02

申请号：US16511985

申请日：2019-07-15

Applicant: KADIMASTEM, LTD.

Inventor： Michel Revel ,  Judith Chebath ,  Arye Hasson ,  Michal Izrael ,  Rosalia Kaufman

IPC: G01N33/50

Abstract: The present invention discloses a method of identifying agents that affect maturation and survival of oligodendrocytes or myelination of neuronal cells using ex-vivo differentiated embryonic stem cells.

公开(公告)号：US20170095512A1

公开(公告)日：2017-04-06

申请号：US15315934

申请日：2015-06-02

Applicant: KADIMASTEM LTD.

Inventor： Michal Izrael ,  Michel Revel ,  Arik Hasson ,  Judith Chebath

IPC: A61K35/30 ,  C12N5/079 ,  A61K31/519

CPC classification number: A61K35/30 ,  A61K31/4418 ,  A61K31/519 ,  A61K38/18 ,  C12N5/0622 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/155 ,  C12N2501/727 ,  C12N2506/02 ,  C12N2506/08 ,  C12N2533/32 ,  C12N2533/90

Abstract: The present invention disclosed methods of inducing maturation of oligodendrocyte cells. A method of inducing myelination in a patient suffering from demyelination is also disclosed