公开(公告)号：US08830573B2

公开(公告)日：2014-09-09

申请号：US12943818

申请日：2010-11-10

Applicant: Meng Cui ,  Changhuei Yang

Inventor： Meng Cui ,  Changhuei Yang

IPC: G02B21/06 ,  G02B21/00

CPC classification number: G02B21/0056 ,  A61B5/0059 ,  A61B5/0066 ,  G01N21/1717 ,  G01N21/4795 ,  G01N21/6456 ,  G01N2021/1708 ,  G01N2021/1727 ,  G02B21/00 ,  G02B21/0004 ,  G02B21/0068 ,  G02B21/0092 ,  Y10T29/49826

Abstract: A 4-Pi microscope for imaging a sample, comprising a first objective for focusing a first light beam on the sample at a spatial point one or more Digital Optical Phase Conjugation (DOPC) devices, wherein the DOPC devices include a sensor for detecting the first light beam that has been transmitted through the sample and inputted on the sensor; and a spatial light modulator (SLM) for outputting, in response to the first light beam detected by the sensor, a second light beam that is an optical phase conjugate of the first light beam; and a second objective positioned to transmit the first light beam to the sensor and focus the second light beam on the sample at the spatial point, so that the first light beam and the second light beam are counter-propagating and both focused to the spatial point.

Abstract translation: 一种用于对样本进行成像的4-Pi显微镜，包括用于在空间点上将第一光束聚焦在一个或多个数字光相位共轭（DOPC）装置上的第一物镜，其中所述DOPC装置包括用于检测所述第一 通过样品传输并输入到传感器上的光束; 以及空间光调制器（SLM），用于响应于由传感器检测到的第一光束，输出作为第一光束的光学相位共轭的第二光束; 以及第二目的，其定位为将第一光束传输到传感器并将第二光束聚焦在空间点处的样本上，使得第一光束和第二光束相反传播并且两者都聚焦到空间点 。

公开(公告)号：US08760661B2

公开(公告)日：2014-06-24

申请号：US13463384

申请日：2012-05-03

Applicant: Meng Cui

Inventor： Meng Cui

IPC: G01J3/45

CPC classification number: H01S3/10 ,  G01J9/00 ,  H01S3/0057 ,  H01S3/10053

Abstract: An apparatus includes a spatial light modulator configured to receive an optical pulse train; and output a modulated optical pulse train; a non-linear optical system that receives the modulated optical pulse train and generates a non-linear optical signal; and a power detector that detects a power of the generated non-linear optical signal. A control system outputs a signal to the spatial light modulator to cause it to modulate the optical pulse train by modulating the spectral phase of the optical pulse at wavelengths within a current wavelength range subset and maintain the spectral phase of the optical pulse constant at wavelengths outside the current wavelength range subset; and based on the detected power, extracts values of the spectral phase for the optical pulse at wavelengths within the current wavelength range subset, the values extracted being those that compress the optical pulses.

Abstract translation: 一种装置，包括配置成接收光脉冲串的空间光调制器; 并输出调制的光脉冲串; 接收经调制的光脉冲串并产生非线性光信号的非线性光学系统; 以及检测所生成的非线性光信号的功率的功率检测器。 控制系统向空间光调制器输出信号，使其通过在当前波长范围子集内的波长处调制光脉冲的光谱相位来调制光脉冲串，并保持光脉冲的光谱相位在波长外恒定 当前波长范围子集; 并且基于检测到的功率，提取在当前波长范围子集内的波长处的光脉冲的光谱相位的值，提取的值是压缩光脉冲的值。

公开(公告)号：US08717574B2

公开(公告)日：2014-05-06

申请号：US12943857

申请日：2010-11-10

Applicant: Changhuei Yang ,  Meng Cui

Inventor： Changhuei Yang ,  Meng Cui

IPC: G01B9/021

CPC classification number: G02B21/0056 ,  A61B5/0059 ,  A61B5/0066 ,  G01N21/1717 ,  G01N21/4795 ,  G01N21/6456 ,  G01N2021/1708 ,  G01N2021/1727 ,  G02B21/00 ,  G02B21/0004 ,  G02B21/0068 ,  G02B21/0092 ,  Y10T29/49826

Abstract: A detector of light transmitted through a turbid medium, comprising: one or more Digital Optical Phase Conjugation (DOPC) devices, wherein the DOPC devices include (1) a sensor for detecting input light that has been transmitted through the turbid medium and inputted on the sensor; and (2) a spatial light modulator (SLM) for outputting, in response to the input light detected by the sensor, output light that is an optical phase conjugate of the input light.

