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公开(公告)号：US4944948A
公开(公告)日：1990-07-31
申请号：US315392
申请日：1989-02-24
CPC分类号： A61K38/1808 , A61K9/127
摘要： A composition and method for treating a wound or surgical incision, by sustained-released delivery of epidermal growth factor (EGF). The composition includes a high-viscosity aqueous dispersion of negatively charged liposomes with liposome-entrapped EGF. The EGF/liposome composition is formed, in one embodiment of the invention, by suspending a lipid mixture typically containing equimolar amounts of neutral and negatively charged phopholipids and cholesterol in a low-conductivity aqueous medium containing EGF and a zwitterionic compound whose isoelectric point is between pH 5.5 and 8.5 to form a gel-like composition. One embodiment of the invention contains EGF entrapped by surface adsorption to the liposomes, for slow release from the composition.
摘要翻译： 用于通过持续释放的表皮生长因子（EGF）递送来治疗伤口或手术切口的组合物和方法。 该组合物包括具有脂质体包埋的EGF的带负电荷的脂质体的高粘度水分散体。 在本发明的一个实施方案中，通过将通常含有等摩尔量的中性和带负电荷的磷脂酰胆碱和胆固醇的脂质混合物悬浮在含有EGF和两性离子化合物的低电导率水性介质中，形成EGF /脂质体组合物，其等电点在 pH 5.5和8.5以形成凝胶状组合物。 本发明的一个实施方案包含通过表面吸附到脂质体上的EGF，从组合物缓慢释放。
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公开(公告)号：US5064655A
公开(公告)日：1991-11-12
申请号：US356262
申请日：1989-05-23
CPC分类号： A61K8/042 , A61K38/1808 , A61K47/183 , A61K8/14 , A61K9/0014 , A61K9/127 , A61Q19/00 , A61Q17/04 , A61Q19/007 , A61Q19/08 , Y10T428/2984
摘要： A liposome gel composition and method of preparing the same. The composition is composed of charged liposomes, at a relatively low lipid concentration, in a low-conductivity medium. The composition preferably contains a zwitterionic compound at its isoelectric point. The liposomes can be designed for cosmetic use, transdermal drug delivery, or enhanced retention on mucosal tissues, such as for ophthalmic use.
摘要翻译： 一种脂质体凝胶组合物及其制备方法。 该组合物由低电导率培养基中以相对低的脂质浓度的带电脂质体组成。 组合物优选在其等电点含有两性离子化合物。 脂质体可以设计用于化妆品用途，透皮药物递送或增强对粘膜组织的保留，例如用于眼科用途。
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公开(公告)号：US6051251A
公开(公告)日：2000-04-18
申请号：US196425
申请日：1998-11-19
申请人： Samuel Zalipsky , Paul S. Uster , George Z. Zhu
发明人： Samuel Zalipsky , Paul S. Uster , George Z. Zhu
IPC分类号： A61K9/127 , A61K31/7056
CPC分类号： A61K31/7036 , A61K31/7008 , A61K31/7056 , A61K31/7072 , A61K9/1278
摘要： A method for loading a therapeutic compound having a cis diol moiety into pre-formed liposomes is described. The method includes adding to a suspension of liposomes (i) the compound to be loaded into the liposomes and (ii) a boronic acid compound, thereby achieving accumulation of the compound within the liposomes.
摘要翻译： 描述了将具有顺式二醇部分的治疗化合物加载到预先形成的脂质体中的方法。 该方法包括加入脂质体的悬浮液（i）待加载到脂质体中的化合物和（ii）硼酸化合物，从而实现化合物在脂质体内的积聚。
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公开(公告)号：US08486043B2
公开(公告)日：2013-07-16
申请号：US12250516
申请日：2008-10-13
申请人： Laxmi Iyer , Paul S. Uster
发明人： Laxmi Iyer , Paul S. Uster
IPC分类号： A61B19/00 , A61M5/31 , A61M37/00 , A61M16/00 , A61K9/14 , A61K9/50 , A62B7/00 , B05D7/14 , B65D35/22 , B65D51/16
CPC分类号： A61J1/067 , A61K9/0078 , A61K47/183 , A61K47/24 , A61M15/0028 , A61M15/0031 , A61M2202/0468
摘要： Described here are unit dose containers, methods, and kits for treating asthma and other pulmonary conditions by nebulization. The unit doses of active agents are provided in a low volume formulation, which results in faster nebulization of the unit doses. The containers are also formed to minimize internal surface area so that effective re-dispersion of the active agents can be achieved while reducing adsorption to the walls of the containers.
摘要翻译： 这里描述的是通过雾化治疗哮喘和其他肺部疾病的单位剂量容器，方法和试剂盒。 活性剂的单位剂量以低体积制剂提供，这导致单位剂量的更快雾化。 还形成容器以最小化内表面积，从而可以在减少对容器壁的吸附的同时有效地重新分散活性剂。
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5.发明授权公开(公告)号：US06818227B1
公开(公告)日：2004-11-16
申请号：US09498704
申请日：2000-02-07
IPC分类号： A61K9127
CPC分类号： A61K41/0038
摘要： A method for administering a radiosensitizer to a tumor site in a subject is described. The method includes preparing liposomes composed of a vesicle-forming lipid and a lipid-derivatized radiosensitizer. In one embodiment, the radiosensitizer is dipalmitoyl-5-iodo-2′-deoxyuridine. A method for preparing the liposome composition including the lipid-derivatized radiosensitizer is also disclosed.
