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公开(公告)号：US06395919B1
公开(公告)日：2002-05-28
申请号：US09647793
申请日：2000-10-05
申请人： Pradip Kumar Bhatnagar , Joelle Lorraine Burgess , James Francis Callahan , Raul Rolando Calvo , Eric G. Del Mar , Maria Amparo Lago , Thomas The Nguyen
发明人： Pradip Kumar Bhatnagar , Joelle Lorraine Burgess , James Francis Callahan , Raul Rolando Calvo , Eric G. Del Mar , Maria Amparo Lago , Thomas The Nguyen
IPC分类号： C07C25503
CPC分类号： C07D209/48 , C07C217/22 , C07C217/60 , C07C255/37 , C07C255/54 , C07C255/57 , C07C311/06
摘要： Novel calcilytic compounds, pharmaceuticals compositions cotaining said compounds and their use as calcium receptor antagonists.
摘要翻译： 新型钙质化合物，与所述化合物相配的药物组合物及其作为钙受体拮抗剂的用途。
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公开(公告)号：US06294531B1
公开(公告)日：2001-09-25
申请号：US09402310
申请日：1999-10-01
申请人： Robert M. Barmore , Pradip Kumar Bhatnagar , William M. Bryan , Joelle Lorraine Burgess , James Francis Callahan , Raul Rolando Calvo , Eric G. Del Mar , Maria Amparo Lago , Thomas The Nguyen , Derek Sheehan , Robert Lawrence Smith , Linda Sue Southall , Bradford C. Van Wagenen
发明人： Robert M. Barmore , Pradip Kumar Bhatnagar , William M. Bryan , Joelle Lorraine Burgess , James Francis Callahan , Raul Rolando Calvo , Eric G. Del Mar , Maria Amparo Lago , Thomas The Nguyen , Derek Sheehan , Robert Lawrence Smith , Linda Sue Southall , Bradford C. Van Wagenen
IPC分类号： C07C25550
CPC分类号： C07D295/192 , C07C255/57 , C07C311/08 , C07C311/21 , C07C311/29 , C07C323/17 , C07C2601/02 , C07C2603/32 , C07D267/20 , C07D295/215
摘要： Novel arylalkylamino compounds exhibiting calcilytic properties are provided.
摘要翻译： 提供了具有钙离子性质的新型芳基烷基氨基化合物
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公开(公告)号：US08637509B2
公开(公告)日：2014-01-28
申请号：US13696601
申请日：2011-05-05
申请人： Joelle Lorraine Burgess , Neil Johnson , Steven D. Knight , Louis LaFrance , William H. Miller , Kenneth Newlander , Stuart Romeril , Meagan B. Rouse , Xinrong Tian , Sharad Kumar Verma , Dominic Suarez
发明人： Joelle Lorraine Burgess , Neil Johnson , Steven D. Knight , Louis LaFrance , William H. Miller , Kenneth Newlander , Stuart Romeril , Meagan B. Rouse , Xinrong Tian , Sharad Kumar Verma , Dominic Suarez
IPC分类号： A61K31/444 , A61P35/00 , A61K31/506 , A61K31/5377 , A61K31/513 , C07D471/04 , A61K31/4545
CPC分类号： C07D471/04 , C07D519/00
摘要： Herein are disclosed azaindazoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.
摘要翻译： 本文公开了式（I）的氮杂吲唑，其中各种基团在本文中定义，并且其可用于治疗癌症。
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公开(公告)号：US20100152112A1
公开(公告)日：2010-06-17
申请号：US12600745
申请日：2008-05-16
申请人： Nicholas D. Adams , Joelle Lorraine Burgess , Michael Gerard Darcy , Carla A. Donatelli , Steven David Knight
发明人： Nicholas D. Adams , Joelle Lorraine Burgess , Michael Gerard Darcy , Carla A. Donatelli , Steven David Knight
IPC分类号： A61K31/4709 , C07D401/14 , C07D413/14 , C07D498/04 , A61K31/5377 , A61K31/5383 , A61K38/22 , A61P35/00 , A61P25/00 , A61P9/00 , A61P1/00 , A61P19/02
CPC分类号： C07D498/04 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K31/549 , A61K45/06 , C07D285/24 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要： Invented is a method of inhibiting the activity/function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives.
