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    Method and apparatus for a microscope image selector
    2.
    发明申请
    Method and apparatus for a microscope image selector 有权

    公开(公告)号：US20080088844A1

    公开(公告)日：2008-04-17

    申请号：US11902874

    申请日：2007-09-26

    申请人： Xinghua Wang ,  Thomas Voigt ,  David Tuschel ,  Chenhui Wang ,  Patrick Treado

    发明人： Xinghua Wang ,  Thomas Voigt ,  David Tuschel ,  Chenhui Wang ,  Patrick Treado

    IPC分类号： G01N21/25

    CPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/36 ,  G01J3/44 ,  G01N21/359 ,  G01N21/59 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/656

    摘要： The disclosure generally relates to a multimode imaging apparatus for simultaneously obtaining multiple wavelength-discriminative spectral images of a sample. In one embodiment, the apparatus includes an image selector having a rotator assembly, the rotator assembly housing a first plurality of optical components, the image selector adapted to receive a illuminating photons having a first wavelength and direct the illuminating photons to the sample, the image selector adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; a microscope turret housing a second plurality of components, the microscope turret adapted to receive illuminating photons having a second wavelength and direct the photons to the sample; the microscopic turret adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; wherein substantially all of the interacted photons are selectively directed one of a plurality of detection sources to form multiple wavelength discriminative spectral images of the sample simultaneously.

    Dynamic imaging of biological cells and other subjects
    3.
    发明申请
    Dynamic imaging of biological cells and other subjects 有权
    生物细胞和其他科目的动态成像

    公开(公告)号：US20070182959A1

    公开(公告)日：2007-08-09

    申请号：US10556038

    申请日：2005-06-30

    申请人： John Maier ,  Patrick Treado ,  David Tuschel ,  Thomas Voigt

    发明人： John Maier ,  Patrick Treado ,  David Tuschel ,  Thomas Voigt

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01N21/6456 ,  G01J3/2803 ,  G01J3/32 ,  G01J3/36 ,  G01J3/44 ,  G01N21/359 ,  G01N21/6486 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/656

    摘要： The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e.g., a visible microscopic image) obtained from the field of view.

    摘要翻译： 本发明涉及动态化学成像方法，包括细胞成像方法。 该方法包括以基本上单色的光照亮电池的至少一部分，并且在多个离散时间评估从照射部分散射的拉曼偏移光。 可以在每个离散时间处以多个拉曼位移（RS）值评估拉曼移位的光，并且可以将每个离散时间的RS值选择为预选择的分量的特征。 如此获得的图像的拉曼光谱特征的多变量分析可以产生视场中部件的位置和化学特性。 该信息可以与从视野获得的其他光谱数据（例如，可见显微镜图像）组合或覆盖。

    Method and apparatus for a microscope image selector
    4.
    发明申请
    Method and apparatus for a microscope image selector 有权
    显微镜图像选择器的方法和装置

    公开(公告)号：US20060170922A1

    公开(公告)日：2006-08-03

    申请号：US11045080

    申请日：2005-01-31

    申请人： Xinghua Wang ,  Thomas Voigt ,  David Tuschel ,  Chenhui Wang ,  Patrick Treado

    发明人： Xinghua Wang ,  Thomas Voigt ,  David Tuschel ,  Chenhui Wang ,  Patrick Treado

    IPC分类号： G01N21/64 ,  G01N21/65

    CPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/36 ,  G01J3/44 ,  G01N21/359 ,  G01N21/59 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/656

    摘要： The disclosure generally relates to a multimode imaging apparatus for simultaneously obtaining multiple wavelength-discriminative spectral images of a sample. In one embodiment, the apparatus includes an image selector having a rotator assembly, the rotator assembly housing a first plurality of optical components, the image selector adapted to receive a illuminating photons having a first wavelength and direct the illuminating photons to the sample, the image selector adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; a microscope turret housing a second plurality of components, the microscope turret adapted to receive illuminating photons having a second wavelength and direct the photons to the sample; the microscopic turret adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; wherein substantially all of the interacted photons are selectively directed one of a plurality of detection sources to form multiple wavelength discriminative spectral images of the sample simultaneously.

