专利检索 ap:("Stephanie Kay DODD" OR "Pascal FURET" OR "Robert Martin GROTZFELD" OR "Darryl Brynley JONES" OR "Paul William MANLEY" OR "Andreas MARZINZIK" OR "Xavier Francois Andre PELLE" OR "Bahaa SALEM" OR "Joseph SCHOEPFER") AND inv:"Bahaa SALEM" 第 1 页

1.

发明申请
COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1 有权
标题翻译：抑制ABL1，ABL2和BCR-ABL1活性的化合物和组合物

公开(公告)号：US20130310395A1

公开(公告)日：2013-11-21

申请号：US13892769

申请日：2013-05-13

申请人： Stephanie Kay DODD , Pascal FURET , Robert Martin GROTZFELD , Darryl Brynley JONES , Paul William MANLEY , Andreas MARZINZIK , Xavier Francois Andre PELLE , Bahaa SALEM , Joseph SCHOEPFER

发明人： Stephanie Kay DODD , Pascal FURET , Robert Martin GROTZFELD , Darryl Brynley JONES , Paul William MANLEY , Andreas MARZINZIK , Xavier Francois Andre PELLE , Bahaa SALEM , Joseph SCHOEPFER

IPC分类号： C07D401/10 , A61K31/4439 , C07D405/14 , C07D401/14 , C07D403/10 , A61K45/06 , A61K31/506 , C07F9/58

CPC分类号： C07D213/82 , A61K31/4439 , A61K31/506 , A61K45/06 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/14 , C07F9/58

摘要： The present invention relates to compounds of formula (I): in which Y, Y1, R1, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.

摘要翻译： 本发明涉及式（I）化合物：其中Y，Y 1，R 1，R 2，R 3和R 4在发明概述中定义; 能够抑制BCR-ABL1及其突变体的活性。本发明还提供了制备本发明化合物的方法，包含这些化合物的药物制剂和使用这些化合物治疗癌症的方法。

2.

发明申请
COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1 审中-公开
标题翻译：抑制ABL1，ABL2和BCR-ABL1活性的化合物和组合物

公开(公告)号：US20140343086A1

公开(公告)日：2014-11-20

申请号：US14448363

申请日：2014-07-31

申请人： Stephanie Kay DODD , Pascal FURET , Robert Martin GROTZFELD , Wolfgang JAHNKE , Darryl Brynley JONES , Paul William MANLEY , Andreas MARZINZIK , Xavier Francois Andre PELLE , Bahaa SALEM , Joseph SCHOEPFER

发明人： Stephanie Kay DODD , Pascal FURET , Robert Martin GROTZFELD , Wolfgang JAHNKE , Darryl Brynley JONES , Paul William MANLEY , Andreas MARZINZIK , Xavier Francois Andre PELLE , Bahaa SALEM , Joseph SCHOEPFER

IPC分类号： C07D213/82 , A61K31/506 , C07D401/14 , C07D401/04 , A61K31/4439 , C07D405/14

CPC分类号： C07D213/82 , A61K31/4439 , A61K31/506 , A61K45/06 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/14 , C07F9/58

摘要： The present invention relates to compounds of formula (I): in which Y, Y1, R1, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.

摘要翻译： 本发明涉及式（I）化合物：其中Y，Y 1，R 1，R 2，R 3和R 4在发明概述中定义; 能够抑制BCR-ABL1及其突变体的活性。本发明还提供了制备本发明化合物的方法，包含这些化合物的药物制剂和使用这些化合物治疗癌症的方法。

3.

发明申请
BENZAMIDE DERIVATIVES FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1 审中-公开
标题翻译：用于抑制ABL1，ABL2和BCR-ABL1活性的苯扎明星衍生物

公开(公告)号：US20160200705A1

公开(公告)日：2016-07-14

申请号：US15075620

申请日：2016-03-21

申请人： Pascal FURET , Robert Martin GROTZFELD , Wolfgang JAHNKE , Darryl JONES , Paul William MANLEY , Andreas MARZINZIK , Xavier Francois Andre PELLE , Bahaa SALEM , Joseph SCHOEPFER

发明人： Pascal FURET , Robert Martin GROTZFELD , Wolfgang JAHNKE , Darryl JONES , Paul William MANLEY , Andreas MARZINZIK , Xavier Francois Andre PELLE , Bahaa SALEM , Joseph SCHOEPFER

IPC分类号： C07D401/14 , A61K45/06 , C07D403/10 , A61K31/4155 , A61K31/4439 , C07D487/10

CPC分类号： C07D417/14 , A61K31/4025 , A61K31/4155 , A61K31/427 , A61K31/4439 , A61K31/5377 , A61K45/06 , C07D401/04 , C07D401/14 , C07D403/10 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/10 , C07D487/10

摘要： The present invention relates to compounds of formula (I): in which Y, Y1, R1, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the tyrosine kinase enzymatic activity of the Abelson protein (ABL1), the Abelson-related protein (ABL2) and related chimeric proteins, in particular BCR-ABL1. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.

摘要翻译： 本发明涉及式（I）化合物：其中Y，Y 1，R 1，R 2，R 3和R 4在本发明概述中定义; 能够抑制Abelson蛋白（ABL1），Abelson相关蛋白（ABL2）和相关嵌合蛋白（特别是BCR-ABL1）的酪氨酸激酶酶活性。本发明还提供了制备本发明化合物的方法，包含这些化合物的药物制剂和使用这些化合物治疗癌症的方法。