公开(公告)号：US20080300643A1

公开(公告)日：2008-12-04

申请号：US12221332

申请日：2008-08-01

Applicant: Rodney Salo ,  Angelo Auricchio

Inventor： Rodney Salo ,  Angelo Auricchio

IPC: A61N1/37

CPC classification number: A61N1/3627 ,  A61N1/056 ,  A61N1/36564 ,  A61N1/368 ,  A61N2001/0585

Abstract: Pacing left and right ventricles of the heart for delivery of heart failure therapy involves measuring right ventricular (RV) pressure and a left ventricular (LV) pressure, and computing a parameter developed from one or both of the RV and LV pressure measurements. The parameter is indicative of a degree of left and right ventricular synchronization. At least one parameter of a heart failure pacing therapy is adjusted based on the parameter to improve synchronization of the right and left ventricles.

Abstract translation: 心脏左心室和右心室起搏用于心力衰竭治疗，用于测量右心室压（RV）压力和左心室压（LV）压力，并计算从RV和LV压力测量中的一个或两个发展的参数。 该参数表示左心室和右心室同步的程度。 基于参数调整心力衰竭起搏治疗的至少一个参数，以改善右心室和左心室的同步。

公开(公告)号：US07409244B2

公开(公告)日：2008-08-05

申请号：US10745031

申请日：2003-12-23

Applicant: Rodney Salo ,  Angelo Auricchio

Inventor： Rodney Salo ,  Angelo Auricchio

IPC: A61N1/365

CPC classification number: A61N1/3627 ,  A61N1/056 ,  A61N1/36564 ,  A61N1/368 ,  A61N2001/0585

Abstract: A method and apparatus for pacing left and right ventricles of the heart involve measuring one or both of a right ventricular (RV) pressure and a left ventricular (LV) pressure, and computing a parameter developed from one or both of the RV and LV pressure measurements. The parameter is indicative of a degree of left and right ventricular synchronization. The parameter is assessed, and an interventricular (V-V) delay is adjusted in response to the parameter assessment. The V-V delay is adjusted to effect a change in the parameter that improves synchronization of the right and left ventricles. The computed parameter is a parameter indicative of hemodyamic state, such as a PP Loop or a pre-ejection period.

Abstract translation: 用于起搏心脏左心室和右心室的方法和装置包括测量右心室（RV）压力和左心室（LV）压力之一或两者，以及计算从RV和LV压力中的一个或两个所产生的参数 测量。 该参数表示左心室和右心室同步的程度。 评估参数，并根据参数评估调整室间（V-V）延迟。 调整V-V延迟以改变参数，改善右心室和左心室的同步。 所计算的参数是指示血液动力学状态的参数，例如PP环或预喷射期。

公开(公告)号：US08571657B2

公开(公告)日：2013-10-29

申请号：US12221332

申请日：2008-08-01

Applicant: Rodney Salo ,  Angelo Auricchio

Inventor： Rodney Salo ,  Angelo Auricchio

IPC: A61N1/37

CPC classification number: A61N1/3627 ,  A61N1/056 ,  A61N1/36564 ,  A61N1/368 ,  A61N2001/0585

Abstract: Pacing left and right ventricles of the heart for delivery of heart failure therapy involves measuring right ventricular (RV) pressure and a left ventricular (LV) pressure, and computing a parameter developed from one or both of the RV and LV pressure measurements. The parameter is indicative of a degree of left and right ventricular synchronization. At least one parameter of a heart failure pacing therapy is adjusted based on the parameter to improve synchronization of the right and left ventricles.

Abstract translation: 心脏左心室和右心室起搏用于心力衰竭治疗，用于测量右心室压（RV）压力和左心室压（LV）压力，并计算从RV和LV压力测量中的一个或两个发展的参数。 该参数表示左心室和右心室同步的程度。 基于参数调整心力衰竭起搏治疗的至少一个参数，以改善右心室和左心室的同步。

公开(公告)号：US06666826B2

公开(公告)日：2003-12-23

申请号：US10038936

申请日：2002-01-04

Applicant: Rodney Salo ,  Angelo Auricchio

Inventor： Rodney Salo ,  Angelo Auricchio

IPC: A61B502

CPC classification number: A61N1/3627 ,  A61N1/056 ,  A61N1/36564 ,  A61N1/368 ,  A61N2001/0585

