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公开(公告)号：US08496931B2
公开(公告)日：2013-07-30
申请号：US12377015
申请日：2007-08-10
申请人： Sarah L. Pogue , Alan J. Korman , Josephine M. Cardarelli , Mohan Srinivasan , Bingliang Chen , Alasdair F. Bell
发明人： Sarah L. Pogue , Alan J. Korman , Josephine M. Cardarelli , Mohan Srinivasan , Bingliang Chen , Alasdair F. Bell
IPC分类号： A61K39/395
CPC分类号： C07K16/24 , A61K2039/505 , C07K2299/00 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to SDF-1 with high affinity. Nucleic acid molecules encoding SDF-1 antibodies, expression vectors, host cells and methods for expressing the SDF-1 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the SDF-1 antibodies are also provided. Methods for detecting SDF-1, as well as methods for treating various B cell malignancies, including breast cancer, multiple myeloma and non-Hodgkin's lymphoma, and autoimmune disorders are disclosed.
摘要翻译： 本公开提供以高亲和力特异性结合SDF-1的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码SDF-1抗体的核酸分子，表达载体，宿主细胞和用于表达SDF-1抗体的方法。 还提供了免疫偶联物，双特异性分子和包含SDF-1抗体的药物组合物。 公开了用于检测SDF-1的方法，以及用于治疗各种B细胞恶性肿瘤（包括乳腺癌，多发性骨髓瘤和非霍奇金淋巴瘤）和自身免疫性疾病的方法。
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公开(公告)号：US20100158902A1
公开(公告)日：2010-06-24
申请号：US12377015
申请日：2007-08-10
申请人： Sarah L. Pogue , Alan J. Korman , Josephine M. Cardarelli , Mohan Srinivasan , Bingliang Chen , Alasdir F. Bell
发明人： Sarah L. Pogue , Alan J. Korman , Josephine M. Cardarelli , Mohan Srinivasan , Bingliang Chen , Alasdir F. Bell
IPC分类号： A61K39/395 , C07K16/00 , C07H21/00 , C12N15/74 , C12N5/10 , C12P21/00 , A61P37/06 , A61P35/00
CPC分类号： C07K16/24 , A61K2039/505 , C07K2299/00 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to SDF-1 with high affinity. Nucleic acid molecules encoding SDF-1 antibodies, expression vectors, host cells and methods for expressing the SDF-1 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the SDF-1 antibodies are also provided. Methods for detecting SDF-1, as well as methods for treating various B cell malignancies, including breast cancer, multiple myeloma and non-Hodgkin's lymphoma, and autoimmune disorders are disclosed.
摘要翻译： 本公开提供以高亲和力特异性结合SDF-1的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码SDF-1抗体的核酸分子，表达载体，宿主细胞和用于表达SDF-1抗体的方法。 还提供了免疫偶联物，双特异性分子和包含SDF-1抗体的药物组合物。 公开了用于检测SDF-1的方法，以及用于治疗各种B细胞恶性肿瘤（包括乳腺癌，多发性骨髓瘤和非霍奇金淋巴瘤）和自身免疫性疾病的方法。
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3.发明申请Human Monoclonal Antibodies To Programmed Death 1(PD-1) And Methods For Treating Cancer Using Anti-PD-1 Antibodies Alone or in Combination with Other Immunotherapeutics 有权使用单独或与其他免疫治疗组合的抗PD-1抗体治疗癌症的人单克隆抗体编程死亡1（PD-1）和方法公开(公告)号：US20090217401A1
公开(公告)日：2009-08-27
申请号：US11913217
申请日：2006-05-02
申请人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bing Chen , Josephine M. Cardarelli
发明人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bing Chen , Josephine M. Cardarelli
IPC分类号： A01K67/027 , A61K39/395 , C07H21/00 , C12N15/74 , C12N5/10 , C12N5/16 , C07K16/18 , A61P35/00
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
摘要翻译： 本发明提供以高亲和力特异性结合PD-1的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PD-1的方法，以及使用抗PD-1抗体治疗各种疾病（包括癌症和感染性疾病）的方法。 本发明还提供了使用组合免疫治疗如抗CTLA-4和抗-PD-1抗体的组合来治疗过度增殖性疾病如癌症的方法。 本发明还提供用于改变与用这种抗体单独治疗相关的不良事件的方法。
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4.发明授权Human monoclonal antibodies to programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics 有权程序性死亡1（PD-1）的人单克隆抗体和单独使用抗PD-1抗体或与其他免疫治疗剂组合治疗癌症的方法公开(公告)号：US08008449B2
公开(公告)日：2011-08-30
申请号：US11913217
申请日：2006-05-02
申请人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bingliana Chen , Josephine M. Cardarelli
发明人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bingliana Chen , Josephine M. Cardarelli
IPC分类号： C07K16/28
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
摘要翻译： 本发明提供以高亲和力特异性结合PD-1的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PD-1的方法，以及使用抗PD-1抗体治疗各种疾病（包括癌症和感染性疾病）的方法。 本发明还提供了使用组合免疫治疗如抗CTLA-4和抗-PD-1抗体的组合来治疗过度增殖性疾病如癌症的方法。 本发明还提供用于改变与用这种抗体单独治疗相关的不良事件的方法。
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公开(公告)号：US08779105B2
公开(公告)日：2014-07-15
申请号：US13210137
申请日：2011-08-15
