公开(公告)号：US12123887B2

公开(公告)日：2024-10-22

申请号：US16613296

申请日：2018-07-17

Applicant: HORIBA Advanced Techno, Co., Ltd.

Inventor： Hideki Nakayama ,  Kazuya Nakagawa ,  Hiroshi Iida ,  Yoko Nakai

IPC: G01N35/04 ,  B01L3/00 ,  B01L9/06 ,  G01N21/64 ,  G01N35/10

CPC classification number: G01N35/04 ,  B01L3/5082 ,  B01L9/06 ,  G01N21/6428 ,  G01N35/1002 ,  B01L2200/04 ,  B01L2200/0605 ,  B01L2300/0609 ,  B01L2300/08 ,  G01N2035/103

Abstract: The present invention is one for achieving an improvement in analysis accuracy, and a sample analyzing device that measures light emitted by introducing a reagent to a sample contained in a container to analyze the sample, and the sample analyzing device includes: a holder that holds the container; a casing that has a door for taking in/out the holder; a nozzle to/from which a pipette tip for injecting the reagent into the container can be attached/detached; a photodetector that measures the light emitted from the sample in the container supported by the holder; and a disposal box into which the pipette tip after injection is disposed of, in which the disposal box is configured to be arranged in the casing and to be taken in/out via the door.

公开(公告)号：US20240316552A1

公开(公告)日：2024-09-26

申请号：US18575009

申请日：2021-06-30

Applicant: QuantuMDx Group Limited

Inventor： Eduardo BOADA ORTIZ ,  Lothar SCHMID ,  Heather MURTON

IPC: B01L3/00

CPC classification number: B01L3/502761 ,  B01L2200/0652 ,  B01L2300/0645 ,  B01L2300/08 ,  B01L2400/0424 ,  B01L2400/084

Abstract: Disclosed herein is a microfluidic device for concentrating target particles in a fluid sample using dielectrophoresis (DEP). The microfluidic device comprises an inlet chamber comprising a fluid inlet for receiving a fluid sample, an outlet chamber comprising a fluid outlet for discharging the fluid sample, and a plurality of DEP channels. Each DEP channel is fluidically connected to the inlet chamber and to the outlet chamber such a fluid path from the fluid inlet to the fluid outlet is provided through each of the DEP channels, wherein the microfluidic device is configured such that each of the fluid paths has substantially the same fluid resistance.

公开(公告)号：US12017222B2

公开(公告)日：2024-06-25

申请号：US17465732

申请日：2021-09-02

Applicant: STMICROELECTRONICS S.R.L.

Inventor： Marco Cereda ,  Lillo Raia ,  Danilo Pirola

IPC: B01L3/00 ,  A61B5/15 ,  A61B5/154 ,  B01F33/30 ,  B01F33/40 ,  B01F33/452 ,  B01L9/00 ,  C12M3/06 ,  C12Q1/6806 ,  C12Q1/6844

CPC classification number: B01L3/502753 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150351 ,  A61B5/154 ,  B01F33/30 ,  B01F33/406 ,  B01F33/452 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/5029 ,  B01L3/508 ,  B01L3/5082 ,  B01L3/52 ,  B01L3/527 ,  B01L9/527 ,  C12M23/16 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150732 ,  B01L3/5023 ,  B01L3/502707 ,  B01L3/50825 ,  B01L3/523 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/0621 ,  B01L2200/0642 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/141 ,  B01L2200/16 ,  B01L2300/022 ,  B01L2300/023 ,  B01L2300/044 ,  B01L2300/0609 ,  B01L2300/0681 ,  B01L2300/08 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/0848 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/12 ,  B01L2300/16 ,  B01L2300/1827 ,  B01L2400/04 ,  B01L2400/0406 ,  B01L2400/043 ,  B01L2400/0487 ,  B01L2400/049 ,  B01L2400/0677 ,  C12Q1/6806 ,  C12Q1/6844 ,  C12Q1/6806 ,  C12Q2565/629 ,  C12Q1/6844 ,  C12Q2565/629

Abstract: An analysis unit formed by an analysis body housing an analysis chamber and having a sample inlet and a supply channel configured to fluidically connect the sample inlet to the analysis chamber. Dried assay reagents are arranged in the analysis chamber and are contained in an alveolar mass. For instance, the alveolar mass is a lyophilized mass formed by excipients and by assay-specific reagents.