Abstract: A body implantable system employs a lead system having at least one electrode and at least one pressure transducer at a distal end. The lead system is implanted within a patient's heart in a coronary vein of the left ventricle. The lead system includes an occlusion device at a distal end to occlude flow in the coronary vein. The pressure transducer is attached to a catheter that is disposed within an open lumen of the lead system. The pressure transducer senses a coronary vein pressure, the coronary vein pressure being proportional to the left ventricular pressure. The sensed coronary vein pressure gives indications of hemodynamic state of the left ventricle, and measured coronary vein pressure can be used to change a signal sent to the electrode to adaptively pace the patient's heart. The body implantable system can further utilize a right ventricular pressure measurement in concert with the left ventricular pressure measurement to modify pacing therapy parameters.

Abstract translation: 身体可植入系统采用在远端具有至少一个电极和至少一个压力换能器的引导系统。 引导系统植入患者的心脏左心室冠状静脉。 引导系统包括在远端处的阻塞装置以阻塞冠状静脉中的流动。 压力传感器连接到设置在引导系统的开口腔内的导管。 压力传感器感测冠状静脉压力，冠状静脉压力与左心室压力成比例。 感测到的冠状静脉压力给出了左心室的血液动力学状态的指示，并且可以使用测量的冠状静脉压力来改变发送到电极的信号，以适应性地调节患者的心脏。 身体可植入系统可以进一步利用与左心室压力测量一致的右心室压力测量来修改起搏治疗参数。

公开(公告)号：US07725185B2

公开(公告)日：2010-05-25

申请号：US12070080

申请日：2008-02-15

Applicant: Lili Liu ,  Rodney Salo

Inventor： Lili Liu ,  Rodney Salo

IPC: A61N1/365 ,  A61N1/05

CPC classification number: A61N1/368 ,  A61N1/3627 ,  A61N1/3684

Abstract: An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.

Abstract translation: 用电刺激治疗逆转心室重构的装置和方法。 通过递送一个或多个刺激脉冲以使得相对于其它区域预激励心肌的应激区域以使受压区域在收缩期间减轻预负荷和后负荷来起搏心室。 随着时间的推移，应力心肌的卸载会影响不良心室重构的逆转。

公开(公告)号：US20080097541A1

公开(公告)日：2008-04-24

申请号：US11931718

申请日：2007-10-31

Applicant: Rodney Salo ,  Julio Spinelli ,  Bruce KenKnight

Inventor： Rodney Salo ,  Julio Spinelli ,  Bruce KenKnight

IPC: A61N1/368

CPC classification number: A61N1/368 ,  A61N1/3622 ,  A61N1/3627

Abstract: A cardiac electro-stimulatory device and method for operating same in which stimulation pulses are distributed among a plurality of electrodes fixed at different sites of the myocardium in order to reduce myocardial hypertrophy brought about by repeated pacing at a single site and/or increase myocardial contractility. In order to spatially and temporally distribute the stimulation, the pulses are delivered through a switchable pulse output configuration during a single cardiac cycle, with each configuration comprising one or more electrodes fixed to different sites in the myocardium.

公开(公告)号：US20070100383A1

公开(公告)日：2007-05-03

申请号：US11261202

申请日：2005-10-28

Applicant: Joseph Pastore ,  Rodney Salo ,  Ronald Heil ,  Randy Westlund

Inventor： Joseph Pastore ,  Rodney Salo ,  Ronald Heil ,  Randy Westlund

IPC: A61N1/36

CPC classification number: A61N1/0587 ,  A61N1/059 ,  A61N1/3627

Abstract: A method includes mounting an anchor member to a surface of a heart, the anchor member having a tension member coupled to the anchor member, advancing a lead body along the tension member, the lead body including a plurality of electrodes disposed along the lead body, identifying an MI region of the heart, positioning the plurality of electrodes at or near the MI region, affixing the tension member to the lead body to hold the electrodes in position, and delivering pulses through the plurality of electrodes to the heart.

