-
公开(公告)号:US20220220101A1
公开(公告)日:2022-07-14
申请号:US17710386
申请日:2022-03-31
发明人: Jean-Simon Diallo , Christopher Noyce Boddy , Mark Dornan , Ramya Krishnan , Rozanne Arulanandam , Fabrice Le Boeuf , Jeffrey Smith , Andrew Macklin
IPC分类号: C07D413/06 , C07D237/14 , C07D207/38 , C07D307/60 , C07D307/66 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D409/06 , C07D307/30 , C07D307/58 , C07D405/06 , A61K45/06 , A61K31/501 , C12N7/00 , C07D207/36 , C07D207/456 , C07D317/64 , C07D417/06 , C07D471/04 , A61P35/02 , C07D209/48 , C07D231/08
摘要: Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.
-
公开(公告)号:US10654839B2
公开(公告)日:2020-05-19
申请号:US15546167
申请日:2016-01-26
发明人: Jean-Simon Diallo , Christopher Noyce Boddy , Mark Dornan , Ramya Krishnan , Rozanne Arulanandam , Fabrice Le Boeuf , Jeffrey Smith , Andrew Macklin
IPC分类号: C07D207/36 , C07D413/06 , C07D237/14 , C07D207/38 , C07D307/60 , C07D307/66 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D409/06 , C07D307/30 , C07D307/58 , C07D405/06 , A61K45/06 , C12N7/00 , C07D207/456 , C07D317/64 , C07D417/06 , C07D471/04 , A61P35/02 , C07D209/48 , C07D231/08 , A61K31/341
摘要: Provided are compounds of Formula (II) that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided. Compounds of Formula (II):
-
公开(公告)号:US20180112190A1
公开(公告)日:2018-04-26
申请号:US15546167
申请日:2016-01-26
发明人: Jean-Simon Diallo , Christopher Noyce Boddy , Mark Dornan , Ramya Krishnan , Rozanne Arulanandam , Fabrice Le Boeuf , Jeffrey Smith , Andrew Macklin
IPC分类号: C12N7/00 , C07D207/36 , C07D307/60 , C07D307/66 , C07D307/58 , C07D317/64 , C07D237/14 , C07D207/456 , C07D405/04 , C07D471/04 , C07D403/06 , C07D405/12 , C07D401/06 , C07D307/30 , C07D417/06 , C07D413/06
CPC分类号: C07D413/06 , A61K31/341 , A61K45/06 , A61K2300/00 , A61P35/02 , C07D207/36 , C07D207/38 , C07D207/456 , C07D209/48 , C07D231/08 , C07D237/14 , C07D307/30 , C07D307/58 , C07D307/60 , C07D307/66 , C07D317/64 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/06 , C07D417/06 , C07D471/04 , C12N7/00 , C12N2710/10334 , C12N2710/10351 , C12N2710/10352 , C12N2710/16651 , C12N2710/24151 , C12N2750/14151 , C12N2760/16134 , C12N2760/16151 , C12N2760/16152 , C12N2760/20234 , C12N2760/20251 , C12N2760/20252
摘要: Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.
-
公开(公告)号:US11339146B2
公开(公告)日:2022-05-24
申请号:US16877291
申请日:2020-05-18
发明人: Jean-Simon Diallo , Christopher Noyce Boddy , Mark Dornan , Ramya Krishnan , Rozanne Arulanandam , Fabrice Le Boeuf , Jeffrey Smith , Andrew Macklin
IPC分类号: A61K31/501 , C07D413/06 , C07D237/14 , C07D207/38 , C07D307/60 , C07D307/66 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D409/06 , C07D307/30 , C07D307/58 , C07D405/06 , A61K45/06 , C12N7/00 , C07D207/36 , C07D207/456 , C07D317/64 , C07D417/06 , C07D471/04 , A61P35/02 , C07D209/48 , C07D231/08 , A61K31/341
摘要: Provided are compounds of Formula (II) that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.
