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公开(公告)号:US09061030B2
公开(公告)日:2015-06-23
申请号:US13883910
申请日:2011-11-02
Applicant: Charles Kim , Takashi Nakai , Thomas Wai-Ho Lee , Joel Moore , Nicholas Robert Perl , Jason Rohde
Inventor: Charles Kim , Takashi Nakai , Thomas Wai-Ho Lee , Joel Moore , Nicholas Robert Perl , Jason Rohde
IPC: A61K31/506 , C07D401/04 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D405/14 , A61K31/427 , A61K31/4439 , A61K31/444
CPC classification number: A61K31/5377 , A61K31/427 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61K45/06 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/04 , C07D417/14
Abstract: Compounds of Formula IA and Formula IB are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
Abstract translation: 描述了式IA和式IB的化合物。 它们作为sGC的刺激剂是有用的,特别是NO不依赖于血红素依赖性刺激物。 这些化合物可用于治疗,预防或治疗本文公开的各种疾病。
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公开(公告)号:US08922597B2
公开(公告)日:2014-12-30
申请号:US13415457
申请日:2012-03-08
Applicant: Takashi Nakai , Goki Toshima , Ryutaro Oke , Junichi Maruyama
Inventor: Takashi Nakai , Goki Toshima , Ryutaro Oke , Junichi Maruyama
IPC: G09G3/36
CPC classification number: G09G3/3614 , G09G3/3648 , G09G3/3688 , G09G2320/0204 , G09G2320/0223 , G09G2320/0257
Abstract: A liquid crystal display device includes a plurality of pixel circuits, data lines, and a data-line driving circuit connected to the data lines. Each of the pixel circuits includes a pixel capacitance having one end provided with a common potential. In accordance with a grayscale value for one of the plurality of pixel circuits, the data-line driving circuit selectively outputs a positive-polarity signal and a negative-polarity signal to the one pixel circuit. The data-line driving circuit outputs the positive-polarity signal and the negative-polarity signal so that an average of a potential of the positive-polarity signal and a potential of the negative-polarity signal corresponding to the grayscale value changes in accordance with the grayscale value, a temperature, and a position of the one pixel circuit.
Abstract translation: 液晶显示装置包括连接到数据线的多个像素电路,数据线和数据线驱动电路。 每个像素电路包括一端具有公共电位的像素电容。 根据多个像素电路中的一个像素电路的灰度值,数据线驱动电路选择性地向一个像素电路输出正极性信号和负极性信号。 数据线驱动电路输出正极性信号和负极性信号,使得正极性信号的电位的平均值和对应于灰度值的负极性信号的电位根据 灰度值,温度和一个像素电路的位置。
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公开(公告)号:US08795586B2
公开(公告)日:2014-08-05
申请号:US11720585
申请日:2005-11-14
Applicant: Kinya Kawase , Takashi Nakai
Inventor: Kinya Kawase , Takashi Nakai
IPC: B22F1/00
CPC classification number: B22F3/02 , B22F2998/10 , B22F2999/00 , B22F1/0059 , B22F3/10 , B22F2203/11
Abstract: A sinter of stable quality is produced by molding a powder for powder metallurgy. This process includes successively conducting the following steps: charging a powder and a solid lubricant into a mold compact formation in which the powder charged into the mold is compacted; releasing the compact from the mold; and the powder for powder metallurgy is charged again into the mold after the release step. The temperature of the mold is set at a value in the range of from the boiling point of water to the melting point of the solid lubricant. The compact can be continuously formed without causing, e.g., a failure in the feeding of the powder for powder metallurgy. The sinter obtained by sintering the compact is almost even in strength and density.