Abstract translation: 透射通过混浊介质的光检测器，包括：一个或多个数字光相位共轭（DOPC）装置，其中所述DOPC装置包括（1）用于检测通过所述混浊介质传输并输入到所述混浊介质上的输入光的传感器 传感器; 以及（2）空间光调制器（SLM），用于响应于由传感器检测的输入光输出作为输入光的光学相位共轭的输出光。

公开(公告)号：US20110122416A1

公开(公告)日：2011-05-26

申请号：US12943857

申请日：2010-11-10

Applicant: Changhuei Yang ,  Meng Cui

Inventor： Changhuei Yang ,  Meng Cui

IPC: G01B9/021 ,  G01N21/00 ,  B23P11/00

CPC classification number: G02B21/0056 ,  A61B5/0059 ,  A61B5/0066 ,  G01N21/1717 ,  G01N21/4795 ,  G01N21/6456 ,  G01N2021/1708 ,  G01N2021/1727 ,  G02B21/00 ,  G02B21/0004 ,  G02B21/0068 ,  G02B21/0092 ,  Y10T29/49826

Abstract: A detector of light transmitted through a turbid medium, comprising: one or more Digital Optical Phase Conjugation (DOPC) devices, wherein the DOPC devices include (1) a sensor for detecting input light that has been transmitted through the turbid medium and inputted on the sensor; and (2) a spatial light modulator (SLM) for outputting, in response to the input light detected by the sensor, output light that is an optical phase conjugate of the input light.

Abstract translation: 透射通过混浊介质的光检测器，包括：一个或多个数字光相位共轭（DOPC）装置，其中所述DOPC装置包括（1）用于检测通过所述混浊介质传输并输入到所述混浊介质上的输入光的传感器 传感器; 以及（2）空间光调制器（SLM），用于响应于由传感器检测的输入光输出作为输入光的光学相位共轭的输出光。

公开(公告)号：US08866107B2

公开(公告)日：2014-10-21

申请号：US13548011

申请日：2012-07-12

Applicant: Meng Cui

Inventor： Meng Cui

IPC: G01J1/58 ,  G02B26/06 ,  G01J9/02 ,  G01N21/64 ,  G01J9/04 ,  G01N21/49 ,  G02B21/00

CPC classification number: G01N21/49 ,  G01J9/02 ,  G01J9/04 ,  G01N21/64 ,  G02B21/0004 ,  G02B21/0072 ,  G02B26/06

Abstract: Wavefront distortions of an optical beam are measured. The transverse optical modes of the optical beam are partitioned into a plurality of subsets of transverse optical modes, one of the subsets of transverse optical modes is selected as the current subset, and the optical beam is modulated based on the current subset by maintaining the transverse optical modes of the optical beam that are outside the current subset stable, and modulating the transverse optical modes of the optical beam within the current subset. A non-linear optical signal is generated from the modulated optical beam by directing the modulated optical beam through a non-linear optical system that includes a random scattering medium, the power of the generated non-linear optical signal is measured, and, based on the measured power, values of the spatial phase for the optical beam at transverse optical modes are extracted within the current subset.

Abstract translation: 测量光束的波前失真。 光束的横向光学模式被划分为多个横向光学子集，横向光学模式的子集中的一个被选择为当前子集，并且基于当前子集来调整光束，通过保持横向 在当前子集之外的光束的光学模式是稳定的，并且调制当前子集内的光束的横向光学模式。 通过将调制光束引导通过包括随机散射介质的非线性光学系统，从调制光束产生非线性光信号，测量所生成的非线性光信号的功率，并且基于 在当前子集内提取测量的功率，横向光学模式下光束的空间相位值。

公开(公告)号：US20130182253A1

公开(公告)日：2013-07-18

申请号：US13548011

申请日：2012-07-12

Applicant: Meng Cui

Inventor： Meng Cui

IPC: G01N21/49 ,  G01N21/64

CPC classification number: G01N21/49 ,  G01J9/02 ,  G01J9/04 ,  G01N21/64 ,  G02B21/0004 ,  G02B21/0072 ,  G02B26/06

