公开(公告)号：US20160185733A1

公开(公告)日：2016-06-30

申请号：US15060723

申请日：2016-03-04

申请人： Pascal FURET ,  Robert Martin GROTZFELD ,  Wolfgang JAHNKE ,  Darryl JONES ,  Paul William Manley ,  Andreas MARZINZIK ,  Saliha MOUSSAOUI ,  Xavier Francois Andre PELLE ,  Bahaa SALEM ,  Joseph SCHOEPFER

发明人： Pascal FURET ,  Robert Martin GROTZFELD ,  Wolfgang JAHNKE ,  Darryl JONES ,  Paul William Manley ,  Andreas MARZINZIK ,  Saliha MOUSSAOUI ,  Xavier Francois Andre PELLE ,  Bahaa SALEM ,  Joseph SCHOEPFER

IPC分类号： C07D239/26 ,  C07D239/34 ,  C07D401/04 ,  A61K31/506 ,  C07D241/20 ,  A61K31/4965 ,  C07D241/12 ,  C07D333/38 ,  A61K31/381 ,  C07D409/06 ,  A61K31/4025 ,  C07D233/56 ,  A61K31/4164 ,  C07D277/30 ,  A61K31/426 ,  C07D231/12 ,  A61K31/415 ,  C07D405/14 ,  A61K31/4439 ,  C07D403/04 ,  C07D317/60 ,  A61K31/36 ,  C07D333/22 ,  A61K31/5377 ,  A61K45/06 ,  A61K31/505

CPC分类号： C07D239/26 ,  A61K31/36 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/4965 ,  A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D213/81 ,  C07D213/85 ,  C07D231/12 ,  C07D233/38 ,  C07D233/54 ,  C07D233/56 ,  C07D239/30 ,  C07D239/34 ,  C07D241/12 ,  C07D241/20 ,  C07D277/22 ,  C07D277/30 ,  C07D317/60 ,  C07D333/22 ,  C07D333/38 ,  C07D401/04 ,  C07D403/04 ,  C07D405/14 ,  C07D407/14 ,  C07D409/06

摘要： The present invention relates to compounds of formula I: in which Y, Y1, Y4, Y5, Y6, R1, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.

公开(公告)号：US20210071252A1

公开(公告)日：2021-03-11

申请号：US16644812

申请日：2018-09-05

申请人： Hueseyin FIRAT ,  Saliha MOUSSAOUI ,  Eric SCHORDAN ,  AMONETA DIAGNOSTICS

发明人： Hueseyin FIRAT ,  Saliha MOUSSAOUI ,  Eric SCHORDAN

IPC分类号： C12Q1/6883

摘要： The present invention describes a method for the diagnosis of a cognitive disorder including but not limited to Alzheimer disease in a subject at risk of having or developing a cognitive disorder.