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公开(公告)号：US5247067A
公开(公告)日：1993-09-21
申请号：US666719
申请日：1991-03-08
IPC分类号： C07K14/18
CPC分类号： C07K14/005 , C12N2770/24222 , Y10S530/806
摘要： The present invention relates to a peptide having the amino acid sequence: Lys Arg Ser Thr Asn, Arg Arg Tyr Lys Glu Lys Glu Lys or Ala Ile Ile Pro Asp Arg Glu Val Leu Tyr and which peptide is capable of specifically binding to the antibody which is specific to the non-A, non-B hepatitis associated antigen. The peptide can be used as an anti-HCV antibody assay reagent with high sensitivity.
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2.发明授权DNA sequence and encoded polypeptide useful in the diagnosis of hepatitis disease 失效DNA序列和编码的多肽可用于诊断肝炎病毒
公开(公告)号：US5437974A
公开(公告)日：1995-08-01
申请号：US833838
申请日：1992-02-04
申请人： Terence E. Ryan , Badr Saeed , Mark K. Kieselburg , Robert E. Byrne , Priscilla W. Stevens , Terukatsu Arima , John Todd
发明人： Terence E. Ryan , Badr Saeed , Mark K. Kieselburg , Robert E. Byrne , Priscilla W. Stevens , Terukatsu Arima , John Todd
IPC分类号： A61K39/29 , A61K39/00 , A61K39/395 , A61P31/12 , C07K14/005 , C07K14/02 , C07K14/10 , C07K14/18 , C07K16/00 , C12N1/21 , C12N15/09 , C12P21/02 , C12Q1/68 , C12Q1/70 , C12R1/19 , G01N33/53 , G01N33/576
CPC分类号： G01N33/5767 , C07K14/005 , C12Q1/707 , A61K39/00 , C12N2770/24222 , Y10S436/82
摘要： A novel cDNA clone, 20E, has been isolated and characterized as encoding a previously unknown polypeptide antigen recognized by antibodies in the serum of certain patients with non-A non-B hepatitis (NANBH). The nucleic acid sequence is not represented in the genome of the Hepatitis C Virus (HCV). Neither is the nucleic acid sequence represented in the human genome. The data suggest that the RNA sequence corresponding to clone 20E is contained within the genome of an external infective agent other than HCV, and therefore may represent an additional etiologic agent or contributing factor to the development of NANBH in human patients. The 20E nucleic acid and corresponding polypeptide and respective variants thereof will be useful in a variety of procedures directed at prevention and diagnosis of NANBH.
摘要翻译： 已经分离了一种新的cDNA克隆20E，并将其表征为编码在某些非A非乙型肝炎（NANBH）患者的血清中由抗体识别的先前未知的多肽抗原。 核酸序列不在丙型肝炎病毒（HCV）的基因组中表示。 核酸序列也不在人类基因组中表示。 数据表明，对应于克隆20E的RNA序列被包含在HCV以外的外部感染因子的基因组中，因此可能代表另外的病原体或人类患者中NANBH发展的促成因子。 20E核酸和相应的多肽及其相应变体可用于针对NANBH的预防和诊断的多种方法。
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3.发明授权Peptides immunochemically reactive with antibodies directed against hepatitis Non-A, Non-B virus 失效抗生素对抗乙型肝炎病毒的非抗体，非乙型病毒的免疫细胞免疫反应
公开(公告)号：US5229491A
公开(公告)日：1993-07-20
申请号：US676677
申请日：1991-03-28
IPC分类号： C07K14/18 , G01N33/576
CPC分类号： C07K14/005 , G01N33/5767 , C12N2770/24222 , Y10S436/80
摘要： The invention concerns peptides which react immunochemically with antibodies directed against NANBH. A method for the detection of NANBH or anti-NANBH in a test fluid, an immunochemical reagent and a testkit to be used when applying said detection methods belong to the invention.
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公开(公告)号：US5635346A
公开(公告)日：1997-06-03
申请号：US372723
申请日：1995-01-17
申请人： David C. Leahy , John A. Todd , Michael E. Jolley , Dinesh O. Shah , Delia R. Bethell , Terukatsu Arima
发明人： David C. Leahy , John A. Todd , Michael E. Jolley , Dinesh O. Shah , Delia R. Bethell , Terukatsu Arima
IPC分类号： A61K39/00 , C07K14/005 , C07K14/18 , G01N33/53 , G01N33/543 , G01N33/551 , G01N33/553 , G01N33/576 , C12Q1/70
CPC分类号： C07K14/005 , G01N33/5767 , C12N2770/24222
摘要： New assays for diagnosing NANBH utilizing novel peptide fragments derived from polypeptide antigens reactive to antibodies present in the sera of infected patients are disclosed. In producing these peptides, the portion of the polypeptide contributing to high backgrounds is deleted thereby resulting in assays with an exceptionally high signal to background ratio.
