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公开(公告)号：US20090012813A1
公开(公告)日：2009-01-08
申请号：US12167744
申请日：2008-07-03
申请人： Kristie Innocenti Berzansky , Stanton McComb , Binny John , Hamsa Konanur , David Barber , Paras Desai , Kruti Goswami , Denise Williams , Shabari Madappa
发明人： Kristie Innocenti Berzansky , Stanton McComb , Binny John , Hamsa Konanur , David Barber , Paras Desai , Kruti Goswami , Denise Williams , Shabari Madappa
摘要： Systems and methods for managing medical information for medical service providers are provided. Personnel are able to manage and track workflow operations, evaluate profitability, and maintain records in an integrated and streamlined manner by executing various modules of a software application. A Dashboard module provides a unitary display of information regarding employee efficiency and operational profitability; a Virtual Will Call module allows for the virtual placement of items in storage areas reflecting the corresponding physical will call storage locations; an Rx Tracker module provides information regarding the status of prescriptions as they go through the process from ordered to dispensed; the Maintenance module allows personnel to define customized delivery methods; and the Archive Viewer module provides a way for personnel to archive images in any accessible drive or memory device, including portable storage media, and to view such images independently of the module using an archive viewer executable.
摘要翻译： 提供了医疗服务提供者医疗信息管理系统和方法。 人员能够通过执行软件应用程序的各种模块来管理和跟踪工作流操作，评估盈利能力以及以集成和简化的方式维护记录。 仪表板模块提供有关员工效率和运营盈利能力的信息的统一显示; 虚拟呼叫模块允许在反映相应物理的存储区域中的项目的虚拟放置将调用存储位置; Rx跟踪器模块提供关于处方从订购到分发的过程中的状态的信息; 维护模块允许人员定义定制的交货方式; 并且存档查看器模块为人员提供了在任何可访问的驱动器或存储设备（包括便携式存储介质）中归档映像的方式，并使用归档查看器可执行文件独立于模块来查看这些图像。
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公开(公告)号：US20120253839A1
公开(公告)日：2012-10-04
申请号：US13433914
申请日：2012-03-29
申请人： Kristi Innocenti Berzansky , Binny John , Hamsa Konanur , David Barber , Paras Desai , Kruti Goswami , Denise Williams , Shabari Madappa
发明人： Kristi Innocenti Berzansky , Binny John , Hamsa Konanur , David Barber , Paras Desai , Kruti Goswami , Denise Williams , Shabari Madappa
IPC分类号： G06Q50/22
摘要： Systems and methods for managing medical information for medical service providers are provided. Personnel are able to manage and track workflow operations, evaluate profitability, and maintain records in an integrated and streamlined manner by executing various modules of a software application. A Dashboard module provides a unitary display of information regarding employee efficiency and operational profitability; a Virtual Will Call module allows for the virtual placement of items in storage areas reflecting the corresponding physical will call storage locations; an Rx Tracker module provides information regarding the status of prescriptions as they go through the process from ordered to dispensed; the Maintenance module allows personnel to define customized delivery methods; and the Archive Viewer module provides a way for personnel to archive images in any accessible drive or memory device, including portable storage media, and to view such images independently of the module using an archive viewer executable.
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公开(公告)号：US08670999B2
公开(公告)日：2014-03-11
申请号：US13433914
申请日：2012-03-29
申请人： Kristi Innocenti Berzansky , Denise Williams , Binny John , Kruti Goswami , Paras Desai , Shabari Madappa , Hamsa Konanur , David Barber
发明人： Kristi Innocenti Berzansky , Denise Williams , Binny John , Kruti Goswami , Paras Desai , Shabari Madappa , Hamsa Konanur , David Barber
摘要： Systems and methods for managing medical information for medical service providers are provided. Personnel are able to manage and track workflow operations, evaluate profitability, and maintain records in an integrated and streamlined manner by executing various modules of a software application. A Dashboard module provides a unitary display of information regarding employee efficiency and operational profitability; a Virtual Will Call module allows for the virtual placement of items in storage areas reflecting the corresponding physical will call storage locations; an Rx Tracker module provides information regarding the status of prescriptions as they go through the process from ordered to dispensed; the Maintenance module allows personnel to define customized delivery methods; and the Archive Viewer module provides a way for personnel to archive images in any accessible drive or memory device, including portable storage media, and to view such images independently of the module using an archive viewer executable.
摘要翻译： 提供了医疗服务提供者医疗信息管理系统和方法。 人员能够通过执行软件应用程序的各种模块来管理和跟踪工作流操作，评估盈利能力以及以集成和简化的方式维护记录。 仪表板模块提供有关员工效率和运营盈利能力的信息的统一显示; 虚拟呼叫模块允许在反映相应物理的存储区域中的项目的虚拟放置将调用存储位置; Rx跟踪器模块提供关于处方从订购到分发的过程中的状态的信息; 维护模块允许人员定义定制的交货方式; 并且存档查看器模块为人员提供了在任何可访问的驱动器或存储设备（包括便携式存储介质）中归档映像的方式，并使用归档查看器可执行文件独立于模块来查看这些图像。
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公开(公告)号：US08025882B2
公开(公告)日：2011-09-27
申请号：US12551250
申请日：2009-08-31
申请人： Alison J. Witte , Denise Williams , Josephine M. Cardarelli , David J. King , David B. Passmore
发明人： Alison J. Witte , Denise Williams , Josephine M. Cardarelli , David J. King , David B. Passmore
IPC分类号： A61K39/395
CPC分类号： C07K16/249 , A61K51/1021 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/76
摘要： The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.