-
公开(公告)号:US20180305345A1
公开(公告)日:2018-10-25
申请号:US15542480
申请日:2016-01-26
发明人: Jean-Simon Diallo , Christopher Noyce Boddy , Mark Dornan , Ramya Krishnan , Fabrice Le Boeuf , John C. Bell , Andrew Macklin , Jeffrey Smith
IPC分类号: C07D413/06 , C07D207/38 , C07D207/456 , C07D209/48 , C07D231/08 , C07D237/14 , C07D307/58 , C07D307/60 , C07D307/66 , C07D317/64 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D409/06 , C07D471/04 , A61P35/02
CPC分类号: C07D413/06 , A61K31/341 , A61K31/4015 , A61K31/402 , A61K2300/00 , A61P35/02 , C07D207/36 , C07D207/38 , C07D207/456 , C07D209/48 , C07D231/08 , C07D237/14 , C07D307/30 , C07D307/58 , C07D307/60 , C07D307/66 , C07D317/64 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/06 , C07D417/06 , C07D471/04 , C12N7/00 , C12N2710/10334 , C12N2710/10351 , C12N2710/10352 , C12N2710/16651 , C12N2710/24151 , C12N2750/14151 , C12N2760/16134 , C12N2760/16151 , C12N2760/16152 , C12N2760/20234 , C12N2760/20251 , C12N2760/20252
摘要: Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the cytotoxicity of virus to cells. Other uses, compositions and methods of using same are also provided.
-
公开(公告)号:US09283254B2
公开(公告)日:2016-03-15
申请号:US14569416
申请日:2014-12-12
发明人: John Bell , Jean-Simon Diallo , Fabrice Le Boeuf
IPC分类号: A61K35/766 , A61K31/341 , A61K45/06 , C07C49/675 , C07C49/747 , C07C205/37 , C07C217/84 , C07C233/32 , C07C233/38 , C07C243/38 , C07C255/37 , C07C311/44 , C07C323/42 , C07C323/60 , C07C335/16 , C07C337/06 , C07C337/08 , C07D213/75 , C07D233/90 , C07D257/04 , C07D307/58 , C07D319/20 , C07D333/04 , C07D403/12 , C07D409/12 , C12N7/00 , A61K31/275 , A61K31/365 , A61K38/00
CPC分类号: A61K35/766 , A61K31/275 , A61K31/341 , A61K31/365 , A61K38/00 , A61K45/06 , C07C49/675 , C07C49/747 , C07C205/37 , C07C217/84 , C07C233/32 , C07C233/38 , C07C243/38 , C07C255/37 , C07C311/44 , C07C323/42 , C07C323/60 , C07C335/16 , C07C337/06 , C07C337/08 , C07C2601/02 , C07C2601/14 , C07C2603/26 , C07C2603/34 , C07D213/75 , C07D233/90 , C07D257/04 , C07D307/58 , C07D319/20 , C07D333/04 , C07D403/12 , C07D409/12 , C12N7/00 , C12N2760/20232 , C12N2760/20251 , A61K2300/00
摘要: Provided are viral sensitizing compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the cytotoxicity of virus to cells. Other uses, compositions and methods of using same are also provided.
-
公开(公告)号:US20200276253A1
公开(公告)日:2020-09-03
申请号:US16763013
申请日:2018-11-23
发明人: Jean-Simon Diallo , Mohammed Selman , Rozanne Arulanandam , Nicole Elise Forbes , Ramya Krishnan
IPC分类号: A61K35/766 , A61K31/225 , C12N7/00 , A61P35/00
摘要: Provided herein are fumaric and maleic acid-containing compounds, compositions comprising the same and methods for using such compounds to enhance production, growth, spread or titer of interferon-sensitive viruses in cells, particularly cancer and tumor cells. Also provided are methods of treating tumors or cancers in a subject by administering the compounds and compositions.
-
8.
