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公开(公告)号：US20210395771A9
公开(公告)日：2021-12-23
申请号：US16934495
申请日：2020-07-21
发明人： Louis PICKER , Klaus FRÜH , Scott G. Hansen
摘要： Disclosed herein are recombinant CMV vectors which may comprise a heterologous antigen that can repeatedly infect an organism while inducing a CD8+ T cell response to immunodominant epitopes of the heterologous antigen. The CMV vector may comprise a deleterious mutation in the US11 glycoprotein or a homolog thereof.
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公开(公告)号：US20190211356A1
公开(公告)日：2019-07-11
申请号：US15827649
申请日：2017-11-30
发明人： Louis Picker , Klaus Früh , Scott G. Hansen
摘要： Disclosed herein are recombinant CMV vectors which may comprise a heterologous antigen that can repeatedly infect an organism while inducing a CD8+ T cell response to immunodominant epitopes of the heterologous antigen. The CMV vector may comprise a deleterious mutation in the US11 glycoprotein or a homolog thereof.
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公开(公告)号：US11266732B2
公开(公告)日：2022-03-08
申请号：US15965246
申请日：2018-04-27
发明人： Louis Picker , Jay A. Nelson , Klaus Frueh , Michael A. Jarvis , Scott G. Hansen
IPC分类号： A61K39/12 , C12N15/86 , A61K39/21 , A61K39/00 , A61K39/13 , A61K39/145 , A61K39/275 , C12N15/869 , C12N7/00 , A61K39/08 , C07K14/16 , C07K14/005 , C07K14/045
摘要： The present disclosure relates to recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens, which may be used, for example, for the treatment or prevention of infectious disease or cancer. The recombinant RhCMV or HCMV vectors elicit and maintain high level cellular immune responses specific for the heterologous antigen while including deletions in one or more genes essential or augmenting for CMV replication, dissemination or spread.
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公开(公告)号：US09982241B2
公开(公告)日：2018-05-29
申请号：US14872756
申请日：2015-10-01
发明人： Louis Picker , Jay A. Nelson , Klaus Frueh , Michael A. Jarvis , Scott G. Hansen
IPC分类号： C12N7/00 , A61K39/00 , C12N15/86 , A61K39/12 , C07K14/005 , A61K39/08 , A61K39/13 , A61K39/145 , A61K39/275 , C12N15/869 , C07K14/16 , C07K14/045
CPC分类号： A61K39/12 , A61K39/0011 , A61K39/08 , A61K39/13 , A61K39/145 , A61K39/21 , A61K39/275 , A61K2039/5254 , A61K2039/5256 , A61K2039/552 , A61K2039/572 , A61K2039/58 , C07K14/005 , C07K14/045 , C07K14/16 , C07K14/161 , C07K14/162 , C07K14/163 , C12N7/00 , C12N15/86 , C12N15/869 , C12N2710/16111 , C12N2710/16134 , C12N2710/16141 , C12N2710/16143 , C12N2710/16162 , C12N2710/16171 , C12N2710/24134 , C12N2730/10134 , C12N2740/15022 , C12N2740/15034 , C12N2740/16034 , C12N2760/14134 , C12N2760/16134 , C12N2770/32634 , Y02A50/383 , Y02A50/386 , Y02A50/412 , Y02A50/466
摘要： The recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors of this invention encode heterologous antigens, such as pathogen-specific antigens or tumor antigens, which may be used, for example, for the treatment or prevention of infectious disease or cancer. The recombinant RhCMV or HCMV vectors elicit and maintain high level cellular immune responses specific for the heterologous antigen while including deletions in one or more genes essential or augmenting for CMV replication, dissemination or spread.
