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公开(公告)号：US08389756B2
公开(公告)日：2013-03-05
申请号：US12671809
申请日：2008-07-29
IPC分类号： C07F9/09
CPC分类号： C07F9/113 , A61K8/556 , A61K2800/48 , C08G65/327
摘要： The invention relates to a method for producing phosphoric acid triesters of formula (I). According to said method, phosphoric acid or a phosphoric acid derivative selected from orthophosphoric acid, tetraphosphoric decaoxide and polyphosphoric acid is reacted with alkoxylated alcohols of formulae (II) R1—(OA1)x-OH, (III) R2—(OA2)y-OH, and (IV) R3—(OA3)Z-OH, in the molar ratio phosphoric acid or phosphoric acid derivative to alkoxylated alcohol of 1:2.5 to 1:3.3, at between 200 and 240° C.
摘要翻译： 本发明涉及一种制备式（I）的磷酸三酯的方法。 根据所述方法，将磷酸或选自正磷酸，四磷酸十四烷和多磷酸的磷酸衍生物与式（II）R1-（OA1）x-OH，（Ⅲ）R2-（OA2）y的烷氧基化醇反应 -OH和（IV）R3-（OA3）Z-OH，以磷酸或磷酸衍生物与烷氧基化醇的摩尔比为1:2.5至1:3.3，在200和240℃之间。
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2.发明申请公开(公告)号：US20110230449A1
公开(公告)日：2011-09-22
申请号：US12671802
申请日：2008-07-29
CPC分类号： A61Q19/00 , A61K8/86 , C07F9/091 , C08G65/327
摘要： The invention relates to alkoxylated phosphoric acid triesters of formula (I) wherein x, y and z respectively stand for a number between 51 and 200. The alkoxylated phosphoric acid triesters of formula (I) are characterised especially by advantageous thickening properties.
摘要翻译： 本发明涉及式（I）的烷氧基化磷酸三酯，其中x，y和z分别代表51到200之间的数字。式（I）的烷氧基化磷酸三酯的特征特别是有利的增稠性质。
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3.发明申请公开(公告)号：US20110229427A1
公开(公告)日：2011-09-22
申请号：US12671792
申请日：2008-07-29
CPC分类号： A61Q19/00 , A61K8/86 , A61K8/90 , A61Q1/14 , A61Q5/02 , A61Q15/00 , A61Q17/04 , A61Q19/02 , A61Q19/04 , A61Q19/10 , C08G65/327 , C08G65/3353
摘要： The invention relates to phosphoric acid esters containing A) at least one structural unit derived from substances of constituent a), the substances of constituent a) being selected from orthophosphoric acid and at least one of the derivatives thereof; B) at least one structural unit derived from substances of constituent b), the substances of constituent b) being selected from at least one compound of formula (I) R2—O—(CH2CH2O)U(C3H6O)V(DO)w—H; and C) at least one structural unit derived from substances of constituent c), the substances of constituent c) being selected from at least one polyol which has more than 2 OH groups and can also carry at least one alkoxylate group. The alkoxylate groups are respectively formed from at least one unit selected from CH2CH2O, C3H6O and C4H8O units that can respectively be arranged in a block or in a statistically distributed manner inside the alkoxylate groups. The phosphoric acid esters contain at least two phosphorus atoms per molecule, said phosphorus atoms being bridged by a structural unit derived from the polyols having more than two OH groups or from the polyols having more than two OH groups and carrying at least one of the alkoxylate groups. The phosphoric acid esters according to the invention can be used advantageously for producing cosmetic, pharmaceutical and dermatological compositions.
