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    Sequences upstream of the carp gene, vectors containing them and uses thereof
    2.
    发明申请
    Sequences upstream of the carp gene, vectors containing them and uses thereof 审中-公开
    鲤鱼基因上游序列，含有它们的载体及其用途

    公开(公告)号：US20070150971A1

    公开(公告)日：2007-06-28

    申请号：US11508239

    申请日：2006-08-23

    申请人： Patrick Benoit ,  Bertrand Schwartz ,  Didier Branellec ,  Kenneth Chien ,  Ju Chen

    发明人： Patrick Benoit ,  Bertrand Schwartz ,  Didier Branellec ,  Kenneth Chien ,  Ju Chen

    IPC分类号： A01K67/027 ,  A61K48/00 ,  C12N15/86

    CPC分类号： C12N15/85 ,  A01K2217/05 ,  C07K14/47 ,  C12N2830/00 ,  C12N2830/008 ,  C12N2830/15 ,  C12N2830/60 ,  C12N2830/85

    摘要： The invention relates to novel promoter sequences derived from a portion upstream of the coding sequence of the gene for the CARP protein (Cardiac Ankyrin Repeat Protein), and which are capable of controlling the level and the specificity of expression of a transgene in vivo in cardiac muscle cells. The invention thus describes novel compositions, constructs, vectors and their uses in vivo for the transfer and expression of a nucleic acid in vivo in cardiac muscle cells. The subject of the present invention is also the use of the promoter sequences for generating transgenic animals which constitute models for studying certain cardiac pathologies.

    摘要翻译： 本发明涉及衍生自CARP蛋白（Cardiac Ankyrin Repeat Protein）基因编码序列上游部分的新型启动子序列，其能够控制心脏中体内转基因表达的水平和特异性 肌肉细胞。 因此，本发明描述了新的组合物，构建体，载体及其在体内用于在心肌细胞中体内转移和表达核酸的用途。 本发明的主题还是用于产生转基因动物的启动子序列的用途，其构成研究某些心脏病理学的模型。

    Nucleic acid-containing composition, preparation and use thereof
    8.
    发明授权
    Nucleic acid-containing composition, preparation and use thereof 失效
    含有核酸的组合物，其制备和用途

    公开(公告)号：US06200956B1

    公开(公告)日：2001-03-13

    申请号：US09306044

    申请日：1999-05-06

    申请人： Daniel Scherman ,  Gérardo Byk ,  Bertrand Schwartz

    发明人： Daniel Scherman ,  Gérardo Byk ,  Bertrand Schwartz

    IPC分类号： A61K3800

    CPC分类号： A61K48/00 ,  C12N15/87

    摘要： Pharmaceutical composition useful for transfecting a nucleic acid and characterised in that it contains, in addition to the nucleic acid, at least one transfecting agent and a compound causing the condensation of the nucleic acid, wherein the compound is totally or partly derived from a histone, a nucleoline, a protamine and/or a derivative thereof. The use of the composition for transferring nucleic acids in vitro, ex vivo and/or in vivo is also described.

    摘要翻译： 用于转染核酸的药物组合物，其特征在于除了核酸外，其还含有至少一种转染试剂和引起核酸缩合的化合物，其中该化合物完全或部分衍生自组蛋白， 核仁，鱼精蛋白和/或其衍生物。 还描述了组合物在体外，离体和/或体内转运核酸的用途。