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公开(公告)号：US20220145231A1
公开(公告)日：2022-05-12
申请号：US17582257
申请日：2022-01-24
Applicant: Life Technologies Corporation
Inventor： Nephi Jones , Steven Kjar , Daniel Price , Mark Smith , Paul Thacker , Tony Hsiao
IPC: C12M1/42 , C12M1/00 , C12N5/071 , C12M1/06 , B01F23/233 , B01F27/054 , B01F27/92 , B01F27/114 , B01F27/213 , B01F35/43 , B01F35/513 , B01F35/32 , B01F35/41 , C12M1/36
Abstract: A method of installing a flexible bioprocess container in a bioprocessing system having a rigid housing with an interior compartment and extending between a top and an opposing base. The method includes coupling a first surface of the flexible bioprocess container to a moveable platform positioned within the interior compartment of the rigid housing; coupling a second surface of the flexible bioprocess container to the base of the rigid housing; and moving the movable platform relative to the rigid housing and toward the top of the rigid housing so as to at least partially expand the flexible bioprocess container within the interior compartment of the rigid housing.
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公开(公告)号：US20220243165A1
公开(公告)日：2022-08-04
申请号：US17726987
申请日：2022-04-22
Applicant: Life Technologies Corporation
Inventor： Nephi Jones , Steven Kjar , Brycen Mills , Mark Smith , Derik West
IPC: C12M1/42 , C12M1/00 , C12N5/071 , C12M1/06 , B01F23/233 , B01F27/054 , B01F27/92 , B01F27/114 , B01F27/213 , B01F35/43 , B01F35/513 , B01F35/32 , B01F35/41 , C12M1/36
Abstract: A bioproduction mixing system includes a flexible compartment having a first end, a second end, and a sidewall extending therebetween, a center axis passing through the flexible compartment between the first end and the second end. A helical assembly is disposed within the flexible compartment and is suspended between the first end and the second end, the helical assembly being offset from the center axis of the flexible compartment.
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公开(公告)号：US20190218494A1
公开(公告)日：2019-07-18
申请号：US16238656
申请日：2019-01-03
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Nephi Jones , Steven KJAR , Daniel PRICE , Mark SMITH , Paul THACKER
CPC classification number: B01F7/00391 , B01F3/04531 , B01F7/0005 , B01F7/00725 , B01F7/24 , B01F15/00538 , B01F15/00707 , B01F15/0085 , B01F2003/04673 , B01F2015/0011 , B01F2015/00603 , B01F2215/0073 , C12M23/58 , C12M27/02 , C12M27/06 , C12M35/04 , C12N5/0602 , C12N2527/00
Abstract: The present set of embodiments relate a system, method, and various devices for installation of a bioproduction system. The bioproduction system includes a rigid housing having a moveable platform to assist in the installation of a bioprocessing container within. The system also includes mounting systems for a variety of peripherals originating from the flexible container while safeguarding operators. More specifically, the system includes systems and methods for mounting bearings, organizing tube sets, and placement of the flexible container in its proper orientation.
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公开(公告)号：US20250154445A1
公开(公告)日：2025-05-15
申请号：US19019877
申请日：2025-01-14
Applicant: Life Technologies Corporation
Inventor： Christopher Brau , Nephi Jones , Mark Smith
IPC: C12M1/42 , B01F23/233 , B01F27/054 , B01F27/114 , B01F27/213 , B01F27/90 , B01F27/92 , B01F35/30 , B01F35/32 , B01F35/41 , B01F35/43 , B01F35/513 , B01F101/44 , C12M1/00 , C12M1/06 , C12M1/36 , C12N5/071
Abstract: The present set of embodiments relate to a bioproduction system, method, and apparatus for creating a scalable bioreactor system. Specifically, the present set of embodiments enable the determination of bioreaction performance characteristics of a commercial scale by matching operational parameters between a small test scale bioreaction to that of a commercial scale bioreaction. The system and methods do not rely on simply making bioreactor apparatuses across scales the same dimensionally which would not account for differences in fluid dynamic properties between very small to very large volumes, but requires tuning of a variety of systems (mixing assembly, sparger system, and headspace airflow system) in conjunction with one another to achieve predictive outcomes.
