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1.发明授权Process for preparing a heat-stable aqueous solution of human urine kallikrein and product prepared 失效制备人尿激肽释放酶热稳定水溶液的方法和制备的产品
公开(公告)号：US4500514A
公开(公告)日：1985-02-19
申请号：US557107
申请日：1983-12-01
IPC分类号： C12N9/96 , A61K38/48 , A61L2/00 , A61K37/553
CPC分类号： A61L2/0023 , A61K38/4853
摘要： Human urine kallikrein dissolved in water is made heat-stable by the addition of a citric acid salt such as sodium citrate, so that an aqueous solution containing the kallikrein and the citric acid salt can be sterilized at 60.degree. to 70.degree. C.
摘要翻译： 溶解在水中的人尿激肽释放酶通过加入柠檬酸钠等柠檬酸盐而使其稳定，使得含有激肽释放酶和柠檬酸盐的水溶液可以在60℃至70℃下灭菌。
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公开(公告)号：US5750650A
公开(公告)日：1998-05-12
申请号：US67180
申请日：1993-05-24
摘要： A novel peptide having molecular weight of 31,000 (SDS-PAGE) is obtained from aqueous extract of Natto or the culture of Bacillus natto by purification procedures including alcohol fractionation and/or salting out and hydrophobic chromatography, and the physicochemical properties, including the amino acid sequence, of the peptide are determined. The peptide is active in fibrinolysis, exhibits strong thrombolytic activity by oral administration and is useful as an oral thrombolytic agent.
摘要翻译： 通过包括醇分馏和/或盐析和疏水色谱法的纯化方法从Natto的水提取物或纳豆芽孢杆菌的培养物获得分子量为31,000的新型肽（SDS-PAGE），并且包括氨基酸的物理化学性质 确定肽的序列。 该肽在纤维蛋白溶解中有活性，通过口服给药具有强烈的溶栓活性，可用作口服溶栓剂。
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公开(公告)号：US5296223A
公开(公告)日：1994-03-22
申请号：US960259
申请日：1992-10-13
申请人： Koichiro Nakanishi , Hajime Hiratani , Kazuo Kato
发明人： Koichiro Nakanishi , Hajime Hiratani , Kazuo Kato
IPC分类号： A61K38/46 , A61K9/48 , A61K38/48 , A61P7/02 , A61K37/547
CPC分类号： A61K38/482
摘要： There are provided thrombolytic agents suited for oral administration. The agent comprises a proteolytic enzyme of subtilisin family, such as subtilisin BPN', subtilisin Carsberg, subtilisin amylosacchariticus, etc., produced by microorganisms belonging to genus Bacillus, such as Bacillus subtilis, Bacillus licheniformis, Bacillus amyloliquefaciens, etc. and, even when administered orally, exhibits thrombolytic activity.
摘要翻译： 提供适合口服给药的溶栓剂。 该试剂包括枯草杆菌蛋白酶家族的蛋白水解酶，如枯草杆菌蛋白酶BPN'，枯草杆菌蛋白酶Carsberg，枯草杆菌蛋白酶淀粉酵母等，由属于芽孢杆菌属的微生物如枯草芽孢杆菌，地衣芽孢杆菌，解淀粉芽孢杆菌等产生，并且即使 口服给药，具有溶栓活性。
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公开(公告)号：US4946785A
公开(公告)日：1990-08-07
申请号：US208156
申请日：1988-06-17
CPC分类号： C12N9/6462 , C12N9/96 , C12Y304/21073
摘要： The thermal degradation of urokinase in an aqueous solution is suppressed by heating an aqueous solution containing urokinase in the presence of citric acid or a water-soluble salt thereof such as sodium, potassium or lithium citrate at about 60.degree. C. for about 10 hours.
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5.发明授权Process for concentrating and separating trypsin inhibitor and kallidinogenase in human urine 失效浓缩和分离人尿中胰蛋白酶抑制剂和杀鼠肽素酶的方法
公开(公告)号：US4780209A
公开(公告)日：1988-10-25
申请号：US104634
申请日：1987-10-02
CPC分类号： C12N9/6445 , C07K14/8114 , Y10S435/814 , Y10S435/815
摘要： Two components, trypsin and kallidinogenase, in human urine are concentrated simultaneously by allowing human urine at neutral pH, collecting bubbles thus formed to obtain the concentrate of the two components, adjusting the concentrate to weak acidity, contacting the acidified concentrate with chitosan to allow the two components to be adsorbed onto chitosan, eluting the components from the adsorbent with aqueous ammonia solution, and neutralizing and heating the eluate at about 60.degree. C. for about 10 hours to make the eluate virus-free, followed by separating the components from the eluate.
