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公开(公告)号：US10677708B2
公开(公告)日：2020-06-09
申请号：US16100726
申请日：2018-08-10
Applicant: The Regents of the University of Michigan
Inventor： Sunitha Nagrath , Hyeun Joong Yoon , Eric Lin , Max S. Wicha , Lianette Rivera Baez , Diane M. Simeone
Abstract: A microfluidic device for detecting rare cells in a fluid sample comprises the rare cell and other cells. The microfluidic device comprises an inlet for receiving the fluid sample, a labyrinth channel structure in fluid communication with the inlet, and an outlet in fluid communication with the labyrinth channel structure for collecting the rare cells separated from the other cells in the fluid sample. The labyrinth channel structure comprises at least one channel through which the fluid sample flows. The at least one channel has a plurality of segments and a plurality of corners with each corner defined between adjacent segments. The presence of the plurality of corners induces separation of the rare cells from the other cells in the fluid sample as the rare cells move to a first equilibrium position within the at least one channel when a ratio of inertial lift forces (FZ) and Dean flow (FD) of the fluid sample is from 2 to 10.
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公开(公告)号：US10073024B2
公开(公告)日：2018-09-11
申请号：US14439429
申请日：2013-10-29
Applicant: The Regents Of The University Of Michigan
Inventor： Sunitha Nagrath , Hyeun Joong Yoon , Eric Lin , Max S. Wicha , Lianette Rivera Baez , Diane M. Simeone
CPC classification number: G01N15/1056 , B01L3/502715 , B01L3/502753 , B01L3/502761 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2300/0883 , G01N15/0272 , G01N33/5005 , G01N33/574 , G01N2015/0065 , G01N2015/008 , G01N2015/0288 , G01N2015/1006 , G01N2015/1081
Abstract: A microfluidic device for detecting rare cells in a fluid sample comprises the rare cell and other cells. The microfluidic device comprises an inlet for receiving the fluid sample, a labyrinth channel structure in fluid communication with the inlet, and an outlet in fluid communication with the labyrinth channel structure for collecting the rare cells separated from the other cells in the fluid sample. The labyrinth channel structure comprises at least one channel through which the fluid sample flows. The at least one channel has a plurality of segments and a plurality of corners with each corner defined between adjacent segments. The presence of the plurality of corners induces separation of the rare cells from the other cells in the fluid sample as the rare cells move to a first equilibrium position within the at least one channel when a ratio of inertial lift forces (FZ) and Dean flow (FD) of the fluid sample is from 2 to 10.
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公开(公告)号：US20190017919A1
公开(公告)日：2019-01-17
申请号：US16100726
申请日：2018-08-10
Applicant: The Regents of the University of Michigan
Inventor： Sunitha Nagrath , Hyeun Joong Yoon , Eric Lin , Max S. Wicha , Lianette Rivera Baez , Diane M. Simeone
CPC classification number: G01N15/1056 , B01L3/502715 , B01L3/502753 , B01L3/502761 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2300/0883 , G01N15/0272 , G01N33/5005 , G01N33/574 , G01N2015/0065 , G01N2015/008 , G01N2015/0288 , G01N2015/1006 , G01N2015/1081
Abstract: A microfluidic device for detecting rare cells in a fluid sample comprises the rare cell and other cells. The microfluidic device comprises an inlet for receiving the fluid sample, a labyrinth channel structure in fluid communication with the inlet, and an outlet in fluid communication with the labyrinth channel structure for collecting the rare cells separated from the other cells in the fluid sample. The labyrinth channel structure comprises at least one channel through which the fluid sample flows. The at least one channel has a plurality of segments and a plurality of corners with each corner defined between adjacent segments. The presence of the plurality of corners induces separation of the rare cells from the other cells in the fluid sample as the rare cells move to a first equilibrium position within the at least one channel when a ratio of inertial lift forces (FZ) and Dean flow (FD) of the fluid sample is from 2 to 10.
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公开(公告)号：US20150293010A1
公开(公告)日：2015-10-15
申请号：US14439429
申请日：2013-10-29
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor： Sunitha Nagrath , Hyeun Joong Yoon , Eric Lin , Max S. Wicha , Lianette Rivera Baez , Diane M. Simeone
CPC classification number: G01N15/1056 , B01L3/502715 , B01L3/502753 , B01L3/502761 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2300/0883 , G01N15/0272 , G01N33/5005 , G01N33/574 , G01N2015/0065 , G01N2015/008 , G01N2015/0288 , G01N2015/1006 , G01N2015/1081
Abstract: A microfluidic device for detecting rare cells in a fluid sample comprises the rare cell and other cells. The microfluidic device comprises an inlet for receiving the fluid sample, a labyrinth channel structure in fluid communication with the inlet, and an outlet in fluid communication with the labyrinth channel structure for collecting the rare cells separated from the other cells in the fluid sample. The labyrinth channel structure comprises at least one channel through which the fluid sample flows. The at least one channel has a plurality of segments and a plurality of corners with each corner defined between adjacent segments. The presence of the plurality of corners induces separation of the rare cells from the other cells in the fluid sample as the rare cells move to a first equilibrium position within the at least one channel when a ratio of inertial lift forces (FZ) and Dean flow (FD) of the fluid sample is from 2 to 10.
Abstract translation: 用于检测流体样品中稀有细胞的微流体装置包括稀有细胞和其它细胞。 微流体装置包括用于接收流体样品的入口，与入口流体连通的迷宫式通道结构，以及与迷宫式通道结构流体连通的出口，用于收集与流体样品中的其它细胞分离的稀有细胞。 迷宫通道结构包括流体样品流过的至少一个通道。 所述至少一个通道具有多个段和多个角，其中每个角在相邻段之间限定。 当惯性提升力（FZ）和Dean流量的比率（FZ）和Dean流动时，多个拐角的存在引起稀少细胞与流体样本中的其它细胞的分离，因为稀有细胞移动到至少一个通道内的第一平衡位置 （FD）为2〜10。
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