公开(公告)号：US20240272116A1

公开(公告)日：2024-08-15

申请号：US18441769

申请日：2024-02-14

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Manish KOCHAR ,  Mark BILLADEAU ,  Charles M. CLINTON ,  Scott DOWDELL ,  Aaron H. LEIMKUEHLER ,  Alexander K. TUCKER-SCHWARTZ ,  Jules VANDERSARL ,  Jon WILLOUGHBY ,  Jacob N. WOHLSTADTER

IPC: G01N27/417 ,  G01N27/30 ,  G01N27/327

CPC classification number: G01N27/417 ,  G01N27/301 ,  G01N27/305 ,  G01N27/308 ,  G01N27/3277

Abstract: Electrochemical cells and methods for their production are provided. In particular, multi-well assay plates including multi-electrode wells are provided. The multi-electrode wells contain multiple electrodes that are electrically isolated from one another, permitting the various electrodes of the various wells to be addressed in any suitable combination.

公开(公告)号：US20250102511A1

公开(公告)日：2025-03-27

申请号：US18971325

申请日：2024-12-06

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Alexander K. TUCKER-SCHWARTZ ,  George SIGAL

IPC: G01N33/58 ,  G01N21/66

Abstract: The present disclosure provides compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the disclosure relates to an assay composition for detecting luminescence, which comprises an alkyl diethanolamine, for example, N-butyldiethanolamine (BDEA). In emodiments, the assay composition comprises 2-dibutylaminoethanol (BDAE).

公开(公告)号：US20240409983A1

公开(公告)日：2024-12-12

申请号：US18734455

申请日：2024-06-05

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： David ROUTENBERG ,  Evan GIZZIE ,  Alexander K. TUCKER-SCHWARTZ ,  George SIGAL ,  Khondaker RAHMAN ,  Deepak NANJAPPA

IPC: C12Q1/6823 ,  C12Q1/6806 ,  C12Q1/6834 ,  C12Q1/6851

Abstract: Provided herein are methods for analyzing a sample for an analyte using proximity-based extension, such as proximity extension strand displacement. Also provided are multiplexed methods for analyzing a sample using proximity-based extension. Provided herein are methods for screening for pairwise combination of binding moieties, for use in a sandwich-type assay. Also provided are compositions that find use in the present methods.

公开(公告)号：US20230020070A1

公开(公告)日：2023-01-19

申请号：US17849917

申请日：2022-06-27

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： John KENTEN ,  George SIGAL ,  Alexander K. TUCKER-SCHWARTZ

IPC: G01N21/64 ,  C07F15/00 ,  C12Q1/6816 ,  G01N21/66 ,  G01N33/533 ,  G01N33/58

Abstract: The invention relates to methods, compositions, kits, and assay systems for assay signal amplification. Also provided herein is a signal amplification reagent, wherein the signal amplification reagent is an antibody or antigen-binding fragment thereof.

公开(公告)号：US20220018785A1

公开(公告)日：2022-01-20

申请号：US17363758

申请日：2021-06-30

Applicant: Meso Scale Technologies, LLC.

Inventor： Alexander K. TUCKER-SCHWARTZ ,  George SIGAL

IPC: G01N21/76 ,  G01N33/58 ,  G01N33/543

Abstract: The invention relates to novel compositions comprising an electrochemiluminescence (ECL) co-reactant. In embodiments, the composition further comprises an ionic component, a surfactant, or combination thereof. In embodiments, the ECL co-reactant is triethanolamine (TEA), tert-butyldiethanolamine (tBDEA), methyldibutylethanolamine (MDEA), 3-[Bis-(2-hydroxy-ethyl)-amino]-propane-1-sulfonic acid (DEA-PS), or a combination thereof. Methods of using the compositions and kits comprising the compositions are also provided herein.

公开(公告)号：US20210382043A1

公开(公告)日：2021-12-09

申请号：US17287341

申请日：2019-10-23

Applicant: Meso Scale Technologies, LLC.

Inventor： David ROUTENBERG ,  Alexander K. TUCKER-SCHWARTZ ,  Sigal SHACHAR

IPC: G01N33/543 ,  C12Q1/6834 ,  C12N15/10

Abstract: The invention relates to method and kits for highly specific isolation of surface marker displaying agents by targeting at least two surface markers. The invention further relates to methods and kits for analyzing surface marker displaying agents and their contents.

公开(公告)号：US20230175043A1

公开(公告)日：2023-06-08

申请号：US17607731

申请日：2020-04-30

Applicant: Meso Scale Technologies, LLC.

Inventor： John KENTEN ,  Sudeep KUMAR ,  Galina NIKOLENKO ,  Laukik SARDESAI ,  Alexander K. TUCKER-SCHWARTZ ,  George SIGAL ,  Seth Beebe HARKINS ,  Robert UMEK ,  Timothy J. BREAK ,  Laure MOLLER

IPC: C12Q1/6825

CPC classification number: C12Q1/6825 ,  C12Q1/6837 ,  C12Q2600/16

Abstract: Oligonucleotides, methods and kits are provided for detecting, identifying or quantifying one or more target analytes in a sample as well as methods for immobilizing oligonucleotides onto a support surface.

公开(公告)号：US20220373554A1

公开(公告)日：2022-11-24

申请号：US17813722

申请日：2022-07-20

Applicant: Meso Scale Technologies, LLC.

Inventor： Alexander K. TUCKER-SCHWARTZ ,  George SIGAL

IPC: G01N33/58 ,  G01N21/66

Abstract: The present disclosure provides compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the disclosure relates to an assay composition for detecting Ituninescence, which comprises an alkyl diethanolamine, for example, N-butyldiethanolamnine (BDEA). In emodiments, the assay composition comprises 2-dihutylaminoethanol (BDAE),

公开(公告)号：US20220018846A1

公开(公告)日：2022-01-20

申请号：US17264489

申请日：2019-12-23

Applicant: Meso Scale Technologies, LLC.

Inventor： Alexander K. TUCKER-SCHWARTZ ,  George SIGAL

IPC: G01N33/58 ,  G01N21/66

Abstract: The present disclosure provides compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the disclosure relates to an assay composition for detecting luminescence, which comprises an alkyl diethanolamine, for example, N-butyldiethanolamine (BDEA). In embodiments, the assay composition comprises 2-dibutylaminoethanol (BDAE).