公开(公告)号：US11964268B2

公开(公告)日：2024-04-23

申请号：US17576364

申请日：2022-01-14

Applicant: Zhejiang Orient Gene Biotech Co., Ltd

Inventor： Siyu Lei ,  Lili Shen ,  Jianqiu Fang

IPC: B01L1/00 ,  B01L3/00 ,  G01N1/10

CPC classification number: B01L1/52 ,  B01L3/5023 ,  B01L3/523 ,  B01L3/565 ,  G01N1/10 ,  B01L2300/08 ,  B01L2300/0809 ,  B01L2300/123

Abstract: The present invention provides a detecting apparatus, including a storage chamber containing a treating fluid; wherein, the detecting apparatus is internally provided with a sharp-pointed portion; the storage chamber may make a movement relative to the sharp-pointed portion; the storage chamber will be pierced by the sharp-pointed portion during the moving process, such that the treating fluid in the storage chamber is released. The detecting apparatus further includes a collecting chamber; the released treating fluid may flow into the collecting chamber; the collecting chamber is disposed inside a first shell and used to contain a sample; an opening is disposed at an upper position of the first shell; the collecting chamber is internally provided with a testing element for detecting an analyte; the testing element is disposed on a carrier, and the carrier has a specific matching form with the collecting chamber. A buffer solution is disposed in an independent chamber of the detecting apparatus, and may be obtained at any time in need of detection and thus, is easy to be used. The carrier has a specific matching form with the collecting chamber in the first shell, such that the carrier has a definite and unique directional position after being inserted into the collecting chamber.

公开(公告)号：US11904315B2

公开(公告)日：2024-02-20

申请号：US17158130

申请日：2021-01-26

Applicant: WAINAMICS, INC.

Inventor： Arturo M. Escajeda ,  Huyen Tran ,  Ming X. Tan

IPC: C12Q1/6844 ,  B01L3/00

CPC classification number: B01L3/502715 ,  C12Q1/6844 ,  B01L2200/04 ,  B01L2200/0605 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/16 ,  B01L2300/08

Abstract: The invention is directed to devices and methods for performing rapid low-cost bioassays in self-contained disposable cartridges that provide efficient mixing of sample and reactants under a layer of liquid wax. Some embodiments additionally use gravity assisted distribution of sample and assay reagents in conjunction with an appliance containing all necessary valves, pneumatic sources, heat sources and detection stations.

公开(公告)号：US11850594B2

公开(公告)日：2023-12-26

申请号：US16977099

申请日：2019-07-12

Applicant: ZHEJIANG UNIVERSITY

Inventor： Yancheng Wang ,  Chengyao Xu ,  Deqing Mei ,  Chenyang Han

IPC: B01L3/00 ,  B06B1/02 ,  B06B1/06 ,  H10N30/87 ,  H10N30/80 ,  H10N30/853

CPC classification number: B01L3/502761 ,  B01L3/50273 ,  B01L3/502707 ,  B01L3/502715 ,  B06B1/0284 ,  B06B1/0644 ,  H10N30/802 ,  H10N30/8542 ,  H10N30/87 ,  B01L2200/0652 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/08 ,  B01L2300/123 ,  B01L2400/0436 ,  B06B2201/55 ,  B06B2201/77

Abstract: The invention discloses microparticle multi-channel time-sharing separation device and method based on an arcuate interdigital transducer. An arcuate interdigitated electrode is connected to an output channel of a signal generator. The arcuate interdigitated electrode and a polydimethylsiloxane (PDMS) microfluidic channel are placed on a lithium niobate chip. The arcuate interdigitated electrode is mainly formed by an interdigitated electrode being asymmetrically bent from a straight line into an arcuate curve. Two electrode ends of the arcuate interdigitated electrodes are asymmetrically arranged with one end big and another end small. The PDMS microfluidic channel includes a main flow channel, two inlet ends, and multiple outlet ends. The main flow channel is an approximately arcuate flow channel arranged around an outer side of the arcuate interdigitated electrode. Particles are patterned in a coverage section of surface acoustic waves to complete separation of microparticles.

