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公开(公告)号：US5686422A
公开(公告)日：1997-11-11
申请号：US468491
申请日：1995-06-06
CPC分类号： C07K5/0812 , C07K5/06078 , C07K5/06086 , A61K38/00
摘要： The present invention relates to compounds of the formula: R.sub.1 SCH(R.sub.2)CH(R.sub.3)CO-AA.sub.1 �AA.sub.2 !.sub.m �AA.sub.3 !.sub.n --X or HSCH.sub.2 �CH.sub.2 CH(CH.sub.3).sub.2 !CO--Nal--NH.sub.2 wherein Nal is L-3-(2-naphthyl)alanine; m is the integer 0 or 1; n is an integer from 0-2; AA.sub.1 is a non-polar hydrophobic aromatic amino acid; AA.sub.2 is alanine, glycine, leucine, isoleucine or phenylalanine; AA.sub.3 is one of the twenty naturally occurring amino acids, preferably glutamine or arginine; R.sub.1 is hydrogen, alkyl having from 1-10 carbon atoms, alkanoyl having from 2-10 carbon atoms, or aroyl having from 7-10 carbon atoms; R.sub.2 is hydrogen or alkyl having from 1-6 carbon atoms; R.sub.3 is hydrogen, alkyl having from 2-10 carbon atoms, cycloalkyl having from 3-6 carbon atoms, aryl or arylalkyl, wherein aryl moieties have from 6-10 carbon atoms; X is NH.sub.2, OH, OCH.sub.3 or OCH.sub.2 CH.sub.3 ; and salts thereof.
摘要翻译： 本发明涉及下式的化合物：R1SCH（R2）CH（R3）CO-AA1 [AA2] m [AA3] nX或HSCH2 [CH2CH（CH3）2] CO-Nal-NH2，其中Nal是L-3-（2 - 萘基）丙氨酸; m是整数0或1; n是0-2的整数; AA1是非极性疏水性芳香族氨基酸; AA2是丙氨酸，甘氨酸，亮氨酸，异亮氨酸或苯丙氨酸; AA3是二十种天然存在的氨基酸之一，优选为谷氨酰胺或精氨酸; R1是氢，具有1-10个碳原子的烷基，具有2-10个碳原子的烷酰基，或具有7-10个碳原子的芳酰基; R2是氢或具有1-6个碳原子的烷基; R3是氢，具有2-10个碳原子的烷基，具有3-6个碳原子的环烷基，芳基或芳烷基，其中芳基部分具有6-10个碳原子; X是NH 2，OH，OCH 3或OCH 2 CH 3; 及其盐。
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公开(公告)号：US4980901A
公开(公告)日：1990-12-25
申请号：US242350
申请日：1988-09-09
申请人： Robert B. Miller
发明人： Robert B. Miller
IPC分类号： G01N23/221 , G01V5/00 , G21G1/12
CPC分类号： G01V5/0008 , G01N23/221 , G01V5/0069
摘要： A beam of energy in a first form, such as electrons, is provided in a first direction. The beam may be pulsed or continuous. The beam is intercepted by a member, such as a converter target, to produce energy in a second form such as x-rays. The converter target may be formed from a heavy material such as tungsten or tantalum. The interaction of the electron beam with the converter target will produce energetic bremsstrahlung x-rays in an energy range including 10.6 Mev to approximately 13.0 Mev. This range is sufficient to excite the abundant nitrogen atoms in common explosives to induce the production of annihilation photons but is not sufficient to substantially excite atom of the most abundant elements of the earth's crust (e.g. oxygen, silicon, iron, aluminum, carbon, hydrogen, etc.), which comprise most common fabricated articles and soils. The converter target is disposed relative to an object (e.g. a suitcase in an airport) to obtain the production of energy in a third form, such as photons, from the object. The photons pass to a detector such as a scintillation counter which determines the concentration of the nitrogen in the object. The detector may be gated so as to be activated only when the photons are passing from the object to the detector. When the object is a suitcase which is moved along a conveyor, the detector may be downstream from the source in the direction of movement of the conveyor.