申请人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bing Chen , Josephine M. Cardarelli , Haichun Huang
发明人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bing Chen , Josephine M. Cardarelli , Haichun Huang
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
摘要翻译： 本发明提供以高亲和力特异性结合PD-1的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PD-1的方法，以及使用抗PD-1抗体治疗各种疾病（包括癌症和感染性疾病）的方法。 本发明还提供了使用组合免疫治疗如抗CTLA-4和抗-PD-1抗体的组合来治疗过度增殖性疾病如癌症的方法。 本发明还提供用于改变与用这种抗体单独治疗相关的不良事件的方法。
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6.发明申请Human Monoclonal Antibodies To Programmed Death 1 (PD-1) And Methods For Treating Cancer Using Anti-PD-1 Antibodies Alone Or In Combination With Other Immunotherapeutics 有权人单克隆抗体编程死亡1（PD-1）和使用抗PD-1抗体单独或与其他免疫治疗组合治疗癌症的方法公开(公告)号：US20130133091A1
公开(公告)日：2013-05-23
申请号：US13210137
申请日：2011-08-15
申请人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Sellby , Bing Chen , Josephine M. Cardarelli , Haichun Huang
发明人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Sellby , Bing Chen , Josephine M. Cardarelli , Haichun Huang
IPC分类号： C07K16/18
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
摘要翻译： 本发明提供以高亲和力特异性结合PD-1的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PD-1的方法，以及使用抗PD-1抗体治疗各种疾病（包括癌症和感染性疾病）的方法。 本发明还提供了使用组合免疫治疗如抗CTLA-4和抗-PD-1抗体的组合来治疗过度增殖性疾病如癌症的方法。 本发明还提供用于改变与用这种抗体单独治疗相关的不良事件的方法。
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公开(公告)号：US20080247944A1
公开(公告)日：2008-10-09
申请号：US11794606
申请日：2006-01-12
CPC分类号： C07K16/283 , C07K2317/21 , C07K2317/92 , C07K2319/30
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-2 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-2, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma.
摘要翻译： 本发明提供以高亲和力特异性结合IRTA-2的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了用于检测IRTA-2的方法，以及用于治疗各种B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法。
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公开(公告)号：US20080187547A1
公开(公告)日：2008-08-07
申请号：US11958683
申请日：2007-12-18
IPC分类号： A61K39/395 , C07K16/18 , A61P43/00
CPC分类号： C07K16/3061 , A61K2039/505 , C07K16/283 , C07K2317/21 , C07K2317/565 , C07K2317/92
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-5 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-5, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma.
摘要翻译： 本发明提供以高亲和力特异性结合IRTA-5的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了用于检测IRTA-5的方法，以及用于治疗各种B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法。
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公开(公告)号：US08258266B2
公开(公告)日：2012-09-04
申请号：US12472877
申请日：2009-05-27
申请人： Shrikant Deshpande , Haichun Huang , Mohan Srinivasan , Josephine M. Cardarelli , Changyu Wang , David B. Passmore , Vangipuram Rangan , Thomas E. Lane , Hans S. Keirstead , Michael T. Liu
发明人： Shrikant Deshpande , Haichun Huang , Mohan Srinivasan , Josephine M. Cardarelli , Changyu Wang , David B. Passmore , Vangipuram Rangan , Thomas E. Lane , Hans S. Keirstead , Michael T. Liu
CPC分类号： C07K16/24 , A61K2039/505 , C07K14/522 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
摘要翻译： 本发明提供以高亲和力结合IP-10的分离的单克隆抗体，特别是人抗体，抑制IP-10与其受体的结合，抑制IP-10诱导的钙通量并抑制IP-10诱导的细胞迁移 。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体来抑制IP-10活性的方法，包括治疗各种炎性和自身免疫性疾病的方法。
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公开(公告)号：US20100143369A1
公开(公告)日：2010-06-10
申请号：US12704948
申请日：2010-02-12
IPC分类号： A61K39/395 , A61P37/06
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/76 , C07K2317/92
摘要： The present invention provides isolated human monoclonal antibodies that bind to IFNAR-1 and that are capable of inhibiting the biological activity of Type I interferons. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting Type I interferon-mediated disorders using the antibodies of the invention, including methods for treating autoimmune disorders, transplant rejection or Graft Versus Host Disease using the antibodies of the invention.
摘要翻译： 本发明提供了与IFNAR-1结合并且能够抑制I型干扰素的生物活性的分离的人单克隆抗体。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体抑制I型干扰素介导的病症的方法，包括使用本发明的抗体治疗自身免疫疾病，移植排斥或移植物抗宿主病的方法。
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