公开(公告)号：US11806714B2

公开(公告)日：2023-11-07

申请号：US17075116

申请日：2020-10-20

Applicant: Massachusetts Institute of Technology

Inventor： Armon R. Sharei ,  Viktor A. Adalsteinsson ,  Nahyun Cho ,  Robert S. Langer ,  J. Christopher Love ,  Klavs F. Jensen

IPC: B01L3/00 ,  C12N5/09 ,  C12N5/078 ,  G01N15/14 ,  C12Q1/04 ,  G01N33/574 ,  G01N1/30 ,  G01N15/10 ,  B82Y30/00 ,  C12M3/06 ,  G01N15/00

CPC classification number: B01L3/502761 ,  C12N5/0634 ,  C12N5/0693 ,  C12Q1/04 ,  G01N15/1459 ,  G01N15/1484 ,  G01N33/574 ,  B01L2200/0652 ,  B01L2300/08 ,  B01L2400/0487 ,  B82Y30/00 ,  C12M23/16 ,  G01N1/30 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1081

Abstract: Isolating or identifying a cell based on a physical property of said cell can include providing a cell suspension; passing said suspension through a microfluidic channel that includes a constriction; passing the cell suspension through the constriction; and, contacting said cell suspension solution with a compound. The constriction can be sized to preferentially deform a relatively larger cell compared to a relatively smaller cell.

公开(公告)号：US20230234064A1

公开(公告)日：2023-07-27

申请号：US18157001

申请日：2023-01-19

Applicant: Samsung Electronics Co., Ltd.

Inventor： Vinayak Narasimhan ,  Radwanul Hasan Siddique ,  Wonjong Jung ,  Kak Namkoong ,  Youngzoon Yoon

IPC: B01L3/00 ,  B82Y40/00 ,  G01N21/552

CPC classification number: B01L3/50851 ,  B82Y40/00 ,  G01N21/554 ,  B01L2300/08 ,  B01L2300/1805 ,  B01L2300/1861

Abstract: An assay repository device for photothermal or joule heating includes an assay container having an interior surface and being configured to house an assay solution, and a nanostructure layer conformally integrated onto the assay container and directly contacting the interior surface, the nanostructure layer being plasmonic and thermally conductive, and including a plurality of nanofeatures having non-uniform sizes and/or non-uniform shapes.

公开(公告)号：US20230184637A1

公开(公告)日：2023-06-15

申请号：US17924279

申请日：2021-05-13

Applicant: Andrea RAGGI

Inventor： Andrea RAGGI

IPC: G01N1/28 ,  B01L3/00

CPC classification number: G01N1/286 ,  B01L3/502 ,  G01N2001/2873 ,  B01L2300/049 ,  B01L2300/027 ,  B01L2300/043 ,  B01L2400/02 ,  B01L2300/08 ,  B01L2400/0496

Abstract: An apparatus for processing biological material includes a supporting structure, provided with a seat and with a rotation device supplied with constraining means, and a container for biological material, provided with a shaped body, with a base, shaped to match the seat of the supporting structure, with at least one valve (24a) for extracting the biological material, and with movable cutting means equipped with coupling means for coupling to the constraining means of the rotation device, in such a way as to acquire a relative motion relative to the container.

公开(公告)号：US20230152011A1

公开(公告)日：2023-05-18

申请号：US17989938

申请日：2022-11-18

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Amir SADRI ,  Nenad KIRCANSKI ,  Thanh-Vi TRAN ,  Carl MARLOWE ,  Brian David WILSON

IPC: F25B21/04 ,  B01L7/00 ,  H10N10/10 ,  H10N10/80

CPC classification number: F25B21/04 ,  B01L7/00 ,  B01L7/52 ,  H10N10/10 ,  H10N10/80 ,  B01L2300/1805 ,  B01L2300/08 ,  B01L2300/123

Abstract: A heat pump that includes a thermoelectric device(s) and a heat sink having a raised portion with a top surface for thermally coupling with a planar face of the thermoelectric device(s). The raised portion of the heat sink includes an outer periphery and a raised central region surrounded by a void region to provide more uniform thermal conductivity when clamped within an assembly. The raised central region is shaped in an any shape corresponding to a shape of uneven thermal conductivity due to clamping pressure applied to the heat sink. The void region can be substantially contiguous and entirely circumscribe the central raised region. The device can optionally include discrete supports formed of a less thermally-conductive material within the void region. The supports can be elastomeric, such as O-rings, and disposed within pockets defined within the void region.