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公开(公告)号：US4583025A
公开(公告)日：1986-04-15
申请号：US547279
申请日：1983-10-31
摘要： An autogenerating apparatus provides secondary intense relativistic current beam pulses in response to an injected beam pulse. One or more electromagnetic energy storage devices are provided in conjunction with gaps along a beam propagation path for the injected beam pulse. For injected beam pulses which are no longer than double the transit time of electromagnetic waves within the storage devices (which may be resonant cavities), distinct secondary beam pulses are generated by each of the energy storage devices. The beam propagation path, together with the one or more gaps provided therein, operates as a pulse forming transmission line cavity, in which the separate cavities associated with the gaps provide delays for electromagnetic waves generated at the gaps. After doubly traversing the cavity, the electromagnetic waves cause the gap to generate the secondary beam pulses, which are thus delayed by a time interval equal to the double transit time for the induced wave within the cavity.
摘要翻译： 自动生成装置响应于注入的束脉冲提供二次强相对论电流束脉冲。 一个或多个电磁能量存储装置与用于注入的束脉冲的光束传播路径的间隙一起提供。 对于不超过存储装置（其可以是谐振腔）内的电磁波的传播时间的两倍的注入光束脉冲，由每个能量存储装置产生不同的次光束脉冲。 光束传播路径与其中提供的一个或多个间隙一起作为脉冲形成传输线腔进行操作，其中与间隙相关联的分离的空腔为在间隙处产生的电磁波提供延迟。 在双向穿过腔体之后，电磁波使间隙产生次级束脉冲，因此延迟等于空腔内感应波的双通道时间的时间间隔。
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公开(公告)号：US4133566A
公开(公告)日：1979-01-09
申请号：US809489
申请日：1977-06-23
申请人： Robert B. Miller
发明人： Robert B. Miller
CPC分类号： F16L13/002 , Y10T29/49893 , Y10T29/49915 , Y10T29/49936 , Y10T29/49954
摘要： A method and apparatus for permanently and sealably connecting two duct sections, the duct sections having peripheral flanges forming opposite and corresponding halves of a composite, T-shaped peripheral flange extending outwardly from the duct sections. The composite flange has an upper cross-piece portion and a lower upright portion, the lower upright portion of the T-shaped flange containing a continuous reservoir of deformable gasket material. The method comprises the steps of first placing square-cornered, U-shaped clamps over the upper cross-piece portion of the T-shaped flange at spaced intervals thereon; secondly, pressing sides of each of the clamps inwardly and crimping the clamps to upper and lower surfaces of the upper cross-piece portion, forcing a portion of the gasket material to flow from the reservoir between the flange halves, towards the duct sections, thereby producing a sealed joint between the duct sections; and thirdly, rippling each of the clamps simultaneously with the upper cross-piece portion adjacent each of the clamps, causing undulations in both which prevent the clamps from slipping out of clamping contact with the upper portion of the T-shaped flange, thereby permanently connecting the duct sections.
摘要翻译： 一种用于永久和密封地连接两个管道部分的方法和装置，所述管道部分具有形成从所述管道部分向外延伸的复合的T形周边凸缘的相对且相应的半部的周边凸缘。 复合凸缘具有上横截面部分和下直立部分，T形凸缘的下直立部分包含可变形垫片材料的连续储存器。 该方法包括以下步骤：首先将方形的U形夹具以间隔的间隔放置在T形凸缘的上横截面部分上; 其次，将每个夹具的侧面向内按压，并将夹具压接在上横截面部分的上表面和下表面上，迫使垫圈材料的一部分从凸缘半部之间的容器流向管道部分，从而 在管道部分之间产生密封接头; 第三，每个夹具与每个夹具相邻的上横截面部分同时涟漪，引起两者的起伏，从而阻止夹具与T形凸缘的上部夹紧接触，从而永久连接 管段。
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公开(公告)号：US5101168A
公开(公告)日：1992-03-31
申请号：US561942
申请日：1990-08-01
申请人： Robert B. Miller
发明人： Robert B. Miller
IPC分类号： H01J25/04
CPC分类号： H01J25/04
摘要： An electron gun emits a steady stream of electrons. The electrons pass to a modulating cavity which accelerates some of the electrons and decelerates other electrons in a particular timed relationship so that the electrons become periodically bunched. The bunched electrons are then accelerated in an accelerator to a constant speed such as the speed of light to maintain the bunching of the electrons and to substantially increase the energy of the electrons. The kinetic energy in the bunches of electrons is then converted to microwave energy. The conversion may occur in one output cavity or in a series of output cavities. Apparatus such as described above may be connected in parallel to further increase the output microwave energy.
