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    Interferon alpha antibodies and their uses
    2.
    发明授权
    Interferon alpha antibodies and their uses 有权
    干扰素α抗体及其用途

    公开(公告)号：US08025882B2

    公开(公告)日：2011-09-27

    申请号：US12551250

    申请日：2009-08-31

    申请人： Alison J. Witte ,  Denise Williams ,  Josephine M. Cardarelli ,  David J. King ,  David B. Passmore

    发明人： Alison J. Witte ,  Denise Williams ,  Josephine M. Cardarelli ,  David J. King ,  David B. Passmore

    IPC分类号： A61K39/395

    CPC分类号： C07K16/249 ,  A61K51/1021 ,  A61K2039/505 ,  C07K16/24 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/76

    摘要： The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.

    摘要翻译： 本发明提供分离的抗干扰素α单克隆抗体，特别是人单克隆抗体，其抑制多种干扰素（IFN）α亚型的生物学活性，但基本上不抑制IFNα21的生物活性或IFNβ的生物学活性 或IFNγ。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体抑制IFNα的生物学活性的方法，以及通过施用本发明的抗体来治疗由IFNα介导的疾病或病症的方法，例如自身免疫疾病，移植排斥反应和移植物抗宿主病 本发明的抗体。

    Interferon alpha antibodies and their uses
    4.
    发明授权
    Interferon alpha antibodies and their uses 有权
    干扰素α抗体及其用途

    公开(公告)号：US08475797B2

    公开(公告)日：2013-07-02

    申请号：US13211092

    申请日：2011-08-16

    申请人： Alison Witte ,  Denise Williams ,  Josphine M Cardelli ,  David King ,  David Passmore

    发明人： Alison Witte ,  Denise Williams ,  Josphine M Cardelli ,  David King ,  David Passmore

    IPC分类号： A61K39/395

    CPC分类号： C07K16/249 ,  A61K51/1021 ,  A61K2039/505 ,  C07K16/24 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/76

    摘要： The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.

    摘要翻译： 本发明提供分离的抗干扰素α单克隆抗体，特别是人单克隆抗体，其抑制多种干扰素（IFN）α亚型的生物学活性，但基本上不抑制IFNα21的生物活性或IFNβ的生物学活性 或IFNγ。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体抑制IFNα的生物学活性的方法，以及通过施用本发明的抗体来治疗由IFNα介导的疾病或病症的方法，例如自身免疫疾病，移植排斥反应和移植物抗宿主病 本发明的抗体。

    Interferon alpha antibodies and their uses
    7.
    发明申请
    Interferon alpha antibodies and their uses 有权
    干扰素α抗体及其用途

    公开(公告)号：US20070014724A1

    公开(公告)日：2007-01-18

    申请号：US11009410

    申请日：2004-12-10

    申请人： Alison Witte ,  Denise Williams ,  Josephine Cardarelli ,  David King ,  David Passmore

    发明人： Alison Witte ,  Denise Williams ,  Josephine Cardarelli ,  David King ,  David Passmore

    IPC分类号： A61K51/00 ,  C07H21/04 ,  C12P21/06 ,  A61K39/395 ,  C12N5/06 ,  C07K16/24 ,  C07K16/46

    CPC分类号： C07K16/249 ,  A61K51/1021 ,  A61K2039/505 ,  C07K16/24 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/76

    摘要： The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.

    摘要翻译： 本发明提供分离的抗干扰素α单克隆抗体，特别是人单克隆抗体，其抑制多种干扰素（IFN）α亚型的生物学活性，但基本上不抑制IFNα21的生物活性或IFNβ的生物学活性 或IFNγ。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体抑制IFNα的生物学活性的方法，以及通过施用本发明的抗体来治疗由IFNα介导的疾病或病症的方法，例如自身免疫疾病，移植排斥反应和移植物抗宿主病 本发明的抗体。

    SYSTEMS AND METHODS FOR MANAGING MEDICAL INFORMATION
    10.
    发明申请
    SYSTEMS AND METHODS FOR MANAGING MEDICAL INFORMATION 审中-公开
    管理医疗信息的系统和方法

    公开(公告)号：US20090012813A1

    公开(公告)日：2009-01-08

    申请号：US12167744

    申请日：2008-07-03

    申请人： Kristie Innocenti Berzansky ,  Stanton McComb ,  Binny John ,  Hamsa Konanur ,  David Barber ,  Paras Desai ,  Kruti Goswami ,  Denise Williams ,  Shabari Madappa

    发明人： Kristie Innocenti Berzansky ,  Stanton McComb ,  Binny John ,  Hamsa Konanur ,  David Barber ,  Paras Desai ,  Kruti Goswami ,  Denise Williams ,  Shabari Madappa

    IPC分类号： G06Q50/00 ,  G06Q10/00

    CPC分类号： G06Q10/06 ,  G06Q10/10 ,  G06Q50/22 ,  G06Q50/24

    摘要： Systems and methods for managing medical information for medical service providers are provided. Personnel are able to manage and track workflow operations, evaluate profitability, and maintain records in an integrated and streamlined manner by executing various modules of a software application. A Dashboard module provides a unitary display of information regarding employee efficiency and operational profitability; a Virtual Will Call module allows for the virtual placement of items in storage areas reflecting the corresponding physical will call storage locations; an Rx Tracker module provides information regarding the status of prescriptions as they go through the process from ordered to dispensed; the Maintenance module allows personnel to define customized delivery methods; and the Archive Viewer module provides a way for personnel to archive images in any accessible drive or memory device, including portable storage media, and to view such images independently of the module using an archive viewer executable.

    摘要翻译： 提供了医疗服务提供者医疗信息管理系统和方法。 人员能够通过执行软件应用程序的各种模块来管理和跟踪工作流操作，评估盈利能力以及以集成和简化的方式维护记录。 仪表板模块提供有关员工效率和运营盈利能力的信息的统一显示; 虚拟呼叫模块允许在反映相应物理的存储区域中的项目的虚拟放置将调用存储位置; Rx跟踪器模块提供关于处方从订购到分发的过程中的状态的信息; 维护模块允许人员定义定制的交货方式; 并且存档查看器模块为人员提供了在任何可访问的驱动器或存储设备（包括便携式存储介质）中归档映像的方式，并使用归档查看器可执行文件独立于模块来查看这些图像。