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公开(公告)号：US20110059436A1
公开(公告)日：2011-03-10
申请号：US12419660
申请日：2009-04-07
申请人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
CPC分类号： C12Q1/6869 , C12Q2565/101 , C12Q2565/301 , C12Q2537/143
摘要： A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.
摘要翻译： 公开了一种测序方法，其允许单个DNA或RNA分子或其部分直接和基本实时地进行测序。 该方法涉及工程化具有原子和/或分子标签的聚合酶和/或dNTP，其具有由检测系统监测的可检测特性。
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2.发明申请Enzymatic nucleic acid synthesis: methods for inhibiting pyrophosphorolysis during sequencing synthesis 审中-公开酶学核酸合成：测序合成期间抑制焦磷酸分解的方法公开(公告)号：US20070172869A1
公开(公告)日：2007-07-26
申请号：US11648723
申请日：2006-12-29
申请人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
CPC分类号： C12Q1/6869 , C07H19/06 , C07H19/10 , C07H19/20 , C12N9/1241 , C12N9/1252 , C12Q1/6806 , C12Q1/6853 , C12Q2525/101 , C12Q2565/301 , C12Q2533/101 , C12Q2525/113
摘要： Nucleotide triphosphate probes containing a molecular and/or atomic tag on a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents are disclosed.
摘要翻译： 公开了在γ和/或β磷酸基团和/或具有可检测性质的碱基部分上含有分子和/或原子标签的核苷酸三磷酸探针，以及在测序反应和各种测定中使用标记的核苷酸的试剂盒和方法。 此外，公开了磷酸盐和聚磷酸盐分子保真改性剂。
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3.发明申请Compositions for sequence determination using tagged polymerizing agents and tagged monomers 审中-公开使用标记聚合剂和标记单体进行序列测定的组合物公开(公告)号：US20070172868A1
公开(公告)日：2007-07-26
申请号：US11648722
申请日：2006-12-29
申请人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
CPC分类号： C12Q1/6869 , C12Q2565/101 , C12Q2565/301 , C12Q2537/143
摘要： A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.
摘要翻译： 公开了一种测序方法，其允许单个DNA或RNA分子或其部分直接和基本实时地进行测序。 该方法涉及工程化具有原子和/或分子标签的聚合酶和/或dNTP，其具有由检测系统监测的可检测特性。
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公开(公告)号：US20070172863A1
公开(公告)日：2007-07-26
申请号：US11648138
申请日：2006-12-29
申请人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
CPC分类号： C12Q1/6869 , C12Q2565/101 , C12Q2565/301 , C12Q2537/143
摘要： A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.
摘要翻译： 公开了一种测序方法，其允许单个DNA或RNA分子或其部分直接和基本实时地进行测序。 该方法涉及工程化具有原子和/或分子标签的聚合酶和/或dNTP，其具有由检测系统监测的可检测特性。
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5.发明申请Enzymatic nucleic acid synthesis: methods for direct detection of tagged monomers 审中-公开酶促核酸合成：用于直接检测标记单体的方法公开(公告)号：US20070172859A1
公开(公告)日：2007-07-26
申请号：US11648107
申请日：2006-12-29
申请人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
CPC分类号： C12Q1/6869 , C07H19/06 , C07H19/10 , C07H19/20 , C12N9/1241 , C12N9/1252 , C12Q1/6806 , C12Q1/6853 , C12Q2525/101 , C12Q2565/301 , C12Q2533/101 , C12Q2525/113
摘要： Nucleotide triphosphate probes containing a molecular and/or atomic tag on a a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents are disclosed.
摘要翻译： 公开了在γ和/或β磷酸基团和/或具有可检测性质的碱基部分上含有分子和/或原子标签的核苷酸三磷酸探针，以及在测序反应和各种测定中使用标记的核苷酸的试剂盒和方法。 此外，公开了磷酸盐和聚磷酸盐分子保真改性剂。
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6.发明申请公开(公告)号：US20090275036A1
公开(公告)日：2009-11-05
申请号：US12414417
申请日：2009-03-30
申请人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
CPC分类号： C12Q1/6869 , C12Q2565/101 , C12Q2565/301 , C12Q2537/143
摘要： A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.
摘要翻译： 公开了一种测序方法，其允许单个DNA或RNA分子或其部分直接和基本实时地进行测序。 该方法涉及工程化具有原子和/或分子标签的聚合酶和/或dNTP，其具有由检测系统监测的可检测特性。
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公开(公告)号：US20070172861A1
公开(公告)日：2007-07-26
申请号：US11648115
申请日：2006-12-29
申请人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
CPC分类号： C12Q1/6869 , C12Q2565/101 , C12Q2565/301 , C12Q2537/143
摘要： A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.
摘要翻译： 公开了一种测序方法，其允许单个DNA或RNA分子或其部分直接和基本实时地进行测序。 该方法涉及工程化具有原子和/或分子标签的聚合酶和/或dNTP，其具有由检测系统监测的可检测特性。
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公开(公告)号：US20070172860A1
公开(公告)日：2007-07-26
申请号：US11648114
申请日：2006-12-29
申请人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
CPC分类号： C12Q1/6869 , C07H19/06 , C07H19/10 , C07H19/20 , C12N9/1241 , C12N9/1252 , C12Q1/6806 , C12Q1/6853 , C12Q2525/101 , C12Q2565/301 , C12Q2533/101 , C12Q2525/113
摘要： Nucleotide triphosphate probes containing a molecular and/or atomic tag on a a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents are disclosed.
摘要翻译： 公开了在γ和/或β磷酸基团和/或具有可检测性质的碱基部分上含有分子和/或原子标签的核苷酸三磷酸探针，以及在测序反应和各种测定中使用标记的核苷酸的试剂盒和方法。 此外，公开了磷酸盐和聚磷酸盐分子保真改性剂。
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9.发明申请Enzymatic nucleic acid synthesis: compositions including pyrophosphorolysis inhibitors 审中-公开酶促核酸合成：包含焦磷酸分解抑制剂的组合物公开(公告)号：US20070172819A1
公开(公告)日：2007-07-26
申请号：US11648108
申请日：2006-12-29
申请人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
CPC分类号： C12Q1/6869 , C07H19/06 , C07H19/10 , C07H19/20 , C12N9/1241 , C12N9/1252 , C12Q1/6806 , C12Q1/6853 , C12Q2525/101 , C12Q2565/301 , C12Q2533/101 , C12Q2525/113
摘要： Nucleotide triphosphate probes containing a molecular and/or atomic tag on a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents are disclosed.
摘要翻译： 公开了在γ和/或β磷酸基团和/或具有可检测性质的碱基部分上含有分子和/或原子标签的核苷酸三磷酸探针，以及在测序反应和各种测定中使用标记的核苷酸的试剂盒和方法。 此外，公开了磷酸盐和聚磷酸盐分子保真改性剂。
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公开(公告)号：US20070292867A1
公开(公告)日：2007-12-20
申请号：US11648137
申请日：2006-12-29
申请人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q2565/101 , C12Q2565/301 , C12Q2537/143
摘要： A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.
摘要翻译： 公开了一种测序方法，其允许单个DNA或RNA分子或其部分直接和基本实时地进行测序。 该方法涉及工程化具有原子和/或分子标签的聚合酶和/或dNTP，其具有由检测系统监测的可检测特性。
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