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公开(公告)号：US11931429B2
公开(公告)日：2024-03-19
申请号：US17451536
申请日：2021-10-20
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Doron Shabat , Ronit Satchi-Fainaro , Nir Hananya , Ori Green , Tal Eilon
IPC: A61K49/00 , C07D321/00 , C07F5/02 , C07F5/04 , C07F7/18 , C07F9/12 , C07F9/655 , C07H15/203 , C07H15/26 , C09B11/24 , C09B23/01 , C09B23/04 , C09B23/08 , C09K11/06
CPC classification number: A61K49/0052 , C07D321/00 , C07F5/025 , C07F5/04 , C07F7/1804 , C07F9/12 , C07F9/65512 , C07H15/203 , C07H15/26 , C09B11/24 , C09B23/0066 , C09B23/04 , C09B23/083 , C09K11/06 , C09K2211/1018
Abstract: The present invention provides dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.
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公开(公告)号：US10660974B2
公开(公告)日：2020-05-26
申请号：US16072848
申请日：2017-01-24
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Doron Shabat , Ronit Satchi-Fainaro , Nir Hananya , Ori Green , Tal Eilon
IPC: A61K49/00 , C07F5/04 , C07D321/00 , C07D405/00 , C07F9/655 , C07H15/26 , C09B11/24 , C09B23/04 , C09B23/08 , C09K11/06 , C07F9/12 , C09B23/01 , C07F5/02 , C07H15/203 , C07F7/18
Abstract: Dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and π* acceptor group-containing dioxetane based chemiluminescence probes can be included in compositions. The chemiluminescence probes are useful for both diagnostics and in vivo imaging.
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公开(公告)号：US09682098B2
公开(公告)日：2017-06-20
申请号：US14803155
申请日：2015-07-20
Inventor： Rainer Haag , Wiebke Fischer , Abdul Mohiuddin Quadir , Ronit Satchi-Fainaro , Paula Ofek
IPC: A61K38/00 , A61K31/713 , C12N15/113 , A61K45/06 , C07C229/22 , C07C217/28 , C07C271/20
CPC classification number: A61K31/713 , A61K45/06 , C07C217/28 , C07C229/22 , C07C271/20 , C12N15/1135
Abstract: The invention relates to a compound suited as entity carrier, having the general formula (I) wherein X is an amine-containing residue further defined herein. The invention further relates to the use of such compounds, a nanocarrier system, a kit comprising such compounds and methods for gene silencing and anti-cancer treatment.
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公开(公告)号：US09427474B2
公开(公告)日：2016-08-30
申请号：US14816228
申请日：2015-08-03
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Ronit Satchi-Fainaro , Keren Miller , Doron Shabat , Rotem Erez
IPC: A61K31/74 , A61K47/48 , A61K49/00 , C07F9/38 , C07F9/655 , C07F9/6558 , C07K5/065 , C07K5/103 , A61K31/337 , A61K9/16
CPC classification number: A61K47/48084 , A61K9/1676 , A61K31/337 , A61K47/548 , A61K47/58 , A61K47/65 , A61K49/0017 , A61K49/0054 , A61K2800/57 , C07F9/3873 , C07F9/65517 , C07F9/65586 , C07K5/06078 , C07K5/1008
Abstract: Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and a bisphosphonate bone targeting agent, and processes of preparing same, are disclosed.Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of bone related disorders are also disclosed.
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公开(公告)号：US11666656B2
公开(公告)日：2023-06-06
申请号：US16079123
申请日：2017-02-24
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Ronit Satchi-Fainaro , Evgeni Pisarevsky , Anat Eldar-Boock , Dikla Ben-Shushan , Yana Epshtein , Anna Scomparin
IPC: A61K47/65 , A61K9/51 , A61P35/00 , A61K47/64 , A61K47/59 , A61P35/04 , A61K31/4184 , A61K31/506 , A61K31/4745
CPC classification number: A61K47/65 , A61K9/5153 , A61K31/4184 , A61K31/506 , A61K47/59 , A61K47/645 , A61P35/00 , A61P35/04 , A61K31/4745 , A61K2300/00
Abstract: Polymeric conjugates comprising a polymeric matrix having associated therewith an agent that down-regulates an activity or expression of a polypeptide associated with onset or progression of melanoma, and optionally and preferably, an additional agent that acts in synergy with said agent, are provided. Synthetic methodologies for preparing these conjugates and uses thereof in treating melanoma and other cancerous diseases are also provided.
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Patent Agency Ranking
公开(公告)号：US10532113B2
公开(公告)日：2020-01-14
申请号：US15124360
申请日：2015-03-13
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Ronit Satchi-Fainaro , Doron Shabat , Rachel Blau , Yana Epshtein , Hemda Baabur-Cohen , Shiran Ferber , Orit Redy-Keisar , Einat Kisin-Finfer
IPC: A61K49/00 , A61K31/337 , A61K47/65 , A61K47/58 , A61K47/59
Abstract: Polymeric systems useful for theranostic applications are disclosed. The polymeric systems comprise a fluorescent or fluorogenic moiety and a therapeutically active agent, each attached to the same or different polymeric moiety. The polymeric systems are designed such that a fluorescent signal is generated in response to a chemical event, preferably upon contacting an analyte (e.g., an enzyme) that is over-expressed in a diseased tissue or organ. Probes useful for inclusion in such polymeric systems, processes of preparing such probes and the polymeric systems, and uses thereof in diagnostic and/or theranostic applications are also disclosed.
