公开(公告)号：US11911768B2

公开(公告)日：2024-02-27

申请号：US16380195

申请日：2019-04-10

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Reiner Stein ,  Martin Mertens ,  Werner Heidt

IPC: B01L7/04 ,  B01L9/00 ,  G01N21/84 ,  G01N27/327 ,  G01N33/487 ,  G01N33/49 ,  H05K1/02 ,  H05K1/14 ,  H05K3/36

CPC classification number: B01L7/04 ,  B01L9/52 ,  G01N21/84 ,  G01N27/3271 ,  G01N33/48707 ,  G01N33/4905 ,  H05K1/0212 ,  H05K1/144 ,  H05K3/368 ,  B01L2300/0609 ,  B01L2300/0663 ,  B01L2300/08 ,  B01L2300/1805 ,  B01L2300/1883 ,  H05K2201/041 ,  H05K2201/062 ,  H05K2201/09063 ,  H05K2201/10151 ,  H05K2203/1115

Abstract: A test element support comprises a heating element for heating a test element for analytical examination of a sample. The heating element comprises a substrate, which is made of at least one substrate material. The substrate comprises at least one active area configured for being heated and at least one non-active area outside the active area. The active and the non-active areas are separated by at least one thermal insulation element. The thermal insulation element has a lower thermal conductivity than the substrate material. The thermal insulation element is fully or partially embedded into the substrate. The test element support further comprises at least one heater. The heater comprises at least one heater substrate and the heater substrate is attached to the substrate, wherein the heater substrate is attached to a back face of the substrate. The back face opposes a front face of the substrate contacting the test element.

公开(公告)号：US11774395B2

公开(公告)日：2023-10-03

申请号：US17106620

申请日：2020-11-30

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Klaus Andreas Bauer-Espindola ,  Michael Marquant ,  Christine Nortmeyer ,  Reiner Stein

IPC: G01N27/327 ,  C12Q1/00

CPC classification number: G01N27/3272 ,  C12Q1/006 ,  G01N27/3274

Abstract: A test element for electrochemically detecting at least one analyte in a bodily fluid is disclosed. The test element comprises at least one first electrode and at least one second electrode. The first electrode is designed as a working electrode and the second electrode is designed as a counter electrode. The test element comprises at least one capillary capable of receiving a sample of the body fluid. The first electrode and the second electrode are arranged on opposing sides of the capillary. The first electrode and the second electrode are arranged such that during a capillary filling the first electrode and the second electrode are wetted simultaneously and at an equal rate.

公开(公告)号：US20200315508A1

公开(公告)日：2020-10-08

申请号：US16908963

申请日：2020-06-23

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Klaus Thome ,  Reiner Stein ,  Lars Fischheiter ,  Jerome Greenhalgh

IPC: A61B5/145 ,  G01N33/487 ,  G01N35/00

Abstract: A medical instrument and method thereof for performing a measurement on a biological sample using a test strip are disclosed. The medical instrument may comprise: an analytical unit for analyzing the test strip, wherein the analytical unit comprises a test strip mount which receives the test strip to perform the measurement; a test strip port which receives the test strip, wherein the test strip port is aligned with the test strip mount along an insertion direction; and a shutter movable between open and closed positions, the shutter comprises a test strip opening, wherein the test strip opening is aligned with the test strip port and the test strip mount when the shutter is in the open position, wherein the shutter comprises a shutter mechanism that rotates the shutter parallel to the insertion direction about a rotational axis to move the shutter between the open position and the closed position.

公开(公告)号：US20210080420A1

公开(公告)日：2021-03-18

申请号：US17106620

申请日：2020-11-30

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Klaus Andreas Bauer-Espindola ,  Michael Marquant ,  Christine Nortmeyer ,  Reiner Stein

IPC: G01N27/327 ,  C12Q1/00

Abstract: A test element for electrochemically detecting at least one analyte in a bodily fluid is disclosed. The test element comprises at least one first electrode and at least one second electrode. The first electrode is designed as a working electrode and the second electrode is designed as a counter electrode. The test element comprises at least one capillary capable of receiving a sample of the body fluid. The first electrode and the second electrode are arranged on opposing sides of the capillary. The first electrode and the second electrode are arranged such that during a capillary filling the first electrode and the second electrode are wetted simultaneously and at an equal rate.

公开(公告)号：US20190234884A1

公开(公告)日：2019-08-01

申请号：US16380140

申请日：2019-04-10

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Lars Fischheiter ,  Reiner Stein ,  Martin Goebel

IPC: G01N21/78 ,  G01N33/487

CPC classification number: G01N21/78 ,  G01N21/77 ,  G01N21/8483 ,  G01N33/487 ,  G01N2021/7723 ,  G01N2021/7759 ,  G01N2021/7766 ,  G01N2035/00128

Abstract: A test element analysis system for analytical examination of a sample. The system comprises a measurement device, which comprises a test element receptacle for receiving at least one test element at least partially, wherein the receptacle comprises at least one first and at least one second part, wherein the first part comprises at least one support surface for placement of the test element, wherein the second part comprises at least one optical detector for detecting at least one detection reaction of at least one test chemical contained in the test element, wherein the second part is movable relative to the first part, wherein the receptacle is configured to position the second part such that a test element may be inserted into the receptacle and to subsequently position the second part in a closed position such that at least one abutment surface of the second part rests on the test element.

