公开(公告)号：US10456343B2

公开(公告)日：2019-10-29

申请号：US15416781

申请日：2017-01-26

Applicant: L'OREAL

Inventor： Zhi Pan ,  Yan Yu ,  Anne-Laure Suzanne Bernard

IPC: A61K8/60 ,  A61K8/06 ,  A61K8/67 ,  A61K8/85 ,  A61K8/41 ,  A61K8/92 ,  A61K8/34 ,  A61K8/46 ,  A61Q19/00

Abstract: The instant disclosure relates to microemulsion compositions comprising polydatin, which are useful as cosmetic and/or pharmaceutical compositions for application to the skin and/or hair. The microemulsion compositions comprise: (a) polydatin; (b) optionally, niacinamide; (c) optionally, baicalin; (d) one or more oils; (e) water; and (f) one or more emulsifiers. Furthermore, the ratio of the total amount of the one or more emulsifiers to the total amount of the one or more oils is typically 1.7 to 2.5.

公开(公告)号：US20190175679A1

公开(公告)日：2019-06-13

申请号：US15840580

申请日：2017-12-13

Applicant: L'OREAL ,  Yale University

Inventor： Kelly Marie GEORGE ,  Zhi Pan ,  Laurent Marrot ,  Miao Wang ,  Douglas Edgar Brash ,  Sanjay Premi ,  Leticia C.P. Goncalves

IPC: A61K36/704 ,  A61K31/366 ,  A61K36/04 ,  A61K47/12 ,  A61K47/24 ,  A61K36/539 ,  A61K36/287 ,  A61K31/192 ,  A61K31/12 ,  A61K31/353 ,  A61K36/48 ,  A61K31/19 ,  A61K31/44 ,  A61K36/355 ,  A61K31/015 ,  A61K31/01

Abstract: A method for decreasing formation of one or more chemiexcitation-induced dark cyclobutane pyrimidine dimers (dCPDs) in a cell or DNA molecule in a subject, who has been exposed to UV radiation, is provided. The method comprises administering to the subject an effective amount of a dCPD quencher within 8 hours after the exposure. The dCPD quencher is selected from the group consisting of ellagic acid, Porphyra Umbilicalis Extract (including Porphyra Umbilicalis Extract (and) Sodium Lactate (and) Lecithin), mycosporine-like amino acids (MAAs) and synthetic analogues thereof, Scutellaria Baicalensis Root Extract, Chrysanthemum Morifolium Leaf Extract, ferulic acid, fused-ring cyanoacrylates, curcumin, epigallocatechin gallate, Scutellaria Baicalensis Root Extract (and) Acacia Catechu Wood Extract, sorbic acid, Polygonum Cuspidatum Root Extract, Acacia Catechu Extract, dipicolinic acid, squalene, Lonicera Japonica (Honeysuckle) Flower Extract, beta-carotene and combinations thereof. The dCPD quencher may be administered to the subject in the absence of UV radiation.

公开(公告)号：US10137072B2

公开(公告)日：2018-11-27

申请号：US15087662

申请日：2016-03-31

Applicant: L'OREAL

Inventor： Zhi Pan ,  Maolin Guo ,  Jean-Thierry Simonnet

IPC: A61K8/00 ,  A61K8/60 ,  A61Q17/04 ,  A61K8/365 ,  A61K8/49 ,  A61K8/97 ,  A61K8/89 ,  A61K8/891 ,  A61K8/35 ,  A61K8/06

Abstract: The present disclosure relates to methods and compositions for providing at least broad spectrum photo protection to skin, which includes protection from at least infrared (IR) radiation and/or visible light. The methods typically entail applying to skin a cosmetic composition comprising: (a) one or more antioxidants selected from the group consisting of baicalin, Venuceane™, ferulic acid, polydatin, silymarin, punica granatum extract, mango leaf extract, soliprin, catechin, hesperetin, astilbin, and DHC V; (b) optionally, one or more solubilizers; and (c) a cosmetically acceptable carrier; wherein the combination of (a), optional (b), and (c) alone, provide at least broad spectrum protection from both infrared (IR) radiation and visible light. UV filters can also optionally be included to provide additional protection from UV light.

