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    Polysaccharide conjugates of biomolecules
    1.
    发明申请
    Polysaccharide conjugates of biomolecules 审中-公开
    生物分子的多糖共轭物

    公开(公告)号：US20050281833A1

    公开(公告)日：2005-12-22

    申请号：US11180245

    申请日：2005-07-13

    申请人： Rajendra Singh ,  Harshvardhan Mehta

    发明人： Rajendra Singh ,  Harshvardhan Mehta

    IPC分类号： A01N43/16 ,  G01N33/564 ,  A61K39/00 ,  C07K14/705 ,  C07K16/46

    CPC分类号： C08B37/0021 ,  A01N43/16 ,  C08H1/00 ,  G01N33/564 ,  G01N2333/988

    摘要： Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified polysaccharide. Also disclosed is a method fore introducing an amine-reactive functionality into a dextran. The method comprises (a) reacting the dextran with an alkylating agent having a functionality that reacts with an hydroxyl group of the dextran thereby forming an alkylated dextran wherein the alkylating agent has an olefin group and (b) treating the alkylated dextran to convert the olefin group to an amine-reactive functionality. A polysaccharide can be conjugated to a biomolecule by carrying out the above method and reacting the amine-reactive functionality with an amine functionality on the biomolecule to produce polysaccharide conjugated to the biomolecule.

    摘要翻译： 公开了具有侧醛官能团的改性多糖的化合物。 每个醛官能团通过接头连接到对应于未修饰多糖的不同羟基的氢原子的位置。 还公开了将胺反应性功能引入葡聚糖的方法。 该方法包括（a）使葡聚糖与具有与葡聚糖羟基反应的官能团的烷基化剂反应，从而形成烷基化葡聚糖，其中烷基化剂具有烯烃基团，和（b）处理烷基化葡聚糖以转化烯烃 与胺反应性官能团。 通过进行上述方法并使胺反应性官能团与胺官能团在生物分子上反应以产生与生物分子缀合的多糖，可以将多糖与生物分子缀合。

    Polysaccharide conjugates of biomolecules
    2.
    发明授权
    Polysaccharide conjugates of biomolecules 有权
    生物分子的多糖共轭物

    公开(公告)号：US06949524B2

    公开(公告)日：2005-09-27

    申请号：US10188578

    申请日：2002-07-02

    申请人： Rajendra Singh ,  Harshvardhan Mehta

    发明人： Rajendra Singh ,  Harshvardhan Mehta

    IPC分类号： A01N43/16 ,  G01N33/564 ,  A61K31/715 ,  C08B37/00

    CPC分类号： C08B37/0021 ,  A01N43/16 ,  C08H1/00 ,  G01N33/564 ,  G01N2333/988

    摘要： Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified polysaccharide. Also disclosed is a method for introducing an amine-reactive functionality into a dextran. The method comprises (a) reacting the dextran with an alkylating agent having a functionality that reacts with an hydroxyl group of the dextran thereby forming an alkylated dextran wherein the alkylating agent has an olefin group and (b) treating the alkylated dextran to convert the olefin group to an amine-reactive functionality. A polysaccharide can be conjugated to a biomolecule by carrying out the above method and reacting the amine-reactive functionality with an amine functionality on the biomolecule to produce polysaccharide conjugated to the biomolecule.

    摘要翻译： 公开了具有侧醛官能团的改性多糖的化合物。 每个醛官能团通过接头连接到对应于未修饰多糖的不同羟基的氢原子的位置。 还公开了将胺反应性功能引入葡聚糖的方法。 该方法包括（a）使葡聚糖与具有与葡聚糖羟基反应的官能团的烷基化剂反应，从而形成烷基化葡聚糖，其中烷基化剂具有烯烃基团，和（b）处理烷基化葡聚糖以转化烯烃 与胺反应性官能团。 通过进行上述方法并使胺反应性官能团与胺官能团在生物分子上反应以产生与生物分子缀合的多糖，可以将多糖与生物分子缀合。