Abstract translation: 一种方法包括将锚定构件安装到心脏的表面，所述锚定构件具有联接到所述锚定构件的张紧构件，使所述引线体沿着所述张紧构件前进，所述引线主体包括沿着所述引线主体设置的多个电极， 识别心脏的MI区域，将多个电极定位在MI区域处或附近，将张紧构件固定到引线体以将电极保持在适当位置，并且将脉冲通过多个电极传递到心脏。

公开(公告)号：US20060293714A1

公开(公告)日：2006-12-28

申请号：US11168024

申请日：2005-06-28

Applicant: Rodney Salo ,  Joseph Pastore ,  Andrew Kramer ,  Jeffrey Stahmann ,  Jesse Hartley

Inventor： Rodney Salo ,  Joseph Pastore ,  Andrew Kramer ,  Jeffrey Stahmann ,  Jesse Hartley

IPC: A61N1/36

CPC classification number: A61N1/3627 ,  A61M5/14276 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/3756

Abstract: Devices and methods for therapy control based on electromechanical timing involve detecting electrical activation of a patient's heart, and detecting mechanical cardiac activity resulting from the electrical activation. A timing relationship is determined between the electrical activation and the mechanical activity. A therapy is controlled based on the timing relationship. The therapy may improve intraventricular dyssynchrony of the patient's heart, or treat at least one of diastolic and systolic dysfunction and/or dyssynchrony of the patient's heart, for example. Electrical activation may be detected by sensing delivery of an electrical stimulation pulse to the heart or sensing intrinsic depolarization of the patient's heart. Mechanical activity may be detected by sensing heart sounds, a change in one or more of left ventricular impedance, ventricular pressure, right ventricular pressure, left atrial pressure, right atrial pressure, systemic arterial pressure and pulmonary artery pressure.

Abstract translation: 基于机电定时的治疗控制的装置和方法涉及检测患者心脏的电激活，以及检测由电激活引起的机械心脏活动。 在电激活和机械活动之间确定时序关系。 基于时间关系控制治疗。 该治疗可以改善患者心脏的心室内不同步，或治疗患者心脏的舒张期和收缩功能障碍和/或不同步中的至少一种。 可以通过感测向心脏传递电刺激脉冲或感测患者心脏的固有去极化来检测电激活。 可以通过感测心脏声音，左心室阻抗，心室压力，右心室压力，左心房压力，右心房压力，全身动脉压力和肺动脉压力中的一个或多个的变化来检测机械活动。

公开(公告)号：US20060173504A1

公开(公告)日：2006-08-03

申请号：US11046215

申请日：2005-01-28

Applicant: Qingsheng Zhu ,  Joseph Pastore ,  Allan Shuros ,  Rodney Salo

Inventor： Qingsheng Zhu ,  Joseph Pastore ,  Allan Shuros ,  Rodney Salo

IPC: A61N1/362

CPC classification number: A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

Abstract: A method and apparatus are disclosed for treating mitral or tricuspid regurgitation with electrical stimulation. By providing pacing stimulation to a selected region of the left ventricle, such as one in proximity to the mitral valve apparatus in a manner which pre-excites the region during early ventricular systole, a beneficial effect is obtained which can prevent or reduce the extent of mitral regurgitation.

Abstract translation: 公开了一种用于用电刺激治疗二尖瓣或三尖瓣反流的方法和装置。 通过以在早期心室收缩期间预激活该区域的方式向左心室的选定区域（例如二尖瓣装置附近的一个）提供起搏刺激，可获得有益效果，其可以防止或减少 二尖瓣反流。

公开(公告)号：US20060161210A1

公开(公告)日：2006-07-20

申请号：US11037723

申请日：2005-01-18

Applicant: Joseph Pastore ,  Rodney Salo ,  Gerrard Carlson ,  Andrew Kramer ,  Jiang Ding ,  Yinghong Yu

Inventor： Joseph Pastore ,  Rodney Salo ,  Gerrard Carlson ,  Andrew Kramer ,  Jiang Ding ,  Yinghong Yu

IPC: A61N1/362

CPC classification number: A61B5/02405 ,  A61B5/4035 ,  A61N1/36114 ,  A61N1/36592 ,  A61N1/368

Abstract: A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used to adjust a maximum tracking rate in an atrial tracking pacing mode.