公开(公告)号：US20240366095A1

公开(公告)日：2024-11-07

申请号：US18561132

申请日：2022-05-23

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： Gerard L. COTE ,  Justin MCMURRAY ,  Kimberly BRANAN ,  Myeong NAMKOONG ,  Limei TIAN ,  Sung II PARK

IPC: A61B5/021 ,  A61B5/024 ,  A61B5/0531

Abstract: Technologies for multimodal sensing include a wearable device having a flexible substrate and at least one multimodal sensor coupled to the flexible substrate. The multimodal sensor includes a photoplethysmography sensor and a bioimpedance sensor. The wearable device may include context sensors such as an accelerometer, a gyroscope, a temperature sensor, or a pressure sensor. The multimodal sensor may include an integrated pressure sensor. A processor of the wearable device is configured to receive sensor data from the photoplethysmography sensor and the bioimpedance sensor of the multimodal sensor that is indicative of a pulse curve of a user. The processor is further configured to correct the sensor data based on data received from the context sensors and to determine blood pressure data based on the corrected sensor data. The processor may be configured to store the blood pressure data or to transmit the blood pressure data to a remote computing device.

公开(公告)号：US20210003581A1

公开(公告)日：2021-01-07

申请号：US16316127

申请日：2017-08-07

Applicant: The Texas A&M University System

Inventor： Gerard L. COTE ,  Javier T. GARZA

IPC: G01N33/58 ,  G01N33/543 ,  G01N21/65

Abstract: Provided are methods of quantifying analyte concentration in a sample by providing a pre-screened amount of an enzyme that has been pre-screened against the analyte in the sample; associating the pre-screened enzyme with a Raman reporter molecule that reacts with the enzyme to result in a change in the Raman spectrum pattern of the Raman reporter molecule; detecting the change in the Raman spectrum pattern of the Raman reporter molecule; and correlating the change (e.g., change rate) to the concentration of the analyte in the sample. Pre-screening may affect the concentration or activity of the enzyme in proportion to analyte concentration. Correlation may occur by correlating the change in the Raman spectrum pattern of the Raman reporter molecule to the concentration of the pre-screened amount of the enzyme, and correlating the concentration of the pre-screened amount of the enzyme to the concentration of the analyte in the sample.

公开(公告)号：US20250034621A1

公开(公告)日：2025-01-30

申请号：US18782100

申请日：2024-07-24

Applicant: The Texas A&M University System

Inventor： Sayantan TRIPATHY ,  Samuel MABBOTT ,  Gerard L. COTE

IPC: C12Q1/682 ,  G01N33/543 ,  G01N33/68

Abstract: In one aspect, the disclosure relates to a universal method for biomarker extraction and detection from clinical samples using magnetic nanoparticles (MNPs) coupled with a locked aptamer-initiator approach. The MNP bound locked aptamer undergoes a conformational change in the presence of the target biomarker and the unfolded initiator triggers a hybridization chain reaction with a structurally stabilized catalytic trimeric triplex DNAzyme hairpin. Amplicons from the hybridization chain reaction can be incubated with hemin to obtain a stable triplex structure that has horseradish peroxidase-like activity in the presence of H2O2 and a substrate molecule. The intensity of the signal is directly proportional to the amount of biomarker present. Binding one or more reagents on a nanoparticle can be coupled with this approach for use in a microfluidic or paper fluidic platform. In any of these aspects, the assay can detect as low as femtogram amounts of biomarker from the clinical sample.

公开(公告)号：US20240249553A1

公开(公告)日：2024-07-25

申请号：US18418887

申请日：2024-01-22

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： Kimberly BRANAN ,  Gerard L. COTE ,  Justin MCMURRAY

IPC: G06V40/145 ,  G06F3/01

CPC classification number: G06V40/145 ,  G06F3/014

Abstract: Wearable optical devices, methods and systems for obtain dynamic and static physiological parameters from a subject are disclosed. Example devices can be worn around an appendage, such as a finger, and utilize PPG sensors to obtain signals from the appendage. The PPG sensors are positioned to acquire signals suitable to reconstruct an image of the inner appendage using, for example, diffuse optical tomography, to provide additional information. The devices, methods, and systems can obtain dynamic and static physiological parameters and accurate images in real-time.

公开(公告)号：US20240245307A1

公开(公告)日：2024-07-25

申请号：US18418861

申请日：2024-01-22

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： Kimberly BRANAN ,  Cody LEWIS ,  Richard HORNER ,  Gerard L. COTE ,  Darpit DAVE ,  Kathan VYAS ,  Madhav ERRAGUNTLA ,  Ricardo GUTIERREZ-OSUNA ,  Justin MCMURRAY

IPC: A61B5/0205 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0295 ,  A61B5/0533 ,  A61B5/08 ,  A61B5/11 ,  A61B5/282 ,  A61B5/346

CPC classification number: A61B5/02055 ,  A61B5/11 ,  A61B5/282 ,  A61B5/6824 ,  A61B5/7235 ,  A61B5/7275 ,  A61B5/7282 ,  A61B5/01 ,  A61B5/0295 ,  A61B5/0533 ,  A61B5/08 ,  A61B5/346 ,  A61B2562/0219 ,  A61B2562/0233 ,  A61B2562/0271

Abstract: A wearable multi-sensor device for measuring physiological properties includes a plurality of non-invasive sensors, such as a single-sided electrocardiography sensor, a bioimpedance and electrodermal activity sensor, a skin temperature sensor, and a photoplethysmography sensor. The device is configured to secure a skin-facing side of the sensors to exposed skin of a user and includes a communication module configured to receive signals from the plurality of non-invasive sensors and output data from the device, the being suitable for use in predicting glycemic events in the user.