公开(公告)号：US08097592B2

公开(公告)日：2012-01-17

申请号：US12296056

申请日：2007-04-04

申请人： Masakazu Imamura ,  Keita Nakanishi ,  Ryota Shiraki ,  Kenichi Onda ,  Daisuke Sasuga ,  Masamichi Yuda

发明人： Masakazu Imamura ,  Keita Nakanishi ,  Ryota Shiraki ,  Kenichi Onda ,  Daisuke Sasuga ,  Masamichi Yuda

IPC分类号： A61K31/70 ,  C07H1/00

CPC分类号： C07D207/16 ,  C07D409/10

摘要： A cocrystal of (1S)-1,5-anhydro-1-[3-(1-benzothien-2-ylmethyl)-4-fluorophenyl]-D-glucitol and L-proline. It is a cocrystal of known compound A, which has a constant quality, is superior in storage stability, has no moisture absorptivity, and is suitable as a crystal of a drug substance used for preparing pharmaceuticals.

摘要翻译： （1S）-1,5-脱水-1- [3-（1-苯并噻吩-2-基甲基）-4-氟苯基] -D-葡萄糖醇和L-脯氨酸的共结晶体。 已知的化合物A的共晶体具有恒定的质量，储存稳定性优异，不具有吸湿性，并且适合作为用于制备药物的药物的晶体。

公开(公告)号：US20090143316A1

公开(公告)日：2009-06-04

申请号：US12296056

申请日：2007-04-04

申请人： Masakazu Imamura ,  Keita Nakanishi ,  Ryota Shiraki ,  Kenichi Onda ,  Daisuke Sasuga ,  Masamichi Yuda

发明人： Masakazu Imamura ,  Keita Nakanishi ,  Ryota Shiraki ,  Kenichi Onda ,  Daisuke Sasuga ,  Masamichi Yuda

IPC分类号： A61K31/7004 ,  C07H17/02 ,  A61P3/10

CPC分类号： C07D207/16 ,  C07D409/10

摘要： A cocrystal of (1S)-1,5-anhydro-1-[3-(1-benzothien-2-ylmethyl)-4-fluorophenyl]-D-glucitol and L-proline. It is a cocrystal of known compound A, which has a constant quality, is superior in storage stability, has no moisture absorptivity, and is suitable as a crystal of a drug substance used for preparing pharmaceuticals.

摘要翻译： （1S）-1,5-脱水-1- [3-（1-苯并噻吩-2-基甲基）-4-氟苯基] -D-葡萄糖醇和L-脯氨酸的共结晶体。 已知的化合物A的共晶体具有恒定的质量，储存稳定性优异，不具有吸湿性，并且适合作为用于制备药物的药物的晶体。

公开(公告)号：US20090182039A1

公开(公告)日：2009-07-16

申请号：US11988383

申请日：2006-07-06

申请人： Masakazu Imamura ,  Takayuki Suzuki ,  Takeshi Murakami ,  Keita Nakanishi ,  Hiroshi Uebayashi ,  Haruka Nakamura ,  Masamichi Yuda ,  Naoko Amenomiya ,  Yuuji Awamura ,  Hiroshi Tomiyama

发明人： Masakazu Imamura ,  Takayuki Suzuki ,  Takeshi Murakami ,  Keita Nakanishi ,  Hiroshi Uebayashi ,  Haruka Nakamura ,  Masamichi Yuda ,  Naoko Amenomiya ,  Yuuji Awamura ,  Hiroshi Tomiyama

IPC分类号： A61K31/351 ,  C07D315/00

CPC分类号： C07C215/90 ,  C07D309/10

摘要： A choline salt crystal of (1S)-1,5-anhydro-1-[5-(azulen-2-ylmethyl)-2-hydroxyphenyl]-D-glucitol which shows an endothermic peak at 194 to 198° C. as measured by differential scanning calorimetry (DSC analysis) and shows main peaks at about 2θ (°) 5.58, 14.72, 16.80, 17.82, 21.02, and 22.46 as measured by X-ray powder diffraction. Thus, a crystal of an azulene compound can be produced which is in a single crystal form, has a constant quality, can be produced with good reproducibility, can be provided stably as a crystal of an drug substance for use in the preparation of a pharmaceutical and is excellent in storage stability.

