公开(公告)号：US20050124873A1

公开(公告)日：2005-06-09

申请号：US11039269

申请日：2005-01-19

申请人： Mark Shults ,  Stuart Updike ,  Rathbun Rhodes ,  Barbara Gilligan ,  Mark Tapsak

发明人： Mark Shults ,  Stuart Updike ,  Rathbun Rhodes ,  Barbara Gilligan ,  Mark Tapsak

IPC分类号： A61B5/00 ,  C12Q1/00 ,  A61B5/05 ,  G01N27/26

CPC分类号： C12Q1/006 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14558 ,  A61B5/14865

摘要： Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that slows accurate date to be obtained over long periods of time.

摘要翻译： 描述了用于确定分析物水平的装置和方法。 装置和方法允许植入分析物监测装置，例如葡萄糖监测装置，其导致输送可靠的血液流以将样品输送到植入装置。 这些设备在传感器区域中包括独特的架构布置，可以减慢长时间获得的准确日期。

公开(公告)号：US20050033132A1

公开(公告)日：2005-02-10

申请号：US10846150

申请日：2004-05-14

申请人： Mark Shults ,  James Brauker ,  Victoria Carr-Brendel ,  Mark Tapsak ,  Dubravka Markovic ,  Stuart Updike ,  Rathbun Rhodes

发明人： Mark Shults ,  James Brauker ,  Victoria Carr-Brendel ,  Mark Tapsak ,  Dubravka Markovic ,  Stuart Updike ,  Rathbun Rhodes

IPC分类号： A61B5/00 ,  A61K9/22 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  C12Q1/00 ,  A61B5/05

CPC分类号： A61L31/10 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/1495 ,  A61L31/14 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/00 ,  B33Y80/00 ,  C12Q1/006

摘要： An implantable analyte-measuring device including a membrane adapted to promote vascularization and/or interfere with barrier cell layer formation. The membrane includes any combination of materials, architecture, and bioactive agents that facilitate analyte transport to provide long-term in vivo performance of the implantable analyte-measuring device.

摘要翻译： 一种可植入分析物测量装置，其包括适于促进血管形成和/或干扰屏障细胞层形成的膜。 膜包括材料，结构和生物活性剂的任何组合，其促进分析物传输以提供可植入分析物测量装置的长期体内性能。

公开(公告)号：US20070032718A1

公开(公告)日：2007-02-08

申请号：US11546157

申请日：2006-10-10

申请人： Mark Shults ,  Stuart Updike ,  Rathbun Rhodes ,  Barbara Gilligan ,  Mark Tapsak

发明人： Mark Shults ,  Stuart Updike ,  Rathbun Rhodes ,  Barbara Gilligan ,  Mark Tapsak

IPC分类号： A61B5/05

CPC分类号： C12Q1/006 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14558 ,  A61B5/14865

摘要： Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

摘要翻译： 描述了用于确定分析物水平的装置和方法。 装置和方法允许植入分析物监测装置，例如葡萄糖监测装置，其导致输送可靠的血液流以将样品输送到植入装置。 这些设备在传感器区域中包括独特的架构布置，可以在长时间内获得准确的数据。

公开(公告)号：US20050177036A1

公开(公告)日：2005-08-11

申请号：US11021046

申请日：2004-12-22

申请人： Mark Shults ,  Stuart Updike ,  Rathbun Rhodes

发明人： Mark Shults ,  Stuart Updike ,  Rathbun Rhodes

IPC分类号： G01N27/30 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1495 ,  C12Q1/00 ,  G01N27/327 ,  A61B5/05

CPC分类号： A61B5/14865 ,  A61B5/0004 ,  A61B5/14532 ,  A61B5/1495 ,  C12Q1/006

摘要： Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

摘要翻译： 描述了用于确定分析物水平的装置和方法。 装置和方法允许植入分析物监测装置，例如葡萄糖监测装置，其导致输送可靠的血液流以将样品递送到植入的装置。 这些设备包括传感器区域中的独特的微架构布置，允许在长时间段内获得准确的数据。

公开(公告)号：US20060258761A1

公开(公告)日：2006-11-16

申请号：US11404418

申请日：2006-04-14

申请人： Robert Boock ,  Monica Rixman ,  Mark Tapsak ,  Mark Shults ,  Rathbun Rhodes

发明人： Robert Boock ,  Monica Rixman ,  Mark Tapsak ,  Mark Shults ,  Rathbun Rhodes

IPC分类号： C08J9/00

CPC分类号： C08L83/04 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/6848 ,  B01D69/141 ,  B01D71/54 ,  B01D71/80 ,  C08G77/12 ,  C08G77/20 ,  C08G77/46 ,  C12Q1/002 ,  C08L2666/14

摘要： Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.

公开(公告)号：US20060068208A1

公开(公告)日：2006-03-30

申请号：US11280102

申请日：2005-11-16

申请人： Mark Tapsak ,  Rathbun Rhodes ,  Mark Shults ,  Jason McClure

发明人： Mark Tapsak ,  Rathbun Rhodes ,  Mark Shults ,  Jason McClure

IPC分类号： B32B27/40

CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/1486 ,  A61B2562/028 ,  A61B2562/125 ,  A61L31/12 ,  B01D69/141 ,  B01D71/54 ,  B01D71/80 ,  B05D3/007 ,  B05D5/00 ,  C12Q1/002 ,  C12Q1/006 ,  Y10T428/31551

摘要： The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.

