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公开(公告)号：US20120184510A1
公开(公告)日：2012-07-19
申请号：US13006810
申请日：2011-01-14
申请人： Raymond W. Colburn , Scott L. Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark A. Youngman
发明人： Raymond W. Colburn , Scott L. Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark A. Youngman
IPC分类号： A61K31/675 , C07F9/28 , C07F9/02 , C07D333/50 , A61K31/67
CPC分类号： C07F9/655354 , C07F9/5728 , C07F9/6541 , C07F9/65517 , C07F9/655345 , C07F9/65586 , C07F9/6561
摘要： The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.
摘要翻译： 本发明涉及式（I）的TRPM8拮抗剂。 更具体地说，本发明涉及某些新化合物，制备化合物，组合物，中间体及其衍生物的方法和治疗TRPM8介导的病症的方法。 还描述了使用本发明化合物治疗疼痛和各种其它疾病状态或病症的药物和兽医组合物和方法。
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公开(公告)号：US20080027029A1
公开(公告)日：2008-01-31
申请号：US11746318
申请日：2007-05-09
申请人： Raymond Colburn , Scott Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark Youngman
发明人： Raymond Colburn , Scott Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark Youngman
IPC分类号： A61K31/67 , A61K31/665 , A61K31/675 , A61P25/00 , A61P29/00 , A61P9/00 , A61P9/12 , C07D495/00 , C07F9/572 , C07F9/655 , C07F9/6553
CPC分类号： C07F9/655354 , C07F9/5728 , C07F9/65517 , C07F9/65586 , C07F9/6561
摘要： The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.
摘要翻译： 本发明涉及式（I）的TRPM8拮抗剂。 更具体地说，本发明涉及某些新化合物，制备化合物，组合物，中间体及其衍生物的方法和治疗TRPM8介导的病症的方法。 还描述了使用本发明化合物治疗疼痛和各种其它疾病状态或病症的药物和兽医组合物和方法。
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公开(公告)号：US08629281B2
公开(公告)日：2014-01-14
申请号：US13006810
申请日：2011-01-14
申请人： Raymond W. Colburn , Scott L. Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark A. Youngman
发明人： Raymond W. Colburn , Scott L. Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark A. Youngman
IPC分类号： C07F9/28
CPC分类号： C07F9/655354 , C07F9/5728 , C07F9/6541 , C07F9/65517 , C07F9/655345 , C07F9/65586 , C07F9/6561
摘要： The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.
摘要翻译： 本发明涉及式（I）的TRPM8拮抗剂。 更具体地说，本发明涉及某些新化合物，制备化合物，组合物，中间体及其衍生物的方法和治疗TRPM8介导的病症的方法。 还描述了使用本发明化合物治疗疼痛和各种其它疾病状态或病症的药物和兽医组合物和方法。
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公开(公告)号：US07517676B2
公开(公告)日：2009-04-14
申请号：US11651705
申请日：2007-01-10
申请人： Ning Qin , Ellen E. Codd , Christopher Flores , Sui-Po Zhang
发明人： Ning Qin , Ellen E. Codd , Christopher Flores , Sui-Po Zhang
CPC分类号： C12N9/0083 , A61K38/00
摘要： The present invention provides nucleic acid and polypeptide sequences describing a neve isozyme of the cyclooxygenase enzyme, herein named as human cyclooxygenase 3. The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays, gene therapy, and screening assays.
摘要翻译： 本发明提供描述环氧合酶的神经同工酶的核酸和多肽序列，本文命名为人环加氧酶3.本发明的分离的核酸或多肽分子可用于检测测定，基因治疗和筛选测定。
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公开(公告)号：US20070105155A1
公开(公告)日：2007-05-10
申请号：US11590503
申请日：2006-10-31
申请人： Ning Qin , Christopher Flores
发明人： Ning Qin , Christopher Flores
IPC分类号： G01N33/53
CPC分类号： C07K14/705 , G01N33/6872 , G01N2333/4727 , G01N2500/02
摘要： The present invention discovered that a mammalian TRPM8 binds to calmodulin. The present invention provides a polypeptide complex comprising a cold-menthol receptor (TRPM8) or an active fragment or derivative of TRPM8 and a calmodulin or an active fragment or derivative of calmodulin, and the uses of the polypeptide complex.