Abstract: Wavefront distortions of an optical beam are measured. The transverse optical modes of the optical beam are partitioned into a plurality of subsets of transverse optical modes, one of the subsets of transverse optical modes is selected as the current subset, and the optical beam is modulated based on the current subset by maintaining the transverse optical modes of the optical beam that are outside the current subset stable, and modulating the transverse optical modes of the optical beam within the current subset. A non-linear optical signal is generated from the modulated optical beam by directing the modulated optical beam through a non-linear optical system that includes a random scattering medium, the power of the generated non-linear optical signal is measured, and, based on the measured power, values of the spatial phase for the optical beam at transverse optical modes are extracted within the current subset.

Abstract translation: 测量光束的波前失真。 光束的横向光学模式被划分为多个横向光学子集，横向光学模式的子集中的一个被选择为当前子集，并且基于当前子集来调整光束，通过保持横向 在当前子集之外的光束的光学模式是稳定的，并且调制当前子集内的光束的横向光学模式。 通过将调制光束引导通过包括随机散射介质的非线性光学系统，从调制光束产生非线性光信号，测量所生成的非线性光信号的功率，并且基于 在当前子集内提取测量的功率，横向光学模式下光束的空间相位值。

公开(公告)号：US08450674B2

公开(公告)日：2013-05-28

申请号：US12943841

申请日：2010-11-10

Applicant: Changhuei Yang ,  Charles DiMarzio ,  Meng Cui ,  Ying Min Wang

Inventor： Changhuei Yang ,  Charles DiMarzio ,  Meng Cui ,  Ying Min Wang

IPC: H01L27/00

CPC classification number: G02B21/0056 ,  A61B5/0059 ,  A61B5/0066 ,  G01N21/1717 ,  G01N21/4795 ,  G01N21/6456 ,  G01N2021/1708 ,  G01N2021/1727 ,  G02B21/00 ,  G02B21/0004 ,  G02B21/0068 ,  G02B21/0092 ,  Y10T29/49826

Abstract: A light microscope for imaging a sample containing one or more fluorescent agents, comprising a source for generating acoustic waves that are focused at a focus in the sample, wherein the acoustic waves frequency shift a frequency of light passing through the focus, thereby creating a frequency shifted light beam; at least one spatial light modulator (SLM) positioned to illuminate the sample with an output beam that is an optical phase conjugate of the frequency shifted light beam, wherein the output beam is a reflection of a first reference beam off one or more pixels of the SLM, and the pixels are for modulating the first reference beam to create the output beam; and a detector positioned to detect fluorescence generated by the output beam exciting the fluorescent agents at the focus in the sample, thereby imaging the sample.

Abstract translation: 一种用于对含有一种或多种荧光剂的样品进行成像的光学显微镜，其包括用于产生聚焦在样品中的聚焦的声波的源，其中所述声波使通过所述焦点的光的频率偏移，由此产生频率 移动光束; 至少一个空间光调制器（SLM），定位成用作为所述频移光束的光学相位共轭的输出光束照射所述样本，其中所述输出光束是第一参考光束的反射离开所述第一参考光束的一个或多个像素 SLM，并且像素用于调制第一参考光束以产生输出光束; 以及检测器，用于检测在样品中焦点处激发荧光剂的输出光束产生的荧光，从而对样品进行成像。

公开(公告)号：US08716677B2

公开(公告)日：2014-05-06

申请号：US13353029

申请日：2012-01-18

Applicant: Meng Cui

Inventor： Meng Cui

IPC: G01J1/58 ,  G01B9/02 ,  G02B27/00 ,  A61B5/00 ,  G01J3/45

CPC classification number: G01B9/02091 ,  A61B5/0062 ,  A61B5/0066 ,  G01J3/45 ,  G01J9/02 ,  G01J9/04 ,  G02B26/06 ,  G02B27/0031

Abstract: An apparatus includes a transverse scanning optical system in the path of a first light beam traveling along a first optic axis; a wavefront correction system in the path of a second light beam traveling along a second optic axis, the wavefront correction system including a wavefront correction device having a spatial phase profile on its surface; a beam combiner that receives the first light beam and the second light beam and outputs an interference beam having a beat frequency equal to a difference frequency between the first light beam and second light beam; and a detection system placed relative to a random scattering medium, which is in the path of the interference beam. The detection system detects measurement light produced by the random scattering medium while the interference beam strikes the random scattering medium.