摘要翻译： 本发明涉及含有A）至少一种衍生自组分a）物质的结构单元的磷酸酯，a）选自正磷酸及其至少一种衍生物的组分物质; B）至少一种衍生自组分b）的物质的结构单元，组分物质b）选自至少一种式（I）化合物R 2 -O-（CH 2 CH 2 O）U（C 3 H 6 O）V（DO）w- H; 和C）至少一种衍生自组分c）的物质的结构单元，组分的物质c）选自至少一种具有多于2个OH基团并且还可以携带至少一个烷氧基化物的多元醇。 烷氧基化物基分别由选自可以分别以烷基化物或嵌段分布的方式排列在烷氧基化物基团内的至少一个选自CH 2 CH 2 O，C 3 H 6 O和C 4 H 8 O单元的单元形成。 磷酸酯每分子含有至少两个磷原子，所述磷原子由衍生自具有多于两个OH基团的多元醇的结构单元或多于两个OH基团的多元醇桥接，并携带至少一种烷氧基化物 团体 根据本发明的磷酸酯可有利地用于生产化妆品，药物和皮肤病学组合物。
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公开(公告)号：US20110040116A1
公开(公告)日：2011-02-17
申请号：US12671809
申请日：2008-07-29
IPC分类号： C07F9/09
CPC分类号： C07F9/113 , A61K8/556 , A61K2800/48 , C08G65/327
摘要： The invention relates to a method for producing phosphoric acid triesters of formula (I). According to said method, phosphoric acid or a phosphoric acid derivative selected from orthophosphoric acid, tetraphosphoric decaoxide and polyphosphoric acid is reacted with alkoxylated alcohols of formulae (II) R1—(OA1)x-OH, (Ill) R2—(OA2)y-OH, and (IV) R3—(OA3)z-OH, in the molar ratio phosphoric acid or phosphoric acid derivative to alkoxylated alcohol of 1:2.5 to 1:3.3, at between 200 and 240° C.
摘要翻译： 本发明涉及一种制备式（I）的磷酸三酯的方法。 根据所述方法，将磷酸或选自正磷酸，四磷酸十四烷和多磷酸的磷酸衍生物与式（II）R1-（OA1）x-OH，（III）R2-（OA2）y的烷氧基化醇反应 -OH和（IV）R3-（OA3）z-OH，其中磷酸或磷酸衍生物与烷氧基化醇的摩尔比为1:2.5至1:3.3，在200和240℃之间。
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5.发明授权公开(公告)号：US08686033B2
公开(公告)日：2014-04-01
申请号：US12671422
申请日：2008-07-29
CPC分类号： C08G65/327 , A61K8/86 , A61K8/90 , A61K2800/48 , A61K2800/52 , A61Q5/02 , A61Q19/00 , C08G65/3312 , C08G65/3353 , C08L71/02
摘要： Phosphoric esters comprise A) one or more structural units derived from substances of component a), the substances of component a) being selected from orthophosphoric acid and one or more of its derivatives, B) one or more structural units derived from substances of component b), the substances of component b) being selected from one or more compounds of formula (I) R2—O—(CH2CH2O)u(C3H6O)v(DO)w—H (I) and C) one or more structural units derived from substances of component c), the substances of component c) being selected from one or more diols of formula (II) HO—(CH2CH2O)a(C3H6O)b(DO)c—H (II) where the sum total a+b+c is ≧1, and the phosphoric ester contains 2 or more phosphorus atoms per molecule which are bridged via a structural unit derived from the compounds of formula (II). The phosphoric esters of the invention are very useful in the manufacture of cosmetic, pharmaceutical and dermatological compositions.