摘要翻译： 描述了将放射增敏剂施用于受试者的肿瘤部位的方法。 该方法包括制备由形成小泡的脂质和脂质衍生的放射增敏剂组成的脂质体。 在一个实施方案中，放射增敏剂是二棕榈酰基-5-碘-2'-脱氧尿苷。 还公开了包含脂质衍生的放射增敏剂的脂质体组合物的制备方法。
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公开(公告)号：US20090157037A1
公开(公告)日：2009-06-18
申请号：US12250516
申请日：2008-10-13
申请人： Laxmi Iyer , Paul S. Uster
发明人： Laxmi Iyer , Paul S. Uster
IPC分类号： A61J1/06
CPC分类号： A61J1/067 , A61K9/0078 , A61K47/183 , A61K47/24 , A61M15/0028 , A61M15/0031 , A61M2202/0468
摘要： Described here are unit dose containers, methods, and kits for treating asthma and other pulmonary conditions by nebulization. The unit doses of active agents are provided in a low volume formulation, which results in faster nebulization of the unit doses. The containers are also formed to minimize internal surface area so that effective re-dispersion of the active agents can be achieved while reducing adsorption to the walls of the containers.
摘要翻译： 这里描述的是通过雾化治疗哮喘和其他肺部疾病的单位剂量容器，方法和试剂盒。 活性剂的单位剂量以低体积制剂提供，这导致单位剂量的更快雾化。 还形成容器以最小化内表面积，从而可以在减少对容器壁的吸附的同时有效地重新分散活性剂。
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公开(公告)号：US4828837A
公开(公告)日：1989-05-09
申请号：US32512
申请日：1987-03-30
申请人： Paul S. Uster , Yolanda P. Quinn
发明人： Paul S. Uster , Yolanda P. Quinn
IPC分类号： A61K8/00 , A61K8/14 , A61K8/46 , A61K8/49 , A61K8/92 , A61K9/107 , A61K9/127 , A61K31/505 , A61P17/00 , A61Q5/00 , A61Q7/00
CPC分类号： A61K8/14 , A61K31/505 , A61K47/48038 , A61K47/48053 , A61K8/4953 , A61K9/1075 , A61K9/1272 , A61Q7/00 , Y10S436/829 , Y10S514/944 , Y10S514/947 , Y10S514/969 , Y10T428/2984
摘要： An aqueous, noncrystalline minoxidil composition for topical use. The composition contains minoxidil complexed with an amphipathic compound having a pK less than about 5 and containing a single lipophilic chain moiety and a sulfate, sulfonate, phosphate and phosphonate polar moiety. The composition may be formulated in ointment form, in an aqueous vehicle, or dispersed in a fluorochlorocarbon solvent, for spray delivery from a self-propelled spray device.
摘要翻译： 用于局部使用的水性非结晶米诺地尔组合物。 该组合物含有与pK小于约5的两亲化合物络合的米诺地尔，并含有单个亲脂性链部分和硫酸酯，磺酸酯，磷酸酯和膦酸酯极性部分。 组合物可以以软膏形式，在水性载体中配制或分散在氟氯化碳溶剂中，用于从自推进喷雾装置喷射。
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公开(公告)号：US5030442A
公开(公告)日：1991-07-09
申请号：US333660
申请日：1989-04-04
申请人： Paul S. Uster , Yolanda P. Quinn
发明人： Paul S. Uster , Yolanda P. Quinn
CPC分类号： A61K31/505 , A61K47/48038 , A61K47/48053 , A61K8/14 , A61K8/4953 , A61K9/1075 , A61K9/1272 , A61Q7/00 , Y10S514/88 , Y10S514/944 , Y10S514/947 , Y10S514/969 , Y10S514/975 , Y10T428/2984
摘要： An aqueous, noncrystalline minoxidil composition for topical use which has significantly improved flux of the drug through human cadaver skin. The composition contains minoxidil complexed with an amphipathic compound, oleic acid and with pharmaceutically acceptable excipients. The composition may be formulated in an aqueous vehicle, or dispersed in fluorochlorocarbon solvent for spray delivery from a self- propelled spray device.
摘要翻译： 用于局部使用的水性非结晶米诺地尔组合物，其通过人类尸体皮肤显着改善药物的通量。 组合物含有与两亲化合物，油酸和药学上可接受的赋形剂复合的米诺地尔。 组合物可以配制在水性载体中，或分散在氟氯化碳溶剂中，用于从自推进喷雾装置喷射输送。
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公开(公告)号：US20090149432A1
公开(公告)日：2009-06-11
申请号：US12268394
申请日：2008-11-10
IPC分类号： A61K31/58
CPC分类号： A61K9/007 , A61K9/0078 , A61K31/56 , A61K31/58
摘要： Described here are methods for the treatment of respiratory conditions using nebulized corticosteroids. The methods administer a dose of corticosteroid twice a day or more with nebulization times of 5 minutes or less. The faster nebulization times improve patient compliance. The methods also employ a lower corticosteroid dose while achieving therapeutic efficacy similar to commercially available formulations. This results in improved patient safety by reducing the systemic exposure of the corticosteroid.
摘要翻译： 这里描述的是使用雾化皮质类固醇治疗呼吸病症的方法。 该方法每天服用一次皮质激素两次或更长时间，雾化时间为5分钟或更短。 更快的雾化时间提高患者的依从性。 该方法还采用较低的皮质类固醇剂量，同时实现与市售制剂类似的治疗功效。 这导致通过减少皮质类固醇的全身暴露来改善患者的安全性。
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