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    IMMOBILIZED SUBSTRATE ENZYMATIC SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) ASSAYS
    1.
    发明申请
    IMMOBILIZED SUBSTRATE ENZYMATIC SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) ASSAYS 有权

    公开(公告)号：US20210003581A1

    公开(公告)日：2021-01-07

    申请号：US16316127

    申请日：2017-08-07

    申请人： The Texas A&M University System

    发明人： Gerard L. COTE ,  Javier T. GARZA

    IPC分类号： G01N33/58 ,  G01N33/543 ,  G01N21/65

    摘要： Provided are methods of quantifying analyte concentration in a sample by providing a pre-screened amount of an enzyme that has been pre-screened against the analyte in the sample; associating the pre-screened enzyme with a Raman reporter molecule that reacts with the enzyme to result in a change in the Raman spectrum pattern of the Raman reporter molecule; detecting the change in the Raman spectrum pattern of the Raman reporter molecule; and correlating the change (e.g., change rate) to the concentration of the analyte in the sample. Pre-screening may affect the concentration or activity of the enzyme in proportion to analyte concentration. Correlation may occur by correlating the change in the Raman spectrum pattern of the Raman reporter molecule to the concentration of the pre-screened amount of the enzyme, and correlating the concentration of the pre-screened amount of the enzyme to the concentration of the analyte in the sample.

    MULTISPECTRAL OPTICAL FINGER SYSTEM FOR PHYSIOLOGICAL MEASUREMENTS
    2.
    发明公开
    MULTISPECTRAL OPTICAL FINGER SYSTEM FOR PHYSIOLOGICAL MEASUREMENTS 审中-公开

    公开(公告)号：US20240249553A1

    公开(公告)日：2024-07-25

    申请号：US18418887

    申请日：2024-01-22

    申请人： THE TEXAS A&M UNIVERSITY SYSTEM

    发明人： Kimberly BRANAN ,  Gerard L. COTE ,  Justin MCMURRAY

    IPC分类号： G06V40/145 ,  G06F3/01

    CPC分类号： G06V40/145 ,  G06F3/014

    摘要： Wearable optical devices, methods and systems for obtain dynamic and static physiological parameters from a subject are disclosed. Example devices can be worn around an appendage, such as a finger, and utilize PPG sensors to obtain signals from the appendage. The PPG sensors are positioned to acquire signals suitable to reconstruct an image of the inner appendage using, for example, diffuse optical tomography, to provide additional information. The devices, methods, and systems can obtain dynamic and static physiological parameters and accurate images in real-time.