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公开(公告)号:US20210030937A1
公开(公告)日:2021-02-04
申请号:US17067699
申请日:2020-10-11
Applicant: Medtronic, Inc.
Inventor: Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
Abstract: Apparatuses, systems, and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. A first sorbent cartridge is provided for use in a portable treatment module having activated carbon and zirconium oxide. The system also provides for the monitoring of an inlet and outlet conductivity of a sorbent cartridge containing urease to provide a facility to quantify or monitor the removal of urea by a detachable urea removal module.
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公开(公告)号:US20200330674A1
公开(公告)日:2020-10-22
申请号:US16907408
申请日:2020-06-22
Applicant: Medtronic, Inc.
Inventor: Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
Abstract: Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.
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公开(公告)号:US10040021B2
公开(公告)日:2018-08-07
申请号:US14593588
申请日:2015-01-09
Applicant: MEDTRONIC, INC.
Inventor: Andrew J. Ries , SuPing Lyu , Catherine M. Asgian , David Engmark , Ananta Pandey , Todd Schaefer , Erik Scott , Joachim Hossick-Schott
Abstract: Frame structures, assemblies and methods for use in implantable medical devices. The frames may include one or more first polymeric portions and one or more second polymeric portions coupled to the one or more first polymeric portions. The one or more first polymeric portions may have a higher durometer than the one or more second polymeric portions. The one or more second polymeric portions may provide an interference fit between the one or more second polymeric portions and the housing and/or between the one or more second polymeric portions and one or more components disposed in the housing.
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公开(公告)号:US20200306439A1
公开(公告)日:2020-10-01
申请号:US16877758
申请日:2020-05-19
Applicant: Medtronic, Inc.
Inventor: Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
Abstract: Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.
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公开(公告)号:US20150367055A1
公开(公告)日:2015-12-24
申请号:US14642847
申请日:2015-03-10
Applicant: Medtronic, Inc.
Inventor: Bryant J. Pudil , SuPing Lyu , Eric Grovender , Christopher M. Hobot , Martin T. Gerber
CPC classification number: A61M1/1696 , B01J39/09 , C01B25/45
Abstract: Methods and related apparatuses for sorbent recharging are provided. The methods and related apparatuses for recharging can recharge a specific rechargeable layer of a sorbent material such as zirconium phosphate in a sorbent cartridge. The methods and apparatuses include passing solutions containing combinations of acids, bases and salts through a module containing a rechargeable sorbent material such as zirconium phosphate in order to replace ions bound to the zirconium phosphate with hydrogen and sodium ions. The method allows for a customizable zirconium phosphate, with control over the ratios of sodium to hydrogen on the recharged zirconium phosphate.
Abstract translation: 提供吸附剂再充电的方法和相关设备。 用于再充电的方法和相关装置可以对吸附剂盒中的吸附剂材料例如磷酸锆的特定可再充电层进行再充电。 所述方法和装置包括通过含有可再充电的吸附剂材料如磷酸锆的模块来传递含有酸,碱和盐的组合的溶液,以便用氢和钠离子代替与磷酸锆结合的离子。 该方法允许可定制的磷酸锆,控制再充电的磷酸锆上钠与氢的比例。
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公开(公告)号:US20150196867A1
公开(公告)日:2015-07-16
申请号:US14593588
申请日:2015-01-09
Applicant: MEDTRONIC, INC.
Inventor: Andrew J. Ries , SuPing Lyu , Catherine M. Asgian , David Engmark , Ananta Pandey , Todd Schaefer , Erik Scott , Joachim Hossick-Schott
CPC classification number: B01D53/0407 , A61N1/375 , A61N1/3758 , B01D2253/102 , B01D2253/1122 , B01D2253/202 , B01D2257/108 , B01D2257/80 , H01M2/1022 , H01M10/4264 , H01M2220/30 , Y10T29/49108
Abstract: Frame structures, assemblies and methods for use in implantable medical devices. The frames may include one or more first polymeric portions and one or more second polymeric portions coupled to the one or more first polymeric portions. The one or more first polymeric portions may have a higher durometer than the one or more second polymeric portions. The one or more second polymeric portions may provide an interference fit between the one or more second polymeric portions and the housing and/or between the one or more second polymeric portions and one or more components disposed in the housing.