摘要翻译： 磷酸酯包括A）一种或多种衍生自组分a）的物质的结构单元，组分a）的物质选自正磷酸及其一种或多种衍生物，B）一种或多种衍生自组分b的物质的结构单元 ），组分b）的物质选自一种或多种式（I）R 2 -O-（CH 2 CH 2 O）u（C 3 H 6 O）v（DO）w-H（I））的化合物和C）一种或多种衍生的结构单元 从组分c）的物质中，组分c）的物质选自一种或多种式（II）的二醇HO-（CH 2 CH 2 O）a（C 3 H 6 O）b（DO）c-H（II），其中总和a + b + c为≥1，磷酸酯每分子含有2个以上的磷原子，该磷原子通过衍生自式（II）化合物的结构单元桥连。 本发明的磷酸酯在制造化妆品，药物和皮肤病学组合物中非常有用。
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6.发明申请公开(公告)号：US20110003010A1
公开(公告)日：2011-01-06
申请号：US12671422
申请日：2008-07-29
IPC分类号： A61K31/765 , C07F9/11 , A61K8/86 , A61K8/55 , A61K31/6615 , A61K31/661 , A61P31/00 , A61K33/40 , A61Q5/00 , A61Q19/00 , A61Q15/00 , A61Q1/00 , C11D3/36 , A61Q19/10
CPC分类号： C08G65/327 , A61K8/86 , A61K8/90 , A61K2800/48 , A61K2800/52 , A61Q5/02 , A61Q19/00 , C08G65/3312 , C08G65/3353 , C08L71/02
摘要： Phosphoric esters comprise A) one or more structural units derived from substances of component a), the substances of component a) being selected from orthophosphoric acid and one or more of its derivatives, B) one or more structural units derived from substances of component b), the substances of component b) being selected from one or more compounds of formula (I) R2—O—(CH2CH2O)u(C3H6O)v(DO)w—H (I) and C) one or more structural units derived from substances of component c), the substances of component c) being selected from one or more diols of formula (II) HO—(CH2CH2O)a(C3H6O)b(DO)c—H (II) where the sum total a+b+c is ≧1 and the phosphoric ester contains 2 or more phosphorus atoms per molecule which are bridged via a structural unit derived from the compounds of formula (II).The phosphoric esters of the invention are very useful in the manufacture of cosmetic, pharmaceutical and dermatological compositions.
摘要翻译： 磷酸酯包括A）一种或多种衍生自组分a）的物质的结构单元，组分a）的物质选自正磷酸及其一种或多种衍生物，B）一种或多种衍生自组分b的物质的结构单元 ），组分b）的物质选自一种或多种式（I）R 2 -O-（CH 2 CH 2 O）u（C 3 H 6 O）v（DO）w-H（I））的化合物和C）一种或多种衍生的结构单元 从组分c）的物质中，组分c）的物质选自一种或多种式（II）的二醇HO-（CH 2 CH 2 O）a（C 3 H 6 O）b（DO）c-H（II），其中总和a + b + c为≥1，磷酸酯每分子含有2个或更多个磷原子，该磷原子通过衍生自式（II）化合物的结构单元桥连。 本发明的磷酸酯在制造化妆品，药物和皮肤病学组合物中非常有用。
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7.发明申请公开(公告)号：US20100260696A1
公开(公告)日：2010-10-14
申请号：US12671441
申请日：2008-07-29
CPC分类号： C08L71/02 , A61K8/86 , A61Q1/14 , A61Q5/02 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/04 , A61Q19/08 , A61Q19/10 , B01F17/0064 , C08G65/327 , C08G65/3312 , C08G65/3353
摘要： The invention relates to compositions containing A) at least one phosphoric acid ester of formula (I) wherein R1, R2 and R3 can be the same or different and stand for a linear or branched, saturated alkyl group comprising between 6 and 30 carbon atoms, a linear or branched, monounsaturated or polyunsaturated alkenyl group comprising between 6 and 30 carbon atoms, or an aryl group that can be substituted with between 1 and 3 branched alkyl groups each independently containing between 3 and 18 carbon atoms, the individual groups (OA1)x, (A2O)y and (A3O)z each independently consisting of units selected from CH2CH2O, C3H6O and C4H8O, the units CH2CH2O, C3H6O and C4H8O being arranged inside the individual groups (OA1)X, (A2O)y and (A3O), in blocks or in a statistically distributed manner, and x, y and z each independently standing for a number between 30 and 150, and B); water in a proportion of >50.0 wt. % in relation to the finished composition. The compositions according to the invention are preferably cosmetic, pharmaceutical or dermatological compositions.