摘要翻译： （1S）-1,5-脱水-1- [5-（薁-2-基甲基）-2-羟基苯基] -D-葡萄糖醇的胆碱盐晶体，其在194至198℃下显示吸热峰 通过差示扫描量热法（DSC分析），并且通过X射线粉末衍射测量显示在约2θ（°）5.58,14.72,16.80,17.82,21.02和22.46处的主峰。 因此，可以制造az烯化合物的结晶，其为单晶形式，具有恒定的质量，可以以良好的再现性制备，可以稳定地提供用作制备药物的药物的晶体 储存稳定性优异。

公开(公告)号：US08198464B2

公开(公告)日：2012-06-12

申请号：US12520484

申请日：2007-12-20

申请人： Kousuke Komenoi ,  Atsushi Nakamura ,  Makoto Kasai ,  Masakazu Imamura ,  Ryota Shiraki ,  Keita Nakanishi

发明人： Kousuke Komenoi ,  Atsushi Nakamura ,  Makoto Kasai ,  Masakazu Imamura ,  Ryota Shiraki ,  Keita Nakanishi

IPC分类号： C07D409/08

CPC分类号： C07D409/10 ,  C07D333/54

摘要： The present invention provides a method for producing a C-glycoside derivative, which can produce the C-glycoside derivative at a high yield and at a low cost, which conforms to environmental protection, and which is applicable industrially. The C-glycoside derivative is useful for treating and preventing diabetes such as insulin-dependent diabetes (type 1 diabetes), non-insulin-dependent diabetes (type 2 diabetes) and the like and various diabetes-related diseases including insulin-resistant diseases and obesity.

摘要翻译： 本发明提供一种生产C-糖苷衍生物的方法，该方法可以以高产率和低成本生产符合环境保护并且在工业上可应用的C-糖苷衍生物。 C-糖苷衍生物可用于治疗和预防诸如胰岛素依赖性糖尿病（1型糖尿病），非胰岛素依赖性糖尿病（2型糖尿病）等糖尿病和各种糖尿病相关疾病，包括胰岛素抵抗性疾病和 肥胖。

公开(公告)号：US20100094025A1

公开(公告)日：2010-04-15

申请号：US12520484

申请日：2007-12-20

申请人： Kousuke Komenoi ,  Atsushi Nakamura ,  Makoto Kasai ,  Masakazu Imamura ,  Ryota Shiraki ,  Keita Nakanishi

发明人： Kousuke Komenoi ,  Atsushi Nakamura ,  Makoto Kasai ,  Masakazu Imamura ,  Ryota Shiraki ,  Keita Nakanishi

IPC分类号： C07D333/56

CPC分类号： C07D409/10 ,  C07D333/54

摘要： The present invention provides a method for producing a C-glycoside derivative, which can produce the C-glycoside derivative at a high yield and at a low cost, which conforms to environmental protection, and which is applicable industrially. The C-glycoside derivative is useful for treating and preventing diabetes such as insulin-dependent diabetes (type 1 diabetes), non-insulin-dependent diabetes (type 2 diabetes) and the like and various diabetes-related diseases including insulin-resistant diseases and obesity.

摘要翻译： 本发明提供一种生产C-糖苷衍生物的方法，该方法可以以高产率和低成本生产符合环境保护并且在工业上可应用的C-糖苷衍生物。 C-糖苷衍生物可用于治疗和预防诸如胰岛素依赖性糖尿病（1型糖尿病），非胰岛素依赖性糖尿病（2型糖尿病）等糖尿病和各种糖尿病相关疾病，包括胰岛素抵抗性疾病和 肥胖。