公开(公告)号:US20190231832A1
公开(公告)日:2019-08-01
申请号:US16339294
申请日:2017-10-03
发明人: Mohammed Selman , Jean-Simon Diallo
IPC分类号: A61K35/768 , A61K33/24 , A61P35/00 , C12N15/86
CPC分类号: A61K35/768 , A61K33/24 , A61K35/76 , A61K2039/5254 , A61P35/00 , C12N7/00 , C12N15/86 , C12N2760/20221 , C12N2760/20232 , C12N2760/20243 , C12N2760/20271
摘要: Provided herein are methods for enhancing infection, growth, spread, or titer of an oncolytic RNA virus in a cancer or tumor cell; enhancing the oncolytic activity, cytokine-induced cell death activity, and/or cytotoxic activity of an oncolytic RNA virus in a cancer or tumor cell; upregulating cytokine response to, and/or enhancing the immunotherapeutic activity of an oncolytic RNA virus in a cancer or tumor cell; and/or treating a tumor or cancer in a subject in need thereof. Such methods employ a vanadium-containing compound, administered to the cancer or tumor cells before, after, or concurrently with infection of the cancer or tumor cells with the oncolytic RNA virus. Related compositions, uses, and kits therefor are also provided. Methods for producing RNA viruses, RNA virus-based cancer vaccines, and RNA virus-based cancer gene therapy vectors are also provided.
-
公开(公告)号:US20150202240A1
公开(公告)日:2015-07-23
申请号:US14569416
申请日:2014-12-12
发明人: John Bell , Jean-Simon Diallo , Fabrice Le Boeuf
IPC分类号: A61K35/766 , A61K31/275 , C12N7/00 , A61K31/365
CPC分类号: A61K35/766 , A61K31/275 , A61K31/341 , A61K31/365 , A61K38/00 , A61K45/06 , C07C49/675 , C07C49/747 , C07C205/37 , C07C217/84 , C07C233/32 , C07C233/38 , C07C243/38 , C07C255/37 , C07C311/44 , C07C323/42 , C07C323/60 , C07C335/16 , C07C337/06 , C07C337/08 , C07C2601/02 , C07C2601/14 , C07C2603/26 , C07C2603/34 , C07D213/75 , C07D233/90 , C07D257/04 , C07D307/58 , C07D319/20 , C07D333/04 , C07D403/12 , C07D409/12 , C12N7/00 , C12N2760/20232 , C12N2760/20251 , A61K2300/00
摘要: Provided are viral sensitizing compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the cytotoxicity of virus to cells. Other uses, compositions and methods of using same are also provided.
摘要翻译: 提供的病毒敏化化合物通过增加病毒在细胞中的扩散,增加病毒在细胞中的滴度或增加病毒对细胞的细胞毒性而增强病毒的功效。 还提供了其他用途,组合物和使用方法。
-
公开(公告)号:US11517598B2
公开(公告)日:2022-12-06
申请号:US16339294
申请日:2017-10-03
发明人: Mohammed Selman , Jean-Simon Diallo
IPC分类号: A61K35/768 , A61K33/24 , A61P35/00 , C12N15/86 , A61K35/76 , C12N7/00 , A61K33/243 , A61K39/00
摘要: Provided herein are methods for enhancing infection, growth, spread, or titer of an oncolytic RNA virus in a cancer or tumor cell; enhancing the oncolytic activity, cytokine-induced cell death activity, and/or cytotoxic activity of an oncolytic RNA virus in a cancer or tumor cell; upregulating cytokine response to, and/or enhancing the immunotherapeutic activity of an oncolytic RNA virus in a cancer or tumor cell; and/or treating a tumor or cancer in a subject in need thereof. Such methods employ a vanadium-containing compound, administered to the cancer or tumor cells before, after, or concurrently with infection of the cancer or tumor cells with the oncolytic RNA virus. Related compositions, uses, and kits therefor are also provided. Methods for producing RNA viruses, RNA virus-based cancer vaccines, and RNA virus-based cancer gene therapy vectors are also provided.
-
-
-
-
-
-
-
-
-