摘要翻译： 电子枪发出稳定的电子流。 电子传递到调制腔，其加速一些电子并以特定的定时关系减速其他电子，使得电子变得周期性地聚束。 然后将聚束的电子在加速器中加速至恒定速度，例如光速以保持电子的聚束并显着增加电子的能量。 然后将电束束中的动能转换成微波能量。 转换可能发生在一个输出腔或一系列输出腔中。 如上所述的装置可以并联连接以进一步增加输出微波能量。
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公开(公告)号：US5710246A
公开(公告)日：1998-01-20
申请号：US618547
申请日：1996-03-19
申请人： Kenneth W. Funk , Edwin O. Lundell , Robert B. Miller , Jane L. Chang , Vimal Kishore , James J. Napier , Michael A. Staeger
发明人： Kenneth W. Funk , Edwin O. Lundell , Robert B. Miller , Jane L. Chang , Vimal Kishore , James J. Napier , Michael A. Staeger
IPC分类号： C07D307/24 , A61K31/00 , A61K31/34 , A61K31/341 , A61K38/00 , A61K38/04 , A61P5/00 , A61P5/08 , C07D307/14 , C07K1/06 , C07K5/06 , C07K5/068 , C07K5/078 , C07K5/08 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/10 , C07K5/103 , C07K5/11 , C07K7/23 , C07K1/02 , C07K4/00
CPC分类号： C07K5/06165 , C07D307/14 , C07K5/06086 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/1008 , C07K5/1013 , C07K5/1019 , C07K7/23 , A61K38/00
摘要： A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.
摘要翻译： 提供了通过溶液相肽化学制备LHRH的十肽和十一肽衍生物以及以相同方法有用的中间体肽的方法。
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公开(公告)号：US4734586A
公开(公告)日：1988-03-29
申请号：US836883
申请日：1986-03-06
IPC分类号： H01J33/00 , H01J37/301 , H05H7/00 , H01J33/04
CPC分类号： H05H7/00 , H01J33/00 , H01J37/301
摘要： A self-contained hermetically sealed foil changer for advancing a portion of foil web into a position normal to the path of a high energy particle beam. The path of the beam is defined generally by an aperture plate and cooperating axially movable barrel such that the barrel can be advanced toward the plate thereby positioning a portion of the foil across the beam path and sealing the foil between the barrel and the plate to form a membrane across said beam path. A spooling apparatus contained in the foil changer permits selectively advancing a fresh supply of foil across the beam path without breaking the foil changer seal.
摘要翻译： 一种独立的密封箔片更换器，用于将箔片的一部分推进到垂直于高能粒子束路径的位置。 梁的路径通常由孔板和配合的可轴向移动的筒限定，使得筒可朝向板推进，从而将箔的一部分定位在梁路径上并将箔密封在筒和板之间以形成 穿过所述光束路径的膜。 包含在箔片更换器中的缠绕装置允许选择性地将新鲜的箔片供给穿过光束路径而不破坏箔片更换器密封件。
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8.发明授权Apparatus for the acceleration of ions in the virtual cathode of an intense relativistic electron beam 失效用于加速强相对论电子束虚拟阴极中的离子的装置
公开(公告)号：US4070595A
公开(公告)日：1978-01-24
申请号：US748583
申请日：1976-12-08
申请人： Robert B. Miller
发明人： Robert B. Miller
CPC分类号： H01J27/02
摘要： The acceleration of large numbers of ions to high energies uses an intense relativistic electron beam produced by a vacuum diode. An electron beam radial profile is maintained by a strong longitudinal magnetic field. A virtual cathode, characterized by an electrostatic potential depression whose depth corresponds to the injected electron beam kinetic energy will form. The virtual cathode is caused to move backwards toward the vacuum diode by utilizing the time history of the injected electron beam voltage and current, and by appropriately flaring the drift tube. Ions trapped in the potential well associated with the virtual cathode move with the virtual cathode and are synchronously accelerated.