公开(公告)号：US08367702B2

公开(公告)日：2013-02-05

申请号：US12680301

申请日：2008-09-25

申请人： Kenichi Onda ,  Kenichiro Imamura ,  Fumie Sato ,  Hiroyuki Moritomo ,  Yasuharu Urano ,  Yuki Sawada ,  Naoki Ishibashi ,  Keita Nakanishi ,  Kazuhiro Yokoyama ,  Shigetada Furukawa ,  Kazuhiro Momose

发明人： Kenichi Onda ,  Kenichiro Imamura ,  Fumie Sato ,  Hiroyuki Moritomo ,  Yasuharu Urano ,  Yuki Sawada ,  Naoki Ishibashi ,  Keita Nakanishi ,  Kazuhiro Yokoyama ,  Shigetada Furukawa ,  Kazuhiro Momose

IPC分类号： A61K31/04 ,  C07D215/38

CPC分类号： C07D401/12 ,  C07D215/233 ,  C07D401/06 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D491/107

摘要： As a result of extensive studies on NAD(P)H oxidase inhibitors, the present inventors found that a quinolone derivative having, at the 2-position, an alkyl group substituted with a heteroatom or the like has an excellent NAD(P)H oxidase inhibitory activity, and accomplished the present invention. The compound of the present invention has a reactive oxygen species production inhibitory activity based on the NAD(P)H oxidase inhibitory activity, and therefore can be used as an agent for preventing and/or treating diabetes, impaired glucose tolerance, hyperlipidemia, fatty liver, diabetic complications and the like.

摘要翻译： 作为对NAD（P）H氧化酶抑制剂的广泛研究的结果，本发明人发现，在2位具有被杂原子等取代的烷基的喹诺酮衍生物具有优异的NAD（P）H氧化酶 抑制活性，完成了本发明。 本发明的化合物具有基于NAD（P）H氧化酶抑制活性的活性氧产生抑制活性，因此可用作糖尿病预防和/或治疗药物，糖耐量异常，高脂血症，脂肪肝 ，糖尿病并发症等。

公开(公告)号：US20100256113A1

公开(公告)日：2010-10-07

申请号：US12680301

申请日：2008-09-25

申请人： Kenichi Onda ,  Kenichiro Imamura ,  Fumie Sato ,  Hiroyuki Moritomo ,  Yasuharu Urano ,  Yuki Sawada ,  Naoki Ishibashi ,  Keita Nakanishi ,  Kazuhiro Yokoyama ,  Shigetada Furukawa ,  Kazuhiro Momose

发明人： Kenichi Onda ,  Kenichiro Imamura ,  Fumie Sato ,  Hiroyuki Moritomo ,  Yasuharu Urano ,  Yuki Sawada ,  Naoki Ishibashi ,  Keita Nakanishi ,  Kazuhiro Yokoyama ,  Shigetada Furukawa ,  Kazuhiro Momose

IPC分类号： A61K31/4709 ,  C07D215/233 ,  C07D405/12 ,  C07D401/12 ,  C07D413/12 ,  A61K31/47 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/4725 ,  A61K31/55 ,  A61K31/553

CPC分类号： C07D401/12 ,  C07D215/233 ,  C07D401/06 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D491/107

摘要： As a result of extensive studies on NAD(P)H oxidase inhibitors, the present inventors found that a quinolone derivative having, at the 2-position, an alkyl group substituted with a heteroatom or the like has an excellent NAD(P)H oxidase inhibitory activity, and accomplished the present invention. The compound of the present invention has a reactive oxygen species production inhibitory activity based on the NAD(P)H oxidase inhibitory activity, and therefore can be used as an agent for preventing and/or treating diabetes, impaired glucose tolerance, hyperlipidemia, fatty liver, diabetic complications and the like.

