公开(公告)号：US12253535B2

公开(公告)日：2025-03-18

申请号：US17328214

申请日：2021-05-24

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Claudio Cherubini ,  Andreas Drechsler ,  Reto Huesser ,  Ivan Heinzer

IPC: G01N35/04 ,  B01L9/02 ,  G05D3/20 ,  G06T1/00 ,  G06T7/30 ,  G06T7/70 ,  G16H10/40

Abstract: A module for an automated laboratory system is disclosed. The module comprises a module connector configured to releasably connect to a component of the automated laboratory system, a detector at least configured to detect at least one component marker located at the component so as to obtain position data of the module indicating an actual position of the module, a processor configured to calculate a position deviation of the module from a target position defined by the component based on the position data and to calculate position alignment data based on the position deviation, and a alignment device configured to align the module to the target position based on the position alignment data. Further, an automated laboratory system and a method for aligning a module are disclosed.

公开(公告)号：US11226348B2

公开(公告)日：2022-01-18

申请号：US15843867

申请日：2017-12-15

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Urs Vollenweider ,  Gottlieb Schacher ,  Goran Savatic ,  Marco Maetzler ,  Christoph Ludwig ,  Christian Loewenstein ,  Yves Laloux ,  Rik Harbers ,  Matthias Edelmann ,  Andreas Drechsler

IPC: G01N35/04

Abstract: A storage module for a laboratory automation system, a method of operating a laboratory automation system, and a laboratory automation system are presented. Items used by laboratory stations are stored centrally in a storage module and can be transported to the laboratory stations using a laboratory sample distribution system.

公开(公告)号：US20190242921A1

公开(公告)日：2019-08-08

申请号：US16388797

申请日：2019-04-18

Applicant: Ventana Medical Systems, Inc. ,  Roche Diagnostics Operations, Inc.

Inventor： Andreas Drechsler ,  Oliver Gutmann ,  Melis Hazar ,  Reto Huesser ,  Raymond T. Kozikowski, III ,  Daniel Mueller ,  Chris Steinert

IPC: G01N35/10 ,  G01N1/31

CPC classification number: G01N35/1016 ,  G01N1/312 ,  G01N35/1002 ,  G01N35/1009 ,  G01N35/1011 ,  G01N2001/317 ,  G01N2035/1041

Abstract: A system and method for treatment of biological samples is disclosed. In some embodiments, an automated biological sample staining system (100), comprising at least one microfluidic reagent applicator (118); at least one bulk fluid applicator (116); at least one fluid aspirator; at least one sample substrate holder; at least one relative motion system; and a control system (102) that is programmed to execute at least one staining protocol on a sample mounted on a substrate that is held in the at least one sample substrate holder.

公开(公告)号：US20230258680A1

公开(公告)日：2023-08-17

申请号：US18137254

申请日：2023-04-20

Applicant: Ventana Medical Systems, Inc. ,  Roche Diagnostics Operations, Inc.

Inventor： Andreas Drechsler ,  Oliver Gutmann ,  Melis Hazar ,  Reto Huesser ,  Raymond T. Kozikowski, III ,  Daniel Mueller ,  Chris Steinert

IPC: G01N35/10 ,  G01N1/31

CPC classification number: G01N35/1016 ,  G01N1/312 ,  G01N35/1002 ,  G01N35/1011 ,  G01N35/1009 ,  G01N2001/317 ,  G01N2035/1041

Abstract: A system and method for treatment of biological samples is disclosed. In some embodiments, an automated biological sample staining system (100), comprising at least one microfluidic reagent applicator (118); at least one bulk fluid applicator (116); at least one fluid aspirator; at least one sample substrate holder; at least one relative motion system; and a control system (102) that is programmed to execute at least one staining protocol on a sample mounted on a substrate that is held in the at least one sample substrate holder.

公开(公告)号：US11668726B2

公开(公告)日：2023-06-06

申请号：US16388797

申请日：2019-04-18

Applicant: Ventana Medical Systems, Inc. ,  Roche Diagnostics Operations, Inc.

Inventor： Andreas Drechsler ,  Oliver Gutmann ,  Melis Hazar ,  Reto Huesser ,  Raymond T. Kozikowski, III ,  Daniel Mueller ,  Chris Steinert

IPC: G01N35/10 ,  G01N1/31

CPC classification number: G01N35/1016 ,  G01N1/312 ,  G01N35/1002 ,  G01N35/1009 ,  G01N35/1011 ,  G01N2001/317 ,  G01N2035/1041

Abstract: A system and method for treatment of biological samples is disclosed. In some embodiments, an automated biological sample staining system (100), comprising at least one microfluidic reagent applicator (118); at least one bulk fluid applicator (116); at least one fluid aspirator; at least one sample substrate holder; at least one relative motion system; and a control system (102) that is programmed to execute at least one staining protocol on a sample mounted on a substrate that is held in the at least one sample substrate holder.