Abstract translation: 通过成型用于粉末冶金的粉末来制造质量稳定的烧结体。 该方法包括依次进行以下步骤:将粉末和固体润滑剂装入模压成型体中,在其中将装入模具中的粉末压实; 从模具中释放压块; 粉末冶金粉末在脱模步骤后再次装入模具中。 模具的温度设定在从水的沸点到固体润滑剂的熔点的范围内的值。 可以连续地形成压块,而不会导致例如用于粉末冶金的粉末的供给失败。 通过烧结所得到的烧结体的强度和密度几乎均匀。
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公开(公告)号:US08748442B2
公开(公告)日:2014-06-10
申请号:US13174676
申请日:2011-06-30
Applicant: Charles Kim , Takashi Nakai , Thomas Wai-Ho Lee , Joel Moore , Nicholas Robert Perl , Jason Rohde , Rajesh R Iyengar , Ara Mermerian , Angelika Fretzen
Inventor: Charles Kim , Takashi Nakai , Thomas Wai-Ho Lee , Joel Moore , Nicholas Robert Perl , Jason Rohde , Rajesh R Iyengar , Ara Mermerian , Angelika Fretzen
IPC: A01N43/54 , A61K31/505 , A01N43/40 , A61K31/44 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC classification number: C07D401/04 , A61K31/4155 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/522 , A61K31/5365 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D473/34 , C07D491/048 , C07D498/04 , A61K2300/00
Abstract: Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
Abstract translation: 描述式I化合物。 它们作为sGC的刺激剂是有用的,特别是NO不依赖于血红素依赖性刺激物。 这些化合物可用于治疗,预防或治疗本文公开的各种疾病。
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公开(公告)号:US20140088071A1
公开(公告)日:2014-03-27
申请号:US13883910
申请日:2011-11-02
Applicant: Takashi Nakai , Thomas Wai-Ho Lee , Charles Kim , Joel Moore , Nicholas Robert Perl , Jason Rohde
Inventor: Takashi Nakai , Thomas Wai-Ho Lee , Charles Kim , Joel Moore , Nicholas Robert Perl , Jason Rohde
IPC: A61K31/506 , A61K31/4439 , C07D401/14 , A61K31/427 , C07D401/04 , C07D417/14 , C07D405/14 , C07D403/04 , C07D413/14 , A61K31/444
CPC classification number: A61K31/5377 , A61K31/427 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61K45/06 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/04 , C07D417/14
Abstract: Compounds of Formula (IA) and Formula (IB) are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
Abstract translation: 描述了式(IA)和式(IB)的化合物。 它们作为sGC的刺激剂是有用的,特别是NO不依赖于血红素依赖性刺激物。 这些化合物可用于治疗,预防或治疗本文公开的各种疾病。
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公开(公告)号:US20130178453A1
公开(公告)日:2013-07-11
申请号:US13578009
申请日:2011-02-09
Applicant: Jason Rohde , Bo Peng , Takashi Nakai , Kevin Sprott , Ara Mermerían , Wayne C. Schairer , Galen John Carey
Inventor: Jason Rohde , Bo Peng , Takashi Nakai , Kevin Sprott , Ara Mermerían , Wayne C. Schairer , Galen John Carey
IPC: C07D495/04 , C07D491/048 , A61K31/5377 , A61K31/437 , A61K31/4709 , A61K31/429 , C07D513/04 , A61K45/06 , A61K31/407 , A61K31/404 , A61K31/424
CPC classification number: C07D495/04 , A61K31/404 , A61K31/407 , A61K31/424 , A61K31/429 , A61K31/437 , A61K31/4709 , A61K31/5377 , A61K45/06 , C07D491/048 , C07D513/04 , C07D519/00
Abstract: The present disclosure relates to compounds useful as agonists of the cannabinoid receptors. The disclosure also provides pharmaceutically acceptable compositions comprising the compounds of the disclosure and methods of using the compositions in the treatment of various disorders, either alone or in combination therapy. The compounds of the invention have Formula (I).
Abstract translation: 本公开涉及可用作大麻素受体的激动剂的化合物。 本公开还提供药学上可接受的组合物,其包含本公开的化合物和使用组合物单独或联合治疗中各种疾病的治疗方法。 本发明的化合物具有式(I)。
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7.