    Polysaccharide conjugates of biomolecules
    3.
    发明授权
    Polysaccharide conjugates of biomolecules 有权
    生物分子的多糖共轭物

    公开(公告)号：US06489309B1

    公开(公告)日：2002-12-03

    申请号：US09314055

    申请日：1999-05-18

    申请人： Rajendra Singh ,  Harshvardhan Mehta

    发明人： Rajendra Singh ,  Harshvardhan Mehta

    IPC分类号： A01N4304

    CPC分类号： C08B37/0021 ,  A01N43/16 ,  C08H1/00 ,  G01N33/564 ,  G01N2333/988

    摘要： Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified polysaccharide. Also disclosed is a method for introducing an amine-reactive functionality into a dextran. The method comprises (a) reacting the dextran with an alkylating agent having a functionality that reacts with an hydroxyl group of the dextran thereby forming an alkylated dextran wherein the alkylating agent has an olefin group and (b) treating the alkylated dextran to convert the olefin group to an amine-reactive functionality. A polysaccharide can be conjugated to a biomolecule by carrying out the above method and reacting the amine-reactive functionality with an amine functionality on the biomolecule to produce polysaccharide conjugated to the biomolecule.

    摘要翻译： 公开了具有侧醛官能团的改性多糖的化合物。 每个醛官能团通过接头连接到对应于未修饰多糖的不同羟基的氢原子的位置。 还公开了将胺反应性功能引入葡聚糖的方法。 该方法包括（a）使葡聚糖与具有与葡聚糖羟基反应的官能团的烷基化剂反应，从而形成烷基化葡聚糖，其中烷基化剂具有烯烃基团，和（b）处理烷基化葡聚糖以转化烯烃 与胺反应性官能团。 通过进行上述方法并使胺反应性官能团与胺官能团在生物分子上反应以产生与生物分子缀合的多糖，可以将多糖与生物分子缀合。

    Polysaccharide conjugates of biomolecules
    4.
    发明授权
    Polysaccharide conjugates of biomolecules 失效

    公开(公告)号：US5929049A

    公开(公告)日：1999-07-27

    申请号：US907842

    申请日：1997-08-08

    申请人： Rajendra Singh ,  Harshvardhan Mehta

    发明人： Rajendra Singh ,  Harshvardhan Mehta

    IPC分类号： A01N43/16 ,  G01N33/564 ,  A01N43/04

    CPC分类号： C08B37/0021 ,  A01N43/16 ,  C08H1/00 ,  G01N33/564 ,  G01N2333/988

    摘要： Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified polysaccharide. Also disclosed is a method for introducing an amine-reactive functionality into a dextran. The method comprises (a) reacting the dextran with an alkylating agent having a functionality that reacts with an hydroxyl group of the dextran thereby forming an alkylated dextran wherein the alkylating agent has an olefin group and (b) treating the alkylated dextran to convert the olefin group to an amine-reactive functionality. A polysaccharide can be conjugated to a biomolecule by carrying out the above method and reacting the amine-reactive functionality with an amine functionality on the biomolecule to produce polysaccharide conjugated to the biomolecule.

    Mobile device mode enablement responsive to a proximity criterion
    5.
    发明授权
    Mobile device mode enablement responsive to a proximity criterion 有权
    响应于接近度标准的移动设备模式启用

    公开(公告)号：US09462411B2

    公开(公告)日：2016-10-04

    申请号：US12264711

    申请日：2008-11-04

    申请人： Peter D. Karabinis ,  Rajendra Singh

    发明人： Peter D. Karabinis ,  Rajendra Singh

    IPC分类号： H04W64/00 ,  H04W4/02 ,  G06Q30/06 ,  H04L29/08

    CPC分类号： H04W48/04 ,  G06Q30/0601 ,  H04L67/18 ,  H04W4/02 ,  H04W4/023 ,  H04W4/80 ,  H04W76/10 ,  H04W88/06

    摘要： A system (10) and method (30) comprises a detector that is configured to enable a mode of a first device (14) and/or to enable a mode of a second device (15) responsive to a detection that a proximity criterion is satisfied between the first device and an entity (Entity 1) and responsive to at least one of a position, velocity and a Time-of-Day and where the second device is not the entity and is not associated with the entity, and where the entity is not involved in providing a communications service to the first and/or second device.

