摘要:
A choline salt crystal of (1S)-1,5-anhydro-1-[5-(azulen-2-ylmethyl)-2-hydroxyphenyl]-D-glucitol which shows an endothermic peak at 194 to 198° C. as measured by differential scanning calorimetry (DSC analysis) and shows main peaks at about 2θ (°) 5.58, 14.72, 16.80, 17.82, 21.02, and 22.46 as measured by X-ray powder diffraction. Thus, a crystal of an azulene compound can be produced which is in a single crystal form, has a constant quality, can be produced with good reproducibility, can be provided stably as a crystal of an drug substance for use in the preparation of a pharmaceutical and is excellent in storage stability.
摘要:
The present invention provides an azulene derivative and a salt thereof, wherein an azulene ring is bonded to a benzene ring directly or via a lower alkylene which may be substituted with a halogen atom and the benzene ring is directly bonded to the glucose residue, and it is usable as a Na+-glucose cotransporter inhibitor, especially for a therapeutic and/or preventive agent for diabetes such as insulin-dependent diabetes (type 1 diabetes) and insulin-independent diabetes (type 2 diabetes), as well as diabetes-related diseases such as insulin-resistant diseases and obesity.
摘要:
The present invention provides an azulene derivative and a salt thereof, wherein an azulene ring is bonded to a benzene ring directly or via a lower alkylene which may be substituted with a halogen atom and the benzene ring is directly bonded to the glucose residue, and it is usable as a Na+-glucose cotransporter inhibitor, especially for a therapeutic and/or preventive agent for diabetes such as insulin-dependent diabetes (type 1 diabetes) and insulin-independent diabetes (type 2 diabetes), as well as diabetes-related diseases such as insulin-resistant diseases and obesity.
摘要:
A process for producing an azulene derivative useful as a Na+-glucose cotransporter inhibitor, which is high in yield, is simple in operation, is low in cost, is suited for environmental protection, and is advantageous industrially, the process being characterized by reducing and deprotecting at least one compound selected from penta-acyl compounds and tetra-acyl compounds or salts thereof to obtain a C-glycoside compound; and a useful intermediate for synthesis of such an azulene derivative, obtained in the course of the above process.
摘要:
A pneumatic tire has a plurality of circumferential main grooves extending in a tire circumferential direction and a plurality of ribs partitioned by the circumferential main grooves in a tread portion. When viewing a cross-section from a tire meridian direction a contact patch of the center ribs is formed from a smooth curved line forming a convex on an outer side in a tire radial direction and a contact patch of the shoulder rib is formed from a smooth curved line forming a convex on an inner side in the tire radial direction. The curved line of the center ribs and the curved line of the shoulder rib have a point of intersection. A distance between an extended line of the curved line of the center ribs and the curved line of the shoulder rib increases from the point of intersection towards an outer side in a tire width direction.
摘要:
A radio-wave-transmitting-body position detection system in a vehicle system has a plurality of electronic control devices that are included in a vehicle, and a radio wave transmitting body that transmits a radio signal to the plurality of electronic control devices. The electronic control devices conduct communication with each other using the radio signal. Each electronic control device includes a first electronic control device that conducts communication with the other electronic control device and the radio wave transmitting body using the radio signal, and controls a device included in the vehicle based on a content of the radio signal transmitted from the radio wave transmitting body. The electronic control devices except the first electronic control device include a first transmitting/receiving unit that transmits and receives the radio signal.
摘要:
A method for ligating an internal body tissue using an outer cylinder member and an inner cylinder member including the processes of projecting the inner cylinder from a front end of the outer cylinder member; attaching a ligation band member to an outer peripheral surface of the inner cylinder member; contacting a front end of the inner cylinder member with an internal body tissue; suctioning an inside of the inner cylinder member via a channel communicated with the inside of the inner cylinder member such that the internal body tissue is drawn into the inner cylinder member; and ligating the internal body tissue with the ligation band member by disconnecting the ligation band member from the front end of the inner cylinder member when the inner cylinder member is drawn into the inside the outer cylinder member at a position where the ligation band member is disconnected.
摘要:
A high-strength quenched formed article has a zinc plating layer which is formed at a post-quenching formed steel sheet surface, and which contains 30 g/m2 or more of a phase that contains 5% or more by mass but 30% or less by mass of Fe, and which also contains 0.15% or more by mass but less than 2% by mass of at least one of Al and Si in a separate fashion or a composite fashion, and contains Zn, which makes up substantially a rest portion of the zinc plating layer, and an inevitable impurity, wherein the high-strength quenched formed article has a high-strength portion having a post-quenching-formation tensile strength of 1000 MPa or more, and a low-strength portion having a post-quenching-formation tensile strength of 800 MPa or less.
摘要翻译:高强度淬火成型体具有在后淬火成形钢板表面形成的镀锌层,其含有30g / m 2以上含有5质量%以上且30质量%以下的相 的Fe,并且其还含有0.15%以上且小于2质量%的Al和Si中的至少一种,以单独的方式或复合形式,并且含有Zn,其基本上构成休止部分 的镀锌层和不可避免的杂质,其中高强度骤冷成形体具有淬火后形成抗拉强度为1000MPa以上的高强度部分, 淬火形成抗拉强度在800MPa以下。
摘要:
An image forming apparatus includes: a switch member that selectively switches a blowing direction of an air drawn by a fan and passing through a duct to a direction toward a conveying roller pair or a direction toward a sheet conveying path between the conveying roller pair and a fixing device; and a control portion that switches the switch member, based on a setting by an operation portion to that a gloss mode for an image to be formed on the sheet is set, so that when a mode for forming a high gloss image is set, the blowing direction of the air is switched to the direction toward the pair of rollers, and when a mode for forming a low gloss image is set, the blowing direction of the air is switched to the direction toward the sheet conveying path.
摘要:
Provided is a scroll type compressor which reduces variations in the pressing load of a rotating scroll on a fixed scroll, reduces the impact at the start of the compressor and suppresses noises, and can provide excellent durability. A peripheral elastic body 51 and a bottom-portion elastic body 52, which is brought into a compressed condition in the axis line direction of the main shaft 31, are interposed between a stopper pin 41 on the rotating scroll side and a concave portion 42 on the main shaft 31 side, whereby working errors of each part are compensated and the rotating scroll is constantly brought into close contact with the fixed scroll to maintain the sealing of the compression chamber.