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公开(公告)号：US20160114027A1
公开(公告)日：2016-04-28
申请号：US14872756
申请日：2015-10-01
发明人： Louis Picker , Jay A. Nelson , Klaus Frueh , Michael A. Jarvis , Scott G. Hansen
CPC分类号： A61K39/12 , A61K39/0011 , A61K39/08 , A61K39/13 , A61K39/145 , A61K39/21 , A61K39/275 , A61K2039/5254 , A61K2039/5256 , A61K2039/552 , A61K2039/572 , A61K2039/58 , C07K14/005 , C07K14/045 , C07K14/16 , C07K14/161 , C07K14/162 , C07K14/163 , C12N7/00 , C12N15/86 , C12N15/869 , C12N2710/16111 , C12N2710/16134 , C12N2710/16141 , C12N2710/16143 , C12N2710/16162 , C12N2710/16171 , C12N2710/24134 , C12N2730/10134 , C12N2740/15022 , C12N2740/15034 , C12N2740/16034 , C12N2760/14134 , C12N2760/16134 , C12N2770/32634 , Y02A50/383 , Y02A50/386 , Y02A50/412 , Y02A50/466
摘要： The present disclosure relates to recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens, which may be used, for example, for the treatment or prevention of infectious disease or cancer. The recombinant RhCMV or HCMV vectors elicit and maintain high level cellular immune responses specific for the heterologous antigen while including deletions in one or more genes essential or augmenting for CMV replication, dissemination or spread.
摘要翻译： 本公开涉及可用于例如用于治疗或预防感染性疾病或癌症的编码异源抗原（例如病原体特异性抗原或肿瘤抗原）的重组恒河猴巨细胞病毒（RhCMV）和人巨细胞病毒（HCMV）载体 。 重组RhCMV或HCMV载体引发并保持对异源抗原特异性的高水平细胞免疫应答，同时包括在一个或多个重要或增强CMV复制，传播或扩散的基因中的缺失。
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公开(公告)号：US11692012B2
公开(公告)日：2023-07-04
申请号：US17214598
申请日：2021-03-26
发明人： Klaus Frueh , Scott G. Hansen , Jay Nelson , Louis Picker , Patrizia Caposio
IPC分类号： C07K14/045 , A61K39/12 , C12N15/86 , A61K35/33 , A61K39/00 , A61K39/39 , C12N15/85 , A61K39/21 , C07K14/16 , A61P35/00
CPC分类号： C07K14/045 , A61K35/33 , A61K39/0011 , A61K39/12 , A61K39/39 , C12N15/85 , C12N15/86 , A61K39/21 , A61K2039/5254 , A61K2039/5256 , A61K2039/572 , A61P35/00 , C07K14/161 , C12N2710/16143 , C12N2740/15034 , C12N2740/16234
摘要： Human cytomegalovirus vectors comprising heterologous antigens are disclosed. The vectors derived from the TR strain, are ganciclovir sensitive, include active US2, US3, US6, US7 and UL131A genes, and have a deleterious or inactivating mutation in the UL82 gene preventing the expression of pp71.
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公开(公告)号：US20210222195A1
公开(公告)日：2021-07-22
申请号：US16934495
申请日：2020-07-21
发明人： Louis PICKER , Klaus FRÜH , Scott G. Hansen
摘要： Disclosed herein are recombinant CMV vectors which may comprise a heterologous antigen that can repeatedly infect an organism while inducing a CD8+ T cell response to immunodominant epitopes of the heterologous antigen. The CMV vector may comprise a deleterious mutation in the US11 glycoprotein or a homolog thereof.
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公开(公告)号：US10995121B2
公开(公告)日：2021-05-04
申请号：US16545561
申请日：2019-08-20
发明人： Klaus Frueh , Scott G. Hansen , Jay Nelson , Louis Picker , Patrizia Caposio
IPC分类号： C07K14/045 , A61K39/12 , C12N15/86 , A61K35/33 , A61K39/00 , A61K39/39 , C12N15/85 , A61K39/21 , C07K14/16 , A61P35/00
摘要： Human cytomegalovirus vectors comprising heterologous antigens are disclosed. The vectors derived from the TR strain, are ganciclovir-sensitive, include active US2, US3, US6, US7 and UL131A genes, and have a deleterious or inactivating mutation in the UL82 gene preventing the expression of pp71.