摘要翻译： 公开了利用衍生自对感染患者血清中存在的抗体具有反应性的多肽抗原的新肽片段来诊断NANBH的新的测定法。 在生产这些肽时，有助于高背景的多肽的部分被缺失，从而导致具有非常高的信号与背景比的测定。
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公开(公告)号：US5298394A
公开(公告)日：1994-03-29
申请号：US24976
申请日：1993-03-02
申请人： Terukatsu Arima , Konosuke Fukai
发明人： Terukatsu Arima , Konosuke Fukai
CPC分类号： C07K14/005 , C12Q1/707 , G01N33/5767 , C12N2770/24222 , Y10S436/82 , Y10S530/826
摘要： Disclosed is a non-A, non-B hepatitis virus antigen peptide which exhibits antigen-antibody reaction specificity with at least one of sera from a convalescent patient having acute non-A, non-B hepatitis and sera from a patient having chronic non-A, non-B hepatitis. By the use of the antigen peptide of the present invention, not only the diagnosis of non-A, non-B hepatitis but also the screening of blood for transfusion can be achieved with ease and high reliability. The antigen peptide of the present invention may also be used as the basis for a vaccine against non-A, non-B hepatitis.
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公开(公告)号：US5275947A
公开(公告)日：1994-01-04
申请号：US24973
申请日：1993-03-02
申请人： Terukatsu Arima , Konosuke Fukai
发明人： Terukatsu Arima , Konosuke Fukai
IPC分类号： G01N33/569 , A61K39/29 , C07K14/00 , C07K14/005 , C07K14/02 , C07K14/10 , C07K14/18 , C07K14/195 , C12N1/21 , C12N15/09 , C12N15/51 , C12P21/02 , C12Q1/70 , C12R1/19 , G01N33/576 , G01N33/577 , C12N1/20 , C07H17/00 , C07H19/00
CPC分类号： C07K14/005 , C12Q1/707 , G01N33/5767 , C12N2770/24222
摘要： Disclosed is a non-A, non-B hepatitis virus antigen peptide which exhibits antigen-antibody reaction specificity with at least one of sera from a convalescent patient having acute non-A, non-B hepatitis and sera from a patient having chronic non-A, non-B hepatitis. By the use of the antigen peptide of the present invention, not only the diagnosis of non-A, non-B hepatitis but also the screening of blood for transfusion can be achieved with ease and high reliability. The antigen peptide of the present invention may also be used as the basis for a vaccine against non-A, non-B hepatitis.
摘要翻译： 公开了一种非A非乙型肝炎病毒抗原肽，其与来自具有急性非A型，非B型肝炎的恢复期患者的血清和来自患有慢性非A型非乙型肝炎的患者的血清中的至少一种具有抗原 - 抗体反应特异性， A，非B型肝炎。 通过使用本发明的抗原肽，不仅可以容易且高可靠性地实现非A型，非乙型肝炎的诊断，还可以实现输血用血液的筛选。 本发明的抗原肽也可以用作针对非A非乙型肝炎的疫苗的基础。
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公开(公告)号：US5191064A
公开(公告)日：1993-03-02
申请号：US401271
申请日：1989-08-31
申请人： Terukatsu Arima , Konosuke Fukai
发明人： Terukatsu Arima , Konosuke Fukai
IPC分类号： C07K14/18 , C12N15/51 , C12Q1/70 , G01N33/576
CPC分类号： C07K14/005 , C12Q1/707 , G01N33/5767 , C12N2770/24222 , Y10S436/82 , Y10S530/826
摘要： Disclosed is a non-A, non-B hepatitis virus antigen peptide which exhibits antigen-antibody reaction specificity with at least one of sera from a convalescent patient having acute non-A, non-B hepatitis and sera from a patient having chronic non-A, non-B hepatitis. By the use of the antigen peptide of the present invention, not only the diagnosis of non-A, non-B hepatitis but also the screening of blood for transfusion can be achieved with ease and high reliability. The antigen peptide of the present invention may also be used as the basis for a vaccine against non-A, non-B hepatitis.
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