公开(公告)号：US20060086624A1

公开(公告)日：2006-04-27

申请号：US11280672

申请日：2005-11-16

申请人： Mark Tapsak ,  Rathbun Rhodes ,  Mark Shults ,  Jason McClure

发明人： Mark Tapsak ,  Rathbun Rhodes ,  Mark Shults ,  Jason McClure

IPC分类号： G01N27/26

CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/1486 ,  A61B2562/028 ,  A61B2562/125 ,  A61L31/12 ,  B01D69/141 ,  B01D71/54 ,  B01D71/80 ,  B05D3/007 ,  B05D5/00 ,  C12Q1/002 ,  C12Q1/006 ,  Y10T428/31551

摘要： The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.

公开(公告)号：US20050245795A1

公开(公告)日：2005-11-03

申请号：US10838909

申请日：2004-05-03

申请人： Paul Goode ,  Arnold Holmquist ,  Mark Tapsak ,  Mark Shults ,  Victoria Carr-Brendel ,  James Brauker ,  Paul Neale ,  Jason McClure ,  Mark Brister ,  Peter Simpson ,  Rathbun Rhodes

发明人： Paul Goode ,  Arnold Holmquist ,  Mark Tapsak ,  Mark Shults ,  Victoria Carr-Brendel ,  James Brauker ,  Paul Neale ,  Jason McClure ,  Mark Brister ,  Peter Simpson ,  Rathbun Rhodes

IPC分类号： A61B5/00 ,  A61B5/05 ,  A61B5/07 ,  H04B1/03

CPC分类号： A61B5/0031 ,  A61B5/076 ,  A61B5/14532 ,  A61B5/14865 ,  A61B2560/04 ,  A61B2560/0462 ,  H04B1/03 ,  Y10T29/49117

摘要： Abstract of the DisclosureAn implantable analyte sensor including a sensing region for measuring the analyte and a non-sensing region for immobilizing the sensor body in the host. The sensor is implanted in a precisely dimensioned pocket to stabilize the analyte sensor in vivo and enable measurement of the concentration of the analyte in the host before and after formation of a foreign body capsule around the sensor. The sensor further provides a transmitter for RF transmission through the sensor body, electronic circuitry, and a power source optimized for long-term use in the miniaturized sensor body.

公开(公告)号：US20050103625A1

公开(公告)日：2005-05-19

申请号：US11021162

申请日：2004-12-22

申请人： Rathbun Rhodes ,  Mark Tapsak ,  James Brauker ,  Mark Shults

发明人： Rathbun Rhodes ,  Mark Tapsak ,  James Brauker ,  Mark Shults

IPC分类号： G01N27/416 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1486 ,  C12Q1/00 ,  G01N27/327 ,  G01N27/26

CPC分类号： G01N27/3272 ,  A61B5/14532 ,  A61B5/14865 ,  C12Q1/002 ,  C12Q1/006 ,  G01N33/48707 ,  G01N33/48785

摘要： The present invention provides a sensor head for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode, a reference electrode and a counter electrode, wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode is greater than the surface area of the working electrode; and a multi-region membrane affixed to the nonconductive body and covering the working electrode, reference electrode and counter electrode. In addition, the present invention provides an implantable device including at least one of the sensor heads of the invention and methods of monitoring glucose levels in a host utilizing the implantable device of the invention.

摘要翻译： 本发明提供了一种用于可植入装置的传感器头，其用于测量生物流体中分析物的浓度，其包括：非导电体; 工作电极，参考电极和对电极，其中电极穿过非导电体，其在身体的一个位置处形成电化学反应性表面，并在身体的另一位置形成电子连接，其中电化学反应性 对电极的表面大于工作电极的表面积; 以及附着在非导体上并覆盖工作电极，参比电极和对电极的多区域膜。 此外，本发明提供一种可植入装置，其包括本发明的至少一个传感器头和利用本发明的可植入装置监测主机中的葡萄糖水平的方法。

公开(公告)号：US07471972B2

公开(公告)日：2008-12-30

申请号：US11021162

申请日：2004-12-22

申请人： Rathbun Rhodes ,  Mark A. Tapsak ,  James H. Brauker ,  Mark C. Shults

发明人： Rathbun Rhodes ,  Mark A. Tapsak ,  James H. Brauker ,  Mark C. Shults

IPC分类号： A61B5/05

CPC分类号： G01N27/3272 ,  A61B5/14532 ,  A61B5/14865 ,  C12Q1/002 ,  C12Q1/006 ,  G01N33/48707 ,  G01N33/48785

摘要： The present invention provides a sensor head for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode, a reference electrode and a counter electrode, wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode is greater than the surface area of the working electrode; and a multi-region membrane affixed to the nonconductive body and covering the working electrode, reference electrode and counter electrode. In addition, the present invention provides an implantable device including at least one of the sensor heads of the invention and methods of monitoring glucose levels in a host utilizing the implantable device of the invention.

摘要翻译： 本发明提供了一种用于可植入装置的传感器头，其用于测量生物流体中分析物的浓度，其包括：非导电体; 工作电极，参考电极和对电极，其中电极穿过非导电体，其在身体的一个位置处形成电化学反应性表面，并在身体的另一位置形成电子连接，其中电化学反应性 对电极的表面大于工作电极的表面积; 以及附着在非导体上并覆盖工作电极，参比电极和对电极的多区域膜。 此外，本发明提供一种可植入装置，其包括本发明的至少一个传感器头和利用本发明的可植入装置监测主机中的葡萄糖水平的方法。