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公开(公告)号：US09249427B2
公开(公告)日：2016-02-02
申请号：US13694280
申请日：2012-11-14
发明人： Louis Picker , Jay A. Nelson , Klaus Frueh , Michael A. Jarvis , Scott G. Hansen
IPC分类号： A61K39/21 , C12N15/63 , A61P31/18 , C12N15/38 , C12N15/48 , C12N15/49 , C07K14/045 , C07K14/16 , C12N15/869 , A61K39/12 , C12N15/86 , A61K39/00 , A61K39/08 , A61K39/13 , A61K39/145 , A61K39/275
CPC分类号： A61K39/12 , A61K39/0011 , A61K39/08 , A61K39/13 , A61K39/145 , A61K39/21 , A61K39/275 , A61K2039/5254 , A61K2039/5256 , A61K2039/552 , A61K2039/572 , A61K2039/58 , C07K14/005 , C07K14/045 , C07K14/16 , C07K14/161 , C07K14/162 , C07K14/163 , C12N7/00 , C12N15/86 , C12N15/869 , C12N2710/16111 , C12N2710/16134 , C12N2710/16141 , C12N2710/16143 , C12N2710/16162 , C12N2710/16171 , C12N2710/24134 , C12N2730/10134 , C12N2740/15022 , C12N2740/15034 , C12N2740/16034 , C12N2760/14134 , C12N2760/16134 , C12N2770/32634 , Y02A50/383 , Y02A50/386 , Y02A50/412 , Y02A50/466
摘要： The present invention relates to recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens, which may be used, for example, for the treatment or prevention of infectious disease or cancer. The recombinant RhCMV or HCMV vectors elicit and maintain high level cellular immune responses specific for the heterologous antigen while including deletions in one or more genes essential or augmenting for CMV replication, dissemination or spread.
摘要翻译： 本发明涉及编码异源抗原如病原体特异性抗原或肿瘤抗原的重组恒河猴巨细胞病毒（RhCMV）和人巨细胞病毒（HCMV）载体，其可用于例如治疗或预防感染性疾病或癌症 。 重组RhCMV或HCMV载体引发并保持对异源抗原特异性的高水平细胞免疫应答，同时包括在一个或多个重要或增强CMV复制，传播或扩散的基因中的缺失。
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公开(公告)号：US20130136768A1
公开(公告)日：2013-05-30
申请号：US13694280
申请日：2012-11-14
发明人： Louis Picker , Jay A. Nelson , Klaus Frueh , Michael A. Jarvis , Scott G. Hansen
IPC分类号： C12N15/869 , A61K39/08 , A61K39/00 , A61K39/12 , A61K39/275 , A61K39/21 , A61K39/13 , A61K39/145
CPC分类号： A61K39/12 , A61K39/0011 , A61K39/08 , A61K39/13 , A61K39/145 , A61K39/21 , A61K39/275 , A61K2039/5254 , A61K2039/5256 , A61K2039/552 , A61K2039/572 , A61K2039/58 , C07K14/005 , C07K14/045 , C07K14/16 , C07K14/161 , C07K14/162 , C07K14/163 , C12N7/00 , C12N15/86 , C12N15/869 , C12N2710/16111 , C12N2710/16134 , C12N2710/16141 , C12N2710/16143 , C12N2710/16162 , C12N2710/16171 , C12N2710/24134 , C12N2730/10134 , C12N2740/15022 , C12N2740/15034 , C12N2740/16034 , C12N2760/14134 , C12N2760/16134 , C12N2770/32634 , Y02A50/383 , Y02A50/386 , Y02A50/412 , Y02A50/466
摘要： Described herein are recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens. The recombinant vectors elicit and maintain high level cellular and humoral immune responses specific for the heterologous antigen. The recombinant RhCMV and HCMV vectors may be used, for example, for the treatment or prevention of infectious disease or cancer. In some examples, the recombinant RhCMV or HCMV vectors may include deletions in genes encoding immunomodulatory proteins. In some examples, the recombinant RhCMV or HCMV vectors may be deficient or impaired in their ability to replicate within a cell, disseminate within the host or spread among hosts by including a deletion in one or more genes essential or augmenting for CMV replication, dissemination or spread.
摘要翻译： 本文描述了编码异源抗原如病原体特异性抗原或肿瘤抗原的重组恒河猴巨细胞病毒（RhCMV）和人巨细胞病毒（HCMV）载体。 重组载体引发和维持对异源抗原特异性的高水平细胞和体液免疫应答。 重组RhCMV和HCMV载体可用于例如治疗或预防感染性疾病或癌症。 在一些实例中，重组RhCMV或HCMV载体可以包括编码免疫调节蛋白的基因中的缺失。 在一些实例中，重组RhCMV或HCMV载体在细胞内复制的能力可能是缺陷或受损的，在宿主内扩散或通过在一个或多个基因或增加CMV复制，扩散或扩增的基因中包含缺失而在宿主间扩散 传播。
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