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公开(公告)号：US20120134975A1
公开(公告)日：2012-05-31
申请号：US12228869
申请日：2008-08-13
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： A61K35/18 , A61P31/00 , C12N5/10 , A61P31/10 , A61P33/00 , C12N5/078 , A61P35/00 , A61P31/12
CPC分类号： A61K41/0071 , A61K35/18 , A61K47/6803 , A61K47/6898 , A61K2035/124 , B82Y5/00
摘要： Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein pharmaceuticals using modified red blood cells are described. Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the same and methods of diagnosis and treatment involving the modified red blood cells are described.
摘要翻译： 描述了改良的红细胞。 在一个实施方案中，修饰的红细胞包括靶结合剂。 描述了使用修饰的红细胞靶向递送成像剂，药物和肽和蛋白质药物。 描述了制备改性红细胞的方法，含有其的药物和诊断组合物以及涉及修饰的红细胞的诊断和治疗方法。
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公开(公告)号：US20100042072A1
公开(公告)日：2010-02-18
申请号：US12228893
申请日：2008-08-13
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
CPC分类号： A61K35/18 , A61K41/0071 , A61K47/6901 , A61K49/0002 , A61K49/0097 , C12N5/0006 , C12N5/0641 , Y02A50/411 , Y02A50/463 , Y02A50/465 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/479 , Y02A50/481
摘要： Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein pharmaceuticals using modified red blood cells are described. Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the same and methods of diagnosis and treatment involving the modified red blood cells are described.
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公开(公告)号：US20100041133A1
公开(公告)日：2010-02-18
申请号：US12228868
申请日：2008-08-13
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： C12N5/06
CPC分类号： A61K41/0071 , A61K47/6901 , A61K49/0002
摘要： Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein pharmaceuticals using modified red blood cells are described. Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the same and methods of diagnosis and treatment involving the modified red blood cells are described.
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公开(公告)号：US20100041014A1
公开(公告)日：2010-02-18
申请号：US12228880
申请日：2008-08-13
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
CPC分类号： G01N33/555 , A61K31/00
摘要： Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein pharmaceuticals using modified red blood cells are described. Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the same and methods of diagnosis and treatment involving the modified red blood cells are described.
摘要翻译： 描述了改良的红细胞。 在一个实施方案中，修饰的红细胞包括靶结合剂。 描述了使用修饰的红细胞靶向递送成像剂，药物和肽和蛋白质药物。 描述了制备改性红细胞的方法，含有其的药物和诊断组合物以及涉及修饰的红细胞的诊断和治疗方法。
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公开(公告)号：US20100040546A1
公开(公告)日：2010-02-18
申请号：US12228892
申请日：2008-08-13
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
CPC分类号： A61K41/0028 , A61K41/0071 , A61K47/6901 , A61K49/0002 , A61K49/0097 , A61K49/0409 , G01N33/542 , G01N33/586 , G01N2458/30 , Y02A50/52 , Y02A50/58
摘要： Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein pharmaceuticals using modified red blood cells are described. Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the same and methods of diagnosis and treatment involving the modified red blood cells are described.
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公开(公告)号：US08211656B2
公开(公告)日：2012-07-03
申请号：US12228880
申请日：2008-08-13
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, Jr. , Victoria Y. H. Wood
CPC分类号： G01N33/555 , A61K31/00
摘要： Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein pharmaceuticals using modified red blood cells are described. Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the same and methods of diagnosis and treatment involving the modified red blood cells are described.
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公开(公告)号：US20100104848A1
公开(公告)日：2010-04-29
申请号：US12291840
申请日：2008-11-12
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Alois A. Langer , Eric C. Leuthardt , Nathan P. Myhrvold , Thomas J. Nugent, JR. , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, JR. , Richard N. Zare
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Alois A. Langer , Eric C. Leuthardt , Nathan P. Myhrvold , Thomas J. Nugent, JR. , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, JR. , Richard N. Zare
IPC分类号： B32B5/18
CPC分类号： B29C67/202 , B29D11/00 , Y10T428/249953
摘要： Articles having porous or foam-like elements are provided. The design, fabrication and structures of the articles exploit properties of reactive composite materials (RCM) and their reaction products. In particular, fluids generated by reacting RCM are utilized to create or fill voids in the porous or foam-like elements.
