公开(公告)号：US20230349920A1

公开(公告)日：2023-11-02

申请号：US18042902

申请日：2021-09-02

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： David ROUTENBERG ,  Sigal SHACHAR

IPC: G01N33/68 ,  G01N33/569 ,  G01N33/543

CPC classification number: G01N33/6863 ,  G01N33/56983 ,  G01N33/6872 ,  G01N33/54313

Abstract: The invention relates to method and kits for highly specific isolation of surface marker displaying agents from the central nervous system by targeting at least two surface markers. The invention further relates to methods and kits for analyzing surface marker displaying agents and their contents.

公开(公告)号：US20240409983A1

公开(公告)日：2024-12-12

申请号：US18734455

申请日：2024-06-05

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： David ROUTENBERG ,  Evan GIZZIE ,  Alexander K. TUCKER-SCHWARTZ ,  George SIGAL ,  Khondaker RAHMAN ,  Deepak NANJAPPA

IPC: C12Q1/6823 ,  C12Q1/6806 ,  C12Q1/6834 ,  C12Q1/6851

Abstract: Provided herein are methods for analyzing a sample for an analyte using proximity-based extension, such as proximity extension strand displacement. Also provided are multiplexed methods for analyzing a sample using proximity-based extension. Provided herein are methods for screening for pairwise combination of binding moieties, for use in a sandwich-type assay. Also provided are compositions that find use in the present methods.

公开(公告)号：US20220003766A1

公开(公告)日：2022-01-06

申请号：US17246360

申请日：2021-04-30

Applicant: Meso Scale Technologies, LLC.

Inventor： Jacob N. WOHLSTADTER ,  George SIGAL ,  Anu MATHEW ,  Anastasia AKSYUK ,  David ROUTENBERG ,  Martin STENGELIN ,  John KENTEN ,  Timothy J. BREAK ,  Seth B. HARKINS ,  Michael TSIONSKY

IPC: G01N33/569 ,  C12Q1/70

Abstract: The invention relates to methods and kits for detecting a virus, e.g., a respiratory virus such as a coronavirus, in a biological sample. The invention also relates to methods and kits for detecting and/or quantifying biomarkers, e.g., antibody biomarkers against a viral antigen; inflammatory and/or tissue damage response biomarkers; and/or extracellular vesicles in response to a viral infection.

公开(公告)号：US20210382043A1

公开(公告)日：2021-12-09

申请号：US17287341

申请日：2019-10-23

Applicant: Meso Scale Technologies, LLC.

Inventor： David ROUTENBERG ,  Alexander K. TUCKER-SCHWARTZ ,  Sigal SHACHAR

IPC: G01N33/543 ,  C12Q1/6834 ,  C12N15/10

Abstract: The invention relates to method and kits for highly specific isolation of surface marker displaying agents by targeting at least two surface markers. The invention further relates to methods and kits for analyzing surface marker displaying agents and their contents.

公开(公告)号：US20250035615A1

公开(公告)日：2025-01-30

申请号：US18791527

申请日：2024-08-01

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： David ROUTENBERG

IPC: G01N33/50 ,  C12N15/10 ,  G01N33/543

Abstract: The invention relates to method and kits for highly specific isolation of extracellular vesicles (EVs) by targeting at least two EV surface markers. The invention further relates to methods and kits for analyzing EVs and their contents.

公开(公告)号：US20240210399A1

公开(公告)日：2024-06-27

申请号：US18557216

申请日：2022-04-20

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Pankaj OBEROI ,  David ROUTENBERG ,  Alexander TUCKER-SCHWARTZ

IPC: G01N33/569 ,  G01N33/53 ,  G01N33/543

CPC classification number: G01N33/56983 ,  G01N33/5308 ,  G01N33/54306 ,  G01N2333/165 ,  G01N2469/10

Abstract: Method and kits for highly specific detection and isolation of a target analyte encapsulated by a surface marker displaying agent (SMDA) are disclosed.

公开(公告)号：US20220357318A1

公开(公告)日：2022-11-10

申请号：US17813965

申请日：2022-07-21

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Anahit AGHVANYAN ,  Eli N. GLEZER ,  John KENTEN ,  George SIGAL ,  Martin STENGELIN ,  David ROUTENBERG

IPC: G01N33/543 ,  C12Q1/6832 ,  C12Q1/6837 ,  C12Q1/6844

Abstract: The present invention is directed to methods for improving assay specificity and performance in binding assays.

公开(公告)号：US20210389304A1

公开(公告)日：2021-12-16

申请号：US17055829

申请日：2019-05-17

Applicant: Meso Scale Technologies, LLC.

Inventor： David ROUTENBERG

IPC: G01N33/50 ,  C12N15/10 ,  G01N33/543

Abstract: The invention relates to method and kits for highly specific isolation of extracellular vesicles (EVs) by targeting at least two EV surface markers. The invention further relates to methods and kits for analyzing EVs and their contents.

公开(公告)号：US20170089892A1

公开(公告)日：2017-03-30

申请号：US15311309

申请日：2015-05-15

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Anahit AGHVANYAN ,  Eli N. GLEZER ,  John KENTEN ,  George SIGAL ,  Martin STENGELIN ,  David ROUTENBERG

IPC: G01N33/543 ,  C12Q1/68

CPC classification number: G01N33/54306 ,  C12Q1/6804 ,  C12Q1/6832 ,  C12Q1/6837 ,  C12Q1/6844 ,  C12Q2525/197 ,  C12Q2531/125 ,  C12Q2563/107 ,  C12Q2565/514

Abstract: The present invention is directed to methods for improving assay specificity and performance in binding assays.