公开(公告)号：US20210154684A1

公开(公告)日：2021-05-27

申请号：US16953868

申请日：2020-11-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Claudio Cherubini ,  Andreas Drechsler

IPC: B04B7/12 ,  B04B5/04

Abstract: A bucket insert for use in a centrifuge is disclosed. The bucket insert comprises an insert body, the insert body comprising a plurality of elongated receptacles for receiving elongated sample vessels. The bucket insert is configured for orienting the elongated sample vessels in a tilted orientation. In the tilted orientation, at least some of the elongated sample vessels are oriented in a non-parallel fashion.

公开(公告)号：US12017216B2

公开(公告)日：2024-06-25

申请号：US17141786

申请日：2021-01-05

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Andreas Drechsler ,  Darko Klinec ,  Michael Koehler ,  Alexander Jakob ,  Michael Zeder

IPC: B01L3/00 ,  G01F23/284 ,  G01F23/292 ,  G01F23/80 ,  G01N23/20 ,  G01N23/20091 ,  G01N35/00 ,  G01N21/3577 ,  G01N21/3581

CPC classification number: B01L3/502715 ,  G01F23/284 ,  G01F23/292 ,  G01F23/804 ,  G01N23/20091 ,  G01N35/00732 ,  B01L2300/1861 ,  G01N21/3577 ,  G01N21/3581

Abstract: A method to process a laboratory carrier in a laboratory system based on a feature of a test liquid in the laboratory carrier is presented. The laboratory system comprises the laboratory carrier comprising the test liquid, a terahertz wave source, a terahertz detector, a laboratory carrier processing device, and a control unit. Using terahertz technology and data analysis, the feature of the test liquid in the laboratory carrier can be determined. In addition, the control unit controls the laboratory carrier processing device based on the determined feature of the test liquid.

公开(公告)号：US11204361B2

公开(公告)日：2021-12-21

申请号：US15875215

申请日：2018-01-19

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Armin Birrer ,  Andreas Drechsler ,  Rik Harbers

IPC: G01N35/10 ,  G01N21/51 ,  G06T7/60 ,  G01N35/04 ,  G06T7/00 ,  G01N35/00 ,  B65G54/02

Abstract: A laboratory automation system for processing sample containers containing laboratory samples and/or for processing the samples is presented. The laboratory automation system comprises a digital camera configured to take an image of the sample container together with a calibration element. The image comprises image data related to the sample container and image data related to the calibration element. The laboratory automation system also comprises an image processing device configured to determine geometrical properties of the sample container depending on the image data related to the sample container and the image data related to the calibration element.

公开(公告)号：US20180224476A1

公开(公告)日：2018-08-09

申请号：US15875215

申请日：2018-01-19

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Armin Birrer ,  Andreas Drechsler ,  Rik Harbers

IPC: G01N35/10 ,  G01N21/51 ,  G06T7/60

CPC classification number: G01N35/10 ,  B65G54/02 ,  G01N21/51 ,  G01N35/00732 ,  G01N35/04 ,  G01N2035/00801 ,  G01N2035/00821 ,  G01N2035/0401 ,  G01N2035/0406 ,  G01N2035/0493 ,  G06T7/0012 ,  G06T7/60

Abstract: A laboratory automation system for processing sample containers containing laboratory samples and/or for processing the samples is presented. The laboratory automation system comprises a digital camera configured to take an image of the sample container together with a calibration element. The image comprises image data related to the sample container and image data related to the calibration element. The laboratory automation system also comprises an image processing device configured to determine geometrical properties of the sample container depending on the image data related to the sample container and the image data related to the calibration element.

公开(公告)号：US20170101272A1

公开(公告)日：2017-04-13

申请号：US15276148

申请日：2016-09-26

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Claudio Cherubini ,  Andreas Drechsler ,  Reto Huesser ,  Nenad Milicevic ,  Gottlieb Schacher

IPC: B65G33/04 ,  B65G33/06

CPC classification number: B65G33/04 ,  B65G33/06 ,  B65G2201/0261 ,  G01N35/04 ,  G01N2035/0406 ,  G01N2035/0465 ,  G01N2035/0487

Abstract: A conveyor device for conveying test tube holders in a laboratory distribution system is presented. The conveyor device is a screw conveyor device comprising a helical track having a helix axis and a drive shaft having an axis of rotation parallel or coaxial to the helix axis, which drive shaft is adapted to be driven to rotate about the axis of rotation for causing a movement of one test tube holder or a plurality of test tube holders contacting the helical track between an entry region and an exit region. The entry region and the exit region are spaced in a direction of the helix axis. A laboratory distribution system for conveying test tube holders and a laboratory automation system comprising a laboratory distribution system are also presented.