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公开(公告)号：US08030354B2
公开(公告)日：2011-10-04
申请号：US12287036
申请日：2008-10-03
申请人： Sean P. Brown , Qiong Cao , Paul John Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , Xian Yun Jiao , Yong-Jae Kim , Todd J. Kohn , SuJen Lai , An-Rong Li , Daniel Lin , Jiwen Liu , Jian Luo , Julio C. Medina , Jeffrey D. Reagan , Vatee Pattaropong , Margrit Schwarz , Wang Shen , Yongli Su , Gayathri Swaminath , Marc Vimolratana , Yingcai Wang , Yumei Xiong , Li Yang , Ming Yu , Jie Zhang , Liusheng Zhu
发明人： Sean P. Brown , Qiong Cao , Paul John Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , Xian Yun Jiao , Yong-Jae Kim , Todd J. Kohn , SuJen Lai , An-Rong Li , Daniel Lin , Jiwen Liu , Jian Luo , Julio C. Medina , Jeffrey D. Reagan , Vatee Pattaropong , Margrit Schwarz , Wang Shen , Yongli Su , Gayathri Swaminath , Marc Vimolratana , Yingcai Wang , Yumei Xiong , Li Yang , Ming Yu , Jie Zhang , Liusheng Zhu
IPC分类号： A61K31/192 , C07C53/134
CPC分类号： C07C323/62 , C07C59/68 , C07C59/72 , C07C217/54 , C07C217/62 , C07C317/22 , C07C323/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D213/64 , C07D309/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US20090137561A1
公开(公告)日：2009-05-28
申请号：US12287036
申请日：2008-10-03
申请人： Sean P. Brown , Qiong Cao , Paul John Dransfield , Xiaohui Du , Jonathan Houze , Xian Yun Jiao , Yong-Jae Kim , Todd J. Kohn , SuJen Lai , An-Rong Li , Daniel Lin , Jian Luo , Julio C. Medina , Jeffrey D. Reagan , Vatee Pattaropong , Margrit Schwarz , Wang Shen , Yongli Su , Gayathri Swaminath , Marc Vimolratana , Xiang Wang , Yumei Xiong , Li Yang , Ming Yu , Jie Zhang , Liusheng Zhu
发明人： Sean P. Brown , Qiong Cao , Paul John Dransfield , Xiaohui Du , Jonathan Houze , Xian Yun Jiao , Yong-Jae Kim , Todd J. Kohn , SuJen Lai , An-Rong Li , Daniel Lin , Jian Luo , Julio C. Medina , Jeffrey D. Reagan , Vatee Pattaropong , Margrit Schwarz , Wang Shen , Yongli Su , Gayathri Swaminath , Marc Vimolratana , Xiang Wang , Yumei Xiong , Li Yang , Ming Yu , Jie Zhang , Liusheng Zhu
IPC分类号： C07C59/48 , A61K31/192 , A61K31/235 , C07C69/76 , C07D309/00 , A61K31/351 , C07D211/20 , A61K31/445 , A61K31/44 , A61K31/55 , C07D223/04 , A61P7/00
CPC分类号： C07C323/62 , C07C59/68 , C07C59/72 , C07C217/54 , C07C217/62 , C07C317/22 , C07C323/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D213/64 , C07D309/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
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公开(公告)号：US20100075974A1
公开(公告)日：2010-03-25
申请号：US12613418
申请日：2009-11-05
申请人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan B. Houze , Xian Yun Jiao , Todd J. Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
发明人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan B. Houze , Xian Yun Jiao , Todd J. Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
IPC分类号： A61K31/498 , C07D261/06 , A61K31/42 , C07D277/22 , A61K31/426 , C07D271/06 , A61K31/4245 , C07D413/02 , A61K31/443 , C07D241/36 , A61P3/10 , A61P9/00
CPC分类号： C07D261/08 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US20080090840A1
公开(公告)日：2008-04-17
申请号：US11900006
申请日：2007-09-06
申请人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan Houze , Xian Yun Jiao , Todd Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Michael Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
发明人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan Houze , Xian Yun Jiao , Todd Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Michael Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
IPC分类号： A61K31/41 , A61K31/42 , A61K31/44 , A61K31/4965 , A61P43/00 , C07D241/36 , C07D261/06 , C07D271/06 , C07D277/30 , C07D413/00
CPC分类号： C07D261/08 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US07572934B2
公开(公告)日：2009-08-11
申请号：US12082645
申请日：2008-04-10
申请人： Sean P. Brown , Paul Dransfield , Zice Fu , Jonathan Houze , Xian Yun Jiao , Todd J. Kohn , Vatee Pattaropong , Marc Vimolratana , Michael J. Schmitt
发明人： Sean P. Brown , Paul Dransfield , Zice Fu , Jonathan Houze , Xian Yun Jiao , Todd J. Kohn , Vatee Pattaropong , Marc Vimolratana , Michael J. Schmitt
IPC分类号： C07C63/33 , C07C335/00 , A01N43/40 , A01N37/10
CPC分类号： C07C59/68 , C07C59/72 , C07D261/08
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US20090111859A1
公开(公告)日：2009-04-30
申请号：US12082645
申请日：2008-04-10