Abstract translation: 一种装置包括在沿着第一光轴行进的第一光束的路径中的横向扫描光学系统; 所述波前校正系统包括沿着第二光轴行进的第二光束的路径中的波前校正系统，所述波前校正系统包括在其表面上具有空间相位轮廓的波前校正装置; 接收第一光束和第二光束并且输出具有等于第一光束和第二光束之间的差分频率的拍频的干涉光束的光束组合器; 以及相对于在干涉光束的路径中的随机散射介质放置的检测系统。 检测系统检测由随机散射介质产生的测量光，同时干涉光束照射随机散射介质。

公开(公告)号：US20130114630A1

公开(公告)日：2013-05-09

申请号：US13463384

申请日：2012-05-03

Applicant: Meng Cui

Inventor： Meng Cui

IPC: H01S3/10

CPC classification number: H01S3/10 ,  G01J9/00 ,  H01S3/0057 ,  H01S3/10053

Abstract: An apparatus includes a spatial light modulator configured to receive an optical pulse train; and output a modulated optical pulse train; a non-linear optical system that receives the modulated optical pulse train and generates a non-linear optical signal; and a power detector that detects a power of the generated non-linear optical signal. A control system outputs a signal to the spatial light modulator to cause it to modulate the optical pulse train by modulating the spectral phase of the optical pulse at wavelengths within a current wavelength range subset and maintain the spectral phase of the optical pulse constant at wavelengths outside the current wavelength range subset; and based on the detected power, extracts values of the spectral phase for the optical pulse at wavelengths within the current wavelength range subset, the values extracted being those that compress the optical pulses.

Abstract translation: 一种装置，包括配置成接收光脉冲串的空间光调制器; 并输出调制的光脉冲串; 接收经调制的光脉冲串并产生非线性光信号的非线性光学系统; 以及检测所生成的非线性光信号的功率的功率检测器。 控制系统向空间光调制器输出信号，使其通过在当前波长范围子集内的波长处调制光脉冲的光谱相位来调制光脉冲串，并保持光脉冲的光谱相位在波长外恒定 当前波长范围子集; 并且基于检测到的功率，提取在当前波长范围子集内的波长处的光脉冲的光谱相位的值，提取的值是压缩光脉冲的值。

公开(公告)号：US20110109962A1

公开(公告)日：2011-05-12

申请号：US12943818

申请日：2010-11-10

Applicant: Meng Cui ,  Changhuei Yang

Inventor： Meng Cui ,  Changhuei Yang

IPC: G02B21/06 ,  G01B9/021

CPC classification number: G02B21/0056 ,  A61B5/0059 ,  A61B5/0066 ,  G01N21/1717 ,  G01N21/4795 ,  G01N21/6456 ,  G01N2021/1708 ,  G01N2021/1727 ,  G02B21/00 ,  G02B21/0004 ,  G02B21/0068 ,  G02B21/0092 ,  Y10T29/49826

Abstract: A 4-Pi microscope for imaging a sample, comprising a first objective for focusing a first light beam on the sample at a spatial point one or more Digital Optical Phase Conjugation (DOPC) devices, wherein the DOPC devices include a sensor for detecting the first light beam that has been transmitted through the sample and inputted on the sensor; and a spatial light modulator (SLM) for outputting, in response to the first light beam detected by the sensor, a second light beam that is an optical phase conjugate of the first light beam; and a second objective positioned to transmit the first light beam to the sensor and focus the second light beam on the sample at the spatial point, so that the first light beam and the second light beam are counter-propagating and both focused to the spatial point.

Abstract translation: 一种用于对样本进行成像的4-Pi显微镜，包括用于在空间点上将第一光束聚焦在一个或多个数字光相位共轭（DOPC）装置上的第一物镜，其中所述DOPC装置包括用于检测所述第一 通过样品传输并输入到传感器上的光束; 以及空间光调制器（SLM），用于响应于由传感器检测到的第一光束，输出作为第一光束的光学相位共轭的第二光束; 以及第二目的，其定位为将第一光束传输到传感器并将第二光束聚焦在空间点处的样本上，使得第一光束和第二光束相反传播并且两者都聚焦到空间点 。