摘要翻译： 本发明提供分离的抗干扰素α单克隆抗体，特别是人单克隆抗体，其抑制多种干扰素（IFN）α亚型的生物学活性，但基本上不抑制IFNα21的生物活性或IFNβ的生物学活性 或IFNγ。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体抑制IFNα的生物学活性的方法，以及通过施用本发明的抗体来治疗由IFNα介导的疾病或病症的方法，例如自身免疫疾病，移植排斥反应和移植物抗宿主病 本发明的抗体。
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公开(公告)号：US07851181B2
公开(公告)日：2010-12-14
申请号：US11835791
申请日：2007-08-08
申请人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan A. Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
发明人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan A. Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
IPC分类号： C12P21/02
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing cancer in a subject. Also included are methods of using and producing the antibodies of the invention.
摘要翻译： 本发明包括针对人胰岛素样生长因子受体-I（IGFR1）的完全人，中和的单克隆抗体。 抗体可用于治疗或预防受试者的癌症。 还包括使用和产生本发明的抗体的方法。
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公开(公告)号：US20060216770A1
公开(公告)日：2006-09-28
申请号：US11441644
申请日：2006-05-26
申请人： Kenneth Kasper , Henry Jeong , Dariush Davalian , Hshiou-tinh Liu , Paul Miller , Denise Williams
发明人： Kenneth Kasper , Henry Jeong , Dariush Davalian , Hshiou-tinh Liu , Paul Miller , Denise Williams
CPC分类号： A61K51/1093 , C07K16/1292 , Y10S436/815
摘要： An IgG1 λ monoclonal antibody to the immunosuppressive drug tacrolimus has improved properties. In particular, this monoclonal antibody, designated 1H6, has reduced cross-reactivity to several tacrolimus metabolites. This antibody is suitable for performance of immunoassays such as homogeneous immunoassays to detect or determine the presence or concentration of tacrolimus in samples such as blood samples. The invention further includes derivatives of tacrolimus derivatized at a non-binding portion of the molecule useful in immunizing antibody-producing animals and in producing such monoclonal antibodies, as well as labeled derivatives of tacrolimus useful as tacrolimus analogues in such assays. The invention further includes immunoassay methods for the detection of tacrolimus and test kits useful in performing such immunoassays.
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公开(公告)号：US08475797B2
公开(公告)日：2013-07-02
申请号：US13211092
申请日：2011-08-16
IPC分类号： A61K39/395
CPC分类号： C07K16/249 , A61K51/1021 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/76
摘要： The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.
摘要翻译： 本发明提供分离的抗干扰素α单克隆抗体，特别是人单克隆抗体，其抑制多种干扰素（IFN）α亚型的生物学活性，但基本上不抑制IFNα21的生物活性或IFNβ的生物学活性 或IFNγ。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体抑制IFNα的生物学活性的方法，以及通过施用本发明的抗体来治疗由IFNα介导的疾病或病症的方法，例如自身免疫疾病，移植排斥反应和移植物抗宿主病 本发明的抗体。
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公开(公告)号：US20110014117A1
公开(公告)日：2011-01-20
申请号：US12663651
申请日：2008-06-25
申请人： Yan Wang , Jonathan A. Pachter , Judith Anne Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Mary Diane Feingersh
发明人： Yan Wang , Jonathan A. Pachter , Judith Anne Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Mary Diane Feingersh
IPC分类号： A61K51/00 , C07K16/00 , A61K39/395 , C07H21/04 , C12N15/63 , C12N5/10 , C12N1/20 , A61P35/00 , A61P35/04 , A61K49/00 , C12N5/12 , C12P21/04 , A61K9/127
CPC分类号： C07K16/2863 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： The present invention relates in part to anti-IGF1R antibodies and antigen-binding compositions thereof along with methods of use thereof. For example, methods of treating medical disorders such as cancer are covered.
摘要翻译： 本发明部分地涉及抗IGF1R抗体及其抗原结合组合物及其使用方法。 例如，涵盖治疗诸如癌症的医学病症的方法。
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公开(公告)号：US20070059241A1
公开(公告)日：2007-03-15
申请号：US11598520
申请日：2006-11-13
申请人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
发明人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
IPC分类号： A61K51/00 , A61K39/395 , A61K31/7072 , A61K31/704 , A61K31/7048 , A61K38/21 , A61K38/16
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing cancer in a subject. Also included are methods of using and producing the antibodies of the invention.
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公开(公告)号：US20070014724A1
公开(公告)日：2007-01-18
申请号：US11009410
申请日：2004-12-10
CPC分类号： C07K16/249 , A61K51/1021 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/76
摘要： The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.
摘要翻译： 本发明提供分离的抗干扰素α单克隆抗体，特别是人单克隆抗体，其抑制多种干扰素（IFN）α亚型的生物学活性，但基本上不抑制IFNα21的生物活性或IFNβ的生物学活性 或IFNγ。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体抑制IFNα的生物学活性的方法，以及通过施用本发明的抗体来治疗由IFNα介导的疾病或病症的方法，例如自身免疫疾病，移植排斥反应和移植物抗宿主病 本发明的抗体。
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