摘要翻译： 作为对NAD（P）H氧化酶抑制剂的广泛研究的结果，本发明人发现，在2位具有被杂原子等取代的烷基的喹诺酮衍生物具有优异的NAD（P）H氧化酶 抑制活性，完成了本发明。 本发明的化合物具有基于NAD（P）H氧化酶抑制活性的活性氧产生抑制活性，因此可用作糖尿病预防和/或治疗药物，糖耐量异常，高脂血症，脂肪肝 ，糖尿病并发症等。

公开(公告)号：US07868504B2

公开(公告)日：2011-01-11

申请号：US12106406

申请日：2008-04-21

申请人： Nakaba Kataoka ,  Keita Nakanishi

发明人： Nakaba Kataoka ,  Keita Nakanishi

IPC分类号： H02K24/00 ,  G01D5/245

CPC分类号： G01P3/488 ,  H02K1/24 ,  H02K11/225 ,  H02K24/00

摘要： A resolver rotor for a variable reluctance resolver includes a plurality of axially stacked rotor pieces. The rotor pieces are jointly fitted into one body. In the fitting of the rotor pieces, deformed portions are provided between a center of the radial thickness of the resolver rotor and a side surface thereof which is opposite to a stator-side surface thereof. The number of deformed portions is the same as that of projecting poles of the resolver rotor. The deformed portions are arranged at circumferential positions of peaks of the respective projecting poles. At those positions, concave portions are provided on the side surface to receive deformations caused by fitting the rotor pieces together. Thus, the stator-side surface of the resolver rotor is less affected by fitting of the rotor pieces together, preventing a reduction in the detection accuracy of the resolver.

摘要翻译： 用于可变磁阻旋转变压器的旋转变压器转子包括多个轴向堆叠的转子件。 转子片共同组装成一体。 在转子件的装配中，变形部分设置在旋转变压器转子的径向厚度的中心和与其定子侧表面相对的侧表面之间。 变形部的数量与旋转变压器转子的突出极的数量相同。 变形部分布置在各个突出极的峰的圆周位置处。 在这些位置处，在侧面上设置有凹部以容纳通过将转子片装配在一起而引起的变形。 因此，旋转变压器转子的定子侧表面较少受到转子片的配合的影响，防止了旋转变压器的检测精度的降低。

公开(公告)号：US07827673B2

公开(公告)日：2010-11-09

申请号：US12773999

申请日：2010-05-05

申请人： Nakaba Kataoka ,  Keita Nakanishi

发明人： Nakaba Kataoka ,  Keita Nakanishi

IPC分类号： H02K15/02

CPC分类号： H02K5/225 ,  G01D5/2013 ,  H02K3/522 ,  H02K11/225 ,  Y10T29/49009 ,  Y10T29/4902 ,  Y10T29/53143 ,  Y10T29/53157

摘要： In a resolver of a motor, a plurality of wires forming a plurality of coils arranged at a resolver stator portion are arranged at a wiring surface which is arranged at a terminal block of a connector portion and extends between an annular shape surface arranged substantially perpendicularly to a central axis at a core back of an insulator and a plurality of terminal pins, and are connected to a control unit via the terminal pins. Each of the wires of the resolver includes a slackened portion formed at a portion thereof between corresponding terminal pins and corresponding coils. The slackened portion is accommodated in a groove portion arranged at the wiring surface of the connector portion in order to minimize the possibility of damaging the wire improving reliability of the connection between the terminal pin and the coil.

公开(公告)号：US5573579A

公开(公告)日：1996-11-12

申请号：US403108

申请日：1995-03-13

申请人： Keita Nakanishi ,  Takuo Ishihara

发明人： Keita Nakanishi ,  Takuo Ishihara

IPC分类号： F16D69/02 ,  C09K3/14

CPC分类号： F16D69/026

摘要： A method for producing friction material free of pill having at least 2 mm in shorter diameter comprising mixing dispersion medium and friction base comprising carbon fiber having weighted mean fiber length of at least 0.3 mm, binder and friction modifier to form a dispersion ranging in a solid content concentration of 0.5 to 50% by weight, filtering the dispersion, drying a filter cake and forming the cake.

摘要翻译： 一种用于生产不含较短直径至少2mm的药丸的摩擦材料的方法，其包括混合分散介质和包含具有至少0.3mm的加权平均纤维长度的碳纤维的摩擦基，粘合剂和摩擦改进剂以形成在固体中的分散体 含量浓度为0.5〜50重量％，过滤分散液，干燥滤饼并形成滤饼。