    摘要翻译： 本公开总体上涉及用于同时获得样本的多个波长鉴别光谱图像的多模式成像装置。 在一个实施例中，该装置包括具有旋转器组件的图像选择器，旋转体组件容纳第一多个光学部件，图像选择器适于接收具有第一波长的照明光子并将照射光子引导到样本，图像 选择器，适于接收与样本相互作用的照明光子，并选择性地将所述相互作用的光子引导到多个检测源之一; 显微镜转台，其容纳第二多个部件，所述显微镜转台适于接收具有第二波长并且将所述光子引导到所述样品的照明光子; 适于接收与样品相互作用的照明光子并且选择性地将所述相互作用的光子引导到多个检测源中的一个的微观炮塔; 其中基本上所有相互作用的光子被选择性地指向多个检测源中的一个，以同时形成样品的多个波长鉴别光谱图像。

    Method and apparatus for a microscope image selector
    6.
    发明授权
    Method and apparatus for a microscope image selector 有权
    显微镜图像选择器的方法和装置

    公开(公告)号：US07414725B2

    公开(公告)日：2008-08-19

    申请号：US11902874

    申请日：2007-09-26

    申请人： Xinghua Wang ,  Thomas Voigt ,  David Tuschel ,  Chenhui Wang ,  Patrick Treado

    发明人： Xinghua Wang ,  Thomas Voigt ,  David Tuschel ,  Chenhui Wang ,  Patrick Treado

    IPC分类号： G01N21/25 ,  G02B21/00

    CPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/36 ,  G01J3/44 ,  G01N21/359 ,  G01N21/59 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/656

    摘要： The disclosure generally relates to a multimode imaging apparatus for simultaneously obtaining multiple wavelength-discriminative spectral images of a sample. In one embodiment, the apparatus includes an image selector having a rotator assembly, the rotator assembly housing a first plurality of optical components, the image selector adapted to receive a illuminating photons having a first wavelength and direct the illuminating photons to the sample, the image selector adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; a microscope turret housing a second plurality of components, the microscope turret adapted to receive illuminating photons having a second wavelength and direct the photons to the sample; the microscopic turret adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; wherein substantially all of the interacted photons are selectively directed one of a plurality of detection sources to form multiple wavelength discriminative spectral images of the sample simultaneously.

    摘要翻译： 本公开总体上涉及用于同时获得样本的多个波长鉴别光谱图像的多模式成像装置。 在一个实施例中，该装置包括具有旋转器组件的图像选择器，旋转体组件容纳第一多个光学部件，图像选择器适于接收具有第一波长的照明光子并将照射光子引导到样本，图像 选择器，适于接收与样本相互作用的照明光子，并选择性地将所述相互作用的光子引导到多个检测源之一; 显微镜转台，其容纳第二多个部件，所述显微镜转台适于接收具有第二波长并且将所述光子引导到所述样品的照明光子; 适于接收与样品相互作用的照明光子并且选择性地将所述相互作用的光子引导到多个检测源中的一个的微观炮塔; 其中基本上所有相互作用的光子被选择性地指向多个检测源中的一个，以同时形成样品的多个波长鉴别光谱图像。

    Method and apparatus for variable-field illumination
    7.
    发明申请
    Method and apparatus for variable-field illumination 审中-公开
    用于可变场照明的方法和装置

    公开(公告)号：US20060170916A1

    公开(公告)日：2006-08-03

    申请号：US11045051

    申请日：2005-01-31

    申请人： Thomas Voigt ,  David Tuschel ,  Jingyun Zhang ,  Patrick Treado

    发明人： Thomas Voigt ,  David Tuschel ,  Jingyun Zhang ,  Patrick Treado

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01J3/44 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0224 ,  G01N21/65

    摘要： The disclosure relates to identifying one or more regions of interest within a broader field of view of a dynamic sample using one or more optical components and illuminating photons. Once the region of interest is identified within a section of the broader field of view, chemical information in the form of Raman spectrum is obtained from the region of interest by focusing the illuminating photons or the optical components on the region of interest.

    摘要翻译： 本公开涉及使用一个或多个光学组件和照射光子来识别动态样本的更宽视野内的一个或多个感兴趣区域。 一旦在较宽视场的一部分内识别出感兴趣区域，则通过将照射光子或光学部件聚焦在感兴趣区域上，从感兴趣的区域获得拉曼光谱形式的化学信息。

    Method and apparatus for counterfeiting protection
    8.
    发明申请
    Method and apparatus for counterfeiting protection 有权
    防伪方法及装置

    公开(公告)号：US20070241177A1

    公开(公告)日：2007-10-18

    申请号：US11641671

    申请日：2006-12-20

    申请人： David Tuschel ,  Wesley Hutchison ,  Thomas Voigt

    发明人： David Tuschel ,  Wesley Hutchison ,  Thomas Voigt

    IPC分类号： G06F17/00 ,  G06K7/10

    CPC分类号： G06K15/00 ,  G06K19/06028 ,  G06K19/10 ,  G06K2017/0064

    摘要： The disclosure relates generally to methods and apparatus for protecting against counterfeit products and for methods and apparatus for providing counterfeiting protection for an object. In one embodiment, the method includes the steps of: (a) accessing an object including an identifying mark having a first portion and a second portion wherein said second portion includes an encrypted feature; (b) reading the first portion to thereby obtain a first set of information; (c) transmitting the first set of information to a remote location; (d) receiving from the remote location a second set of information; and (e) reading the second portion using the second set of information to thereby determine the authenticity of the object.