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公开(公告)号：US11293003B2
公开(公告)日：2022-04-05
申请号：US16238656
申请日：2019-01-03
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Nephi Jones , Steven Kjar , Daniel Price , Mark Smith , Paul Thacker , Tony Hsiao
IPC: C12M1/00 , C12M1/36 , C12M1/02 , B01F15/00 , C12M1/42 , C12N5/071 , C12M1/06 , B01F3/04 , B01F7/00 , B01F7/24 , B01F7/18
Abstract: The present set of embodiments relate a system, method, and various devices for installation of a bioproduction system. The bioproduction system includes a rigid housing having a moveable platform to assist in the installation of a bioprocessing container within. The system also includes mounting systems for a variety of peripherals originating from the flexible container while safeguarding operators. More specifically, the system includes systems and methods for mounting bearings, organizing tube sets, and placement of the flexible container in its proper orientation.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20190217261A1
公开(公告)日：2019-07-18
申请号：US16238618
申请日：2019-01-03
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Nephi Jones , Steven KJAR , Brycen MILLS , Mark SMITH , Derik WEST
CPC classification number: B01F7/00391 , B01F3/04531 , B01F7/0005 , B01F7/00725 , B01F7/24 , B01F15/00538 , B01F15/00707 , B01F15/0085 , B01F2003/04673 , B01F2015/0011 , B01F2015/00603 , B01F2215/0073 , C12M23/58 , C12M27/02 , C12M27/06 , C12M35/04 , C12N5/0602 , C12N2527/00
Abstract: The present set of embodiments relate to a bioproduction system, method, and apparatus for mixing a fluid. The bioproduction mixing system includes an offset helical assembly having a stabilizer and impeller for mixing a fluid within a flexible compartment The bioproduction mixing system is designed for efficient mixing of the fluid and for use with a variety of different impellers that can be located at different locations according to the volume and shape characteristics of the flexible compartment. The bioproduction mixing system is optimized to eliminate stagnation zones while maximizing bulk fluid flow.
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公开(公告)号：US12227732B2
公开(公告)日：2025-02-18
申请号：US18051126
申请日：2022-10-31
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Christopher Brau , Nephi Jones , Mark Smith
IPC: B01F23/00 , B01F23/233 , B01F27/054 , B01F27/114 , B01F27/213 , B01F27/92 , B01F35/32 , B01F35/41 , B01F35/43 , B01F35/513 , C12M1/00 , C12M1/06 , C12M1/36 , C12M1/42 , C12N5/071 , B01F27/90 , B01F35/30 , B01F101/44
Abstract: The present set of embodiments relate to a bioproduction system, method, and apparatus for creating a scalable bioreactor system. Specifically, the present set of embodiments enable the determination of bioreaction performance characteristics of a commercial scale by matching operational parameters between a small test scale bioreaction to that of a commercial scale bioreaction. The system and methods do not rely on simply making bioreactor apparatuses across scales the same dimensionally which would not account for differences in fluid dynamic properties between very small to very large volumes, but requires tuning of a variety of systems (mixing assembly, sparger system, and headspace airflow system) in conjunction with one another to achieve predictive outcomes.
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8.发明授权公开(公告)号：US11352598B2
公开(公告)日：2022-06-07
申请号：US16238618
申请日：2019-01-03
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Nephi Jones , Steven Kjar , Brycen Mills , Mark Smith , Derik West
IPC: B22C5/00 , C12M1/42 , C12M1/00 , C12N5/071 , C12M1/06 , B01F23/233 , B01F27/054 , B01F27/92 , B01F27/114 , B01F27/213 , B01F35/43 , B01F35/513 , B01F35/32 , B01F35/41 , C12M1/36 , B01F27/90 , B01F35/30 , B01F101/44
Abstract: The present set of embodiments relate to a bioproduction system, method, and apparatus for mixing a fluid. The bioproduction mixing system includes an offset helical assembly having a stabilizer and impeller for mixing a fluid within a flexible compartment The bioproduction mixing system is designed for efficient mixing of the fluid and for use with a variety of different impellers that can be located at different locations according to the volume and shape characteristics of the flexible compartment. The bioproduction mixing system is optimized to eliminate stagnation zones while maximizing bulk fluid flow.
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公开(公告)号：US20230110920A1
公开(公告)日：2023-04-13
申请号：US17909509
申请日：2021-04-02
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Nephi Jones , Tony Hsiao , Mason Smith
Abstract: A powder mixing system (12) includes a conduit (40) having a first end and an opposing second end, the conduit bounding a passage; a fluid pump (80) fluid coupled with the conduit, the fluid pump being configured to pump a liquid through the passage of the conduit; and a tubular transfer member (190) in fluid communication with the conduit, the transfer member being configured to couple with a powder bag housing a powder. The mixing system further including: (1) an eductor coupled to the transfer member and disposed in-line with the conduit so that the liquid pumped through the conduit also passes through the eductor; and/or (2) an auger assembly comprising an auger blade, at least a portion of the auger assembly being rotatably disposed within the transfer member.
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公开(公告)号：US20230091993A1
公开(公告)日：2023-03-23
申请号：US18051126
申请日：2022-10-31
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Christopher Brau , Nephi Jones , Mark Smith
IPC: C12M1/42 , C12M1/00 , C12N5/071 , C12M1/06 , B01F23/233 , B01F27/054 , B01F27/92 , B01F27/114 , B01F27/213 , B01F35/43 , B01F35/513 , B01F35/32 , B01F35/41 , C12M1/36
Abstract: The present set of embodiments relate to a bioproduction system, method, and apparatus for creating a scalable bioreactor system. Specifically, the present set of embodiments enable the determination of bioreaction performance characteristics of a commercial scale by matching operational parameters between a small test scale bioreaction to that of a commercial scale bioreaction. The system and methods do not rely on simply making bioreactor apparatuses across scales the same dimensionally which would not account for differences in fluid dynamic properties between very small to very large volumes, but requires tuning of a variety of systems (mixing assembly, sparger system, and headspace airflow system) in conjunction with one another to achieve predictive outcomes.
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