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1.发明公开公开(公告)号：US20240121636A1
公开(公告)日：2024-04-11
申请号：US17957915
申请日：2022-09-30
Inventor： Jia Wang , Amit Kumar Sheoran , Xiaofeng Shi , Chen Qian , Matthew Osinski
IPC: H04W24/04 , H04L41/149 , H04L41/16 , H04W24/08
CPC classification number: H04W24/04 , H04L41/149 , H04L41/16 , H04W24/08
Abstract: Aspects of the subject disclosure may include, for example, training a cell-level machine learning model to predict a likelihood of a cell site in a cellular network having service issues that impact customers of the cellular network, training a user equipment (UE) level machine learning model using output information from the cell-level machine learning model and historical information about UE-level performance metrics, receiving, from a customer associated with a UE device operating on the cellular network, information about a service degradation experienced by the customer on the UE device, providing the information about the service degradation to the UE-level machine learning model; and receiving, from the UE-level machine learning model, information identifying a source of the service degradation. Other embodiments are disclosed.
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公开(公告)号：US20220401960A1
公开(公告)日：2022-12-22
申请号：US17622206
申请日：2020-08-07
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： R. Michael van Dam , Jia Wang , Alejandra Rios , Philip Chao , Jason Jones
Abstract: A radiosynthesis system is disclosed that leverages droplet microfluidic radiosynthesis and its inherent advantages including reduction of reagent consumption and the ability to achieve high molar activity even when using low starting radioactivity. The radiosynthesis system enables the parallel synthesis of radiolabeled compounds using droplet-sized reaction volumes. In some embodiments, a single heater is used to create multiple reaction or synthesis sites. In other embodiments, separate heaters are used to create independently-controlled heating conditions at the multiple reaction or synthesis sites. In one embodiment, a four-heater setup was developed that utilizes a multi-reaction microfluidic chip and was assessed for the suitability with high-throughput radiosynthesis optimization. Replicates of several radiochemical operations including the full synthesis of various PET tracers revealed the platform to have high repeatability (e.g., consistent fluorination efficiency). The system may also be used for synthesis optimization.
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公开(公告)号：US11383235B2
公开(公告)日：2022-07-12
申请号：US16339344
申请日：2017-10-06
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Jia Wang , R. Michael Van Dam
Abstract: A microfluidic synthesis platform includes a microfluidic chip holder that has a computer controlled heating element and cooling element therein. A microfluidic chip is mountable in the microfluidic chip holder. The microfluidic chip is formed by a hydrophobic substrate having patterned thereon a hydrophilic reaction site and a plurality of hydrophilic channels or pathways extending outward from the hydrophilic reaction site and terminating at respective loading sites on the substrate, wherein the hydrophilic channels or pathways are tapered with an increasing width in an inward direction toward the hydrophilic reaction site. A fixture is provided for holding a plurality of non-contact reagent dispensing devices above the microfluidic chip at locations corresponding to the loading sites of the plurality of hydrophilic channels or pathways, the fixture further holding a moveable collection tube disposed above the hydrophilic reaction site of the microfluidic chip for removing droplets containing reaction products.
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公开(公告)号：US20200179927A1
公开(公告)日：2020-06-11
申请号：US16339344
申请日：2017-10-06
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Jia Wang , R. Michael Van Dam
Abstract: A microfluidic synthesis platform includes a microfluidic chip holder that has a computer controlled heating element and cooling element therein. A microfluidic chip is mountable in the microfluidic chip holder. The microfluidic chip is formed by a hydrophobic substrate having patterned thereon a hydrophilic reaction site and a plurality of hydrophilic channels or pathways extending outward from the hydrophilic reaction site and terminating at respective loading sites on the substrate, wherein the hydrophilic channels or pathways are tapered with an increasing width in an inward direction toward the hydrophilic reaction site. A fixture is provided for holding a plurality of non-contact reagent dispensing devices above the microfluidic chip at locations corresponding to the loading sites of the plurality of hydrophilic channels or pathways, the fixture further holding a moveable collection tube disposed above the hydrophilic reaction site of the microfluidic chip for removing droplets containing reaction products.
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5.发明公开公开(公告)号：US20240171480A1
公开(公告)日：2024-05-23
申请号：US17993589
申请日：2022-11-23
Inventor： Amit Kumar Sheoran , Xiaofeng Shi , Jia Wang , Chen Qian , Matthew Osinski
IPC: H04L41/5019 , H04L41/0631 , H04L41/0654 , H04L41/16 , H04L41/5067 , H04W24/04
CPC classification number: H04L41/5019 , H04L41/0631 , H04L41/0654 , H04L41/16 , H04L41/5067 , H04W24/04
Abstract: Aspects of the subject disclosure may include, for example, training a first machine learning model based on a combination of labeled training data and unlabeled training data, the first machine learning model producing augmented training data, training a second machine learning model based on a combination of the labeled training data and the augmented training data, receiving, at a client device, customer information about a service degradation at a user equipment (UE) device of a customer in a cellular network, providing the customer information to the second machine learning model, receiving, at the client device, from the second machine learning model, information identifying a root cause of the service degradation, and modifying a network component of the cellular network or the UE device, based on the information identifying a root cause of the service degradation. Other embodiments are disclosed.
