公开(公告)号：US11578053B2

公开(公告)日：2023-02-14

申请号：US17546284

申请日：2021-12-09

Applicant: NOVARTIS AG

Inventor： Peng Fu ,  Yu Gai ,  Feng Gao ,  Weiyong Kong ,  Yadong Lu ,  Zhongcheng Min ,  Shaofeng Rong ,  Chutian Shu ,  Can Wang ,  Ruidong Wang ,  Jibin Zhao ,  Xianglin Zhao ,  Yi Zhao ,  Jianguang Zhou ,  Benjamin Martin

IPC: C07D401/06 ,  C07D209/04 ,  C07D211/74

Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-(((2S,4S)-(4-ethoxy-1-(((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11434192B2

公开(公告)日：2022-09-06

申请号：US16452452

申请日：2019-06-25

Applicant: Novartis AG

Inventor： Florian Karl Kleinbeck-Riniker ,  Benjamin Martin ,  Gerhard Penn ,  Francesco Venturoni ,  Thierry Schlama ,  Thomas Ruch ,  Thomas Allmendinger ,  Bernhard Wietfeld ,  Paolo Filipponi

IPC: C07C59/84 ,  C07C67/035 ,  C07C213/08 ,  C07C69/738 ,  C07C313/06 ,  C07C229/34 ,  C07D265/02 ,  C07D207/36 ,  C07C251/40 ,  C07C251/66 ,  C07C51/373

Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.

公开(公告)号：US10851059B2

公开(公告)日：2020-12-01

申请号：US16325880

申请日：2017-08-16

Applicant: Novartis AG

Inventor： Florian Karl Kleinbeck-Riniker ,  Ives Mafli ,  Benjamin Martin ,  Gerhard Penn ,  Gottfried Sedelmeier ,  Joerg Sedelmeier ,  Francesco Venturoni

IPC: C07C271/22 ,  C07D213/16 ,  C07C201/12 ,  C07C251/38 ,  C07C201/16 ,  C07C205/53 ,  C07C249/08 ,  C07D213/36 ,  C07C205/51 ,  C07C67/347 ,  C07C231/02 ,  C07C269/00 ,  C07C201/06 ,  C07C227/18 ,  C07C45/49 ,  C07C229/06 ,  C07C249/02 ,  C07D207/267 ,  C07D207/12

Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.

公开(公告)号：US10385004B2

公开(公告)日：2019-08-20

申请号：US15550224

申请日：2016-02-11

Applicant: Novartis AG

Inventor： Benjamin Martin ,  Francesca Mandrelli ,  Francesco Venturoni

IPC: C07C201/10 ,  C07C201/12 ,  C07C227/04 ,  C07C335/16 ,  C07F9/535 ,  C07D207/06 ,  B01J31/02 ,  C07C205/04 ,  C07C205/44 ,  C07C205/51 ,  C07F7/18

Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.

公开(公告)号：US10377697B2

公开(公告)日：2019-08-13

申请号：US15780957

申请日：2016-12-08

Applicant: Novartis AG

Inventor： Florian Karl Kleinbeck-Riniker ,  Benjamin Martin ,  Gerhard Penn ,  Francesco Venturoni ,  Thierry Schlama ,  Thomas Ruch ,  Thomas Allmendinger ,  Bernhard Wietfeld ,  Paolo Filipponi

IPC: C07C51/373 ,  C07C69/738 ,  C07C313/06 ,  C07C229/34 ,  C07D265/02 ,  C07D207/36 ,  C07C251/40 ,  C07C251/66 ,  C07C59/84 ,  C07C67/035

Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.

公开(公告)号：US11208398B2

公开(公告)日：2021-12-28

申请号：US17260393

申请日：2019-07-15

Applicant: NOVARTIS AG

Inventor： Peng Fu ,  Yu Gai ,  Feng Gao ,  Weiyong Kong ,  Yadong Lu ,  Zhongcheng Min ,  Shaofeng Rong ,  Chutian Shu ,  Can Wang ,  Ruidong Wang ,  Jibin Zhao ,  Xianglin Zhao ,  Yi Zhao ,  Jianguang Zhou ,  Benjamin Martin

IPC: C07D401/06 ,  C07D209/04 ,  C07D211/74

Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-((2S,4S)-(4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.