公开(公告)号：US20170281503A1

公开(公告)日：2017-10-05

申请号：US15087662

申请日：2016-03-31

Applicant: L'OREAL

Inventor： Zhi Pan ,  Maolin Guo ,  Jean-Thierry Simonnet

IPC: A61K8/60 ,  A61K8/365 ,  A61K8/49 ,  A61K8/06 ,  A61K8/89 ,  A61K8/891 ,  A61K8/35 ,  A61Q17/04 ,  A61K8/97

CPC classification number: A61K8/602 ,  A61K8/062 ,  A61K8/355 ,  A61K8/365 ,  A61K8/4926 ,  A61K8/4953 ,  A61K8/498 ,  A61K8/89 ,  A61K8/891 ,  A61K8/97 ,  A61K8/9789 ,  A61K8/99 ,  A61K2800/592 ,  A61K2800/5922 ,  A61Q17/04

Abstract: The present disclosure relates to methods and compositions for providing at least broad spectrum photo protection to skin, which includes protection from at least infrared (IR) radiation and/or visible light. The methods typically entail applying to skin a cosmetic composition comprising: (a) one or more antioxidants selected from the group consisting of baicalin, Venuceane™, ferulic acid, polydatin, silymarin, punica granatum extract, mango leaf extract, soliprin, catechin, hesperetin, astilbin, and DHC V; (b) optionally, one or more solubilizers; and (c) a cosmetically acceptable carrier; wherein the combination of (a), optional (b), and (c) alone, provide at least broad spectrum protection from both infrared (IR) radiation and visible light. UV filters can also optionally be included to provide additional protection from UV light.

公开(公告)号：US09018177B2

公开(公告)日：2015-04-28

申请号：US13650933

申请日：2012-10-12

Applicant: L'Oreal S.A.

Inventor： Elizabeth Hunter Lauten ,  Jean-Thierry Simonnet ,  Zhi Pan ,  Guive Balooch

IPC: A61K9/00 ,  A61K47/12 ,  A61K47/22 ,  A61K31/7048 ,  A61K8/368 ,  A61K8/49 ,  A61K8/67 ,  A61Q19/00

CPC classification number: A61K9/0014 ,  A61K8/368 ,  A61K8/4913 ,  A61K8/4953 ,  A61K8/498 ,  A61K8/675 ,  A61K8/676 ,  A61K31/7048 ,  A61K47/12 ,  A61K47/22 ,  A61K2800/10 ,  A61Q19/00

Abstract: Aqueous compositions comprising a) at least one active compound and b) at least one hydrotrope in an amount effective to increase transdermal penetration of the active compound, and methods for increasing bioavailability of active compounds are provided.

Abstract translation: 含水组合物包含a）至少一种活性化合物和b）至少一种有效增加活性化合物透皮渗透量的水溶助长剂，以及提高活性化合物生物利用度的方法。

公开(公告)号：US10729633B2

公开(公告)日：2020-08-04

申请号：US15939422

申请日：2018-03-29

Applicant: L'OREAL

Inventor： Zhi Pan ,  Anne-Laure Suzanne Bernard ,  Yang Deng

IPC: A61K8/34 ,  A61K8/35 ,  A61K8/365 ,  A61K8/60 ,  A61Q17/04 ,  A61K8/36 ,  A61K8/37 ,  A61K8/40 ,  A61K8/49 ,  A61K8/86 ,  A61K8/891 ,  A61K8/895

Abstract: Methods for providing broad spectrum photo protection to skin using antioxidants that provide UVA protection to skin are described. The methods include topically applying a cosmetic composition comprising: (a) at least one antioxidant having an Oxygen Radical Absorbance Capacity (ORAC) of at least 10,000 μmol TE/g and a Hydroxyl Radical Absorbance Capacity (HORAC) of at least 2,600 μmol GAE/g; (b) at least one organic UV filter; and (c) a cosmetically acceptable carrier; wherein the cosmetic composition provides an increase in UVAPPD PF of at least 30% relative to an otherwise identical cosmetic composition without the antioxidant(s) of (a). The disclosure also relates to the cosmetic compositions useful in the described methods.

公开(公告)号：US10149808B2

公开(公告)日：2018-12-11

申请号：US15087672

申请日：2016-03-31

Applicant: L'OREAL

Inventor： Zhi Pan ,  Maolin Guo ,  Anne-Laure Suzanne Bernard

IPC: A61K8/00 ,  A61K8/49 ,  A61Q17/04 ,  A61K8/67 ,  A61K8/365 ,  A61K8/368 ,  A61K8/42 ,  A61K8/60 ,  A61K8/86 ,  A61Q19/08

Abstract: The present disclosure relates to compositions and methods for providing full spectrum photo protection to skin, which includes protection from infrared (IR) radiation and/or visible light in addition to protection from UV radiation. The compositions typically include: (a) silymarin; (b) one or more antioxidants selected from the group consisting of ferulic acid, Vitamin C, polydatin, and hesperetin; (c) optionally, one or more solubilizers; and (d) a cosmetically acceptable carrier. The compositions are unique in that the combination of (a), (b), optional (c), and (d) alone, provide at least full spectrum protection from ultraviolet radiation (UV), visible light, and infrared radiation (IR). The composition can additionally, optionally, include one or more UV filters to further enhance protection from UV radiation.