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公开(公告)号：US20130053397A1
公开(公告)日：2013-02-28
申请号：US13696362
申请日：2011-05-05
申请人： James Brackley, III , Joelle Lorraine Burgess , Seth Grant , Neil Johnson , Steven D. Knight , Louis Lafrance , William H. Miller , Kenneth Newlander , Stuart Romeril , Meagan B. Rouse , Xinrong Tian , Sharad Kumar Verma
发明人： James Brackley, III , Joelle Lorraine Burgess , Seth Grant , Neil Johnson , Steven D. Knight , Louis Lafrance , William H. Miller , Kenneth Newlander , Stuart Romeril , Meagan B. Rouse , Xinrong Tian , Sharad Kumar Verma
IPC分类号： C07D401/14 , A61P35/00 , A61P35/02 , A61P37/06 , A61P37/00 , A61P31/10 , A61P19/02 , A61K31/496 , A61P1/00
CPC分类号： A61K31/496 , A61K31/405 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/551 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D498/04
摘要： Herein are disclosed indoles of formula (I) where the various groups are defined herein, and which are useful in treating cancer.
摘要翻译： 本文公开了式（I）的吲哚，其中各种基团在本文中定义，并且其可用于治疗癌症。
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公开(公告)号：US20120165321A1
公开(公告)日：2012-06-28
申请号：US13411887
申请日：2012-03-05
申请人： Nicholas D. Adams , Joelle Lorraine Burgess , Michael Gerrard Darcy , Carla A. Donatelli , Steven David Knight , Kenneth Allen Newlander , Lance Ridgers , Martha A. Sarpong , Stanley J. Schmidt
发明人： Nicholas D. Adams , Joelle Lorraine Burgess , Michael Gerrard Darcy , Carla A. Donatelli , Steven David Knight , Kenneth Allen Newlander , Lance Ridgers , Martha A. Sarpong , Stanley J. Schmidt
IPC分类号： A61K31/4709 , C07D413/14 , A61K31/5377 , A61K31/496 , C07D471/04 , C07D498/04 , A61K31/5383 , C07D417/14 , A61K31/549 , A61P37/00 , A61P29/00 , A61P9/00 , A61P25/28 , A61P37/08 , A61P11/06 , A61P1/18 , A61P13/12 , A61P7/02 , A61P35/00 , A61P15/08 , A61P37/06 , A61P11/00 , A61P17/06 , A61P19/04 , A61P1/00 , A61P25/14 , A61P25/00 , A61P9/10 , A61P9/08 , A61P21/00 , A61P35/04 , A61P31/04 , A61P31/12 , A61P35/02 , C07D401/14
CPC分类号： C07D498/04 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K31/549 , A61K45/06 , C07D285/24 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要： Invented is a method of inhibiting the activity/function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives.
摘要翻译： 本发明是使用喹啉衍生物抑制PI3激酶的活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法：自身免疫性疾病，炎性疾病，心血管疾病，神经变性疾病，变态反应，哮喘，胰腺炎，多器官功能衰竭，肾脏疾病，血小板聚集，癌症，精子活力，移植排斥反应， 通过给药喹啉衍生物的移植物排斥反应和肺损伤。
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公开(公告)号：US09073924B2
公开(公告)日：2015-07-07
申请号：US14344110
申请日：2012-09-12
申请人： Joelle Lorraine Burgess , Neil W. Johnson , Steven David Knight , Louis Vincent LaFrance, III , William Henry Miller , Kenneth Allen Newlander , Stuart Paul Romeril , Meagan B. Rouse , Dominic Suarez , Xinrong Tian , Sharad Kumar Verma
发明人： Joelle Lorraine Burgess , Neil W. Johnson , Steven David Knight , Louis Vincent LaFrance, III , William Henry Miller , Kenneth Allen Newlander , Stuart Paul Romeril , Meagan B. Rouse , Dominic Suarez , Xinrong Tian , Sharad Kumar Verma
IPC分类号： C07D471/02 , C07D471/04
CPC分类号： C07D471/04
摘要： Herein are disclosed azaindazoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.