    摘要翻译： 本公开总体上涉及用于防止假冒产品的方法和装置以及用于为对象提供假冒保护的方法和装置。 在一个实施例中，该方法包括以下步骤：（a）访问包括具有第一部分和第二部分的识别标记的对象，其中所述第二部分包括加密特征; （b）读取第一部分，从而获得第一组信息; （c）将第一组信息发送到远程位置; （d）从远程位置接收第二组信息; 和（e）使用第二组信息读取第二部分，从而确定对象的真实性。

    Method and apparatus for counterfeiting protection
    9.
    发明申请
    Method and apparatus for counterfeiting protection 有权

    公开(公告)号：US20070152056A1

    公开(公告)日：2007-07-05

    申请号：US11641668

    申请日：2006-12-20

    申请人： David Tuschel ,  Wesley Hutchison ,  Thomas Voigt

    发明人： David Tuschel ,  Wesley Hutchison ,  Thomas Voigt

    IPC分类号： G06K7/10 ,  G06F17/00

    CPC分类号： G06K15/00 ,  G06K19/06037 ,  G06K19/06046 ,  G06K19/10 ,  G06K19/14

    摘要： The disclosure relates generally to methods and apparatus for protecting against counterfeit products and for methods and apparatus for providing counterfeiting protection for an object. In one embodiment, the method includes the steps of: (a) accessing an object including an identifying mark having a first portion and a second portion wherein said second portion includes an encrypted feature; (b) reading the first portion to thereby obtain a first set of information; (c) transmitting the first set of information to a remote location; (d) receiving from the remote location a second set of information; and (e) reading the second portion using the second set of information to thereby determine the authenticity of the object.

    Single detector based dual excitation wavelength spectra display
    10.
    发明授权
    Single detector based dual excitation wavelength spectra display 有权
    基于单探测器的双激发波长光谱显示

    公开(公告)号：US07609370B2

    公开(公告)日：2009-10-27

    申请号：US12017409

    申请日：2008-01-22

    申请人： Thomas Voigt ,  David Tuschel

    发明人： Thomas Voigt ,  David Tuschel

    IPC分类号： G01J3/44 ,  G01J3/443 ,  G01N21/64 ,  G01N21/65

    CPC分类号： G01J3/02 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/1838 ,  G01J3/2823 ,  G01N21/65

    摘要： A single detector based spectroscopy system using FAST (fiber array spectral translator) fibers and two excitation sources in conjunction with a holographic spectrum analyzer (HSA) to obtain simultaneous and selective display of spectroscopic regions of interest. A sample can be illuminated with different laser excitation wavelengths and resulting multiple spectra can be comparatively observed on a single display screen for more fruitful analysis of sample spectral responses (and, hence, sample chemical or physical properties) under different excitations. The HSA may be configured to focus on user-selected spectral regions of interest from different such spectra and a single CCD detector may be configured to collect spectral data from all selected spectral regions of interest in corresponding portions of the CCD pixel array, thereby allowing subsequent simultaneous display of such selected spectral regions of interest. The HSA may also allow simultaneous collection and display of portions of a single spectrum from a single excitation wavelength. A user can perform better comparative analysis when spectral regions of interest are juxtaposed with each other on a single electronic display.

    摘要翻译： 基于单个检测器的光谱系统，使用FAST（光纤阵列光谱转换器）光纤和两个激光源与全息光谱分析仪（HSA）结合，以获得感兴趣的光谱区域的同时和选择性显示。 可以用不同的激光激发波长照射样品，并且可以在单个显示屏上比较观察到所得到的多个光谱，以便在不同激发下对样品光谱响应（以及因此的样品化学或物理性质）进行更有效的分析。 HSA可以被配置为聚焦于来自不同这样的光谱的用户选择的感兴趣的光谱区域，并且单个CCD检测器可以被配置为从CCD像素阵列的对应部分中的所有所选择的光谱区域收集光谱数据，从而允许随后的 同时显示所选择的所选择的光谱区域。 HSA还可以允许从单个激发波长同时收集和显示单个光谱的部分。 当感兴趣的光谱区域在单个电子显示器上彼此并置时，用户可以执行更好的比较分析。