申请人： Sean P. Brown , Paul Dransfield , Zice Fu , Jonathan Houze , Xian Yun Jiao , Todd J. Kohn , Vatee Pattaropong , Marc Vimolratana , Michael J. Schmitt
发明人： Sean P. Brown , Paul Dransfield , Zice Fu , Jonathan Houze , Xian Yun Jiao , Todd J. Kohn , Vatee Pattaropong , Marc Vimolratana , Michael J. Schmitt
IPC分类号： C07C59/68 , C07D261/08 , A61K31/192 , A61K31/42 , C12N5/06 , A61K31/426 , A61K31/155 , A61P35/00 , A61P3/00 , A61P3/10 , A61P9/00
CPC分类号： C07C59/68 , C07C59/72 , C07D261/08
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
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7.发明申请PHENYLANALINE AMIDE DERIVATIVES USEFUL FOR TREATING INSULIN-RELATED DISEASES AND CONDITIONS 有权用于治疗胰岛素相关疾病和病症的苯胺衍生物公开(公告)号：US20120115811A1
公开(公告)日：2012-05-10
申请号：US13148296
申请日：2010-02-12
申请人： Xiaohui Du , Zice Fu , Jonathan B. Houze , Xian Yun Jiao , Yong-Jae Kim , Leping Li , Jinqian Liu , Mike Elias Lizarzaburu , Julio C. Medina , Wang Shen , Simon Turcotte , Ming Yu
发明人： Xiaohui Du , Zice Fu , Jonathan B. Houze , Xian Yun Jiao , Yong-Jae Kim , Leping Li , Jinqian Liu , Mike Elias Lizarzaburu , Julio C. Medina , Wang Shen , Simon Turcotte , Ming Yu
IPC分类号： A61K31/4439 , C07D417/12 , C07D401/14 , C07D401/04 , A61K31/444 , A61K31/506 , A61K31/427 , A61P3/10 , A61P3/04 , A61P3/00 , A61P29/00 , A61P11/06 , A61P17/06 , A61P19/02 , A61P1/00 , A61P35/00 , A61P25/00 , A61K31/702 , C07D417/14
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Provided herein are compounds of formula I: wherein A, B, X, R1, R2 and subscript n are as defined in the following disclosure. Compositions comprising the compounds are also provided, as well as methods for their use, for example, in treatment of type 2 diabetes and type 2 diabetes-related conditions.
摘要翻译： 本文提供了式I的化合物：其中A，B，X，R 1，R 2和下标n如以下公开内容所定义。 还提供了包含该化合物的组合物，以及其用于例如治疗2型糖尿病和2型糖尿病相关病症的方法。
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公开(公告)号：US07071358B2
公开(公告)日：2006-07-04
申请号：US10354922
申请日：2003-01-29
IPC分类号： C07C311/37 , A61K31/18
CPC分类号： C07D207/33 , C07C311/21 , C07C317/32 , C07C2601/08 , C07C2601/16 , C07D207/333 , C07D207/335 , C07D213/30 , C07D213/42 , C07D231/12 , C07D233/61 , C07D233/64 , C07D235/12 , C07D235/14 , C07D239/26 , C07D257/04 , C07D277/24 , C07D277/28 , C07D333/34 , C07F7/081
摘要： Arylsulfonamidobenzyl alcohols, amines and sulfonamides are provided which are useful in treating lipid disorders, metabolic diseases and cell-proliferative diseases.
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公开(公告)号：US07473703B2
公开(公告)日：2009-01-06
申请号：US11501594
申请日：2006-08-08
申请人： Xian Yun Jiao , Frank Kayser , David J. Kopecky , Sharon McKendry , Derek E. Piper , Andrew K. Shiau
发明人： Xian Yun Jiao , Frank Kayser , David J. Kopecky , Sharon McKendry , Derek E. Piper , Andrew K. Shiau
IPC分类号： A61K31/40 , C07D207/325
CPC分类号： C07D207/333 , C07D207/335
摘要： Heterocyclic arylsulfonamidobenzylic compounds are provided which are useful in treating lipid disorders, metabolic disorders and cell-proliferative diseases.
摘要翻译： 提供了可用于治疗脂质疾病，代谢紊乱和细胞增殖性疾病的杂环芳基磺酰氨基苄基化合物。
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![Substituted pyrazolo[3,4-d]pyrimidines as ACK-1 and LCK inhibitors](/abs-image/US/2010/07/27/US07763624B2/abs.jpg.150x150.jpg)
10.发明授权公开(公告)号：US07763624B2
公开(公告)日：2010-07-27
申请号：US11506381
申请日：2006-08-18
申请人： John L. Buchanan , William H. Buckner , Mario G. Cardozo , Erin F. DiMauro , Jiasheng Fu , Xiaolin Hao , Xian Yun Jiao , Frank Kayser , David J. Kopecky , Craig E. Masse , Susan A. Tomlinson , Ryan White , Xiaotian Zhu
发明人： John L. Buchanan , William H. Buckner , Mario G. Cardozo , Erin F. DiMauro , Jiasheng Fu , Xiaolin Hao , Xian Yun Jiao , Frank Kayser , David J. Kopecky , Craig E. Masse , Susan A. Tomlinson , Ryan White , Xiaotian Zhu
IPC分类号： C07D487/04 , A61K31/519 , A61K31/496 , A61P35/00 , C07D231/56 , A61K31/416
CPC分类号： C07D403/06 , C07D231/56 , C07D401/14 , C07D405/06 , C07D487/04
摘要： The present invention relates to compounds of Formula I or a stereomer, a tautomer, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof, pharmaceutical formulations containing the compounds, methods of treatments using the compounds, for example, protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders and methods of preparing medicaments comprising the compounds.
摘要翻译： 本发明涉及式I化合物或立体异构体，互变异构体，溶剂合物，药学上可接受的盐或前药，含有化合物的药物制剂，使用该化合物的治疗方法，例如蛋白质酪氨酸激酶相关 诸如免疫学和肿瘤学障碍的疾病以及制备包含该化合物的药物的方法。
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