摘要:
An object of this invention is to provide an adsorbent for immunosuppressive substance, which adsorbent can highly efficiently and selectively adsorb an excessive immunosuppressive substance directly from the body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. Such an excessive immunosuppressive substance may be involved in growth of cancer cells. An adsorbent for immunosuppressive substance of the invention includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column of the invention contains the adsorbent of the invention. A method for treating cancer of the invention carries out extracorporeal perfusion using the extracorporeal perfusion column of the invention.
摘要:
An adsorbent for immunosuppressive substance, which can adsorb an excessive immunosuppressive substance directly from a body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. The excessive immunosuppressive substance may be involved in growth of cancer cells. The adsorbent for immunosuppressive substance includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column contains the adsorbent of the invention. A method for treating cancer carries out extracorporeal perfusion using the extracorporeal perfusion column. A method of adsorbing the transforming growth factor β which is combined with another protein, includes adsorbing the transforming growth factor β and protein on an adsorbent containing a water-insoluble carrier to which quaternary ammonium groups each having 3 to 18 carbon atoms per one nitrogen atom are attached, and having a specific surface area of 0.1 m2 or more per gram.
摘要:
An adsorbent for immunosuppressive substance, which can adsorb an excessive immunosuppressive substance directly from a body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. The excessive immunosuppressive substance may be involved in growth of cancer cells. The adsorbent for immunosuppressive substance includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column contains the adsorbent of the invention. A method for treating cancer carries out extracorporeal perfusion using the extracorporeal perfusion column. A method of adsorbing the transforming growth factor β which is combined with another protein, includes adsorbing the transforming growth factor β and protein on an adsorbent containing a water-insoluble carrier to which quaternary ammonium groups each having 3 to 18 carbon atoms per one nitrogen atom are attached, and having a specific surface area of 0.1 m2 or more per gram.
摘要:
A metal ion that inhibits enzyme deactivation is bonded to a carrier and inhibits enzyme deactivation when contacted with a substrate for the enzyme. A carrier-bound metal ion such as ions of iron is particularly suitable for inhibiting deactivation of glucose isomerase when isomerizing glucose to fructose. Glucose isomerase life is remarkably prolonged by contacting carrier-bound iron ions with a glucose substrate solution prior to isomerizing with glucose isomerase.
摘要:
An enzymatically active product for use in isomerization of glucose into fructose is provided. The active product comprises an organic polymeric material predominantly comprised of a monovinyl aromatic compound polymer having .beta.-aminopropionamidomethyl group as side chains represented by the formula I: ##STR1## wherein R.sub.1 is selected from H, C(1-6) alkyl and C(2-6) hydroxyalkyl, R.sub.2 is selected from C(1-6) alkyl, C(2-6) hydroxyalkyl, ##STR2## (where X, Z.sub.1 and Z.sub.2 are selected from H and C(1-6) alkyl, and n is from 2 to 6), or R.sub.1 and R.sub.2 form together with the N atom, to which R.sub.1 and R.sub.2 are bonded, heterocyclic structure of the formula: ##STR3## where A is --CH.sub.2 --, --O-- or --NR.sub.6 -- (wherein R.sub.6 is H or C(1-6) alkyl), and R.sub.3, R.sub.4 and R.sub.5 are selected from H and methyl. The organic polymeric material has glucose isomerase immobilized with the .beta.-aminopropionamidomethyl group side chain of the organic polymeric material.
摘要:
An enzymatically active product for use in isomerization of glucose into fructose is provided. The active product comprises an organic polymeric material predominantly comprised of a monovinyl aromatic compound polymer having .beta.-aminopropionamidomethyl group as side chains represented by the formula I: ##STR1## wherein R.sub.1 is selected from H, C(1-6) alkyl and C(2-6) hydroxyalkyl, R.sub.2 is selected from C(1-6) alkyl, C(2-6)hydroxyalkyl, ##STR2## (where X, Z.sub.1 and Z.sub.2 are selected from H and C(1-6) alkyl, and n is from 2 to 6), or R.sub.1 and R.sub.2 form together with the N atom, to which R.sub.1 and R.sub.2 are bonded, a heterocylic structure of the formula: ##STR3## where A is --CH.sub.2 --, --O-- or --NR.sub.6 -- (wherein R.sub.6 is H or C(1-6) alkyl), and R.sub.3, R.sub.4 and R.sub.5 are selected from H and methyl. The organic polymeric material has glucose isomerase immobilized with the .beta.-aminopropionamidomethyl group side chain of the organic polymeric material.
摘要:
A game server provides a second game after a ranking of players is determined based on results of a first game in which plural players have participated is provided with an allocator that allocates a first option of plural first options to each of a predetermined number of high-order players in the ranking of the first game, the first option allocated to one of the high-order players differing from the first option allocated to another of the high-order players; a low-order player entry receiver that receives an entry for participation in the second game from a low-order player other than the predetermined number of high-order players, the entry for participation being received when one of the plural first options is selected; a determination unit that determines one of options including the plural first options; and a benefit awarder that awards benefit to a player having selected the first option determined by the determination unit.
摘要:
The invention provides a flexible metal-clad dielectric including a Be--Cu alloy foil, with an enriched electrical conductivity and a mean grain size of 20 .mu.m or less, which is laminated with a highly flexible resin film. The invention thus has improved bending characteristic and significantly reduces failures in flexible printed circuit boards.
摘要:
The present invention relates to a method for purification of liquids. Fur particulars, the present invention relates to a method for purifying more precisely liquids in atomic power related fields, using a mixture of a polymer in which carboxyl groups are grafted onto a polyamide or a polyester as a cation exchanger and an anion exchanger.
摘要:
An antifouling structure in contact with seawater or at least its surface layer is made up of a beryllium copper alloy having a beryllium content lying in the range of 0.2% by weight to 2.8% by weight. While this antifouling structure is immersed in seawater, a beryllium or copper oxide film is formed on the surface layer of the beryllium copper alloy mother material and beryllium or copper ions are liberated from the exposed surface layer of the beryllium copper alloy mother material into seawater. As years go by, the beryllium or copper oxide film peels away from the beryllium copper alloy mother material. Due to indeterminate repetition of such peeling, the liberation of beryllium or copper ions from the exposed surface layer of the beryllium copper alloy mother material into seawater is sustained.