摘要翻译： 提供具有多孔或泡沫状元件的制品。 制品的设计，制造和结构利用反应性复合材料（RCM）及其反应产物的性质。 特别地，通过使RCM反应产生的流体用于产生或填充多孔或泡沫状元素中的空隙。
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公开(公告)号：US20100104834A1
公开(公告)日：2010-04-29
申请号：US12378086
申请日：2009-02-09
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Alois A. Langer , Eric C. Leuthardt , Nathan P. Myhrvold , Thomas J. Nugent, JR. , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, JR. , Richard N. Zare
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Jordin T. Kare , Alois A. Langer , Eric C. Leuthardt , Nathan P. Myhrvold , Thomas J. Nugent, JR. , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, JR. , Richard N. Zare
IPC分类号： B32B7/00
CPC分类号： C08J9/40 , Y10T428/24802 , Y10T428/24917
摘要： Articles having porous or foam-like elements are provided. The design, fabrication and structures of the articles exploit properties of reactive composite materials (RCM) and their reaction products. In particular, fluids generated by reacting RCM are utilized to create or fill voids in the porous or foam-like elements.
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公开(公告)号：US08475868B2
公开(公告)日：2013-07-02
申请号：US12291840
申请日：2008-11-12
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Jordin T. Kare , Alois A. Langer , Eric C. Leuthardt , Nathan P. Myhrvold , Thomas J. Nugent, Jr. , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, Jr. , Richard N. Zare
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Jordin T. Kare , Alois A. Langer , Eric C. Leuthardt , Nathan P. Myhrvold , Thomas J. Nugent, Jr. , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, Jr. , Richard N. Zare
IPC分类号： B05D5/06
CPC分类号： B29C67/202 , B29D11/00 , Y10T428/249953
摘要： Articles having porous or foam-like elements are provided. The design, fabrication and structures of the articles exploit properties of reactive composite materials (RCM) and their reaction products. In particular, fluids generated by reacting RCM are utilized to create or fill voids in the porous or foam-like elements.
摘要翻译： 提供具有多孔或泡沫状元件的制品。 制品的设计，制造和结构利用反应性复合材料（RCM）及其反应产物的性质。 特别地，通过使RCM反应产生的流体用于产生或填充多孔或泡沫状元素中的空隙。
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公开(公告)号：US5522396A
公开(公告)日：1996-06-04
申请号：US101199
申请日：1993-07-29
申请人： Alois A. Langer , Khalil J. Maalouf
发明人： Alois A. Langer , Khalil J. Maalouf
IPC分类号： A61B5/00 , A61B5/0402
CPC分类号： A61B5/0006 , A61B5/7232 , Y10S128/903 , Y10S128/904
摘要： The present invention pertains to a system for monitoring the health condition of a patient, such as the condition of the patient's heart. The system comprises a patient station having means for monitoring a predetermined bodily function of the patient and a patient transmitter for transmitting information relating to the bodily function. The system is also comprised of a secondary system remote from the patient at the patient station having means for activating the patient station such that information relating to the monitored bodily function can be transmitted from the patient station to the secondary station. The secondary station is in communication with the patient station. The present invention also pertains to a method of monitoring the health condition of a patient. The method comprises the steps of providing the patient with a device for monitoring a predetermined bodily function of the patient at a patient station. Then there is the step of activating the patient station from the secondary station remote from the patient at the patient station such that information relating to the predetermined bodily function of the patient can be transmitted to the secondary station.
摘要翻译： 本发明涉及用于监测患者的健康状况的系统，例如患者心脏的状况。 该系统包括具有用于监视患者的预定身体功能的装置的患者站和用于发送与身体功能相关的信息的患者发射器。 该系统还包括远离病人站的患者的辅助系统，其具有用于激活患者站的装置，使得可以将与所监视的身体功能相关的信息从患者站发送到次站。 次站与患者站通信。 本发明还涉及一种监测患者健康状况的方法。 该方法包括以下步骤：向患者提供用于在病人站监测患者的预定身体功能的装置。 然后，从患者站的远离患者的次站激活病人站，使与病人的预定身体功能有关的信息能够被发送到次站。
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