摘要翻译： 本发明发现哺乳动物TRPM8与钙调蛋白结合。 本发明提供了包含冷薄荷醇受体（TRPM8）或TRPM8的活性片段或衍生物和钙调蛋白或钙调蛋白的活性片段或衍生物的多肽复合物，以及多肽复合物的用途。
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公开(公告)号：US07897781B2
公开(公告)日：2011-03-01
申请号：US11746318
申请日：2007-05-09
申请人： Raymond W. Colburn , Scott L. Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark A. Youngman
发明人： Raymond W. Colburn , Scott L. Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark A. Youngman
IPC分类号： C07F9/28
CPC分类号： C07F9/655354 , C07F9/5728 , C07F9/65517 , C07F9/65586 , C07F9/6561
摘要： The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.
摘要翻译： 本发明涉及式（I）的TRPM8拮抗剂。 更具体地说，本发明涉及某些新化合物，制备化合物，组合物，中间体及其衍生物的方法和治疗TRPM8介导的病症的方法。 还描述了使用本发明化合物治疗疼痛和各种其它疾病状态或病症的药物和兽医组合物和方法。
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公开(公告)号：US20070166789A1
公开(公告)日：2007-07-19
申请号：US11651705
申请日：2007-01-10
申请人： Ning Qin , Ellen Codd , Christopher Flores , Sui-Po Zhang
发明人： Ning Qin , Ellen Codd , Christopher Flores , Sui-Po Zhang
CPC分类号： C12N9/0083 , A61K38/00
摘要： The present invention provides nucleic acid and polypeptide sequences describing a novel isozyme of the cyclooxygenase enzyme, herein named as human cyclooxygenase-3. The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays, gene therapy, and screening assays.
摘要翻译： 本发明提供描述环氧合酶的新型同工酶的核酸和多肽序列，这里命名为人环加氧酶-3。 本发明的分离的核酸或多肽分子可用于检测测定，基因治疗和筛选测定。
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公开(公告)号：US20070105086A1
公开(公告)日：2007-05-10
申请号：US11589340
申请日：2006-10-30
申请人： Ning Qin , Yi Liu , Christopher Flores , Tasha Hutchinson , Michael Neeper
发明人： Ning Qin , Yi Liu , Christopher Flores , Tasha Hutchinson , Michael Neeper
CPC分类号： G01N33/6872 , A61K31/05 , A61K31/352 , G01N33/5058 , G01N33/948 , G01N2500/02
摘要： It has now been discovered that certain cannabinoids specifically activate TRPV2 channel activity. Based on the discovery, novel compositions and methods for screening, identifying and characterizing compounds that increase or decrease the biological activity of a TRPV2.
摘要翻译： 现在已经发现某些大麻素特异性地激活TRPV2通道活性。 基于发现，用于筛选，鉴定和表征增加或降低TRPV2生物活性的化合物的新型组合物和方法。
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公开(公告)号：US20060014246A1
公开(公告)日：2006-01-19
申请号：US11099855
申请日：2005-04-06
申请人： Christopher Flores , Yi Liu , Mary Lubin , Ning Qin
发明人： Christopher Flores , Yi Liu , Mary Lubin , Ning Qin
IPC分类号： A61K38/17 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides nucleic acid and polypeptide sequences describing a novel canine cold- and menthol-sensitive receptor, herein named as canine CMR1 (cCMR1). The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays and screening assays.
摘要翻译： 本发明提供描述新型犬冷和薄荷醇敏感受体的核酸和多肽序列，本文命名为犬CMR1（cCMR1）。 本发明的分离的核酸或多肽分子可用于检测测定和筛选测定。
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公开(公告)号：US07645755B2
公开(公告)日：2010-01-12
申请号：US11408096
申请日：2006-04-20
申请人： Carl R. Illig , Shelley K. Ballentine , Jinsheng Chen , Sanath K. Meegalla , M. Jonathan Rudolph , Mark J. Wall , Kenneth J. Wilson , Renee L. Desjarlais , Carl L. Manthey , Christopher Flores , Christopher J. Molloy
发明人： Carl R. Illig , Shelley K. Ballentine , Jinsheng Chen , Sanath K. Meegalla , M. Jonathan Rudolph , Mark J. Wall , Kenneth J. Wilson , Renee L. Desjarlais , Carl L. Manthey , Christopher Flores , Christopher J. Molloy
IPC分类号： A61K31/5377 , A61K31/454 , C07D413/14 , C07D401/02
CPC分类号： C07D307/71 , A61K45/06 , C07D401/12 , C07D401/14 , C07D407/12 , C07D409/12 , C07D409/14
摘要： The invention is directed to compounds of Formula I: wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.
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