摘要翻译： 将人尿中的两种成分，胰蛋白酶和杀鼠肽素酶同时浓缩，使人尿液处于中性pH值，收集形成的气泡，得到两种成分的浓缩物，将浓缩物调节至弱酸性，将酸化浓缩物与壳聚糖接触， 吸附在壳聚糖上的两种组分，用氨水溶液从吸附剂中洗脱组分，并在约60℃下中和并加热洗脱液约10小时，使洗脱液无病毒，然后将组分从 洗脱液
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公开(公告)号：US4510248A
公开(公告)日：1985-04-09
申请号：US509030
申请日：1983-06-29
CPC分类号： C12N9/6445
摘要： Human urinary kallikrein is concentrated and purified by the following procedures; (a) Human urine is contacted with chitosan, a high molecular agglutinant obtained from chitin, at a pH from 4.0 to 7.0, thereby kallikrein is adsorbed on the chitosan and (b) kallikrein is eluted from the chitosan with an aqueous alkaline solution having a pH from 8.0 to 12.0.
摘要翻译： 人尿激肽释放酶通过以下程序浓缩和纯化; （a）将人尿与壳多糖（几丁质获得的高分子凝集素）在4.0至7.0的pH下接触，由此激肽释放酶被吸附在壳聚糖上，（b）激肽释放酶用含有碱性溶液的水溶性脱乙酰壳多糖 pH 8.0〜12.0。
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7.发明授权公开(公告)号：US08033886B2
公开(公告)日：2011-10-11
申请号：US12689450
申请日：2010-01-19
申请人： Kinya Kamiguchi , Tomonori Nakazawa , Toshimitsu Kawase , Nobuhiro Ito , Mitsutoshi Hasegawa , Koichiro Nakanishi , Kazuo Koyanagi
发明人： Kinya Kamiguchi , Tomonori Nakazawa , Toshimitsu Kawase , Nobuhiro Ito , Mitsutoshi Hasegawa , Koichiro Nakanishi , Kazuo Koyanagi
CPC分类号： H01J9/40 , H01J29/86 , H01J2209/26 , H01J2329/94
摘要： An airtight container manufacturing method includes the steps of exhausting an inside of a container through a through-hole provided in the container, and arranging a spacer member along a periphery of the through-hole on an outer surface of the container. Additional steps include arranging a plate member having, at its periphery, grooves penetrating the plate member in its plate thickness direction so that a sealant will flow from the grooves to a side surface of the spacer member, with the spacer member and the through-hole covered by the plate member, and a gap is formed along the side surface of the spacer member between the plate member and the outer surface of the container, and sealing the container by arranging a cover member to cover the plate member via a sealant. The sealing step includes hardening the sealant after deforming the sealant by pressing the plate member with the cover member so that the sealant flows between the cover member and the outer surface of the container via the grooves and the gap is infilled with the sealant.
摘要翻译： 气密性容器的制造方法包括：通过设置在容器内的贯通孔排出容器内部的步骤，在容器的外表面上沿着贯通孔的周边排列隔离构件。 附加步骤包括布置在其周边处具有在其板厚方向上穿透板构件的凹槽的板构件，使得密封剂将从凹槽流动到间隔构件的侧表面，间隔构件和通孔 并且沿板状部件与容器的外表面之间的间隔部件的侧面形成有间隙，通过配置盖部件，通过密封剂覆盖板部件来密封容器。 密封步骤包括在使密封剂变形之后使密封剂变形以使密封剂硬化，使得密封剂通过凹槽在盖构件和容器的外表面之间流动，并且间隙填充有密封剂。
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8.发明申请公开(公告)号：US20100186350A1
公开(公告)日：2010-07-29
申请号：US12689484
申请日：2010-01-19
申请人： Tomonori Nakazawa , Kinya Kamiguchi , Toshimitsu Kawase , Nobuhiro Ito , Mitsutoshi Hasegawa , Koichiro Nakanishi , Kazuo Koyanagi
发明人： Tomonori Nakazawa , Kinya Kamiguchi , Toshimitsu Kawase , Nobuhiro Ito , Mitsutoshi Hasegawa , Koichiro Nakanishi , Kazuo Koyanagi
IPC分类号： B65B31/00
CPC分类号： H01J9/40 , H01J9/261 , H01J29/86 , H01J2209/26 , Y10T29/49146 , Y10T29/49147 , Y10T29/49826 , Y10T29/49915
摘要： In airtight container manufacturing method including sealing a through-hole by a cover, it secures sealing performance and restrains sealant from flowing into the through-hole. The method comprises: (a) exhausting inside of a container through the through-hole; (b) arranging a spacer along periphery of the through-hole on an outer surface of the container the inside of which has been exhausted; (c) arranging a plate so that the spacer and the through-hole are covered by the plate and gap is formed along a side surface of the spacer between the plate and the container outer surface; and (d) arranging the cover to cover the plate and bonding the cover and the container outer surface via sealant positioned between the cover and the container outer surface, wherein the sealing includes hardening the sealant after deforming the sealant as pressing the plate by the cover so that the gap is infilled with the sealant.