摘要翻译： 本发明涉及包含A）至少一种式（I）的磷酸酯的组合物，其中R 1，R 2和R 3可以相同或不同，代表包含6至30个碳原子的直链或支链饱和烷基， 包含6至30个碳原子的直链或支链单不饱和或多不饱和链烯基，或可被1至3个各自独立地含有3至18个碳原子的支链烷基取代的芳基，各基团（OA1） x，（A 2 O）y和（A3O）z各自独立地由选自CH 2 CH 2 O，C 3 H 6 O和C 4 H 8 O的单元组成，单元CH 2 CH 2 O，C 3 H 6 O和C 4 H 8 O设置在各组（OA1）X，（A2O）y和（A3O） 以块或统计分布的方式，x，y和z各自独立地代表30到150之间的数字，B）; 水比例> 50.0wt。 相对于成品组成的百分比。 根据本发明的组合物优选为化妆品，药物或皮肤病学组合物。
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8.发明授权公开(公告)号：US10406135B2
公开(公告)日：2019-09-10
申请号：US14237028
申请日：2012-07-31
IPC分类号： A61K31/343 , A01N37/10 , A01N39/00 , A01N43/90 , A01N31/14 , A61K8/34 , A61K8/49 , A61K31/045 , A61Q1/00 , A61Q5/06 , A61Q19/00 , A61Q19/04 , A61Q1/14 , A61Q5/02 , A61Q15/00 , A61Q17/04 , A61Q19/02 , A61Q19/08 , A61Q19/10 , A61Q1/02
摘要： Compositions comprising isosorbide monoesters and alcohols comprising at least one aromatic groupWhat are described are compositions comprising a) one or more compounds of the formula (I) in which R is a straight-chain or branched saturated alkyl group having 5 to 11 carbon atoms or a straight-chain or branched mono- or polyunsaturated alkenyl group having 5 to 11 carbon atoms, and b) one or more alcohols comprising at least one aromatic group. The compositions are distinguished in particular by an advantageous antimicrobial activity.
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公开(公告)号：US09662287B2
公开(公告)日：2017-05-30
申请号：US14232844
申请日：2012-07-11
申请人： Peter Klug , Franz-Xaver Scherl
发明人： Peter Klug , Franz-Xaver Scherl
IPC分类号： A61K8/42 , C07C233/47 , A61Q19/00 , C07C233/49 , A61Q19/10 , A61K8/04 , A61K8/44 , C07C231/02
CPC分类号： C07C231/02 , A61K8/046 , A61K8/42 , A61K8/44 , A61K8/442 , A61K2800/10 , A61Q19/00 , A61Q19/10 , C07C233/47 , C07C233/49 , C07C233/02
摘要： A process for preparing acylglycinates of the formula (I) wherein R1 is a linear or branched, saturated alkanoyl group having 6 to 30 carbon atoms, or is a linear or branched, singly or multiply unsaturated alkenoyl group having 6 to 30 carbon atoms, and Q+ is a cation, wherein glycine is reacted with fatty acid chloride R1Cl, in water and in the presence of a basic alkali metal compound which yields cations Q+, but in the absence of organic solvents, at 25-50° C. Also described are compositions comprising acylglycinates of the formula (I).
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公开(公告)号：US09555117B2
公开(公告)日：2017-01-31
申请号：US14237042
申请日：2012-07-31
IPC分类号： A61K31/34 , A61K47/22 , C09D7/00 , C11D3/22 , C11D17/00 , A01N43/90 , A01N25/00 , A61K8/49 , A61Q5/02 , A61Q19/10 , C09D7/12 , C11D3/20 , A61K8/04
CPC分类号： A61K47/22 , A01N25/00 , A01N43/90 , A61K8/042 , A61K8/4973 , A61K2800/10 , A61K2800/48 , A61Q5/02 , A61Q19/10 , C09D7/43 , C09D7/63 , C11D3/2096 , C11D3/221 , C11D17/003
摘要： The use of one or more compounds of the formula (I) in which R is a straight-chain or branched saturated alkyl group having 5 to 11 carbon atoms or a straight-chain or branched mono- or polyunsaturated alkenyl group having 5 to 11 carbon atoms as thickeners is described. The use is preferably in cosmetic, dermatological or pharmaceutical compositions, in crop protection formulations, in washing or cleaning compositions or in paints or coatings.
摘要翻译： 优选使用化妆品，皮肤病学或药物组合物，作物保护制剂，洗涤或清洁组合物或涂料或涂料中。
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