    摘要翻译： 系统（10）和方法（30）包括检测器，其被配置为使能第一设备（14）的模式和/或使第二设备（15）的模式能够响应于接近标准是 在第一设备和实体（实体1）之间满足并响应于位置，速度和时间中的至少一个，并且其中第二设备不是实体并且不与实体相关联，并且其中 实体不涉及向第一和/或第二设备提供通信服务。

    Systems And Methods For A Terrestrial-Based Positioning Beacon Network
    7.
    发明申请
    Systems And Methods For A Terrestrial-Based Positioning Beacon Network 有权
    用于地面定位信标网络的系统和方法

    公开(公告)号：US20120169541A1

    公开(公告)日：2012-07-05

    申请号：US13334997

    申请日：2011-12-22

    申请人： Rajendra Singh

    发明人： Rajendra Singh

    IPC分类号： G01S5/02

    CPC分类号： G01S19/11 ,  G01S1/02 ,  G01S1/042 ,  G01S1/08 ,  G01S5/0215 ,  G01S19/12 ,  G01S19/21 ,  G01S19/22

    摘要： Terrestrial-based positioning beacon networks may include first and second terrestrial-based positioning beacons that are configured to simultaneously transmit signals to a terrestrial receiver. The first terrestrial-based positioning beacon may be configured to modify its transmissions to the terrestrial receiver in response to an identification of potential interference with the transmissions from the first terrestrial-based positioning beacon or the second terrestrial-based positioning beacon to the terrestrial receiver. Related methods, beacons, and receivers are also described.

    摘要翻译： 基于地面的定位信标网络可以包括被配置为同时向陆地接收机发送信号的第一和第二基于地面的定位信标。 第一基于地面的定位信标可以被配置为响应于对从第一地面定位信标或第二地面定位信标到地面接收机的传输的潜在干扰的识别来修改其对地面接收机的传输。 还描述了相关方法，信标和接收机。

    Millimeter microwave point-to-multipoint broadcasting systems, components and methods that monitor and rebroadcast data packets
    10.
    发明授权
    Millimeter microwave point-to-multipoint broadcasting systems, components and methods that monitor and rebroadcast data packets 有权
    毫米微波点对多点广播系统，监视和重播广播数据包的组件和方法

    公开(公告)号：US07499708B2

    公开(公告)日：2009-03-03

    申请号：US10937714

    申请日：2004-09-09

    申请人： Rajendra Singh ,  George Ronald Olexa

    发明人： Rajendra Singh ,  George Ronald Olexa

    IPC分类号： H04Q7/20 ,  H04B7/14 ,  H04B7/00

    CPC分类号： H04L12/189 ,  H04L1/16 ,  H04W76/40

    摘要： Selected data packets that were broadcast over millimeter microwave frequencies to millimeter microwave receiving stations in a millimeter microwave broadcasting system footprint are rebroadcast. Rebroadcasting is selected based upon an indication that is received from a subset of the millimeter microwave receiving stations, that the one or more data packets were not received successfully by the subset of the millimeter microwave receiving stations. Selective rebroadcasting may be performed based upon statistical analysis of indications that are received from the subset of the millimeter microwave receiving stations.

    摘要翻译： 在毫米波微波广播系统覆盖范围内以毫米微波频率广播到毫米微波接收站的所选数据分组被重播。 基于从毫米微波接收站的子集接收到的指示来选择重新广播，所述一个或多个数据分组未被毫米波微波接收站的子集成功接收。 可以基于从毫米波微波接收站的子集接收到的指示的统计分析来执行选择性转播。