公开(公告)号：US09795551B2

公开(公告)日：2017-10-24

申请号：US14315585

申请日：2014-06-26

Applicant: L'OREAL

Inventor： Jean-Marc Sabatier ,  Zhi Pan

IPC: A61K38/00 ,  A61K8/64 ,  C07K5/117 ,  A61Q19/00 ,  A61Q5/00 ,  A23L3/3544 ,  C07K5/09 ,  A23L3/3526

CPC classification number: A61K8/64 ,  A23L3/3526 ,  A23L3/3544 ,  A23V2002/00 ,  A61K2800/10 ,  A61K2800/522 ,  A61Q5/00 ,  A61Q11/00 ,  A61Q19/00 ,  C07K5/0817 ,  C07K5/1024

Abstract: A tetrapeptide having antioxidant activity is provided. The tetrapeptide has a structure comprising, in amino acid sequence from N-terminus to C-terminus: tryptophan-X-tyrosine-X; wherein X is arginine, lysine, histidine or any positively-charged amino acid derivative such as 5-hydroxylysine, ornithine, 2,4-diamino-butyrate and 2,3-diamino-propionate. Each amino acid of the sequence or its Homo-amino acid derivative is independently of the D configuration (D-stereoisomer) or of the L configuration (L-stereoisomer), and the C-terminal comprises one selected from the group consisting of carboxyl (—COOH), and carboxamide (—CONH2). A composition stabilized to oxidation or having antioxidant activity and a method for attenuating effects of free radicals on a keratinous material are also provided.

公开(公告)号：US20170281499A1

公开(公告)日：2017-10-05

申请号：US15087672

申请日：2016-03-31

Applicant: L'OREAL

Inventor： Zhi Pan ,  Maolin Guo ,  Anne-Laure Suzanne Bernard

IPC: A61K8/49 ,  A61K8/60 ,  A61K8/36 ,  A61K8/67 ,  A61Q17/04 ,  A61K8/891

CPC classification number: A61K8/498 ,  A61K8/365 ,  A61K8/368 ,  A61K8/42 ,  A61K8/4913 ,  A61K8/4953 ,  A61K8/602 ,  A61K8/675 ,  A61K8/676 ,  A61K8/86 ,  A61K2800/522 ,  A61Q17/04 ,  A61Q19/08

Abstract: The present disclosure relates to compositions and methods for providing full spectrum photo protection to skin, which includes protection from infrared (IR) radiation and/or visible light in addition to protection from UV radiation. The compositions typically include: (a) silymarin; (b) one or more antioxidants selected from the group consisting of ferulic acid, Vitamin C, polydatin, and hespertin; (c) optionally, one or more solubilizers; and (d) a cosmetically acceptable carrier. The compositions are unique in that the combination of (a), (b), optional (c), and (d) alone, provide at least full spectrum protection from ultraviolet radiation (UV), visible light, and infrared radiation (IR). The composition can additionally, optionally, include one or more UV filters to further enhance protection from UV radiation.

公开(公告)号：US20140107059A1

公开(公告)日：2014-04-17

申请号：US13650774

申请日：2012-10-12

Applicant: L'OREAL S.A.

Inventor： Zhi Pan ,  Jean-Theirry Simonnet

IPC: A61K8/60 ,  A61Q19/08

CPC classification number: A61Q19/08 ,  A61K8/368 ,  A61K8/42 ,  A61K8/492 ,  A61K8/4926 ,  A61K8/4946 ,  A61K8/4953 ,  A61K8/606 ,  A61K8/675 ,  A61K31/4188 ,  A61K31/465 ,  A61K31/7076 ,  A61K47/22 ,  A61K2800/49

Abstract: The present invention provides aqueous compositions comprising (a) at least one compound selected from the group consisting of adenosine and adenosine analogues, and (b) at least one hydrotrope in an amount effective to solubilize said at least one compound (a) in water, for cosmetic uses.

Abstract translation: 本发明提供水性组合物，其包含（a）至少一种选自腺苷和腺苷类似物的化合物，和（b）至少一种水溶助长剂，其量有效地将所述至少一种化合物（a）溶于水， 用于化妆品用途。