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7.发明授权公开(公告)号：US09341630B2
公开(公告)日：2016-05-17
申请号：US14027219
申请日：2013-09-15
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Doron Shabat , Ronit Satchi-Fainaro
CPC classification number: C07D401/14 , A61K47/558 , A61K49/0021 , A61K49/0032 , A61K49/0052 , A61K49/0056 , C07D209/08 , C07D209/12 , C07D213/30 , C07D213/71 , C07D213/76 , C07D213/85 , C09B23/0066 , C09B23/086 , C09B23/12 , G01N33/52 , G01N33/582
Abstract: Novel fluorogenic compounds designed such that upon a chemical event, compounds capable of emitting NIR light are generated, are disclosed. The compounds comprise two or more acceptor-containing moieties and a cleavable donor-containing moiety, being in complete pi-electrons conjugation and being such that no delocalization of pi-electrons is enabled. Also disclosed are fluorescent compounds generated upon subjecting the fluorogenic compounds to a chemical event (e.g., deprotonation). Also disclosed are uses of the fluorogenic compounds as NIR probed with a Turn-ON mechanism in monitoring presence and/or level of various analytes.
Abstract translation: 新的荧光化合物被设计成使得在化学事件上产生能够发射NIR光的化合物被产生。 这些化合物包含两个或多个含受体的部分和可裂解供体的部分，其完全是π-电子共轭并且使得不能使π-电子的离域化。 还公开了在使荧光化合物经历化学事件（例如去质子化）时产生的荧光化合物。 还公开了荧光化合物作为NIR探测的用于监测各种分析物的存在和/或水平的Turn-ON机制的用途。
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8.发明申请公开(公告)号：US20140010763A1
公开(公告)日：2014-01-09
申请号：US14027219
申请日：2013-09-15
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Doron SHABAT , Ronit Satchi-Fainaro
CPC classification number: C07D401/14 , A61K47/558 , A61K49/0021 , A61K49/0032 , A61K49/0052 , A61K49/0056 , C07D209/08 , C07D209/12 , C07D213/30 , C07D213/71 , C07D213/76 , C07D213/85 , C09B23/0066 , C09B23/086 , C09B23/12 , G01N33/52 , G01N33/582
Abstract: Novel fluorogenic compounds designed such that upon a chemical event, compounds capable of emitting NIR light are generated, are disclosed. The compounds comprise two or more acceptor-containing moieties and a cleavable donor-containing moiety, being in complete pi-electrons conjugation and being such that no delocalization of pi-electrons is enabled. Also disclosed are fluorescent compounds generated upon subjecting the fluorogenic compounds to a chemical event (e.g., deprotonation). Also disclosed are uses of the fluorogenic compounds as NIR probed with a Turn-ON mechanism in monitoring presence and/or level of various analytes.
Abstract translation: 新的荧光化合物被设计成使得在化学事件上产生能够发射NIR光的化合物被产生。 这些化合物包含两个或多个含受体的部分和可裂解供体的部分，其完全是π-电子共轭并且使得不能使π-电子的离域化。 还公开了在使荧光化合物经历化学事件（例如去质子化）时产生的荧光化合物。 还公开了荧光化合物作为NIR探测的用于监测各种分析物的存在和/或水平的Turn-ON机制的用途。
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公开(公告)号：US20240197924A1
公开(公告)日：2024-06-20
申请号：US18428591
申请日：2024-01-31
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Doron Shabat , Ronit Satchi-Fainaro , Nir Hananya , Ori Green , Tal Eilon
IPC: A61K49/00 , C07D321/00 , C07F5/02 , C07F5/04 , C07F7/18 , C07F9/12 , C07F9/655 , C07H15/203 , C07H15/26 , C09B11/24 , C09B23/01 , C09B23/04 , C09B23/08 , C09K11/06
CPC classification number: A61K49/0052 , C07D321/00 , C07F5/025 , C07F5/04 , C07F7/1804 , C07F9/12 , C07F9/65512 , C07H15/203 , C07H15/26 , C09B11/24 , C09B23/0066 , C09B23/04 , C09B23/083 , C09K11/06 , C09K2211/1018
Abstract: The present invention provides dioxctane-based chemiluminescence probes, more specifically fluorophore-tethered dioxctane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.
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公开(公告)号：US11179482B2
公开(公告)日：2021-11-23
申请号：US16850333
申请日：2020-04-16
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Doron Shabat , Ronit Satchi-Fainaro , Nir Hananya , Ori Green , Tal Eilon
IPC: A61K49/00 , C07F5/04 , C07D321/00 , C09K11/06 , C07F9/655 , C07H15/26 , C09B11/24 , C09B23/04 , C09B23/08 , C07F9/12 , C09B23/01 , C07F5/02 , C07H15/203 , C07F7/18
Abstract: The present invention provides dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.
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