公开(公告)号:US20130011866A1
公开(公告)日:2013-01-10
申请号:US13595139
申请日:2012-08-27
Applicant: Tomoyuki Igawa , Shinya Ishii , Atsuhiko Maeda , Takashi Nakai
Inventor: Tomoyuki Igawa , Shinya Ishii , Atsuhiko Maeda , Takashi Nakai
IPC: G01N33/53
CPC classification number: C12N15/1037 , A61K39/12 , A61K39/145 , A61K2039/505 , A61K2039/544 , A61K2039/545 , A61K2039/552 , C07K16/244 , C07K16/248 , C07K16/2866 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N2760/16111 , C12N2760/16134 , C12N2770/20071 , G01N33/6854 , G01N2500/00
Abstract: The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.
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8.
公开(公告)号:US08153053B2
公开(公告)日:2012-04-10
申请号:US12645198
申请日:2009-12-22
Applicant: Takashi Nakai , Kinya Kawase
Inventor: Takashi Nakai , Kinya Kawase
IPC: B22F3/12
CPC classification number: B22F3/02 , B22F2003/026 , B22F2003/145 , B30B15/0011
Abstract: A method for forming a compact from a powder wherein a forming portion 1A in a mold body 2 is filled with a raw powder and upper and lower punches 3,4 are fitted into the forming portion 1A to form the compact. Prior to filling the forming portion 1A with the raw powder M, a solution L with a lubricant being uniformly dissolved in a solvent is applied to a peripheral portion of the forming portion 1A, and then the solution is evaporated, thus forming a crystallized layer B thereon. Thus, the reduction of a force for ejecting the compact is realized, while improving the density of the compact, realizing the stable and successive production of the compact.
Abstract translation: 一种从粉末形成压块的方法,其中模具体2中的成形部分1A填充有原料粉末,上冲头3,4和下冲头3,4装配到成形部分1A中以形成压块。 在用原料粉末M填充成形部1A之前,将具有均匀溶解在溶剂中的润滑剂的溶液L施加到成形部1A的周边部分,然后蒸发溶液,从而形成结晶化层B 上。 因此,在提高压实体的密度的同时,实现了用于压出压块的力的减小,实现了压块的稳定且连续的生产。
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公开(公告)号:US20070222849A1
公开(公告)日:2007-09-27
申请号:US11689928
申请日:2007-03-22
Applicant: Takashi Nakai , Yasutoshi Inoue
Inventor: Takashi Nakai , Yasutoshi Inoue
IPC: B41J2/325
CPC classification number: B41J17/32
Abstract: There is provided an ink sheet cartridge that includes a cartridge case having a case body disposed opposite to an upper surface of an ink sheet unit, driving sidewall portions rotatably supporting driving shafts of respective sheet supply and winding bobbins, and a supporting sidewall portion to rotatably support supporting shafts of respective sheet supply and winding bobbins. The ink sheet unit is detachably insertable in the case body, receives an ink sheet wound around the sheet supply bobbin, and includes a supply sheet case capable of drawing out the ink sheet therefrom at the time of receiving the ink sheet. The ink sheet cartridge enables replacement of the ink sheet unit such that the cartridge case is reusable and protects the replacement ink sheet from foreign objects and substances.
Abstract translation: 提供了一种墨盒盒,其包括:盒壳体,其具有与墨片单元的上表面相对的壳体主体,驱动侧壁部分可旋转地支撑各个供纸和卷绕筒管的驱动轴;以及支撑侧壁部分, 支撑各个片材供应和卷绕筒管的支撑轴。 油墨片单元可拆卸地插入到壳体中,接收卷绕在供纸筒管周围的油墨片,并且包括在接收油墨纸时能够从其中拉出油墨纸的供纸盒。 油墨纸盒可以更换油墨单元,使得盒壳可重复使用,并保护更换的油墨纸免受异物和物质的影响。
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公开(公告)号:USD492696S1
公开(公告)日:2004-07-06
申请号:US29141392
申请日:2001-05-07
Applicant: Shozo Minagawa , Toshio Ishikawa , Takashi Nakai , Robert L. Ripley , Takahide Takeda
Designer: Shozo Minagawa , Toshio Ishikawa , Takashi Nakai , Robert L. Ripley , Takahide Takeda
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