Abstract translation: 用于可植入医疗器械的框架结构,组件和方法。 框架可以包括一个或多个第一聚合物部分和联接到一个或多个第一聚合物部分的一个或多个第二聚合物部分。 一个或多个第一聚合物部分可以具有比一个或多个第二聚合物部分更高的硬度。 一个或多个第二聚合物部分可以在一个或多个第二聚合物部分和壳体之间和/或在一个或多个第二聚合物部分和设置在壳体中的一个或多个部件之间提供过盈配合。
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公开(公告)号:US20170361006A1
公开(公告)日:2017-12-21
申请号:US15693535
申请日:2017-09-01
Applicant: Medtronic, Inc.
Inventor: Martin Gerber , John Burnes , SuPing Lyu , VenKatesh R. Manda , Bryant Pudil
IPC: A61M1/16 , A61M1/36 , A61B5/00 , A61B5/026 , A61B5/0295 , A61M1/28 , A61B5/145 , A61M1/00 , A61M1/14 , B01D65/02 , B01D61/32 , B01D61/00 , A61M1/34 , A61B5/053
Abstract: Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patient parameters. By comparing the patient's past responses to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.
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公开(公告)号:US11548974B2
公开(公告)日:2023-01-10
申请号:US17112344
申请日:2020-12-04
Applicant: Medtronic, Inc.
Inventor: Kimberly A. Chaffin , Xiangji Chen , Matthew Jolly , SuPing Lyu , Peter L. Thor , Darrel F. Untereker , Zhaoxu Wang
IPC: C08G18/62 , C08G18/76 , C08G18/32 , A61N1/05 , C08G18/10 , A61L31/16 , A61L31/06 , C08G18/65 , A61B5/145 , A61B5/00 , A61N1/36 , A61N1/362
Abstract: A modified polyisobutylene-based polymer, method of making, and a medical device that includes such polymer, wherein the modified polyisobutylene-based polymer includes urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments include diisocyanate residues and optionally chain extender residues.
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公开(公告)号:US20210115182A1
公开(公告)日:2021-04-22
申请号:US17112344
申请日:2020-12-04
Applicant: Medtronic, Inc.
Inventor: Kimberly A. Chaffin , Xiangji Chen , Matthew Jolly , SuPing Lyu , Peter L. Thor , Darrel F. Untereker , Zhaoxu Wang
IPC: C08G18/62 , A61B5/00 , A61L31/06 , A61L31/16 , A61N1/05 , C08G18/10 , C08G18/32 , C08G18/65 , C08G18/76 , A61B5/145
Abstract: A modified polyisobutylene-based polymer, method of making, and a medical device that includes such polymer, wherein the modified polyisobutylene-based polymer includes urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments include diisocyanate residues and optionally chain extender residues.
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公开(公告)号:US10882945B2
公开(公告)日:2021-01-05
申请号:US16359079
申请日:2019-03-20
Applicant: Medtronic, Inc.
Inventor: Kimberly A. Chaffin , Xiangji Chen , Matthew Jolly , SuPing Lyu , Peter L. Thor , Darrel F. Untereker , Zhaoxu Wang
IPC: C08G18/62 , C08G18/76 , C08G18/32 , A61N1/05 , C08G18/10 , A61L31/16 , A61L31/06 , C08G18/65 , A61B5/145 , A61B5/00 , A61N1/36 , A61N1/362
Abstract: A modified polyisobutylene-based polymer, method of making, and a medical device that includes such polymer, wherein the modified polyisobutylene-based polymer includes urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments include diisocyanate residues and optionally chain extender residues.
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