公开(公告)号：US09834537B2

公开(公告)日：2017-12-05

申请号：US14092151

申请日：2013-11-27

Applicant: Korea Institute of Science and Technology

Inventor： Eun Joo Roh ,  Changjoon Justin Lee ,  Soo Jin Oh ,  Seok Jin Hwang ,  Jong Hoon Jung

IPC: C07C229/56 ,  C07D333/10 ,  C07D333/40 ,  C07C229/58

CPC classification number: C07D333/40 ,  C07C229/56 ,  C07C229/58

Abstract: Disclosed is a novel compound to function as a calcium-dependent chloride channel blocking agent.

公开(公告)号：US08871463B2

公开(公告)日：2014-10-28

申请号：US13948476

申请日：2013-07-23

Applicant: Korea Institute of Science and Technology

Inventor： Changjoon Justin Lee ,  Soo Jin Oh ,  Eun Mi Hwang ,  Dong Ho Woo

IPC: C12Q1/02

CPC classification number: A61K38/45 ,  A61K31/135 ,  A61K31/137 ,  A61K31/185 ,  A61K31/225 ,  A61K31/4045 ,  A61K31/4168 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/49 ,  A61K31/519 ,  A61K31/522 ,  A61K31/5375 ,  A61K31/662 ,  A61K35/74 ,  A61K38/00 ,  A61K38/08 ,  A61K38/10 ,  A61K38/1709 ,  C07K7/06 ,  C07K7/08 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/531 ,  G01N33/5008 ,  G01N33/5058 ,  G01N33/6872

Abstract: The present invention investigate the two modes of glutamate release and the releasing rate of glutamate, and thus can provide a useful technique for neuron protection and acceleration of neurotransmission by controlling the glutamate release in astroctye. Thus, the present invention provides an inhibitor of the fast-mode release and/or the slow-mode release of astrocytic glutamate, a screening method of the inhibitor and a pharmaceutical composition or method of ameliorating, preventing and/or treating the disease associated with the over-release of glutamate via the Ca2+-activated anion channel, with the inhibition of fast-mode glutamate release.

Abstract translation: 本发明研究谷氨酸释放和谷氨酸释放的两种模式，从而通过控制天冬氨酸的谷氨酸释放，为神经元保护和神经传递加速提供了有用的技术。 因此，本发明提供了星形细胞性谷氨酸的快速释放和/或慢速释放抑制剂，抑制剂的筛选方法以及改善，预防和/或治疗与 通过Ca2 +活化的阴离子通道过度释放谷氨酸，抑制快速谷氨酸释放。

公开(公告)号：US09458120B2

公开(公告)日：2016-10-04

申请号：US14361844

申请日：2012-11-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun-Joo Roh ,  Kye-Jung Shin ,  Changjoon Justin Lee ,  Soo Jin Oh ,  Jung-Eun Park ,  Jeong Eun Yang ,  Eun Mi Hwang ,  Dong Ho Woo ,  Soon-Hyouk Lee ,  Dong-Gyu Kim ,  Hee-jung Chun ,  Wan-Keun Ji ,  Yun-Soo Na

IPC: C07D295/15 ,  A61K31/496 ,  C07D295/088 ,  C07D231/40 ,  C07D211/22 ,  C07D211/38 ,  C07D211/52 ,  C07D211/58 ,  C07D233/64 ,  C12N5/071 ,  C07D401/04 ,  C07D403/06 ,  C07D413/04 ,  A61K31/495 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5377

CPC classification number: C07D295/15 ,  C07D211/22 ,  C07D211/38 ,  C07D211/52 ,  C07D211/58 ,  C07D231/40 ,  C07D233/64 ,  C07D295/088 ,  C12N5/0686 ,  C12N2501/999

Abstract: The present invention relates to a novel phenoxypropanol derivative, represented by the structure of Chemical Formula I, and a racemate thereof, a pharmaceutically acceptable salt thereof, a solvate thereof and a hydrate thereof, wherein * represents an (R)-form or an (S)-form, X is selected from the group consisting of hydrogen, halogen and substituted or unsubstituted straight or branched alkyl having 1 to 4 carbon atoms, and n represents the number of X and an integer of 1 to 5, wherein at least a hydrogen is substituted with halogen in the substituted linear or branched alkyl having 1 to 4 carbon atoms. The derivative can be used for blocking T-type calcium channel and/or TREK channel, and for preventing and/or treating T-type calcium channel- and/or TREK channel-associated diseases.

Abstract translation: 其中*表示（R） - 型或（S） - 型，X选自氢，卤素和具有1至4个碳原子的取代或未取代的直链或支链烷基，n表示X 和1〜5的整数，其中在具有1〜4个碳原子的取代的直链或支链烷基中至少有一个氢被卤素取代。 该衍生物可用于阻断T型钙通道和/或TREK通道，以及用于预防和/或治疗T型钙通道和/或TREK通道相关疾病。

公开(公告)号：US20150166496A1

公开(公告)日：2015-06-18

申请号：US14361844

申请日：2012-11-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun-Joo Roh ,  Kye-Jung Shin ,  Changjoon Justin Lee ,  Soo Jin Oh ,  Jung-Eun Park ,  Jeong Eun Yang ,  Eun Mi Hwang ,  Dong Ho Woo ,  Soon-Hyouk Lee ,  Dong-Gyu Kim ,  Hee-jung Chun ,  Wan-Keun Ji ,  Yun-Soo Na

IPC: C07D295/15 ,  C07D233/64 ,  C12N5/071 ,  C07D211/58 ,  C07D211/52 ,  C07D295/088 ,  C07D211/22

CPC classification number: C07D295/15 ,  C07D211/22 ,  C07D211/38 ,  C07D211/52 ,  C07D211/58 ,  C07D231/40 ,  C07D233/64 ,  C07D295/088 ,  C12N5/0686 ,  C12N2501/999

Abstract: The present invention relates to a novel phenoxypropanol derivative, use thereof for blocking T-type calcium channel and/or TREK channel, and use thereof for preventing and/or treating T-type calcium channel- and/or TREK channel-associated diseases.

Abstract translation: 本发明涉及新的苯氧基丙醇衍生物，其用于阻断T型钙通道和/或TREK通道的用途及其用于预防和/或治疗T型钙通道和/或TREK通道相关疾病的用途。