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    Use of L-α-lysophosphatidylcholine to obtain the differentiation of monocytes into mature dendritic cells in vitro
    2.
    发明授权
    Use of L-α-lysophosphatidylcholine to obtain the differentiation of monocytes into mature dendritic cells in vitro 失效
    使用L-α-溶血磷脂酰胆碱在体外获得单核细胞分化成成熟树突状细胞

    公开(公告)号：US07368287B2

    公开(公告)日：2008-05-06

    申请号：US10503402

    申请日：2003-03-07

    申请人： Vincent Lotteau ,  Patrice Andre

    发明人： Vincent Lotteau ,  Patrice Andre

    IPC分类号： C12N5/08

    CPC分类号： A61K31/4439 ,  A61K9/0019 ,  A61K47/10 ,  A61K47/24

    摘要： The present invention relates to the use of L-α-lysophosphatidylcholine and/or an equivalent compound for the differentiation of monocytes into mature denditric cell.The present invention also relates to a method for differentiation monocytes into mature denditric cells according to which monocytes are provided in a medium suitable for their differentiation and L-α-lysophosphatidylcholine and/or an equivalent compound is added to said medium.

    摘要翻译： 本发明涉及使用L-α-溶血磷脂酰胆碱和/或等效化合物将单核细胞分化成成熟树突状细胞。 本发明还涉及将单核细胞分化成成熟树突状细胞的方法，根据该方法，在适于其分化的培养基中提供单核细胞，并将L-α-溶血磷脂酰胆碱和/或等价化合物加入到所述培养基中。

    METHOD FOR INCREASING THE REPLICATION CAPACITY OF AN INFLUENZA VIRUS IN CULTURED CELLS
    8.
    发明申请
    METHOD FOR INCREASING THE REPLICATION CAPACITY OF AN INFLUENZA VIRUS IN CULTURED CELLS 审中-公开
    增加培养细胞中流感病毒的复制能力的方法

    公开(公告)号：US20140024101A1

    公开(公告)日：2014-01-23

    申请号：US14110203

    申请日：2012-04-10

    申请人： Vincent Lotteau ,  Benoit De Chassey ,  Patrice Andre ,  Laurene Meyniel-Schicklin ,  Anne Aublin-Gex

    发明人： Vincent Lotteau ,  Benoit De Chassey ,  Patrice Andre ,  Laurene Meyniel-Schicklin ,  Anne Aublin-Gex

    IPC分类号： C12N7/00

    CPC分类号： C12N7/00 ,  A61K31/435 ,  C12N2760/16151

    摘要： The present invention relates to methods for increasing the replication capacity of an influenza virus in cultured cells. More particularly, the present invention relates to a method for increasing the replication capacity of an influenza virus in a cell comprising the steps consisting of i) infecting said cell with said influenza virus and ii) culturing said infected cell with a least one molecule selected from the group consisting of Dibucaine, Aprindine, Amiloride, Mevinolin, Simvastatin, Promathazine, Pranlukast, Nimodipine, Ibutilide hemifumarate Salt, Risperidone and derivatives or analogues thereof.

    摘要翻译： 本发明涉及提高培养细胞中流感病毒复制能力的方法。 更具体地说，本发明涉及增加细胞中流感病毒的复制能力的方法，包括以下步骤：i）用所述流感病毒感染所述细胞，和ii）用至少一种选自以下的分子培养所述感染细胞： 包括迪布卡因，奥林定宁，阿米洛利，米维林，辛伐他汀，普拉那嗪，普兰司他，尼莫地平，伊碧替利半富马酸盐，利培酮及其衍生物或类似物。

    Use of L-alpha-lysophosphatidylcholine to obtain the differentiation of monocytes into mature dendritic cells in vitro
    9.
    发明申请
    Use of L-alpha-lysophosphatidylcholine to obtain the differentiation of monocytes into mature dendritic cells in vitro 审中-公开
    使用L-α-溶血磷脂酰胆碱在体外获得单核细胞分化成成熟树突状细胞

    公开(公告)号：US20080176820A1

    公开(公告)日：2008-07-24

    申请号：US12076591

    申请日：2008-03-20

    申请人： Vincent Lotteau ,  Patrice Andre

    发明人： Vincent Lotteau ,  Patrice Andre

    IPC分类号： A61K31/685 ,  A61P29/00

    CPC分类号： A61K31/4439 ,  A61K9/0019 ,  A61K47/10 ,  A61K47/24

    摘要： The disclosure relates to a method for in vivo differentiation of monocytes in mature dendritic cells, wherein a) monocytes are provided in an appropriate culture medium, b) the monocycles are differentiated in dendritic cells in the presence of a differentiation factor, c) L-α-lysophosphatidylcholine is added to the medium and mature dendritic cells are obtained. The disclosure also relates to the use of at least one inhibitor of L-α-lysophosphatidylcholine in the production of a medicament for the prevention of an inflammation and/or in order to combat an inflammatory disease and/or autoimmune disease.

    摘要翻译： 本公开涉及成熟树突状细胞中单核细胞的体内分化方法，其中a）在合适的培养基中提供单核细胞，b）在分化因子存在下，单环在树突状细胞中分化，c） 向培养基中加入α-溶血磷脂酰胆碱，得到成熟树突状细胞。 本公开还涉及至少一种L-α-溶血磷脂酰胆碱抑制剂在制备用于预防炎症和/或用于抵抗炎性疾病和/或自身免疫疾病的药物中的用途。

    Use of oxidized lipoproteins for differentiation of precursor cells into mature dendritic cells
    10.
    发明授权
    Use of oxidized lipoproteins for differentiation of precursor cells into mature dendritic cells 失效
    使用氧化脂蛋白将前体细胞分化成成熟树突状细胞

    公开(公告)号：US07259012B2

    公开(公告)日：2007-08-21

    申请号：US10482480

    申请日：2002-07-08

    申请人： Vincent Lotteau ,  Patrice Andre

    发明人： Vincent Lotteau ,  Patrice Andre

    IPC分类号： C12N5/00 ,  C12N5/06 ,  C12N5/08 ,  A61K47/44

    CPC分类号： C12N5/0639 ,  A61K2039/5154 ,  C12N2500/36

    摘要： The invention concerns a method for differentiating precursor cells into mature dendritic cells, comprising placing the precursor cells in a medium suitable for their differentiation and adding to the medium, in a predetermined amount, at least one fraction of oxidized lipoproteins selected among oxidized very low density lipoproteins (VLDLs) and/or oxidized intermediate density lipoproteins (IDLs) and/or oxidized low density lipoproteins (LDLs). The precursor cells are preferably monocytes.

    摘要翻译： 本发明涉及将前体细胞分化为成熟树突状细胞的方法，包括将前体细胞置于适于其分化的培养基中，并以预定量向培养基中加入至少一部分氧化的低密度脂蛋白 脂蛋白（VLDL）和/或氧化的中密度脂蛋白（IDL）和/或氧化的低密度脂蛋白（LDL）。 前体细胞优选为单核细胞。