公开(公告)号：US20190079045A1

公开(公告)日：2019-03-14

申请号：US16185210

申请日：2018-11-09

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Uwe Goebbert ,  Eloisa Lopez-Calle ,  Michael Marquant ,  Christine Nortmeyer ,  Katja Reiter ,  Reiner Stein

IPC: G01N27/327 ,  G01N21/78 ,  B01L3/00

Abstract: A test system for analyzing a sample of a bodily fluid is provided and comprises: at least one test strip comprising at least one capillary channel comprising an inlet opening configured to receive the sample; a vent opening configured to provide an air vent to the capillary channel; and at least one zone consisting of a detection zone and a reagent zone; at least one measuring device configured for interacting with the test strip, the measuring device comprising at least one sealing element for hermetically sealing the vent opening from an ambient atmosphere; and at least one suction device adapted to provide an underpressure to the vent opening; wherein the measuring device further comprises at least one valve or is connectable to the valve, wherein the valve is configured to vent the vent opening of the test strip when the measuring device interacts with the test strip.

公开(公告)号：US11099149B2

公开(公告)日：2021-08-24

申请号：US15604017

申请日：2017-05-24

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Klaus Andreas Bauer-Espindola ,  Michael Marquant ,  Christine Nortmeyer ,  Reiner Stein

IPC: G01N27/327 ,  C12Q1/00

Abstract: A test element for electrochemically detecting at least one analyte in a bodily fluid is disclosed. The test element comprises at least one first electrode and at least one second electrode. The first electrode is designed as a working electrode and the second electrode is designed as a counter electrode. The test element comprises at least one capillary capable of receiving a sample of the body fluid. The first electrode and the second electrode are arranged on opposing sides of the capillary. The first electrode and the second electrode are arranged such that during a capillary filling the first electrode and the second electrode are wetted simultaneously and at an equal rate.

公开(公告)号：US20190232292A1

公开(公告)日：2019-08-01

申请号：US16380195

申请日：2019-04-10

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Reiner Stein ,  Martin Mertens ,  Werner Heidt

IPC: B01L7/04 ,  H05K1/02 ,  H05K3/36 ,  H05K1/14 ,  B01L9/00 ,  G01N33/49

CPC classification number: B01L7/04 ,  B01L9/52 ,  B01L2300/0609 ,  B01L2300/0663 ,  B01L2300/08 ,  B01L2300/1805 ,  B01L2300/1883 ,  G01N21/84 ,  G01N27/3271 ,  G01N33/48707 ,  G01N33/4905 ,  H05K1/0212 ,  H05K1/144 ,  H05K3/368 ,  H05K2201/041 ,  H05K2201/062 ,  H05K2201/09063 ,  H05K2201/10151 ,  H05K2203/1115

Abstract: A test element support comprises a heating element for heating a test element for analytical examination of a sample. The heating element comprises a substrate, which is made of at least one substrate material. The substrate comprises at least one active area configured for being heated and at least one non-active area outside the active area. The active and the non-active areas are separated by at least one thermal insulation element. The thermal insulation element has a lower thermal conductivity than the substrate material. The thermal insulation element is fully or partially embedded into the substrate. The test element support further comprises at least one heater. The heater comprises at least one heater substrate and the heater substrate is attached to the substrate, wherein the heater substrate is attached to a back face of the substrate. The back face opposes a front face of the substrate contacting the test element.

公开(公告)号：US20180120289A1

公开(公告)日：2018-05-03

申请号：US15844794

申请日：2017-12-18

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Klaus Thome ,  Reiner Stein ,  Lars Fischheiter

IPC: G01N33/487 ,  A61B5/145

Abstract: A medical instrument/analyzer for measuring a biological sample using a test strip. The instrument comprises: a housing with an exterior surface, an internal surface, and an interior volume; an analytical unit within the interior volume with a test strip mount; a test strip port between the exterior and the interior surfaces; a shutter configured for sealing the test strip port when closed, wherein the shutter comprises a test strip support aligned with the test strip port and mount when the shutter is in the open position, wherein the shutter has a first sealing surface, the test strip port has a second sealing surface, and the first sealing and second sealing surfaces are configured to mate in the closed position, wherein the shutter comprises a mechanism for moving between the open and the closed position; and an actuator configured for moving the shutter between the open and closed position.

公开(公告)号：US10743799B2

公开(公告)日：2020-08-18

申请号：US15746991

申请日：2016-07-29

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Klaus Thome ,  Reiner Stein ,  Lars Fischheiter ,  Jerome Greenhalgh

IPC: A61B5/145 ,  G01N33/487 ,  G01N35/00

Abstract: A medical instrument (300, 700, 1300, 1400, 1500, 1600) for performing a measurement (1513) on a biological sample using a test strip (310), wherein the medical instrument comprises: a housing (302) and an analytical unit (1508) for analyzing the test strip, wherein the analytical unit is within an interior volume (308). The analytical unit comprises a test strip mount (1510) configured for receiving the test strip to perform the measurement. The instrument further comprises a test strip port (312) between an exterior surface (304) and an interior surface (306). The test strip port is aligned with the test strip mount along an insertion direction (328). The medical instrument further comprises a shutter (100) for sealing the test port. The shutter is configured for being in a open position and a closed position. The shutter is within the interior volume. The shutter is configured for sealing the test port when in the closed position. The shutter comprises a test strip opening (106). The test strip opening is aligned with the test strip port and the test strip mount when the shutter is in the open position. The shutter has a first sealing surface (118). The test strip port has a second sealing surface (120). The first sealing surface and the second sealing surface are configured to mate in the closed position. The shutter comprises a mechanism for moving the shutter between the open position and the closed position. Moving the shutter between the closed position and the open position comprises a rotation of the shutter parallel to the insertion direction. The medical instrument further comprises an actuator (2506) for actuating the mechanism to move the shutter between the open position and the closed position.