公开(公告)号：US20220244228A1

公开(公告)日：2022-08-04

申请号：US17605213

申请日：2020-04-15

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： R. Michael van DAM ,  Jia Wang ,  Alejandra Rios

IPC: G01N30/95 ,  H04N5/372 ,  G01N35/10

Abstract: A method of performing high-throughput radio thin layer chromatography (radio-TLC) includes spotting a plurality of locations on one or more TLC plates with samples containing a radiochemical or a radiopharmaceutical, each location defining an individual lane on the one or more TLC plates for the respective samples. The one or more TLC plates are developed with a developing solution and dried. The TLC plates are imaged with an imaging device comprising a camera, wherein the image obtained from the camera comprises a field of view that contains regions of interest (ROIs) from the plurality of lanes. The ROIs in the images obtained from the camera may then be analyzed by the user. The ROIs may be used, for example, reaction optimization or for quality control check of the production of radiotracers.

公开(公告)号：US20220401960A1

公开(公告)日：2022-12-22

申请号：US17622206

申请日：2020-08-07

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： R. Michael van Dam ,  Jia Wang ,  Alejandra Rios ,  Philip Chao ,  Jason Jones

IPC: B01L7/00 ,  B01L3/00 ,  G01N35/00

Abstract: A radiosynthesis system is disclosed that leverages droplet microfluidic radiosynthesis and its inherent advantages including reduction of reagent consumption and the ability to achieve high molar activity even when using low starting radioactivity. The radiosynthesis system enables the parallel synthesis of radiolabeled compounds using droplet-sized reaction volumes. In some embodiments, a single heater is used to create multiple reaction or synthesis sites. In other embodiments, separate heaters are used to create independently-controlled heating conditions at the multiple reaction or synthesis sites. In one embodiment, a four-heater setup was developed that utilizes a multi-reaction microfluidic chip and was assessed for the suitability with high-throughput radiosynthesis optimization. Replicates of several radiochemical operations including the full synthesis of various PET tracers revealed the platform to have high repeatability (e.g., consistent fluorination efficiency). The system may also be used for synthesis optimization.

公开(公告)号：US12078625B2

公开(公告)日：2024-09-03

申请号：US17605213

申请日：2020-04-15

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： R. Michael van Dam ,  Jia Wang ,  Alejandra Rios

IPC: G01N30/95 ,  G01N35/10 ,  H04N25/71

CPC classification number: G01N30/95 ,  G01N35/10 ,  H04N25/71

Abstract: A method of performing high-throughput radio thin layer chromatography (radio-TLC) includes spotting a plurality of locations on one or more TLC plates with samples containing a radiochemical or a radiopharmaceutical, each location defining an individual lane on the one or more TLC plates for the respective samples. The one or more TLC plates are developed with a developing solution and dried. The TLC plates are imaged with an imaging device comprising a camera, wherein the image obtained from the camera comprises a field of view that contains regions of interest (ROIs) from the plurality of lanes. The ROIs in the images obtained from the camera may then be analyzed by the user. The ROIs may be used, for example, reaction optimization or for quality control check of the production of radiotracers.

公开(公告)号：US20240003858A1

公开(公告)日：2024-01-04

申请号：US18250911

申请日：2021-10-29

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Michael R. Van Dam ,  Travis S. Holloway ,  Alejandra Rios ,  Chelsea Okoro

IPC: G01N30/95 ,  B01J20/28 ,  B01J20/34 ,  B01D15/42

CPC classification number: G01N30/95 ,  B01J20/28035 ,  B01J20/3475 ,  B01D15/426 ,  B01J2220/52 ,  B01J2220/49

Abstract: A method of purifying radiochemical species (e.g., radiopharmaceuticals) using thin layer chromatography (TLC) plates includes loading one or more TLC plates with a sample containing the radiochemical species to be purified. The one or more TLC plates are then developed with a mobile phase. The one or more developed TLC plates are then imaged to obtain radioactivity image(s) of the one or more TLC plates. Optional UV images may also be obtained using the same imaging platform. The location of the radiochemical species on the one or more TLC plates is identified from the radioactivity image(s). The radiochemical species on the one or more TLC plates is/are removed at the identified locations. Removal may be accomplished using a mechanical process such as scraping or punching. Alternatively, non-destructive techniques may be employed to remove the radiochemical species from the TLC plate(s).