摘要翻译： 本文公开了式（I）的氮杂吲唑，其中各种基团在本文中定义，并且其可用于治疗癌症。
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公开(公告)号：US08404837B2
公开(公告)日：2013-03-26
申请号：US12600745
申请日：2008-05-16
申请人： Nicholas D. Adams , Joelle Lorraine Burgess , Michael Gerard Darcy , Carla A. Donatelli , Steven David Knight , Kenneth Allen Newlander , Lance Ridgers , Martha A. Sarpong , Stanley J. Schmidt
发明人： Nicholas D. Adams , Joelle Lorraine Burgess , Michael Gerard Darcy , Carla A. Donatelli , Steven David Knight , Kenneth Allen Newlander , Lance Ridgers , Martha A. Sarpong , Stanley J. Schmidt
IPC分类号： C07D401/14 , C07D413/14 , C07D498/04
CPC分类号： C07D498/04 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K31/549 , A61K45/06 , C07D285/24 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要： Invented is a method of inhibiting the activity/function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives.
摘要翻译： 本发明是使用喹啉衍生物抑制PI3激酶的活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法：自身免疫性疾病，炎性疾病，心血管疾病，神经变性疾病，变态反应，哮喘，胰腺炎，多器官功能衰竭，肾脏疾病，血小板聚集，癌症，精子活力，移植排斥反应， 通过给药喹啉衍生物的移植物排斥反应和肺损伤。
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公开(公告)号：US20130059849A1
公开(公告)日：2013-03-07
申请号：US13696601
申请日：2011-05-05
申请人： Joelle Lorraine Burgess , Neil Johnson , Steven D. Knight , Louis Lafrance , William H. Miller , Kenneth Newlander , Stuart Romeril , Meagan B. Rouse , Xinrong Tian , Sharad Kumar Verma , Dominic Suarez
发明人： Joelle Lorraine Burgess , Neil Johnson , Steven D. Knight , Louis Lafrance , William H. Miller , Kenneth Newlander , Stuart Romeril , Meagan B. Rouse , Xinrong Tian , Sharad Kumar Verma , Dominic Suarez
IPC分类号： A61K31/444 , A61P35/00 , A61K31/506 , A61K31/5377 , A61K31/496 , A61K31/513 , C07D471/04 , A61K31/4545
CPC分类号： C07D471/04 , C07D519/00
摘要： Herein are disclosed azaindazoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.
摘要翻译： 本文公开了式（I）的氮杂吲唑，其中各种基团在本文中定义，并且其可用于治疗癌症。
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公开(公告)号：US20100179144A1
公开(公告)日：2010-07-15
申请号：US12664496
申请日：2008-06-12
申请人： Nicholas D. Adams , Joelle Lorraine Burgess , Michael Gerard Darcy , Steven David Knight , Kenneth Allen Newlander , Lance H. Ridgers , Stanley J. Schmidt
发明人： Nicholas D. Adams , Joelle Lorraine Burgess , Michael Gerard Darcy , Steven David Knight , Kenneth Allen Newlander , Lance H. Ridgers , Stanley J. Schmidt
IPC分类号： A61K31/5377 , C07D401/14 , A61K31/517 , C07D413/14 , A61K31/496 , C07D403/14 , A61K31/501 , A61P35/00
CPC分类号： A61K31/5377 , A61K31/517 , C07D401/04 , C07D401/14 , C07D471/04
摘要： Invented is a method of inhibiting the activity/function of PI3 kinases using quinazoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinazoline derivatives.
摘要翻译： 发明是使用喹唑啉衍生物抑制PI3激酶的活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法：自身免疫性疾病，炎性疾病，心血管疾病，神经变性疾病，变态反应，哮喘，胰腺炎，多器官功能衰竭，肾脏疾病，血小板聚集，癌症，精子活力，移植排斥反应， 通过施用喹唑啉衍生物的移植物排斥和肺损伤。
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