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Patent Agency Ranking
公开(公告)号：US20240121628A1
公开(公告)日：2024-04-11
申请号：US17957981
申请日：2022-09-30
Inventor： Jia Wang , Xiaofeng Shi , Amit Kumar Sheoran , Matthew Osinski , Chen Qian
IPC: H04W24/02 , H04L41/16 , H04L41/507 , H04W36/30
CPC classification number: H04W24/02 , H04L41/16 , H04L41/507 , H04W36/30
Abstract: Aspects of the subject disclosure may include, for example, categorizing users of a cellular network according to a plurality of user categories, identifying, by a machine learning model, a service degradation in the cellular network, identifying at least one affected user, the at least one affected user being affected by the service degradation, identifying one or more affected user categories including the at least one affected user, identifying potentially affected users, the potentially affected users being categorized according to the one or more affected user categories, and taking action to isolate the potentially affected users from the service degradation. Other embodiments are disclosed.
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公开(公告)号：US20220251025A1
公开(公告)日：2022-08-11
申请号：US17612206
申请日：2020-05-22
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： R. Michael van Dam , Jia Wang
IPC: C07C227/16 , B01L9/00 , C07B59/00 , B01J19/00 , B01L3/00
Abstract: A chemical synthesis platform based on a particularly simple chip is described herein, where reactions take place atop a hydrophobic substrate patterned with a circular hydrophilic liquid trap. The overall supporting hardware (heater, rotating carousel of reagent dispensers, etc.) can be packaged into a very compact format (about the size of a coffee cup). We demonstrate the consistent synthesis of [18F]fallypride with high yield, and show that protocols optimized using a high-throughput optimization platform we have developed can be readily translated to this device with no changes or reoptimization.
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公开(公告)号：US20220244228A1
公开(公告)日：2022-08-04
申请号：US17605213
申请日：2020-04-15
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： R. Michael van DAM , Jia Wang , Alejandra Rios
Abstract: A method of performing high-throughput radio thin layer chromatography (radio-TLC) includes spotting a plurality of locations on one or more TLC plates with samples containing a radiochemical or a radiopharmaceutical, each location defining an individual lane on the one or more TLC plates for the respective samples. The one or more TLC plates are developed with a developing solution and dried. The TLC plates are imaged with an imaging device comprising a camera, wherein the image obtained from the camera comprises a field of view that contains regions of interest (ROIs) from the plurality of lanes. The ROIs in the images obtained from the camera may then be analyzed by the user. The ROIs may be used, for example, reaction optimization or for quality control check of the production of radiotracers.
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公开(公告)号：US12078625B2
公开(公告)日：2024-09-03
申请号：US17605213
申请日：2020-04-15
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： R. Michael van Dam , Jia Wang , Alejandra Rios
Abstract: A method of performing high-throughput radio thin layer chromatography (radio-TLC) includes spotting a plurality of locations on one or more TLC plates with samples containing a radiochemical or a radiopharmaceutical, each location defining an individual lane on the one or more TLC plates for the respective samples. The one or more TLC plates are developed with a developing solution and dried. The TLC plates are imaged with an imaging device comprising a camera, wherein the image obtained from the camera comprises a field of view that contains regions of interest (ROIs) from the plurality of lanes. The ROIs in the images obtained from the camera may then be analyzed by the user. The ROIs may be used, for example, reaction optimization or for quality control check of the production of radiotracers.
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公开(公告)号：US20240114362A1
公开(公告)日：2024-04-04
申请号：US17957956
申请日：2022-09-30
Inventor： Jia Wang , Amit Kumar Sheoran , Xiaofeng Shi , Matthew Osinski , Chen Qian
Abstract: Aspects of the subject disclosure may include, for example, receiving, from a machine learning model, information about an event causing a service degradation in a cellular network, wherein the event is external to the cellular network, determining one or more event categories associated with the event causing the service degradation, determining, based on the one or more event categories, likely affected customers, the likely affected customers being likely to experience the service degradation, determining, by the machine learning model, proper resources for resolution of the service degradation, wherein the determining proper resources is based on the one or more event categories, and dispatching the proper resources for resolution of the service degradation. Other embodiments are disclosed.
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