摘要翻译： 大量离子到高能量的加速使用由真空二极管产生的强烈的相对论电子束。 电子束径向轮廓由强纵向磁场保持。 一种虚拟阴极，其特征在于静电势下降，其深度对应于注入的电子束动能将形成。 通过利用注入的电子束电压和电流的时间历程，并通过适当地扩展漂移管，使虚拟阴极向后朝向真空二极管移动。 离子在与虚拟阴极移动的虚拟阴极相关联的潜在阱中被捕获并同步加速。
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公开(公告)号：US3930491A
公开(公告)日：1976-01-06
申请号：US538515
申请日：1975-01-06
申请人： Robert B. Miller
发明人： Robert B. Miller
CPC分类号： F24B1/1886
摘要： A conventional fireplace with a mantel, a hearth and a chimney has an air intake port and an air exhaust port disposed in the mantel. An air intake fan also disposed in the mantel is connected in series with copper pipe, and the fan is connected to the intake port while the remote end of the pipe feeds the exhaust port. The pipe is routed over the hearth and below the chimney. When a fire is lit in the fireplace, and the fan is turned on, the air passed through the pipe is heated by the fire and blown throughout the room.
摘要翻译： 具有壁炉，炉膛和烟囱的常规壁炉具有设置在炉膛中的进气口和排气口。 另外，还配置有与铜管串联连接的进气风扇，风扇与进气口连接，同时管路的远端供给排气口。 管道穿过炉膛和烟囱下面。 当壁炉里的火焰点燃，风扇开启时，通过管道的空气被火加热，并吹遍整个房间。
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公开(公告)号：US5626990A
公开(公告)日：1997-05-06
申请号：US596400
申请日：1996-02-02
申请人： Robert B. Miller , Larry F. Miller
发明人： Robert B. Miller , Larry F. Miller
CPC分类号： H01M10/0436 , H01M10/126 , H01M10/16 , H01M2/0207 , Y02P70/54
摘要： A recombinant lead acid battery is provided having positive and negative plates coated with active material and separated by a compressible separator material containing an electrolyte. A casing provides structural support for the plates and encases the battery's components. The battery is preferably a recombinant lead acid battery with its plates being formed of lead foil sheets. The casing is reinforced and arranged to i) maintain a substantially evenly distributed compressive force on the separator material and ii) maintain a constant spacing between the plates. The battery is arranged to maintain a compressive force of at least eight psi on the plates which has been found to significantly reduce the incidence of premature capacity loss (PCL). By way of example, compressive forces in the range of 8-14 psi work well for conventional separator materials. In one embodiment, the casing includes a plurality of reinforcing support pins extending between upper and lower casing members through the plates and separator material for maintaining the evenly distributed pressure. Plates may be slacked one above another to provide a plurality of cells. A method of making the battery is also described.
摘要翻译： 提供重组铅酸电池，其具有涂覆有活性材料的正极和负极板，并通过包含电解质的可压缩分离器材料分离。 外壳为板提供结构支撑，并包住电池组件。 电池优选为重组铅酸电池，其电池板由铅箔片形成。 套管被加强并且布置成i）在隔板材料上保持基本上均匀分布的压缩力，以及ii）在板之间保持恒定的间隔。 电池被布置成在板上保持至少8psi的压缩力，已经发现它们显着降低了过早的容量损失（PCL）的发生率。 作为示例，在8-14psi范围内的压缩力对于常规的隔板材料起到很好的作用。 在一个实施例中，壳体包括多个加强支撑销，其通过板和隔板材料在上壳体构件和下壳体构件之间延伸，用于保持均匀分布的压力。 板可以彼此之间松弛以提供多个单元。 还描述了制造电池的方法。
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