摘要翻译： 在通过盖密封通孔的密封容器制造方法中，确保密封性能并且限制密封剂流入通孔。 该方法包括：（a）通过通孔排出容器内部; （b）在所述容器的外表面上已经排出了沿着所述通孔的周边的间隔件; （c）布置板，使得间隔件和通孔被板覆盖，并且间隙沿着板和容器外表面之间的间隔件的侧表面形成; 和（d）布置盖子以覆盖板，并且通过位于盖和容器外表面之间的密封剂来接合盖子和容器外表面，其中密封包括在使密封剂变形之后硬化密封剂， 因此密封剂填充间隙。
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9.发明授权Method of producing semiconductor element, semiconductor element, and gyroscope 失效制造半导体元件，半导体元件和陀螺仪的方法公开(公告)号：US06656759B1
公开(公告)日：2003-12-02
申请号：US09572834
申请日：2000-05-18
申请人： Koichiro Nakanishi , Takahiro Numai
发明人： Koichiro Nakanishi , Takahiro Numai
IPC分类号： H01L2100
CPC分类号： H01S5/22 , B82Y20/00 , G01C19/661 , H01S5/0425 , H01S5/1071 , H01S5/2086 , H01S5/2213 , H01S5/2275 , H01S5/34306
摘要： A method of producing a semiconductor element is disclosed which comprises a step of preparing a semiconductor element member comprising a projection region on a substrate, a step of embedding an upper surface of the substrate, and upper and side surfaces of the projection region in a potting material, an exposure step of exposing the upper surface of the projection region, a deposition step of depositing an electrode material on the upper surface of the projection region, and a step of removing the potting material.
摘要翻译： 公开了一种制造半导体元件的方法，该方法包括制备半导体元件部件的步骤，该半导体元件部件包括在基板上的突起区域，嵌入基板的上表面的步骤，以及投影区域的上表面和侧表面在封装 材料，暴露突起区域的上表面的曝光步骤，在投影区域的上表面上沉积电极材料的沉积步骤和去除灌封材料的步骤。
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公开(公告)号：US5072125A
公开(公告)日：1991-12-10
申请号：US592659
申请日：1990-10-04
IPC分类号： H01J37/02
CPC分类号： H01J37/026 , H01J2237/0045 , H01J2237/31701
摘要： An ion implanter has a sample table on which a sample is placed, and means for injecting ions into the sample by applying an ion beam to the sample on the sample table. The ion implanter has magnetic field applying means for generating radial magnetic fields on the surface of the sample from near the center of the sample to outside of the outer periphery of the sample. The secondary electrons generated when the ion beam irradiates the sample table or the sample, including the secondary electrons generated from the sample table near the outer periphery of the sample, are trapped in the magnetic fields and transferred to the central portion of the sample. The secondary electrons are attracted by the electrostatic charge of the ions injected to the surface of the sample and recombine with the ions. Consequently, the electrostatic charge on the surface of the sample is decreased, preventing generation of device defects caused by electrostatic discharge damage.
摘要翻译： 离子注入机具有放置样品的样品台，以及通过向样品台上的样品施加离子束将离子注入样品的装置。 离子注入机具有磁场施加装置，用于从样品中心附近在样品的外周附近产生径向磁场。 当离子束照射样品台或样品时产生的二次电子，包括从样品外周附近的样品台产生的二次电子被捕获在磁场中并转移到样品的中心部分。 二次电子被注入到样品表面的离子的静电荷吸引，并与离子重新结合。 因此，样品表面上的静电电荷减少，防止由静电放电损伤引起的器件缺陷的产生。
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